Elisabeth Gulowsen Celius

  • Group leader, senior consultant, professor MD, PhD
  • +47 221 19202

Medical degree from University of Bonn, Germany 1985, certified in neurology 1993. PhD in 1986. Has worked as a consultant with a special focus on MS at the Oslo University Hospital since 1987. Group leader of the MS Research group from September 2018. Head of the Neurological department 2002-2010. Head of the out-patient clinic at OUS 2010-2018. Member of the steering group of the National MS-Registry, member of reference group preparing guidelines for treatment of MS and priorities Norwegian Directorate of Health, previous member of ECTRIMS Council. Member of steering committees in international trials and national investigator in several trials.

Project/Research interest:
Leader of the MS clinic and the MS team. Special interest in MS epidemiology and clinical studies, but also participating in genetic studies and gene-environment studies. Takes actively part in the development of local, national and international data collections and research projects.


Publications 2019

Barclay K, Carruthers R, Traboulsee A, Bass AD, LaGanke C, Bertolotto A, Boster A, Celius EG, de Seze J, Cruz DD, Habek M, Lee JM, Limmroth V, Meuth SG, Oreja-Guevara C, Pagnotta P, Vos C, Ziemssen T, Baker DP, Wijmeersch BV (2019)
Best Practices for Long-Term Monitoring and Follow-Up of Alemtuzumab-Treated MS Patients in Real-World Clinical Settings
Front Neurol, 10, 253
DOI 10.3389/fneur.2019.00253, PubMed 30967831

Richter S, Wagner B, Celius EG (2019)
Two cases of diabetes mellitus type 1 after alemtuzumab treatment for multiple sclerosis: another probable secondary autoimmune disease
J Neurol, 266 (5), 1270-1271
DOI 10.1007/s00415-019-09257-5, PubMed 30805797

Publications 2018

Celius EG (2018)
[Teaching has low academic status]
Tidsskr Nor Laegeforen, 138 (12)
DOI 10.4045/tidsskr.18.0341, PubMed 30132612

Celius EG (2018)
Teaching has a low status within academia
Tidsskr. Nor. Laegeforen., 138 (12), 1155

Celius EG, Vila C (2018)
The influence of THC:CBD oromucosal spray on driving ability in patients with multiple sclerosis-related spasticity
Brain Behav, 8 (5), e00962
DOI 10.1002/brb3.962, PubMed 29761015

Hobart J, Bowen A, Pepper G, Crofts H, Eberhard L, Berger T, Boyko A, Boz C, Butzkueven H, Celius EG, Drulovic J, Flores J, Horáková D, Lebrun-Frénay C, Marrie RA, Overell J, Piehl F, Rasmussen PV, Sá MJ, Sîrbu CA, Skromne E, Torkildsen Ø, van Pesch V, Vollmer T, Zakaria M et al. (2018)
International consensus on quality standards for brain health-focused care in multiple sclerosis
Mult Scler, 1352458518809326 (in press)
DOI 10.1177/1352458518809326, PubMed 30381987

Kular L, Liu Y, Ruhrmann S, Zheleznyakova G, Marabita F, Gomez-Cabrero D, James T, Ewing E, Lindén M, Górnikiewicz B, Aeinehband S, Stridh P, Link J, Andlauer TFM, Gasperi C, Wiendl H, Zipp F, Gold R, Tackenberg B, Weber F, Hemmer B, Strauch K, Heilmann-Heimbach S, Rawal R, Schminke U et al. (2018)
DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis
Nat Commun, 9 (1), 2397
DOI 10.1038/s41467-018-04732-5, PubMed 29921915

Rhead B, Brorson IS, Berge T, Adams C, Quach H, Moen SM, Berg-Hansen P, Celius EG, Sangurdekar DP, Bronson PG, Lea RA, Burnard S, Maltby VE, Scott RJ, Lechner-Scott J, Harbo HF, Bos SD, Barcellos LF (2018)
Increased DNA methylation of SLFN12 in CD4+ and CD8+ T cells from multiple sclerosis patients
PLoS One, 13 (10), e0206511
DOI 10.1371/journal.pone.0206511, PubMed 30379917

Sowa P, Harbo HF, White NS, Celius EG, Bartsch H, Berg-Hansen P, Moen SM, Bjørnerud A, Westlye LT, Andreassen OA, Dale AM, Beyer MK (2018)
Restriction spectrum imaging of white matter and its relation to neurological disability in multiple sclerosis
Mult Scler, 25 (5), 687-698
DOI 10.1177/1352458518765671, PubMed 29542336

Publications 2017

Celius EG (2017)
Infections in patients with multiple sclerosis: Implications for disease-modifying therapy
Acta Neurol Scand, 136 Suppl 201, 34-36
DOI 10.1111/ane.12835, PubMed 29068490

Celius EG, Andersen O, Fredriksen JL (2017)
Acta Neurol Scand, 136 Suppl 201, 3
DOI 10.1111/ane.12842, PubMed 29068489

de Rodez Benavent SA, Nygaard GO, Harbo HF, Tønnesen S, Sowa P, Landrø NI, Wendel-Haga M, Etholm L, Nilsen KB, Drolsum L, Kerty E, Celius EG, Laeng B (2017)
Fatigue and cognition: Pupillary responses to problem-solving in early multiple sclerosis patients
Brain Behav, 7 (7), e00717
DOI 10.1002/brb3.717, PubMed 28729927

Olafsson S, Stridh P, Bos SD, Ingason A, Euesden J, Sulem P, Thorleifsson G, Gustafsson O, Johannesson A, Geirsson AJ, Thorsson AV, Sigurgeirsson B, Ludviksson BR, Olafsson E, Kristjansdottir H, Jonasson JG, Olafsson JH, Orvar KB, Benediktsson R, Bjarnason R, Kristjansdottir S, Gislason T, Valdimarsson T, Mikaelsdottir E, Sigurdsson S et al. (2017)
Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations
NPJ Genom Med, 2, 24
DOI 10.1038/s41525-017-0027-2, PubMed 29263835

