Ola Myklebost
- Project leader; Professor, dr. philos
- +47-5548 4565
Ola Myklebost is Senior Scientist and part-time Project Leader at the Department of Tumor Biology, Institute for Cancer Research, and Professor at the Department of Clinical Science at the University of Bergen. His new web page is at myklebost.uib.no.
Publications 2024
Multi-omics profiling of longitudinal samples reveals early genomic changes in follicular lymphoma
Blood Cancer J, 14 (1), 147
DOI 10.1038/s41408-024-01124-5, PubMed 39191762
Deciphering the role of FUS::DDIT3 expression and tumor microenvironment in myxoid liposarcoma development
J Transl Med, 22 (1), 389
DOI 10.1186/s12967-024-05211-w, PubMed 38671504
Evolutionary mode and timing of dissemination of high-grade serous carcinomas
JCI Insight, 9 (3)
DOI 10.1172/jci.insight.170423, PubMed 38175731
Systematic analysis of RNA-binding proteins identifies targetable therapeutic vulnerabilities in osteosarcoma
Nat Commun, 15 (1), 2810
DOI 10.1038/s41467-024-47031-y, PubMed 38561347
Publications 2023
The interplay between neoantigens and immune cells in sarcomas treated with checkpoint inhibition
Front Immunol, 14, 1226445
DOI 10.3389/fimmu.2023.1226445, PubMed 37799721
Heritable defects in telomere and mitotic function selectively predispose to sarcomas
Science, 379 (6629), 253-260
DOI 10.1126/science.abj4784, PubMed 36656928
Chromosomal instability and a deregulated cell cycle are intrinsic features of high-risk gastrointestinal stromal tumours with a metastatic potential
Mol Oncol, 17 (11), 2432-2450
DOI 10.1002/1878-0261.13514, PubMed 37622176
Publications 2022
Clonal evolution after treatment pressure in multiple myeloma: heterogenous genomic aberrations and transcriptomic convergence
Leukemia, 36 (7), 1887-1897
DOI 10.1038/s41375-022-01597-y, PubMed 35643867
miR-486-5p expression is regulated by DNA methylation in osteosarcoma
BMC Genomics, 23 (1), 142
DOI 10.1186/s12864-022-08346-6, PubMed 35172717
Clonal evolution in primary breast cancers under sequential epirubicin and docetaxel monotherapy
Genome Med, 14 (1), 86
DOI 10.1186/s13073-022-01090-2, PubMed 35948919
Publications 2021
Clinical and molecular implications of NAB2-STAT6 fusion variants in solitary fibrous tumour
Pathology, 53 (6), 713-719
DOI 10.1016/j.pathol.2020.11.010, PubMed 33745702
Discovery of novel candidates for anti-liposarcoma therapies by medium-scale high-throughput drug screening
PLoS One, 16 (3), e0248140
DOI 10.1371/journal.pone.0248140, PubMed 33690666
Cancer Predisposition Sequencing Reporter (CPSR): A flexible variant report engine for high-throughput germline screening in cancer
Int J Cancer, 149 (11), 1955-1960
DOI 10.1002/ijc.33749, PubMed 34310709
Multimodal analysis of cell-free DNA whole-genome sequencing for pediatric cancers with low mutational burden
Nat Commun, 12 (1), 3230
DOI 10.1038/s41467-021-23445-w, PubMed 34050156
Methylation-dependent SUMOylation of the architectural transcription factor HMGA2
Biochem Biophys Res Commun, 552, 91-97
DOI 10.1016/j.bbrc.2021.02.099, PubMed 33744765
The expressed mutational landscape of microsatellite stable colorectal cancers
Genome Med, 13 (1), 142
DOI 10.1186/s13073-021-00955-2, PubMed 34470667
Publications 2020
Cell Fusion of Mesenchymal Stem/Stromal Cells and Breast Cancer Cells Leads to the Formation of Hybrid Cells Exhibiting Diverse and Individual (Stem Cell) Characteristics
Int J Mol Sci, 21 (24)
DOI 10.3390/ijms21249636, PubMed 33348862
Accurate 3-gene-signature for early diagnosis of liposarcoma progression
Clin Sarcoma Res, 10, 4
DOI 10.1186/s13569-020-0126-1, PubMed 32158531
Mutational dynamics and immune evasion in diffuse large B-cell lymphoma explored in a relapse-enriched patient series
Blood Adv, 4 (9), 1859-1866
DOI 10.1182/bloodadvances.2019001325, PubMed 32374878
Publications 2019
Preclinical Evaluation of the Pan-FGFR Inhibitor LY2874455 in FRS2-Amplified Liposarcoma
Cells, 8 (2)
DOI 10.3390/cells8020189, PubMed 30795553
Publications 2018
Patterns of genomic evolution in advanced melanoma
Nat Commun, 9 (1), 2665
DOI 10.1038/s41467-018-05063-1, PubMed 29991680
Preclinical Evaluation of Vemurafenib as Therapy for BRAFV600E Mutated Sarcomas
Int J Mol Sci, 19 (4)
DOI 10.3390/ijms19040969, PubMed 29570692
Evaluation of commercial DNA and RNA extraction methods for high-throughput sequencing of FFPE samples
