Publications 2024

Bratteteig M, Rueegg CS, Lie HC, Thorsen L, Larsen EH, Larsen MH, Torsvik IK, Götte M, Järvelä LS, Kriemler S, Larsen HB, Anderssen SA, Ruud E, Grydeland M (2024)
Physical activity behaviors and screen time in young childhood cancer survivors: the Physical Activity in Childhood Cancer Survivors Study
J Cancer Surviv (in press)
DOI 10.1007/s11764-024-01671-7, PubMed 39287916

Deng WH, Lie HC, Ruud E, Loge JH, Kiserud CE, Rueegg CS (2024)
Profiles of Fatigue and Psychological Symptoms in Long-Term Childhood, Adolescent, and Young Adult Cancer Survivors-The NOR-CAYACS Study
Cancer Med, 13 (22), e70425
DOI 10.1002/cam4.70425, PubMed 39584526

Egset KS, Stubberud J, Ruud E, Hjort MA, Eilertsen MB, Sund AM, Hjemdal O, Weider S, Reinfjell T (2024)
Neurocognitive outcome and associated factors in long-term, adult survivors of childhood acute lymphoblastic leukemia, treated without cranial radiation therapy
J Int Neuropsychol Soc, 30 (6), 523-532
DOI 10.1017/S1355617724000080, PubMed 38465668

Egset KS, Weider S, Hjemdal O, Ruud E, Hjort MA, Eilertsen MB, Sund AM, Stubberud J, Reinfjell T (2024)
Exploring the Discrepancy Between Subjective and Objective Measures of Executive Functions in Young Adult Survivors of Childhood Acute Lymphoblastic Leukemia
J Adolesc Young Adult Oncol (in press)
DOI 10.1089/jayao.2024.0105, PubMed 39552427

Larsen EH, Wahl AK, Ruud E, Mellblom AV, Ålykkja A, Lie HC (2024)
Adolescent Cancer Survivors and Their Parents' Experiences With the Transition Off Treatment to Survivorship: A Qualitative Interview Study
J Pediatr Hematol Oncol Nurs, 41 (3), 172-187
DOI 10.1177/27527530231214528, PubMed 38656765

Przybyła W, Gjersvoll Paulsen KM, Mishra CK, Nygård S, Engebretsen S, Ruud E, Trøen G, Beiske K, Baumbusch LO (2024)
Correction: Whole exome sequencing of high-risk neuroblastoma identifies novel non-synonymous variants
PLoS One, 19 (7), e0306687
DOI 10.1371/journal.pone.0306687, PubMed 38950054

Publications 2023

Bratteteig M, Rueegg CS, Raastad T, Grydeland M, Torsvik IK, Schindera C, Ruud E, Anderssen SA (2023)
Physical Activity, Fitness, and Cardiovascular Disease Risk in Adolescent Childhood Cancer Survivors Compared to Controls: The Physical Activity in Childhood Cancer Survivors Study
J Adolesc Young Adult Oncol, 13 (2), 338-346
DOI 10.1089/jayao.2023.0063, PubMed 37703544

Engan B, Diab S, Brun H, Raastad T, Torsvik IK, Omdal TR, Ghavidel FZ, Greve G, Ruud E, Edvardsen E, Leirgul E (2023)
Systolic myocardial function measured by echocardiographic speckle-tracking and peak oxygen consumption in pediatric childhood cancer survivors-a PACCS study
Front Cardiovasc Med, 10, 1221787
DOI 10.3389/fcvm.2023.1221787, PubMed 37476575

Grydeland M, Bratteteig M, Rueegg CS, Lie HC, Thorsen L, Larsen EH, Brügmann-Pieper S, Torsvik IK, Götte M, Lähteenmäki PM, Kriemler S, Fridh MK, Anderssen SA, Ruud E (2023)
Physical Activity Among Adolescent Cancer Survivors: The PACCS Study
Pediatrics, 152 (3)
DOI 10.1542/peds.2023-061778, PubMed 37646086

Larsen MH, Larsen EH, Ålykkja A, Underhaug KA, Ruud E, Lie HC (2023)
"The post-it note just said leukemia" - Information exchange challenges of teachers and local stakeholders supporting young childhood cancer survivors at school - A qualitative study from the Physical Activity and Fitness in Childhood Cancer Survivors (PACCS) group
Eur J Oncol Nurs, 68, 102464
DOI 10.1016/j.ejon.2023.102464, PubMed 38029601