Sowa P, Nygaard GO, Bjørnerud A, Celius EG, Harbo HF, Beyer MK (2017)
Magnetic resonance imaging perfusion is associated with disease severity and activity in multiple sclerosis
Neuroradiology, 59 (7), 655-664
DOI 10.1007/s00234-017-1849-4, PubMed 28585082

Wendel-Haga M, Celius EG (2017)
Is the hygiene hypothesis relevant for the risk of multiple sclerosis?
Acta Neurol Scand, 136 Suppl 201, 26-30
DOI 10.1111/ane.12844, PubMed 29068485

Publications 2016

Berge T, Leikfoss IS, Brorson IS, Bos SD, Page CM, Gustavsen MW, Bjølgerud A, Holmøy T, Celius EG, Damoiseaux J, Smolders J, Harbo HF, Spurkland A (2016)
The multiple sclerosis susceptibility genes TAGAP and IL2RA are regulated by vitamin D in CD4+ T cells
Genes Immun, 17 (2), 118-27
DOI 10.1038/gene.2015.61, PubMed 26765264

Bjørnevik K, Riise T, Benjaminsen E, Celius EG, Dahl OP, Kampman MT, Løken-Amsrud KI, Midgard R, Myhr KM, Torkildsen Ø, Vatne A, Grytten N (2016)
Level of education and multiple sclerosis risk over a 50-year period: Registry-based sibling study
Mult Scler, 23 (2), 213-219
DOI 10.1177/1352458516646863, PubMed 27207453

Bos SD, Berge T, Celius EG, Harbo HF (2016)
From genetic associations to functional studies in multiple sclerosis
Eur J Neurol, 23 (5), 847-53
DOI 10.1111/ene.12981, PubMed 26948534

Celius EG, Rocca M, Andersen O (2016)
Acta Neurol Scand, 134 Suppl 200, 3
DOI 10.1111/ane.12653, PubMed 27580898

George MF, Briggs FB, Shao X, Gianfrancesco MA, Kockum I, Harbo HF, Celius EG, Bos SD, Hedström A, Shen L, Bernstein A, Alfredsson L, Hillert J, Olsson T, Patsopoulos NA, De Jager PL, Oturai AB, Søndergaard HB, Sellebjerg F, Sorensen PS, Gomez R, Caillier SJ, Cree BA, Oksenberg JR, Hauser SL et al. (2016)
Multiple sclerosis risk loci and disease severity in 7,125 individuals from 10 studies
Neurol Genet, 2 (4), e87
DOI 10.1212/NXG.0000000000000087, PubMed 27540591

George MF, Briggs FBS, Shao X, Gianfrancesco MA, Kockum I, Harbo HF, Celius EG, Bos SD, Hedstrom A, Shen L, Bernstein A, Alfredsson L, Hiller J, Olsson T, Patsopoulos NA, De Jager PL, Oturai AB, Sondergaard HB, Sellebjerg F, Sorensen PS, Gomez R, Caillier SJ, Cree BAC, Oksenberg JR, Hauser SL et al. (2016)
Multiple sclerosis risk loci and disease severity in 7,125 individuals from 10 studies
Neurol.-Genet., 2 (4), UNSP eB7

Gustavsen MW, Celius EG, Winsvold BS, Moen SM, Nygaard GO, Berg-Hansen P, Lie BA, Zwart JA, Harbo HF (2016)
Migraine and frequent tension-type headache are not associated with multiple sclerosis in a Norwegian case-control study
Mult Scler J Exp Transl Clin, 2, 2055217316682976
DOI 10.1177/2055217316682976, PubMed 28607748

Moen SM, Harbo HF, Celius EG, Sowa P, Nygaard GO, Beyer MK (2016)
S.M. Moen og medarbeidere svarer
Tidsskr Nor Laegeforen, 136 (19), 1608
DOI 10.4045/tidsskr.16.0826, PubMed 27790879

Moen SM, Harbo HF, Celius EG, Sowa P, Nygaard GO, Beyer MK (2016)
S.M. Moen og medarbeidere svarer
Tidsskr Nor Laegeforen, 136 (20), 1702
DOI 10.4045/tidsskr.16.0865, PubMed 27830899

Moen SM, Harbo HF, Sowa P, Celius EG, Nygaard GO, Beyer MK (2016)
MRI- investigations in multiple sclerosis
Tidsskr. Nor. Laegeforen., 136 (16), 1373-1376

Moen SM, Harbo HF, Sowa P, Celius EG, Nygaard GO, Beyer MK (2016)
[MRI in multiple sclerosis]
Tidsskr Nor Laegeforen, 136 (16), 1373-6
DOI 10.4045/tidsskr.15.1361, PubMed 27637059

Simonsen CS, Celius EG, Brunborg C, Tallaksen C, Eriksen EF, Holmøy T, Moen SM (2016)
Bone mineral density in patients with multiple sclerosis, hereditary ataxia or hereditary spastic paraplegia after at least 10 years of disease - a case control study
BMC Neurol, 16 (1), 252
DOI 10.1186/s12883-016-0771-4, PubMed 27919248

Simonsen CS, Edland A, Berg-Hansen P, Celius EG (2016)
High prevalence and increasing incidence of multiple sclerosis in the Norwegian county of Buskerud
Acta Neurol Scand, 135 (4), 412-418
DOI 10.1111/ane.12615, PubMed 27241360

Publications 2015

Berg-Hansen P, Celius EG (2015)
Socio-economic factors and immigrant population studies of multiple sclerosis
Acta Neurol Scand, 132 (199), 37-41
DOI 10.1111/ane.12429, PubMed 26046557

Berg-Hansen P, Moen SM, Harbo HF, Celius EG (2015)
Comments on the review article 'Time trends in the incidence and prevalence of multiple sclerosis in Norway during eight decades'
Acta Neurol Scand, 132 (5), 364-7
DOI 10.1111/ane.12489, PubMed 26423981

Goris A, Pauwels I, Gustavsen MW, van Son B, Hilven K, Bos SD, Celius EG, Berg-Hansen P, Aarseth J, Myhr KM, D'Alfonso S, Barizzone N, Leone MA, Martinelli Boneschi F, Sorosina M, Liberatore G, Kockum I, Olsson T, Hillert J, Alfredsson L, Bedri SK, Hemmer B, Buck D, Berthele A, Knier B et al. (2015)
Genetic variants are major determinants of CSF antibody levels in multiple sclerosis
Brain, 138 (Pt 3), 632-43
DOI 10.1093/brain/awu405, PubMed 25616667