PLoS One, 13 (5), e0197456
DOI 10.1371/journal.pone.0197456, PubMed 29771965
Multifocal Primary Prostate Cancer Exhibits High Degree of Genomic Heterogeneity
Eur Urol, 75 (3), 498-505
DOI 10.1016/j.eururo.2018.08.009, PubMed 30181068
Personal Cancer Genome Reporter: variant interpretation report for precision oncology
Bioinformatics, 34 (10), 1778-1780
DOI 10.1093/bioinformatics/btx817, PubMed 29272339
Noninvasive Detection of ctDNA Reveals Intratumor Heterogeneity and Is Associated with Tumor Burden in Gastrointestinal Stromal Tumor
Mol Cancer Ther, 17 (11), 2473-2480
DOI 10.1158/1535-7163.MCT-18-0174, PubMed 30097488
Real-Time Vital Mineralization Detection and Quantification during In Vitro Osteoblast Differentiation
Biol Proced Online, 20, 14
DOI 10.1186/s12575-018-0079-4, PubMed 30078998
Report from the 4th European Bone Sarcoma Networking meeting: focus on osteosarcoma
Clin. Sarcoma Res., 8, 17
DOI 10.1186/s13569-018-0103-0
Sample-Index Misassignment Impacts Tumour Exome Sequencing
Sci Rep, 8 (1), 5307
DOI 10.1038/s41598-018-23563-4, PubMed 29593270
Publications 2017
Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma
Nat Commun, 8, 15936
DOI 10.1038/ncomms15936, PubMed 28643781
Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies
Mol Cancer, 16 (1), 116
DOI 10.1186/s12943-017-0691-y, PubMed 28683746
Analysis of the miR-34 family functions in breast cancer reveals annotation error of miR-34b
Sci Rep, 7 (1), 9655
DOI 10.1038/s41598-017-10189-1, PubMed 28848235
High number of kinome-mutations in non-small cell lung cancer is associated with reduced immune response and poor relapse-free survival
Int J Cancer, 141 (1), 184-190
DOI 10.1002/ijc.30726, PubMed 28387924
Use of liquid biopsies to monitor disease progression in a sarcoma patient: a case report
BMC Cancer, 17 (1), 29
DOI 10.1186/s12885-016-2992-8, PubMed 28061772
Monitoring multiple myeloma by quantification of recurrent mutations in serum
Haematologica, 102 (7), 1266-1272
DOI 10.3324/haematol.2016.160564, PubMed 28385781
PP2A Regulatory Subunit B55γ is a Gatekeeper of Osteoblast Maturation and Lineage Maintenance
Stem Cells Dev, 26 (19), 1375-1383
DOI 10.1089/scd.2017.0129, PubMed 28805158
Multilevel genomics of colorectal cancers with microsatellite instability-clinical impact of JAK1 mutations and consensus molecular subtype 1
Genome Med, 9 (1), 46
DOI 10.1186/s13073-017-0434-0, PubMed 28539123
Publications 2016
Monogenic and polygenic determinants of sarcoma risk: an international genetic study
Lancet Oncol, 17 (9), 1261-71
DOI 10.1016/S1470-2045(16)30147-4, PubMed 27498913
Genome Analysis of Osteosarcoma Progression Samples Identifies FGFR1 Overexpression as a Potential Treatment Target and CHM as a Candidate Tumor Suppressor Gene
PLoS One, 11 (9), e0163859
DOI 10.1371/journal.pone.0163859, PubMed 27685995
TP53 Mutation Spectrum in Smokers and Never Smoking Lung Cancer Patients
Front Genet, 7, 85
DOI 10.3389/fgene.2016.00085, PubMed 27242894
Preclinical evaluation of potential therapeutic targets in dedifferentiated liposarcoma
Oncotarget, 7 (34), 54583-54595
DOI 10.18632/oncotarget.10518, PubMed 27409346
Corrigendum: Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells
Genome Res, 26 (5), 717.2
DOI 10.1101/gr.206557.116, PubMed 27197245
The ENCCA-WP7/EuroSarc/EEC/PROVABES/EURAMOS 3rd European Bone Sarcoma Networking Meeting/Joint Workshop of EU Bone Sarcoma Translational Research Networks; Vienna, Austria, September 24-25, 2015. Workshop Report
Clin Sarcoma Res, 6, 3
DOI 10.1186/s13569-016-0043-5, PubMed 27315524
Unscrambling the genomic chaos of osteosarcoma reveals extensive transcript fusion, recurrent rearrangements and frequent novel TP53 aberrations
Oncotarget, 7 (5), 5273-88
DOI 10.18632/oncotarget.6567, PubMed 26672768
HSP90 inhibition blocks ERBB3 and RET phosphorylation in myxoid/round cell liposarcoma and causes massive cell death in vitro and in vivo
Oncotarget, 7 (1), 433-45
DOI 10.18632/oncotarget.6336, PubMed 26595521
The Genomic Landscape of Pancreatic and Periampullary Adenocarcinoma
Cancer Res, 76 (17), 5092-102
DOI 10.1158/0008-5472.CAN-16-0658, PubMed 27488532
Publications 2015
Genome sequencing in research requires a new approach to consent
Tidsskr Nor Laegeforen, 135 (22), 2031-2