Richartz N, Pietka W, Yadav A, Bostad M, Bhagwat S, Naderi S, Naderi EH, Stokke T, Ruud E, Blomhoff HK (2023)
N-acetyl cysteine turns EPAC activators into potent killers of acute lymphoblastic leukemia cells
J Biol Chem, 300 (1), 105509
DOI 10.1016/j.jbc.2023.105509, PubMed 38042493

Aalykkja A, Larsen EH, Larsen MH, Ruud E, Puhr A, Lie HC (2023)
Life after paediatric brain tumour; the perspectives of the survivors and their parents
J Adv Nurs, 80 (2), 550-565
DOI 10.1111/jan.15812, PubMed 37537856

Publications 2022

Andries A, Ørstavik K, Rueegg CS, Eng S, Edvardsen E, Allen SM, Torsvik IK, Raastad T, Ruud E, Nilsen KB (2022)
Polyneuropathy in Adolescent Childhood Cancer Survivors: The PACCS Study
Pediatr Neurol, 140, 9-17
DOI 10.1016/j.pediatrneurol.2022.11.012, PubMed 36586183

Bratteteig M, Anderssen SA, Rueegg CS, Ruud E, Torsvik IK, Kriemler S, Grydeland M (2022)
Device-measured physical activity and cardiovascular disease risk in adolescent childhood cancer survivors. A physical activity in childhood cancer survivors (PACCS) study
Front Pediatr, 10, 977365
DOI 10.3389/fped.2022.977365, PubMed 36090557

Dahl AA, Kiserud CE, Fosså SD, Loge JH, Reinertsen KV, Ruud E, Lie HC (2022)
A study of high neuroticism in long-term survivors of childhood, adolescence, and young adult cancers
Sci Rep, 12 (1), 12325
DOI 10.1038/s41598-022-15697-3, PubMed 35853946

Diep PP, Rueegg CS, Burman MM, Brinch L, Bø K, Fosså K, Landrø L, Loge JH, Lund MB, Massey RJ, Myrdal OH, Pathak M, Rimstad L, Tanem KE, Tjønnfjord GE, Aaløkken TM, Ruud E (2022)
Graft-Versus-Host-Disease and Health-Related Quality of Life in Young Long-term Survivors of Cancer and Allogeneic Hematopoietic Stem Cell Transplantation
J Adolesc Young Adult Oncol, 12 (1), 66-75
DOI 10.1089/jayao.2021.0196, PubMed 35544321

Einarsdóttir Egeland S, Lie HC, Woldseth EM, Korsvold L, Ruud E, Larsen MH, Viktoria Mellblom A (2022)
Exploring reported distress before and pain during needle insertion into a venous access port in children with cancer
Scand J Caring Sci, 37 (4), 927-937
DOI 10.1111/scs.13067, PubMed 35076943

Gianinazzi ME, Kiserud CE, Ruud E, Lie HC (2022)
Who Knows? Information Received, and Knowledge about, Cancer, Treatment and Late Effects in a National Cohort of Long-Term Childhood, Adolescent and Young Adult Cancer Survivors
Cancers (Basel), 14 (6)
DOI 10.3390/cancers14061534, PubMed 35326685

Larsen EH, Mellblom AV, Larsen MH, Ruud E, Thorsen L, Petersen NN, Larsen HB, Fridh MK, Lie HC (2022)
Perceived barriers and facilitators to physical activity in childhood cancer survivors and their parents: A large-scale interview study from the International PACCS Study
Pediatr Blood Cancer, 70 (1), e30056
DOI 10.1002/pbc.30056, PubMed 36251019

Larsen EH, Mellblom AV, Ruud E, Wahl AK, Lie HC (2022)
Prepared for survivorship? Multidisciplinary healthcare professionals' experiences with adolescents' transition off cancer treatment: A focus group study
Eur J Oncol Nurs, 58, 102150
DOI 10.1016/j.ejon.2022.102150, PubMed 35653806