Leikfoss IS, Keshari PK, Gustavsen MW, Bjølgerud A, Brorson IS, Celius EG, Spurkland A, Bos SD, Harbo HF, Berge T (2015)
Multiple Sclerosis Risk Allele in CLEC16A Acts as an Expression Quantitative Trait Locus for CLEC16A and SOCS1 in CD4+ T Cells
PLoS One, 10 (7), e0132957
DOI 10.1371/journal.pone.0132957, PubMed 26203907

Moutsianas L, Jostins L, Beecham AH, Dilthey AT, Xifara DK, Ban M, Shah TS, Patsopoulos NA, Alfredsson L, Anderson CA, Attfield KE, Baranzini SE, Barrett J, Binder TMC, Booth D, Buck D, Celius EG, Cotsapas C, D'Alfonso S, Dendrou CA, Donnelly P, Dubois B, Fontaine B, Fugger L, Goris A et al. (2015)
Class II HLA interactions modulate genetic risk for multiple sclerosis
Nat Genet, 47 (10), 1107-1113
DOI 10.1038/ng.3395, PubMed 26343388

Nygaard GO, Celius EG, de Rodez Benavent SA, Sowa P, Gustavsen MW, Fjell AM, Landrø NI, Walhovd KB, Harbo HF (2015)
A Longitudinal Study of Disability, Cognition and Gray Matter Atrophy in Early Multiple Sclerosis Patients According to Evidence of Disease Activity
PLoS One, 10 (8), e0135974
DOI 10.1371/journal.pone.0135974, PubMed 26280173

Nygaard GO, de Rodez Benavent SA, Harbo HF, Laeng B, Sowa P, Damangir S, Bernhard Nilsen K, Etholm L, Tønnesen S, Kerty E, Drolsum L, Inge Landrø N, Celius EG (2015)
Eye and hand motor interactions with the Symbol Digit Modalities Test in early multiple sclerosis
Mult Scler Relat Disord, 4 (6), 585-9
DOI 10.1016/j.msard.2015.08.003, PubMed 26590666

Penner IK, Sivertsdotter EC, Celius EG, Fuchs S, Schreiber K, Berkö S, Svenningsson A, TYNERGY trial investigators (2015)
Improvement in Fatigue during Natalizumab Treatment is Linked to Improvement in Depression and Day-Time Sleepiness
Front Neurol, 6, 18
DOI 10.3389/fneur.2015.00018, PubMed 25755648

Sowa P, Bjørnerud A, Nygaard GO, Damangir S, Spulber G, Celius EG, Due-Tønnessen P, Harbo HF, Beyer MK (2015)
Reduced perfusion in white matter lesions in multiple sclerosis
Eur J Radiol, 84 (12), 2605-12
DOI 10.1016/j.ejrad.2015.09.007, PubMed 26391230

Publications 2014

Berg-Hansen P, Moen SM, Harbo HF, Celius EG (2014)
High prevalence and no latitude gradient of multiple sclerosis in Norway
Mult Scler, 20 (13), 1780-2
DOI 10.1177/1352458514525871, PubMed 24603884

Berg-Hansen P, Moen SM, Sandvik L, Harbo HF, Bakken IJ, Stoltenberg C, Celius EG (2014)
Prevalence of multiple sclerosis among immigrants in Norway
Mult Scler, 21 (6), 695-702
DOI 10.1177/1352458514554055, PubMed 25344371

Gustavsen MW, Celius EG, Moen SM, Bjølgerud A, Berg-Hansen P, Nygaard GO, Sandvik L, Lie BA, Harbo HF (2014)
No association between multiple sclerosis and periodontitis after adjusting for smoking habits
Eur J Neurol, 22 (3), 588-90
DOI 10.1111/ene.12520, PubMed 25041906

Gustavsen MW, Page CM, Moen SM, Bjølgerud A, Berg-Hansen P, Nygaard GO, Sandvik L, Lie BA, Celius EG, Harbo HF (2014)
Environmental exposures and the risk of multiple sclerosis investigated in a Norwegian case-control study
BMC Neurol, 14, 196
DOI 10.1186/s12883-014-0196-x, PubMed 25274070

Gustavsen MW, Viken MK, Celius EG, Berge T, Mero IL, Berg-Hansen P, Aarseth JH, Myhr KM, Søndergaard HB, Sellebjerg F, Oturai AB, Hillert J, Alfredsson L, Olsson T, Kockum I, Lie BA, Harbo HF (2014)
Oligoclonal band phenotypes in MS differ in their HLA class II association, while specific KIR ligands at HLA class I show association to MS in general
J Neuroimmunol, 274 (1-2), 174-9
DOI 10.1016/j.jneuroim.2014.06.024, PubMed 25037176

Lund C, Nakken KO, Edland A, Celius EG (2014)
Multiple sclerosis and seizures: incidence and prevalence over 40 years
Acta Neurol Scand, 130 (6), 368-73
DOI 10.1111/ane.12276, PubMed 25209977

Nygaard GO, Walhovd KB, Sowa P, Chepkoech JL, Bjørnerud A, Due-Tønnessen P, Landrø NI, Damangir S, Spulber G, Storsve AB, Beyer MK, Fjell AM, Celius EG, Harbo HF (2014)
Cortical thickness and surface area relate to specific symptoms in early relapsing-remitting multiple sclerosis
Mult Scler, 21 (4), 402-14
DOI 10.1177/1352458514543811, PubMed 25139946

Torkildsen O, Aarseth J, Benjaminsen E, Celius E, Holmøy T, Kampman MT, Løken-Amsrud K, Midgard R, Myhr KM, Riise T, Grytten N (2014)
Month of birth and risk of multiple sclerosis: confounding and adjustments
Ann Clin Transl Neurol, 1 (2), 141-4
DOI 10.1002/acn3.37, PubMed 25356394

