Ingvild Sørum Leikfoss

  • Research coordinator/senior engineer PhD, MSc
  • +47 230 79021

Address: Oslo University Hospital, Research Unit for Neuroscience, Domus Medica II, 2nd floor, L-260, Gaustadalleen 34, 0372 Oslo

Background:
Ingvild Sørum Leikfoss has a PhD degree in Molecular Immunology from the University of Oslo from 2015, with the following title “Characterization of multiple sclerosis susceptibility genes”. She has a Master of Science degree in Molecular Biology and Immunology from the Department of Molecular Biosciences. The focus of her master thesis was in vitro characterization of the binding between Immunoglobulin G and different Fc receptors from both humans and mice.

PhD-project:
Project title: " Characterization of multiple sclerosis susceptibility genes - Genetic and molecular studies in T cells".
The main objective was to understand the biological implications for the single nucleotide polymorphisms in the CLEC16A gene that show genome-wide significant associations with MS. In addition, using molecular and immunological methods, the aim has been to characterize the function of CLEC16A in human immune cell lines.

Main supervisor: Tone Berge (MSc, PhD)
Co-supervisors: Hanne F Harbo (MD, PhD) and Anne Spurkland (MD, PhD, Professor at the Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo).

Research interest:
• Immunology
• Autoimmunity
• Molecular biology
• Cloning

Methodology:
• Cultivation and transfection of cell lines (Jurkat T cells, Raji B cells)
• Isolation and cultivation of primary, human T - and B- cells
• Western blotting
• Flow cytometry
• Image stream
• RNA and DNA isolation
• Quantitative real-time PCR
• Sub-cloning
• ELISA

 

Publications 2016

Berge T, Leikfoss IS, Brorson IS, Bos SD, Page CM, Gustavsen MW, Bjølgerud A, Holmøy T, Celius EG, Damoiseaux J, Smolders J, Harbo HF, Spurkland A (2016)
The multiple sclerosis susceptibility genes TAGAP and IL2RA are regulated by vitamin D in CD4+ T cells
Genes Immun, 17 (2), 118-27
DOI 10.1038/gene.2015.61, PubMed 26765264

Publications 2015

Bos SD, Page CM, Andreassen BK, Elboudwarej E, Gustavsen MW, Briggs F, Quach H, Leikfoss IS, Bjølgerud A, Berge T, Harbo HF, Barcellos LF (2015)
Genome-wide DNA methylation profiles indicate CD8+ T cell hypermethylation in multiple sclerosis
PLoS One, 10 (3), e0117403
DOI 10.1371/journal.pone.0117403, PubMed 25734800

Leikfoss IS, Keshari PK, Gustavsen MW, Bjølgerud A, Brorson IS, Celius EG, Spurkland A, Bos SD, Harbo HF, Berge T (2015)
Multiple Sclerosis Risk Allele in CLEC16A Acts as an Expression Quantitative Trait Locus for CLEC16A and SOCS1 in CD4+ T Cells
PLoS One, 10 (7), e0132957
DOI 10.1371/journal.pone.0132957, PubMed 26203907

Publications 2014

Eriksen AB, Berge T, Gustavsen MW, Leikfoss IS, Bos SD, Spurkland A, Harbo HF, Blomhoff HK (2014)
Retinoic acid enhances the levels of IL-10 in TLR-stimulated B cells from patients with relapsing-remitting multiple sclerosis
J Neuroimmunol, 278, 11-8
DOI 10.1016/j.jneuroim.2014.11.019, PubMed 25595247

Publications 2013

Berge T, Leikfoss IS, Harbo HF (2013)
From Identification to Characterization of the Multiple Sclerosis Susceptibility Gene CLEC16A
Int J Mol Sci, 14 (3), 4476-97
DOI 10.3390/ijms14034476, PubMed 23439554

Publications 2012

Andersen JT, Foss S, Kenanova VE, Olafsen T, Leikfoss IS, Roopenian DC, Wu AM, Sandlie I (2012)
Anti-carcinoembryonic antigen single-chain variable fragment antibody variants bind mouse and human neonatal Fc receptor with different affinities that reveal distinct cross-species differences in serum half-life
J Biol Chem, 287 (27), 22927-37
DOI 10.1074/jbc.M112.355131, PubMed 22570488

Leikfoss IS, Mero IL, Dahle MK, Lie BA, Harbo HF, Spurkland A, Berge T (2012)
Multiple sclerosis-associated single-nucleotide polymorphisms in CLEC16A correlate with reduced SOCS1 and DEXI expression in the thymus
Genes Immun, 14 (1), 62-6
DOI 10.1038/gene.2012.52, PubMed 23151489

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