DOI 10.4045/tidsskr.15.0944, PubMed 26627287
Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells
Genome Res, 25 (6), 814-24
DOI 10.1101/gr.190470.115, PubMed 25963125
Genomic landscape of liposarcoma
Oncotarget, 6 (40), 42429-44
DOI 10.18632/oncotarget.6464, PubMed 26643872
Personalized cancer therapy for soft tissue sarcomas: progress and pitfalls
Per Med, 12 (6), 593-602
DOI 10.2217/pme.15.20, PubMed 29750616
Bone marrow stroma-derived PGE2 protects BCP-ALL cells from DNA damage-induced p53 accumulation and cell death
Mol Cancer, 14 (1), 14
DOI 10.1186/s12943-014-0278-9, PubMed 25623255
BRAF V600E mutation in early-stage multiple myeloma: good response to broad acting drugs and no relation to prognosis
Blood Cancer J, 5 (3), e299
DOI 10.1038/bcj.2015.24, PubMed 25794135
Metabolic reprogramming of metastatic breast cancer and melanoma by let-7a microRNA
Oncotarget, 6 (4), 2451-65
DOI 10.18632/oncotarget.3235, PubMed 25669981
Publications 2014
Workshop report on the 2nd Joint ENCCA/EuroSARC European bone sarcoma network meeting: integration of clinical trials with tumour biology
Clin. Sarcoma Res., 4, 4
DOI 10.1186/2045-3329-4-4
Reexpression of LSAMP inhibits tumor growth in a preclinical osteosarcoma model
Mol Cancer, 13, 93
DOI 10.1186/1476-4598-13-93, PubMed 24885297
Performance comparison of four exome capture systems for deep sequencing
BMC Genomics, 15 (1), 449
DOI 10.1186/1471-2164-15-449, PubMed 24912484
The architecture and evolution of cancer neochromosomes
Cancer Cell, 26 (5), 653-67
DOI 10.1016/j.ccell.2014.09.010, PubMed 25517748
The regulatory landscape of osteogenic differentiation
Stem Cells, 32 (10), 2780-93
DOI 10.1002/stem.1759, PubMed 24898411
Generation and characterization of an immortalized human mesenchymal stromal cell line
Stem Cells Dev, 23 (19), 2377-89
DOI 10.1089/scd.2013.0599, PubMed 24857590
Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes
Science, 345 (6196), 1251343
DOI 10.1126/science.1251343, PubMed 25082706
Generation and characterisation of novel pancreatic adenocarcinoma xenograft models and corresponding primary cell lines
PLoS One, 9 (8), e103873
DOI 10.1371/journal.pone.0103873, PubMed 25148029
Publications 2013
Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone
Nat Genet, 45 (12), 1479-82
DOI 10.1038/ng.2814, PubMed 24162739
Identification of PPAP2B as a novel recurrent translocation partner gene of HMGA2 in lipomas
Genes Chromosomes Cancer, 52 (6), 580-90
DOI 10.1002/gcc.22055, PubMed 23508853
A small molecule approach to engineering vascularized tissue
Biomaterials, 34 (12), 3053-63
DOI 10.1016/j.biomaterials.2012.12.037, PubMed 23369216
IR/IGF1R signaling as potential target for treatment of high-grade osteosarcoma
BMC Cancer, 13, 245
DOI 10.1186/1471-2407-13-245, PubMed 23688189
Functional characterisation of osteosarcoma cell lines and identification of mRNAs and miRNAs associated with aggressive cancer phenotypes
Br J Cancer, 109 (8), 2228-36
DOI 10.1038/bjc.2013.549, PubMed 24064976
Common fusion transcripts identified in colorectal cancer cell lines by high-throughput RNA sequencing
Transl Oncol, 6 (5), 546-53
DOI 10.1593/tlo.13457, PubMed 24151535
Comparison of glioma stem cells to neural stem cells from the adult human brain identifies dysregulated Wnt- signaling and a fingerprint associated with clinical outcome
Exp Cell Res, 319 (14), 2230-43
DOI 10.1016/j.yexcr.2013.06.004, PubMed 23791939
Epigenetic regulation and functional characterization of microRNA-142 in mesenchymal cells
PLoS One, 8 (11), e79231
DOI 10.1371/journal.pone.0079231, PubMed 24236112
Photochemical internalization of CD133-targeting immunotoxins efficiently depletes sarcoma cells with stem-like properties and reduces tumorigenicity
Biochim Biophys Acta, 1830 (8), 4235-43
DOI 10.1016/j.bbagen.2013.04.033, PubMed 23643966
The tankyrase-specific inhibitor JW74 affects cell cycle progression and induces apoptosis and differentiation in osteosarcoma cell lines
Cancer Med, 3 (1), 36-46
DOI 10.1002/cam4.170, PubMed 24403055
Publications 2012
Integrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma
PLoS One, 7 (11), e48262
DOI 10.1371/journal.pone.0048262, PubMed 23144859
Identification of osteosarcoma driver genes by integrative analysis of copy number and gene expression data
Genes Chromosomes Cancer, 51 (7), 696-706