Torkildsen O, Aarseth J, Celius EG, Holmøy T, Kampman MT, Løken-Amsrud KI, Midgard R, Myhr KM, Riise T, Grytten N (2014)
Reply to comment: Month of birth and risk of multiple sclerosis: confounding and adjustments
Ann Clin Transl Neurol, 1 (5), 376-7
DOI 10.1002/acn3.56, PubMed 25356407

Trojano M, Celius EG, Donzé C, Izquierdo G, Patti F, Pöhlau D (2014)
Clinical case reviews and poster sessions in multiple sclerosis spasticity: main outcomes and highlights
Eur Neurol, 72 Suppl 1, 15-9
DOI 10.1159/000367619, PubMed 25278119

Westerlind H, Imrell K, Ramanujam R, Myhr KM, Celius EG, Harbo HF, Oturai AB, Hamsten A, Alfredsson L, Olsson T, Kockum I, Koski T, Hillert J (2014)
Identity-by-descent mapping in a Scandinavian multiple sclerosis cohort
Eur J Hum Genet, 23 (5), 688-92
DOI 10.1038/ejhg.2014.155, PubMed 25159868

Publications 2013

Ban M, Caillier S, Mero IL, Myhr KM, Celius EG, Aarseth J, Torkildsen Ø, Harbo HF, Oksenberg J, Hauser SL, Sawcer S, Compston A (2013)
No evidence of association between mutant alleles of the CYP27B1 gene and multiple sclerosis
Ann Neurol, 73 (3), 430-2
DOI 10.1002/ana.23833, PubMed 23444327

Berg-Hansen P, Smestad C, Sandvik L, Harbo HF, Celius EG (2013)
Increased disease severity in non-Western immigrants with multiple sclerosis in Oslo, Norway
Eur J Neurol, 20 (12), 1546-52
DOI 10.1111/ene.12227, PubMed 23834430

Harbo HF, Isobe N, Berg-Hansen P, Bos SD, Caillier SJ, Gustavsen MW, Mero IL, Celius EG, Hauser SL, Oksenberg JR, Gourraud PA (2013)
Oligoclonal bands and age at onset correlate with genetic risk score in multiple sclerosis
Mult Scler, 20 (6), 660-8
DOI 10.1177/1352458513506503, PubMed 24099750

International Multiple Sclerosis Genetics Consortium (IMSGC), Beecham AH, Patsopoulos NA, Xifara DK, Davis MF, Kemppinen A, Cotsapas C, Shah TS, Spencer C, Booth D, Goris A, Oturai A, Saarela J, Fontaine B, Hemmer B, Martin C, Zipp F, D'Alfonso S, Martinelli-Boneschi F, Taylor B, Harbo HF, Kockum I, Hillert J, Olsson T, Ban M et al. (2013)
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis
Nat Genet, 45 (11), 1353-60
DOI 10.1038/ng.2770, PubMed 24076602

Kampman MT, Aarseth JH, Grytten N, Benjaminsen E, Celius EG, Dahl OP, Holmøy T, Løken-Amsrud K, Midgard R, Myhr KM, Risberg G, Vatne A, Torkildsen O (2013)
Sex ratio of multiple sclerosis in persons born from 1930 to 1979 and its relation to latitude in Norway
J Neurol, 260 (6), 1481-8
DOI 10.1007/s00415-012-6814-x, PubMed 23292231

Leone MA, Barizzone N, Esposito F, Lucenti A, Harbo HF, Goris A, Kockum I, Oturai AB, Celius EG, Mero IL, Dubois B, Olsson T, Søndergaard HB, Cusi D, Lupoli S, Andreassen BK, International Multiple Sclerosis Genetics Consortium, Wellcome Trust Case Control Consortium 2, Myhr KM, Guerini FR, PROGEMUS Group, PROGRESSO Group, Comi G, Martinelli-Boneschi F, D'Alfonso S (2013)
Association of genetic markers with CSF oligoclonal bands in multiple sclerosis patients
PLoS One, 8 (6), e64408
DOI 10.1371/journal.pone.0064408, PubMed 23785401

Mero IL, Gustavsen MW, Sæther HS, Flåm ST, Berg-Hansen P, Søndergaard HB, Jensen PE, Berge T, Bjølgerud A, Muggerud A, Aarseth JH, International Multiple Sclerosis Genetics Consortium, Myhr KM, Celius EG, Sellebjerg F, Hillert J, Alfredsson L, Olsson T, Oturai AB, Kockum I, Lie BA, Andreassen BK, Harbo HF (2013)
Oligoclonal band status in Scandinavian multiple sclerosis patients is associated with specific genetic risk alleles
PLoS One, 8 (3), e58352
DOI 10.1371/journal.pone.0058352, PubMed 23472185

Svenningsson A, Falk E, Celius EG, Fuchs S, Schreiber K, Berkö S, Sun J, Penner IK, Tynergy Trial Investigators (2013)
Natalizumab treatment reduces fatigue in multiple sclerosis. Results from the TYNERGY trial; a study in the real life setting
PLoS One, 8 (3), e58643
DOI 10.1371/journal.pone.0058643, PubMed 23555589

Publications 2012

Brambilla P, Esposito F, Lindstrom E, Sorosina M, Giacalone G, Clarelli F, Rodegher M, Colombo B, Moiola L, Ghezzi A, Capra R, Collimedaglia L, Coniglio G, Celius EG, Galimberti D, Sørensen PS, Martinelli V, Oturai AB, Harbo HF, Hillert J, Comi G, Martinelli-Boneschi F (2012)
Association between DPP6 polymorphism and the risk of progressive multiple sclerosis in Northern and Southern Europeans
Neurosci Lett, 530 (2), 155-60
DOI 10.1016/j.neulet.2012.10.008, PubMed 23069673

Grytten N, Torkildsen Ø, Aarseth JH, Benjaminsen E, Celius EG, Dahl OP, Holmøy T, Løken-Amsrud K, Midgard R, Myhr KM, Risberg G, Vatne A, Kampman MT (2012)
Month of birth as a latitude-dependent risk factor for multiple sclerosis in Norway
Mult Scler, 19 (8), 1028-34
DOI 10.1177/1352458512471094, PubMed 23257620

