Cover of Traffic

Cover Legend: Ultrastructural morphology of endosomal compartments after simultaneous depletion of all ESCRTs (Endosomal sorting complex required for transport). The brown colouring indicates enlarged, multivesicular endosomes (MVEs), which are still formed independently of ESCRT proteins. The red colour marks areas of endosomal membrane sheets that are docked together, displaying a typical, striated coat between the membrane layers.  Within these membrane accumulations various smaller MVEs (cloured in green) are found. Mitochondria are marked in pink. From the article "Multivesicular endosome biogenesis in the absence of ESCRTs" by Stuffers S, Sem Wegner C, Stenmark H, Brech A., Traffic. 2009 Jul;10(7):925-37.