DOI 10.1002/gcc.21956, PubMed 22454324
Global gene expression profiling of human osteosarcomas reveals metastasis-associated chemokine pattern
Sarcoma, 2012, 639038
DOI 10.1155/2012/639038, PubMed 22518090
Modulation of the osteosarcoma expression phenotype by microRNAs
PLoS One, 7 (10), e48086
DOI 10.1371/journal.pone.0048086, PubMed 23133552
Correlation of TP53 and MDM2 genotypes with response to therapy in sarcoma
Cancer, 119 (5), 1013-22
DOI 10.1002/cncr.27837, PubMed 23165797
[Genome sequencing for personalized cancer treatment]
Tidsskr Nor Laegeforen, 132 (21), 2406-8
DOI 10.4045/tidsskr.12.0784, PubMed 23160594
Characterization of liposarcoma cell lines for preclinical and biological studies
Sarcoma, 2012, 148614
DOI 10.1155/2012/148614, PubMed 22911243
Publications 2011
Tumor-infiltrating macrophages are associated with metastasis suppression in high-grade osteosarcoma: a rationale for treatment with macrophage activating agents
Clin Cancer Res, 17 (8), 2110-9
DOI 10.1158/1078-0432.CCR-10-2047, PubMed 21372215
Genome wide single cell analysis of chemotherapy resistant metastatic cells in a case of gastroesophageal adenocarcinoma
BMC Cancer, 11, 455
DOI 10.1186/1471-2407-11-455, PubMed 22014070
Preclinical xenograft models of human sarcoma show nonrandom loss of aberrations
Cancer, 118 (2), 558-70
DOI 10.1002/cncr.26276, PubMed 21713766
mRNA expression profiles of primary high-grade central osteosarcoma are preserved in cell lines and xenografts
BMC Med Genomics, 4, 66
DOI 10.1186/1755-8794-4-66, PubMed 21933437
MDM2 antagonist Nutlin-3a potentiates antitumour activity of cytotoxic drugs in sarcoma cell lines
BMC Cancer, 11, 211:1-11
DOI 10.1186/1471-2407-11-211, PubMed 21624110
Adipocyte differentiation of human bone marrow-derived stromal cells is modulated by microRNA-155, microRNA-221, and microRNA-222
Stem Cells Dev, 21 (6), 873-83
DOI 10.1089/scd.2010.0503, PubMed 21756067
Liposarcoma Cells with Aldefluor and CD133 Activity have a Cancer Stem Cell Potential
Clin Sarcoma Res, 1 (1), 8
DOI 10.1186/2045-3329-1-8, PubMed 22612877
Workshop Report on the European Bone Sarcoma Networking Meeting: Integration of Clinical Trials with Tumor Biology
J Adolesc Young Adult Oncol, 1 (3), 118-23
DOI 10.1089/jayao.2012.0005, PubMed 26811922
Publications 2010
Genomic alterations reveal potential for higher grade transformation in follicular lymphoma and confirm parallel evolution of tumor cell clones
Blood, 116 (9), 1489-97
DOI 10.1182/blood-2010-03-272278, PubMed 20505157
Identification of target genes for wild type and truncated HMGA2 in mesenchymal stem-like cells
BMC Cancer, 10, 329
DOI 10.1186/1471-2407-10-329, PubMed 20576167
DNA copy number changes in human malignant fibrous histiocytomas by array comparative genomic hybridisation
PLoS One, 5 (11), e15378
DOI 10.1371/journal.pone.0015378, PubMed 21085701
Evaluation of high-resolution microarray platforms for genomic profiling of bone tumours
BMC Res Notes, 3, 223
DOI 10.1186/1756-0500-3-223, PubMed 20691109
A tissue microarray study of osteosarcoma: histopathologic and immunohistochemical validation of xenotransplanted tumors as preclinical models
Appl Immunohistochem Mol Morphol, 18 (5), 453-61
DOI 10.1097/PAI.0b013e3181daace3, PubMed 20436344
Molecular characterization of commonly used cell lines for bone tumor research: a trans-European EuroBoNet effort
Genes Chromosomes Cancer, 49 (1), 40-51
DOI 10.1002/gcc.20717, PubMed 19787792
Extensive adipogenic and osteogenic differentiation of patterned human mesenchymal stem cells in a microfluidic device
Lab Chip, 10 (11), 1401-1409
DOI 10.1039/b926738g, PubMed 20386793
Publications 2009
LSAMP, a novel candidate tumor suppressor gene in human osteosarcomas, identified by array comparative genomic hybridization
Genes Chromosomes Cancer, 48 (8), 679-93
DOI 10.1002/gcc.20675, PubMed 19441093
Upregulation of stem cell genes in multidrug resistant K562 leukemia cells
Leuk Res, 33 (10), 1379-85
DOI 10.1016/j.leukres.2009.03.028, PubMed 19394083
Stamcellenes mørke side
In P2-akademiet, Transit, [Oslo], [Nr] XLI, s. 165-175
BIBSYS 093863438
Bone marrow stroma cells regulate TIEG1 expression in acute lymphoblastic leukemia cells: Role of TGF beta/BMP-6 and TIEG1 in chemotherapy escape. (vol 123, pg 2759, 2008)
Int. J. Cancer, 124 (9), 2250