Link J, Kockum I, Lorentzen AR, Lie BA, Celius EG, Westerlind H, Schaffer M, Alfredsson L, Olsson T, Brynedal B, Harbo HF, Hillert J (2012)
Importance of human leukocyte antigen (HLA) class I and II alleles on the risk of multiple sclerosis
PLoS One, 7 (5), e36779
DOI 10.1371/journal.pone.0036779, PubMed 22586495

Mero IL, Smestad C, Lie BA, Lorentzen ÅR, Sandvik L, Landrø NI, Aarseth JH, Myhr KM, Celius EG, Harbo HF (2012)
Polymorphisms of the BDNF gene show neither association with multiple sclerosis susceptibility nor clinical course
J Neuroimmunol, 244 (1-2), 107-10
DOI 10.1016/j.jneuroim.2012.01.011, PubMed 22341604

Moen SM, Celius EG, Sandvik L, Brustad M, Nordsletten L, Eriksen EF, Holmøy T (2012)
Bone turnover and metabolism in patients with early multiple sclerosis and prevalent bone mass deficit: a population-based case-control study
PLoS One, 7 (9), e45703
DOI 10.1371/journal.pone.0045703, PubMed 23029191

Publications 2011

Hansen B, Oturai AB, Harbo HF, Celius EG, Nissen KK, Laska MJ, Søndergaard HB, Petersen T, Nexø BA (2011)
Genetic association of multiple sclerosis with the marker rs391745 near the endogenous retroviral locus HERV-Fc1: analysis of disease subtypes
PLoS One, 6 (10), e26438
DOI 10.1371/journal.pone.0026438, PubMed 22039488

Harbo HF, Lorentzen AR, Lie BA, Celius EG, Spurkland A (2011)
[New gene map for multiple sclerosis]
Tidsskr Nor Laegeforen, 131 (21), 2126-30
DOI 10.4045/tidsskr.10.0823, PubMed 22048209

Holmøy T, Celius EG (2011)
[Development of new therapies for multiple sclerosis]
Tidsskr Nor Laegeforen, 131 (8), 832-6
DOI 10.4045/tidsskr.10.0077, PubMed 21556088

International Multiple Sclerosis Genetics Consortium, Wellcome Trust Case Control Consortium 2, Sawcer S, Hellenthal G, Pirinen M, Spencer CC, Patsopoulos NA, Moutsianas L, Dilthey A, Su Z, Freeman C, Hunt SE, Edkins S, Gray E, Booth DR, Potter SC, Goris A, Band G, Oturai AB, Strange A, Saarela J, Bellenguez C, Fontaine B, Gillman M, Hemmer B et al. (2011)
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
Nature, 476 (7359), 214-9
DOI 10.1038/nature10251, PubMed 21833088

Lundström W, Greiner E, Lundmark F, Westerlind H, Smestad C, Lorentzen AR, Kockum I, Link J, Brynedal B, Celius EG, Harbo HF, Masterman T, Hillert J (2011)
No influence on disease progression of non-HLA susceptibility genes in MS
J Neuroimmunol, 237 (1-2), 98-100
DOI 10.1016/j.jneuroim.2011.05.003, PubMed 21742385

Moen SM, Celius EG, Nordsletten L, Holmøy T (2011)
Fractures and falls in patients with newly diagnosed clinically isolated syndrome and multiple sclerosis
Acta Neurol Scand Suppl (191), 79-82
DOI 10.1111/j.1600-0404.2011.01548.x, PubMed 21711261

Moen SM, Celius EG, Sandvik L, Nordsletten L, Eriksen EF, Holmøy T (2011)
Low bone mass in newly diagnosed multiple sclerosis and clinically isolated syndrome
Neurology, 77 (2), 151-7
DOI 10.1212/WNL.0b013e3182242d34, PubMed 21747073

Reichenbach A, Celius EG, Fure B, Vatn S, Wyller TB (2011)
[Treatment of stroke--an interdisciplinary challenge]
Tidsskr Nor Laegeforen, 131 (9-10), 934-6
DOI 10.4045/tidsskr.11.0424, PubMed 21606987

Søndergaard HB, Sellebjerg F, Hillert J, Olsson T, Kockum I, Lindén M, Mero IL, Myhr KM, Celius EG, Harbo HF, Christensen JR, Börnsen L, Sørensen PS, Oturai AB (2011)
Alterations in KLRB1 gene expression and a Scandinavian multiple sclerosis association study of the KLRB1 SNP rs4763655
Eur J Hum Genet, 19 (10), 1100-3
DOI 10.1038/ejhg.2011.88, PubMed 21610746

Publications 2010

Beyeen AD, Adzemovic MZ, Ockinger J, Stridh P, Becanovic K, Laaksonen H, Lassmann H, Harris RA, Hillert J, Alfredsson L, Celius EG, Harbo HF, Kockum I, Jagodic M, Olsson T (2010)
IL-22RA2 associates with multiple sclerosis and macrophage effector mechanisms in experimental neuroinflammation
J Immunol, 185 (11), 6883-90
DOI 10.4049/jimmunol.1001392, PubMed 21041731

Holmøy T, Harbo HF, Celius EG (2010)
[Treatment of multiple sclerosis]
Tidsskr Nor Laegeforen, 130 (9), 923; author reply 923
DOI 10.4045/tidsskr.10.0346, PubMed 20453948

International Multiple Sclerosis Genetics Consortium (IMSGC), Booth DR, Heard RN, Stewart GJ, Cox M, Scott RJ, Lechner-Scott J, Goris A, Dobosi R, Dubois B, Saarela J, Leppä V, Peltonen L, Pirttila T, Cournu-Rebeix I, Fontaine B, Bergamaschi L, D'Alfonso S, Leone M, Lorentzen AR, Harbo HF, Celius EG, Spurkland A, Link J, Kockum I et al. (2010)
Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis
Nat Genet, 42 (6), 469-70; author reply 470-1
DOI 10.1038/ng0610-469, PubMed 20502484

Link J, Lorentzen AR, Kockum I, Duvefelt K, Lie BA, Celius EG, Harbo HF, Hillert J, Brynedal B (2010)
Two HLA class I genes independently associated with multiple sclerosis
J Neuroimmunol, 226 (1-2), 172-6
DOI 10.1016/j.jneuroim.2010.07.006, PubMed 20678810

Lorentzen AR, Melum E, Ellinghaus E, Smestad C, Mero IL, Aarseth JH, Myhr KM, Celius EG, Lie BA, Karlsen TH, Franke A, Harbo HF (2010)
Association to the Glypican-5 gene in multiple sclerosis
J Neuroimmunol, 226 (1-2), 194-7
DOI 10.1016/j.jneuroim.2010.07.003, PubMed 20692050

Mero IL, Ban M, Lorentzen ÅR, Smestad C, Celius EG, Sæther H, Saeedi H, Viken MK, Skinningsrud B, Undlien DE, Aarseth J, Myhr KM, Granum S, Spurkland A, Sawcer S, Compston A, Lie BA, Harbo HF (2010)
Exploring the CLEC16A gene reveals a MS-associated variant with correlation to the relative expression of CLEC16A isoforms in thymus
Genes Immun, 12 (3), 191-8
DOI 10.1038/gene.2010.59, PubMed 21179112

Ravnborg M, Sørensen PS, Andersson M, Celius EG, Jongen PJ, Elovaara I, Bartholomé E, Constantinescu CS, Beer K, Garde E, Sperling B (2010)
Methylprednisolone in combination with interferon beta-1a for relapsing-remitting multiple sclerosis (MECOMBIN study): a multicentre, double-blind, randomised, placebo-controlled, parallel-group trial
Lancet Neurol, 9 (7), 672-80
DOI 10.1016/S1474-4422(10)70132-0, PubMed 20542736

Publications 2009

Ban M, Goris A, Lorentzen AR, Baker A, Mihalova T, Ingram G, Booth DR, Heard RN, Stewart GJ, Bogaert E, Dubois B, Harbo HF, Celius EG, Spurkland A, Strange R, Hawkins C, Robertson NP, Dudbridge F, Wason J, De Jager PL, Hafler D, Rioux JD, Ivinson AJ, McCauley JL, Pericak-Vance M et al. (2009)
Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor
Eur J Hum Genet, 17 (10), 1309-13
DOI 10.1038/ejhg.2009.41, PubMed 19293837

Celius EG, Smestad C (2009)
Change in sex ratio, disease course and age at diagnosis in Oslo MS patients through seven decades
Acta Neurol Scand Suppl (189), 27-9
DOI 10.1111/j.1600-0404.2009.01208.x, PubMed 19566494

Kemppinen A, Suvela M, Tienari PJ, Elovaara I, Koivisto K, Pirttilä T, Reunanen M, Rautakorpi I, Hillert J, Lundmark F, Oturai A, Ryder L, Harbo HF, Celius EG, Palotie A, Daly M, Peltonen L, Saarela J (2009)
MYO9B polymorphisms in multiple sclerosis
Eur J Hum Genet, 17 (6), 840-3
DOI 10.1038/ejhg.2008.251, PubMed 19142207

Lorentzen AR, Karlsen TH, Olsson M, Smestad C, Mero IL, Woldseth B, Sun JY, Senitzer D, Celius EG, Thorsby E, Spurkland A, Lie BA, Harbo HF (2009)
Killer immunoglobulin-like receptor ligand HLA-Bw4 protects against multiple sclerosis
Ann Neurol, 65 (6), 658-66
DOI 10.1002/ana.21695, PubMed 19630074

Mero IL, Lorentzen AR, Ban M, Smestad C, Celius EG, Aarseth JH, Myhr KM, Link J, Hillert J, Olsson T, Kockum I, Masterman T, Oturai AB, Søndergaard HB, Sellebjerg F, Saarela J, Kemppinen A, Elovaara I, Spurkland A, Dudbridge F, Lie BA, Harbo HF (2009)
A rare variant of the TYK2 gene is confirmed to be associated with multiple sclerosis
Eur J Hum Genet, 18 (4), 502-4
DOI 10.1038/ejhg.2009.195, PubMed 19888296

Ockinger J, Stridh P, Beyeen AD, Lundmark F, Seddighzadeh M, Oturai A, Sørensen PS, Lorentzen AR, Celius EG, Leppä V, Koivisto K, Tienari PJ, Alfredsson L, Padyukov L, Hillert J, Kockum I, Jagodic M, Olsson T (2009)
Genetic variants of CC chemokine genes in experimental autoimmune encephalomyelitis, multiple sclerosis and rheumatoid arthritis
Genes Immun, 11 (2), 142-54
DOI 10.1038/gene.2009.82, PubMed 19865101

Smestad C, Sandvik L, Celius EG (2009)
Excess mortality and cause of death in a cohort of Norwegian multiple sclerosis patients
Mult Scler, 15 (11), 1263-70
DOI 10.1177/1352458509107010, PubMed 19812114

Smestad C, Sandvik L, Landrø NI, Celius EG (2009)
Cognitive impairment after three decades of multiple sclerosis
Eur J Neurol, 17 (3), 499-505
DOI 10.1111/j.1468-1331.2009.02889.x, PubMed 20050887

Publications 2008

Holmoy T, Celius EG (2008)
Cost-effectiveness of natalizumab in multiple sclerosis
Expert Rev Pharmacoecon Outcomes Res, 8 (1), 11-21
DOI 10.1586/14737167.8.1.11, PubMed 20528351

Lerdal A, Celius EG, Moum T (2008)
Perceptions of illness and its development in patients with multiple sclerosis: a prospective cohort study
J Adv Nurs, 65 (1), 184-92
DOI 10.1111/j.1365-2648.2008.04862.x, PubMed 19032506

Lorentzen AR, Smestad C, Lie BA, Oturai AB, Akesson E, Saarela J, Myhr KM, Vartdal F, Celius EG, Sørensen PS, Hillert J, Spurkland A, Harbo HF (2008)
The SH2D2A gene and susceptibility to multiple sclerosis
J Neuroimmunol, 197 (2), 152-8
DOI 10.1016/j.jneuroim.2008.04.037, PubMed 18554728