DOI 10.1002/ijc.24300
Publications 2008
DNA copy number changes in high-grade malignant peripheral nerve sheath tumors by array CGH
Mol Cancer, 7, 48
DOI 10.1186/1476-4598-7-48, PubMed 18522746
GeneCount: genome-wide calculation of absolute tumor DNA copy numbers from array comparative genomic hybridization data
Genome Biol, 9 (5), R86
DOI 10.1186/gb-2008-9-5-r86, PubMed 18500990
High-resolution analysis of genetic stability of human adipose tissue stem cells cultured to senescence
J Cell Mol Med, 12 (2), 553-63
DOI 10.1111/j.1582-4934.2007.00146.x, PubMed 18419597
Chromosomal aberrations in head and neck squamous cell carcinomas in Norwegian and Sudanese populations by array comparative genomic hybridization
Oncol Rep, 20 (4), 825-43
DOI 10.3892/or_00000080, PubMed 18813824
Publications 2007
Diagnostic and prognostic gene expression signatures in 177 soft tissue sarcomas: hypoxia-induced transcription profile signifies metastatic potential
BMC Genomics, 8, 73
DOI 10.1186/1471-2164-8-73, PubMed 17359542
Gene expression profiles of primary colorectal carcinomas, liver metastases, and carcinomatoses
Mol Cancer, 6, 2
DOI 10.1186/1476-4598-6-2, PubMed 17201907
Potential for treatment of liposarcomas with the MDM2 antagonist Nutlin-3A
Int J Cancer, 121 (1), 199-205
DOI 10.1002/ijc.22643, PubMed 17354236
Publications 2006
Sampling effects on gene expression data from a human tumour xenograft
Scand. J. Lab. Anim. Sci., 33 (1), 17-30
The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements
Nat Biotechnol, 24 (9), 1151-61
DOI 10.1038/nbt1239, PubMed 16964229
Array comparative genomic hybridization reveals distinct DNA copy number differences between gastrointestinal stromal tumors and leiomyosarcomas
Cancer Res, 66 (18), 8984-93
DOI 10.1158/0008-5472.CAN-06-1972, PubMed 16982739
Gain of chromosome 6p is an infrequent cause of increased PIM1 expression in B-cell non-Hodgkin's lymphomas
Leukemia, 20 (3), 539-42
DOI 10.1038/sj.leu.2404094, PubMed 16437153
Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy
Proc Natl Acad Sci U S A, 103 (6), 1888-93
DOI 10.1073/pnas.0507493103, PubMed 16443686
Publications 2005
Expression patterns of cell cycle components in sporadic and neurofibromatosis type 1-related malignant peripheral nerve sheath tumors
J Neuropathol Exp Neurol, 64 (1), 74-81
DOI 10.1093/jnen/64.1.74, PubMed 15715087
[Molecular genetics in the diagnosis of bone and soft tissue tumours]
Tidsskr Nor Laegeforen, 125 (23), 3286-9
PubMed 16327856
Translocation t(14;18) and gain of chromosome 18/BCL2: effects on BCL2 expression and apoptosis in B-cell non-Hodgkin's lymphomas
Leukemia, 19 (12), 2313-23
DOI 10.1038/sj.leu.2403954, PubMed 16193090
Mapping and characterization of the amplicon near APOA2 in 1q23 in human sarcomas by FISH and array CGH
Mol Cancer, 4, 39
DOI 10.1186/1476-4598-4-39, PubMed 16274472
Response of malignant B lymphocytes to ionizing radiation: gene expression and genotype
Int J Cancer, 115 (6), 935-42
DOI 10.1002/ijc.20962, PubMed 15723354
Limitations of mRNA amplification from small-size cell samples
BMC Genomics, 6, 147
DOI 10.1186/1471-2164-6-147, PubMed 16253144
Publications 2004
Analysis of the humoral immune response to immunoselected phage-displayed peptides by a microarray-based method
Proteomics, 4 (9), 2572-82
DOI 10.1002/pmic.200300768, PubMed 15352232
Profound influence of microarray scanner characteristics on gene expression ratios: analysis and procedure for correction
BMC Genomics, 5 (1), 10
DOI 10.1186/1471-2164-5-10, PubMed 15018648
Putting Norway on the gene-therapy map
Nature, 429 (6988), 129
DOI 10.1038/429129b, PubMed 15141186
Lessons from genetic profiling in soft tissue sarcomas
Acta Orthop Scand Suppl, 75 (311), 35-50
DOI 10.1080/00016470410001708310, PubMed 15188664
Amplification of chromosome 1 sequences in lipomatous tumors and other sarcomas
Int J Cancer, 109 (3), 363-9
DOI 10.1002/ijc.11716, PubMed 14961574
Constitutive expression of the AP-1 transcription factors c-jun, junD, junB, and c-fos and the marginal zone B-cell transcription factor Notch2 in splenic marginal zone lymphoma
J Mol Diagn, 6 (4), 297-307
DOI 10.1016/S1525-1578(10)60525-9, PubMed 15507668
M-CGH: analysing microarray-based CGH experiments
BMC Bioinformatics, 5, 74
DOI 10.1186/1471-2105-5-74, PubMed 15189572
Publications 2003