Publications 2007

Datta P, Harbo HF, Ryder LP, Akesson E, Benedikz J, Celius EG, Andersen O, Myhr KM, Sandberg-Wollheim M, Hillert J, Svejgaard A, Sorensen PS, Spurkland A, Oturai A (2007)
A follow-up study of Nordic multiple sclerosis candidate gene regions
Mult Scler, 13 (5), 584-9
DOI 10.1177/1352458506071790, PubMed 17548436

Harbo HF, Utsi E, Lorentzen AR, Kampman MT, Celius EG, Myhr KM, Lie BA, Mellgren SI, Thorsby E (2007)
Low frequency of the disease-associated DRB1*15-DQB1*06 haplotype may contribute to the low prevalence of multiple sclerosis in Sami
Tissue Antigens, 69 (4), 299-304
DOI 10.1111/j.1399-0039.2007.00803.x, PubMed 17389012

Hensiek AE, Seaman SR, Barcellos LF, Oturai A, Eraksoi M, Cocco E, Vecsei L, Stewart G, Dubois B, Bellman-Strobl J, Leone M, Andersen O, Bencsik K, Booth D, Celius EG, Harbo HF, Hauser SL, Heard R, Hillert J, Myhr KM, Marrosu MG, Oksenberg JR, Rajda C, Sawcer SJ, Sørensen PS et al. (2007)
Familial effects on the clinical course of multiple sclerosis
Neurology, 68 (5), 376-83
DOI 10.1212/01.wnl.0000252822.53506.46, PubMed 17261686

Holmøy T, Celius EG (2007)
[A rush job and knowledge handling]
Tidsskr Nor Laegeforen, 127 (15), 1961-2
PubMed 17700745

Holmøy T, Celius EG (2007)
[Incorrect information about treatment of multiple sclerosis from the Knowledge Center]
Tidsskr Nor Laegeforen, 127 (12), 1672-3; author reply 1673
PubMed 17571115

Knudsen GP, Harbo HF, Smestad C, Celius EG, Akesson E, Oturai A, Ryder LP, Spurkland A, Ørstavik KH (2007)
X chromosome inactivation in females with multiple sclerosis
Eur J Neurol, 14 (12), 1392-6
DOI 10.1111/j.1468-1331.2007.01987.x, PubMed 17970735

Lerdal A, Celius EG, Krupp L, Dahl AA (2007)
A prospective study of patterns of fatigue in multiple sclerosis
Eur J Neurol, 14 (12), 1338-43
DOI 10.1111/j.1468-1331.2007.01974.x, PubMed 17903208

Lundmark F, Duvefelt K, Iacobaeus E, Kockum I, Wallström E, Khademi M, Oturai A, Ryder LP, Saarela J, Harbo HF, Celius EG, Salter H, Olsson T, Hillert J (2007)
Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis
Nat Genet, 39 (9), 1108-13
DOI 10.1038/ng2106, PubMed 17660816

Smestad C, Brynedal B, Jonasdottir G, Lorentzen AR, Masterman T, Akesson E, Spurkland A, Lie BA, Palmgren J, Celius EG, Hillert J, Harbo HF (2007)
The impact of HLA-A and -DRB1 on age at onset, disease course and severity in Scandinavian multiple sclerosis patients
Eur J Neurol, 14 (8), 835-40
DOI 10.1111/j.1468-1331.2007.01825.x, PubMed 17662002

Smestad C, Sandvik L, Holmoy T, Harbo HF, Celius EG (2007)
Marked differences in prevalence of multiple sclerosis between ethnic groups in Oslo, Norway
J Neurol, 255 (1), 49-55
DOI 10.1007/s00415-007-0659-8, PubMed 18080855

Publications 2006

Harbo HF, Ekstrøm PO, Lorentzen AR, Sundvold-Gjerstad V, Celius EG, Sawcer S, Spurkland A (2006)
Coding region polymorphisms in T cell signal transduction genes. Prevalence and association to development of multiple sclerosis
J Neuroimmunol, 177 (1-2), 40-5
DOI 10.1016/j.jneuroim.2006.04.021, PubMed 16764945

Lundmark F, Harbo HF, Celius EG, Saarela J, Datta P, Oturai A, Lindgren CM, Masterman T, Salter H, Hillert J (2006)
Association analysis of the LAG3 and CD4 genes in multiple sclerosis in two independent populations
J Neuroimmunol, 180 (1-2), 193-8
DOI 10.1016/j.jneuroim.2006.08.009, PubMed 17020785

Publications 2005

Lorentzen AR, Celius EG, Ekstrøm PO, Wiencke K, Lie BA, Myhr KM, Ling V, Thorsby E, Vartdal F, Spurkland A, Harbo HF (2005)
Lack of association with the CD28/CTLA4/ICOS gene region among Norwegian multiple sclerosis patients
J Neuroimmunol, 166 (1-2), 197-201
DOI 10.1016/j.jneuroim.2005.06.002, PubMed 16005527

Midgard R, Seland JH, Hovdal H, Celius EG, Eriksen K, Jensen D, Heger H, Mellgren SI, Wexler A, Beiske AG, Myhr KM (2005)
[Retraction of article]
Tidsskr Nor Laegeforen, 125 (15), 2056
PubMed 16208878

Midgard R, Seland JH, Hovdal H, Celius EG, Eriksen K, Jensen D, Heger H, Mellgren SI, Wexler A, Beiske AG, Myhr KM (2005)
[Optic neuritis--diagnosis, treatment and follow up]
Tidsskr Nor Laegeforen, 125 (4), 425-8 (Retracted)
PubMed 15742012

Roxburgh RH, Seaman SR, Masterman T, Hensiek AE, Sawcer SJ, Vukusic S, Achiti I, Confavreux C, Coustans M, le Page E, Edan G, McDonnell GV, Hawkins S, Trojano M, Liguori M, Cocco E, Marrosu MG, Tesser F, Leone MA, Weber A, Zipp F, Miterski B, Epplen JT, Oturai A, Sørensen PS et al. (2005)
Multiple Sclerosis Severity Score: using disability and disease duration to rate disease severity
Neurology, 64 (7), 1144-51
DOI 10.1212/01.WNL.0000156155.19270.F8, PubMed 15824338

Publications 2004

Harbo HF, Lie BA, Sawcer S, Celius EG, Dai KZ, Oturai A, Hillert J, Lorentzen AR, Laaksonen M, Myhr KM, Ryder LP, Fredrikson S, Nyland H, Sørensen PS, Sandberg-Wollheim M, Andersen O, Svejgaard A, Edland A, Mellgren SI, Compston A, Vartdal F, Spurkland A (2004)
Genes in the HLA class I region may contribute to the HLA class II-associated genetic susceptibility to multiple sclerosis
Tissue Antigens, 63 (3), 237-47
DOI 10.1111/j.0001-2815.2004.00173.x, PubMed 14989713

Landrø NI, Celius EG, Sletvold H (2004)
Depressive symptoms account for deficient information processing speed but not for impaired working memory in early phase multiple sclerosis (MS)
J Neurol Sci, 217 (2), 211-6
DOI 10.1016/j.jns.2003.10.012, PubMed 14706226

Oturai AB, Ryder LP, Fredrikson S, Myhr KM, Celius EG, Harbo HF, Andersen O, Akesson E, Hillert J, Madsen HO, Nyland H, Spurkland A, Datta P, Svejgaard A, Sorensen PS (2004)
Concordance for disease course and age of onset in Scandinavian multiple sclerosis coaffected sib pairs
Mult Scler, 10 (1), 5-8
DOI 10.1191/1352458504ms975oa, PubMed 14760946

Publications 2003

Bølviken B, Celius EG, Nilsen R, Strand T (2003)
Radon: a possible risk factor in multiple sclerosis
Neuroepidemiology, 22 (1), 87-94
DOI 10.1159/000067102, PubMed 12566959

Harbo HF, Datta P, Oturai A, Ryder LP, Sawcer S, Setakis E, Akesson E, Celius EG, Modin H, Sandberg-Wollheim M, Myhr KM, Andersen O, Hillert J, Sorensen PS, Svejgaard A, Compston A, Vartdal F, Spurkland A (2003)
Two genome-wide linkage disequilibrium screens in Scandinavian multiple sclerosis patients
J Neuroimmunol, 143 (1-2), 101-6
DOI 10.1016/j.jneuroim.2003.08.021, PubMed 14575924

Lerdal A, Celius EG, Moum T (2003)
Fatigue and its association with sociodemographic variables among multiple sclerosis patients
Mult Scler, 9 (5), 509-14
DOI 10.1191/1352458503ms943oa, PubMed 14582778

Midgard R, Beiske AG, Celius EG, Jensen D, Hovdal H, Mellgren SI, Myhr KM (2003)
[New diagnostic criteria in multiple sclerosis]
Tidsskr Nor Laegeforen, 123 (10), 1345-8
PubMed 12806674

Publications 2001

Celius EG, Vandvik B (2001)
Multiple sclerosis in Oslo, Norway: prevalence on 1 January 1995 and incidence over a 25-year period
Eur J Neurol, 8 (5), 463-9
DOI 10.1046/j.1468-1331.2001.00269.x, PubMed 11554910

Dai KZ, Harbo HF, Celius EG, Oturai A, Sørensen PS, Ryder LP, Datta P, Svejgaard A, Hillert J, Fredrikson S, Sandberg-Wollheim M, Laaksonen M, Myhr KM, Nyland H, Vartdal F, Spurkland A (2001)
The T cell regulator gene SH2D2A contributes to the genetic susceptibility of multiple sclerosis
Genes Immun, 2 (5), 263-8
DOI 10.1038/sj.gene.6363774, PubMed 11528519

Publications 2000

Celius EG, Harbo HF, Egeland T, Vartdal F, Vandvik B, Spurkiand A (2000)
Sex and age at diagnosis are correlated with the HLA-DR2, DQ6 haplotype in multiple sclerosis
J Neurol Sci, 178 (2), 132-5
DOI 10.1016/S0022-510X(00)00389-0, PubMed 11018705

Landrø NI, Sletvold H, Celius EG (2000)
Memory functioning and emotional changes in early phase multiple sclerosis
Arch Clin Neuropsychol, 15 (1), 37-46
DOI 10.1016/S0887-6177(98)00151-6, PubMed 14590566

Publications 1999

Harbo HF, Celius EG, Vartdal F, Spurkland A (1999)
CTLA4 promoter and exon 1 dimorphisms in multiple sclerosis
Tissue Antigens, 53 (1), 106-10
PubMed 10082437

Myhr KM, Riise T, Green Lilleås FE, Beiske TG, Celius EG, Edland A, Jensen D, Larsen JP, Nilsen R, Nortvedt MW, Smievoll AI, Vedeler C, Nyland HI (1999)
Interferon-alpha2a reduces MRI disease activity in relapsing-remitting multiple sclerosis. Norwegian Study Group on Interferon-alpha in Multiple Sclerosis
Neurology, 52 (5), 1049-56
DOI 10.1212/wnl.52.5.1049, PubMed 10102427

Publications 1998

Brekke M, Hjortdahl P, Thelle DS, Celius EG, Heldal E, Joner G, Kvien TK (1998)
[Differences in morbidity between the Eastern central city district and the suburban Western district of Oslo]
Tidsskr Nor Laegeforen, 118 (1), 14-7
PubMed 9481903

Publications 1997

Celius EG (1997)
[Neurologic complications in heroin abuse. Illustrated by two unusual cases]
Tidsskr Nor Laegeforen, 117 (3), 356-7
PubMed 9064856

Spurkland A, Celius EG, Knutsen I, Beiske A, Thorsby E, Vartdal F (1997)
The HLA-DQ(alpha 1*0102, beta 1*0602) heterodimer may confer susceptibility to multiple sclerosis in the absence of the HLA-DR(alpha 1*01, beta 1*1501) heterodimer
Tissue Antigens, 50 (1), 15-22
DOI 10.1111/j.1399-0039.1997.tb02828.x, PubMed 9243750

Publications 1996

Celius EG, Andersson S (1996)
Leucoencephalopathy after inhalation of heroin: a case report
J Neurol Neurosurg Psychiatry, 60 (6), 694-5
DOI 10.1136/jnnp.60.6.694, PubMed 8648344

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