Interferon-gamma suppresses S100A4 transcription independently of apoptosis or cell cycle arrest
Br J Cancer, 88 (12), 1995-2001
DOI 10.1038/sj.bjc.6600998, PubMed 12799648
Amplification and overexpression of COPS3 in osteosarcomas potentially target TP53 for proteasome-mediated degradation
Oncogene, 22 (34), 5358-61
DOI 10.1038/sj.onc.1206671, PubMed 12917637
11q13 alterations in two cases of hibernoma: large heterozygous deletions and rearrangement breakpoints near GARP in 11q13.5
Genes Chromosomes Cancer, 37 (4), 389-95
DOI 10.1002/gcc.10223, PubMed 12800150
Effects of mRNA amplification on gene expression ratios in cDNA experiments estimated by analysis of variance
BMC Genomics, 4 (1), 11
DOI 10.1186/1471-2164-4-11, PubMed 12659661
Tumor classification and marker gene prediction by feature selection and fuzzy c-means clustering using microarray data
BMC Bioinformatics, 4, 60
DOI 10.1186/1471-2105-4-60, PubMed 14651757
MGraph: graphical models for microarray data analysis
Bioinformatics, 19 (17), 2210-1
DOI 10.1093/bioinformatics/btg298, PubMed 14630649
Publications 2002
Analysis of repeatability in spotted cDNA microarrays
Nucleic Acids Res, 30 (14), 3235-44
DOI 10.1093/nar/gkf441, PubMed 12136105
Positional cloning identifies a novel cyclophilin as a candidate amplified oncogene in 1q21
Oncogene, 21 (14), 2261-9
DOI 10.1038/sj.onc.1205339, PubMed 11948409
Clustering of the SOM easily reveals distinct gene expression patterns: results of a reanalysis of lymphoma study
BMC Bioinformatics, 3, 36
DOI 10.1186/1471-2105-3-36, PubMed 12445336
MArray: analysing single, replicated or reversed microarray experiments
Bioinformatics, 18 (8), 1139-40
DOI 10.1093/bioinformatics/18.8.1139, PubMed 12176840
The SYT-SSX1 fusion type of synovial sarcoma is associated with increased expression of cyclin A and D1. A link between t(X;18)(p11.2; q11.2) and the cell cycle machinery
Oncogene, 21 (37), 5791-6
DOI 10.1038/sj.onc.1205700, PubMed 12173050
Publications 2001
A well-differentiated liposarcoma with a new type of chromosome 12-derived markers
Cancer Genet Cytogenet, 131 (1), 13-8
DOI 10.1016/s0165-4608(01)00516-7, PubMed 11734312
Amplification and overexpression of PRUNE in human sarcomas and breast carcinomas-a possible mechanism for altering the nm23-H1 activity
Oncogene, 20 (47), 6881-90
DOI 10.1038/sj.onc.1204874, PubMed 11687967
Dedifferentiation of a well-differentiated liposarcoma to a highly malignant metastatic osteosarcoma: amplification of 12q14 at all stages and gain of 1q22-q24 associated with metastases
Cancer Genet Cytogenet, 125 (2), 100-11
DOI 10.1016/s0165-4608(00)00369-1, PubMed 11369052
[Microarray technology--potential in cancer research]
Tidsskr Nor Laegeforen, 121 (21), 2498-503
PubMed 11875927
[Gene therapy in cancer]
Tidsskr Nor Laegeforen, 121 (4), 482-8
PubMed 11255868
Ectopic sequences from truncated HMGIC in liposarcomas are derived from various amplified chromosomal regions
Genes Chromosomes Cancer, 31 (3), 264-73
DOI 10.1002/gcc.1143, PubMed 11391797
[Measurement of gene activity by DNA microarrays]
Tidsskr Nor Laegeforen, 121 (10), 1225-8
PubMed 11402749
Publications 2000
Frequent loss of 9p21 (p16(INK4A)) and other genomic imbalances in human malignant fibrous histiocytoma
Cancer Genet Cytogenet, 118 (2), 89-98
DOI 10.1016/s0165-4608(99)00178-8, PubMed 10748288
Characterization of centromere alterations in liposarcomas
Genes Chromosomes Cancer, 29 (2), 117-29
DOI 10.1002/1098-2264(2000)9999:9999<::aid-gcc1014>3.0.co;2-q, PubMed 10959091
Publications 1999
Chromosome band 9p21 is frequently altered in malignant peripheral nerve sheath tumors: studies of CDKN2A and other genes of the pRB pathway
Genes Chromosomes Cancer, 26 (2), 151-60
DOI 10.1002/(SICI)1098-2264(199910)26:2<151::AID-GCC7>3.0.CO;2-A, PubMed 10469453
Sensitive fluorescent in situ hybridisation method for the characterisation of breast cancer cells in bone marrow aspirates
Mol Pathol, 52 (2), 68-74
DOI 10.1136/mp.52.2.68, PubMed 10474684
Structure of the supernumerary ring and giant rod chromosomes in adipose tissue tumors
Genes Chromosomes Cancer, 24 (1), 30-41
DOI 10.1002/(SICI)1098-2264(199901)24:1<30::AID-GCC5>3.3.CO;2-G, PubMed 9892106
A novel chromosomal region of allelic loss, 4q32-q34, in human osteosarcomas revealed by representational difference analysis
Genes Chromosomes Cancer, 26 (2), 115-24
DOI 10.1002/(SICI)1098-2264(199910)26:2<115::AID-GCC3>3.0.CO;2-E, PubMed 10469449
Characterization of the 17p amplicon in human sarcomas: microsatellite marker analysis
Int J Cancer, 82 (3), 329-33
DOI 10.1002/(sici)1097-0215(19990730)82:3<329::aid-ijc4>3.0.co;2-1, PubMed 10399948
Publications 1998
Molecular characterization of a novel amplicon at 1q21-q22 frequently observed in human sarcomas
Br J Cancer, 78 (4), 495-503
DOI 10.1038/bjc.1998.521, PubMed 9716033
[Molecular biology diagnosis of sarcoma]
Tidsskr Nor Laegeforen, 118 (14), 2188-93
PubMed 9656816
GLI gene and rhabdomyosarcoma
Nat Med, 4 (8), 869
DOI 10.1038/nm0898-869c, PubMed 9701218
Publications 1997
Recurrent gains of 1q, 8 and 12 in the Ewing family of tumours by comparative genomic hybridization
Br J Cancer, 75 (10), 1403-9
DOI 10.1038/bjc.1997.242, PubMed 9166930
HMGIC, the gene for an architectural transcription factor, is amplified and rearranged in a subset of human sarcomas
Oncogene, 14 (24), 2935-41
DOI 10.1038/sj.onc.1201135, PubMed 9205100
Molecular cytogenetics of bone and soft tissue tumors
Cancer Genet Cytogenet, 95 (1), 67-73
DOI 10.1016/s0165-4608(96)00241-5, PubMed 9140455
Complexity of 12q13-22 amplicon in liposarcoma: microsatellite repeat analysis
Genes Chromosomes Cancer, 18 (1), 66-70
DOI 10.1002/(sici)1098-2264(199701)18:1<66::aid-gcc8>3.0.co;2-#, PubMed 8993982
Publications 1996
Separate amplified regions encompassing CDK4 and MDM2 in human sarcomas
Genes Chromosomes Cancer, 17 (4), 254-9
DOI 10.1002/(SICI)1098-2264(199612)17:4<254::AID-GCC7>3.0.CO;2-2, PubMed 8946207
Reversal of the in vivo metastatic phenotype of human tumor cells by an anti-CAPL (mts1) ribozyme
Cancer Res, 56 (23), 5490-8
PubMed 8968106
First for biotech
Nature, 384 (6606), 208
DOI 10.1038/384208b0, PubMed 8918866
Publications 1995
Comparative genomic hybridization analysis of human sarcomas: II. Identification of novel amplicons at 6p and 17p in osteosarcomas
Genes Chromosomes Cancer, 14 (1), 15-21
DOI 10.1002/gcc.2870140104, PubMed 8527379
Comparative genomic hybridization analysis of human sarcomas: I. Occurrence of genomic imbalances and identification of a novel major amplicon at 1q21-q22 in soft tissue sarcomas
Genes Chromosomes Cancer, 14 (1), 8-14
DOI 10.1002/gcc.2870140103, PubMed 8527390
Cloning and characterization of two forms of bovine polymeric immunoglobulin receptor cDNA
DNA Cell Biol, 14 (3), 251-6
DOI 10.1089/dna.1995.14.251, PubMed 7880445
Homozygous deletion frequency and expression levels of the CDKN2 gene in human sarcomas--relationship to amplification and mRNA levels of CDK4 and CCND1
Br J Cancer, 72 (2), 393-8
DOI 10.1038/bjc.1995.344, PubMed 7640224
Identification of two distinct chromosome 12-derived amplification units in neuroblastoma cell line NGP
Cancer Genet Cytogenet, 82 (2), 151-4
DOI 10.1016/0165-4608(95)00034-m, PubMed 7664245
Publications 1994
Expression of the neuroectodermal intermediate filament nestin in human melanomas
Cancer Res, 54 (2), 354-6
PubMed 8275467
MDM2 gene amplification and transcript levels in human sarcomas: relationship to TP53 gene status
J Natl Cancer Inst, 86 (17), 1297-302
DOI 10.1093/jnci/86.17.1297, PubMed 8064888
The protooncogene CHOP/GADD153, involved in growth arrest and DNA damage response, is amplified in a subset of human sarcomas
Cancer Genet Cytogenet, 78 (2), 165-71
DOI 10.1016/0165-4608(94)90085-x, PubMed 7828148
A long range restriction map spanning the myxoid liposarcoma breakpoint in the q13-14 region of human chromosome 12
Hum Genet, 94 (3), 259-64
DOI 10.1007/BF00208280, PubMed 8076941
Comparative genomic hybridization as a tool to define two distinct chromosome 12-derived amplification units in well-differentiated liposarcomas
Genes Chromosomes Cancer, 9 (4), 292-5
DOI 10.1002/gcc.2870090410, PubMed 7519052
Publications 1993
CHROMOSOME-17P ABERRATIONS AND P53 EXPRESSION IN HUMAN SARCOMAS
FRONTIERS OF OSTEOSARCOMA RESEARCH: INTERDISCIPLINARY SURVEY OF CLINICAL AND RESEARCH ADVANCES, 419-422
p53 abnormalities in different subtypes of human sarcomas
Cancer Res, 53 (3), 468-71
PubMed 8425179
Isolation, sequencing, and expression analysis of a bovine apolipoprotein E (APOE) cDNA and chromosomal localization of the APOE locus
Mamm Genome, 4 (1), 53-7
DOI 10.1007/BF00364665, PubMed 8422503
Mapping of amplification units in the q13-14 region of chromosome 12 in human sarcomas: some amplica do not include MDM2
Cell Growth Differ, 4 (12), 1065-70
PubMed 8117620
Publications 1992
Levels of nm23 messenger RNA in metastatic malignant melanomas: inverse correlation to disease progression
Cancer Res, 52 (21), 6088-91
PubMed 1356624
A physical map of a 1.3-Mb region on the long arm of chromosome 12, spanning the GLI and LRP loci
Genomics, 14 (1), 117-20
DOI 10.1016/s0888-7543(05)80292-7, PubMed 1427818
Uptake of chylomicron remnant retinyl esters in human leukocytes in vivo
Eur J Clin Invest, 22 (4), 229-34
DOI 10.1111/j.1365-2362.1992.tb01456.x, PubMed 1499639
Publications 1991
The human genes for complement components 6 (C6) and 9 (C9) are closely linked on chromosome 5
J Med Genet, 28 (9), 587-90
DOI 10.1136/jmg.28.9.587, PubMed 1683409
Publications 1990
Association analysis of lipid levels and apolipoprotein restriction fragment length polymorphisms
Hum Genet, 86 (2), 209-14
DOI 10.1007/BF00197707, PubMed 1979958
Multiple RFLPs of human complement component nine (C9) detected by TaqI
Nucleic Acids Res, 18 (10), 3112
DOI 10.1093/nar/18.10.3112-a, PubMed 1971940
The molecular genetics of genes in lipid metabolism
University of Oslo, Oslo, 1 b. (flere pag.)
BIBSYS 900815221, ISBN 82-90187-68-8
Publications 1989
The gene for the human putative apoE receptor is on chromosome 12 in the segment q13-14
Genomics, 5 (1), 65-9
DOI 10.1016/0888-7543(89)90087-6, PubMed 2548950
Low-density-lipoprotein receptors in different rabbit liver cells
Biochem J, 261 (2), 587-93
DOI 10.1042/bj2610587, PubMed 2549976
The genes for apolipoprotein all (APOA2) and the Duffy blood group (FY) are linked on chromosome 1 in man
Genomics, 4 (2), 169-73
DOI 10.1016/0888-7543(89)90296-6, PubMed 2500391
The gene for human complement C9 is on chromosome 5
Genomics, 5 (1), 149-52
DOI 10.1016/0888-7543(89)90100-6, PubMed 2767685
Publications 1988
Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor
EMBO J, 7 (13), 4119-27
DOI 10.1002/j.1460-2075.1988.tb03306.x, PubMed 3266596
A physical map of the apolipoprotein gene cluster on human chromosome 19
Hum Genet, 78 (3), 244-7
DOI 10.1007/BF00291670, PubMed 2894348
Publications 1987
The isolation and characterisation of a cDNA clone for human lecithin:cholesterol acyl transferase and its use to analyse the genes in patients with LCAT deficiency and fish eye disease
Biochem Biophys Res Commun, 148 (1), 161-9
DOI 10.1016/0006-291x(87)91090-4, PubMed 2823801
Publications 1986
The gene for human apolipoprotein CI is located 4.3 kilobases away from the apolipoprotein E gene on chromosome 19
Hum Genet, 73 (4), 286-9
DOI 10.1007/BF00279087, PubMed 3017837
Confirmation of the close linkage between the loci for human apolipoproteins AI and AIV by the use of a cloned cDNA probe and two restriction site polymorphisms
Hum Genet, 72 (1), 68-71
DOI 10.1007/BF00278820, PubMed 3002953
Publications 1985
Cell cycle traverse and protein metabolism in human NHIK 3025 cells: the role of anchorage
J Cell Physiol, 125 (3), 528-32
DOI 10.1002/jcp.1041250324, PubMed 4066771
The apolipoprotein CII gene: subchromosomal localisation and linkage to the myotonic dystrophy locus
Hum Genet, 70 (3), 271-3
DOI 10.1007/BF00273455, PubMed 2991117
Publications 1984
Familial apolipoprotein CII deficiency: a preliminary analysis of the gene defect in two independent families
Hum Genet, 67 (2), 151-5
DOI 10.1007/BF00272990, PubMed 6547689
The locus for apolipoprotein CII is closely linked to the apolipoprotein E locus on chromosome 19 in man
Hum Genet, 67 (3), 309-12
DOI 10.1007/BF00291359, PubMed 6088388
The isolation and characterization of cDNA clones for human apolipoprotein CII
J Biol Chem, 259 (7), 4401-4
PubMed 6546757
Publications 1983
A DNA polymorphism adjacent to the human apolipoprotein CII gene
Mol Biol Med, 1 (5), 463-71
PubMed 6094958
Publications 1981
Hepatocyte fusion: A critical discussion of the mechanism of artificial cellfusion and an experimental study of the possibilities and limitations of cell fusion techniques applied to isolated rat hepatocytes, including polyethyleneglycol-mediated fusion, sendai virus-mediated fusion and erythrocyte ghost-mediated microinjection
O. Myklebust, Oslo, 175 s.
BIBSYS 961353198