Larsen MH, Hansson KE, Larsen EH, Fridh MK, Petersen NN, Mellblom AV, Ruud E, Larsen HB, Lie HC (2022)
The gap between expectations and reality: A qualitative study of psychosocial challenges of young childhood cancer survivors from the PACCS study
Eur J Cancer Care (Engl), 31 (6), e13696
DOI 10.1111/ecc.13696, PubMed 36029045

Lie HC, Anderssen S, Rueegg CS, Raastad T, Grydeland M, Thorsen L, Stensrud T, Edvardsen E, Larsen MH, Torsvik IK, Bovim LP, Götte M, Lähteenmäki PM, Kriemler S, Larsen HB, Fridh MK, Ørstavik K, Brun H, Matthews I, Hornset E, Ruud E (2022)
The Physical Activity and Fitness in Childhood Cancer Survivors (PACCS) Study: Protocol for an International Mixed Methods Study
JMIR Res Protoc, 11 (3), e35838
DOI 10.2196/35838, PubMed 35258456

Massey RJ, Myrdal OH, Diep PP, Burman MM, Brinch L, Gullestad LL, Ruud E, Aakhus S, Beitnes JO (2022)
Reduced exercise capacity is associated with left ventricular systolic dysfunction in long-term survivors of allogeneic hematopoietic stem-cell transplantation
J Clin Ultrasound, 51 (1), 5-15
DOI 10.1002/jcu.23264, PubMed 35788941

Przybyła W, Gjersvoll Paulsen KM, Mishra CK, Nygård S, Engebretsen S, Ruud E, Trøen G, Beiske K, Baumbusch LO (2022)
Whole exome sequencing of high-risk neuroblastoma identifies novel non-synonymous variants
PLoS One, 17 (8), e0273280
DOI 10.1371/journal.pone.0273280, PubMed 36037157

Richartz N, Pietka W, Gilljam KM, Skah S, Skålhegg BS, Bhagwat S, Naderi EH, Ruud E, Blomhoff HK (2022)
cAMP-Mediated Autophagy Promotes Cell Survival via ROS-Induced Activation of PARP1: Implications for Treatment of Acute Lymphoblastic Leukemia
Mol Cancer Res, 20 (3), 400-411
DOI 10.1158/1541-7786.MCR-21-0652, PubMed 34880123

Tanem KE, Wilberg P, Diep PP, Ruud E, Skaare AB, Brinch L, Herlofson BB (2022)
Oral chronic GVHD after allogeneic stem cell transplantation without total body irradiation performed at a young age
Support Care Cancer, 30 (5), 4121-4128
DOI 10.1007/s00520-022-06836-7, PubMed 35075489

Publications 2021

Dahl AA, Kiserud CE, Fosså SD, Loge JH, Reinertsen KV, Ruud E, Lie HC (2021)
A Controlled Study of Major Depressive Episodes in Long-Term Childhood, Adolescence, and Young Adult Cancer Survivors (The NOR-CAYACS Study)
Cancers (Basel), 13 (22)
DOI 10.3390/cancers13225800, PubMed 34830953

Egset KS, Weider S, Stubberud J, Hjemdal O, Ruud E, Hjort MA, Eilertsen MB, Sund AM, Røkke ME, Reinfjell T (2021)
Cognitive Rehabilitation for Neurocognitive Late Effects in Adult Survivors of Childhood Acute Lymphoblastic Leukemia: A Feasibility and Case-Series Study
Front Psychol, 12, 724960
DOI 10.3389/fpsyg.2021.724960, PubMed 34777103

Larsen MH, Larsen EH, Ruud E, Mellblom A, Helland S, Lie HC (2021)
"I have to do things differently now, but I make it work"-young childhood cancer survivors' experiences of self-management in everyday living
J Cancer Surviv, 16 (4), 728-740
DOI 10.1007/s11764-021-01066-y, PubMed 34097249

Massey RJ, Diep PP, Burman MM, Kvaslerud AB, Brinch L, Aakhus S, Gullestad L, Ruud E, Beitnes JO (2021)
Impaired right ventricular function in long-term survivors of allogeneic haematopoietic stem-cell transplantation
Open Heart, 8 (2)
DOI 10.1136/openhrt-2021-001768, PubMed 34933961

Mellblom AV, Ruud E, Loge JH, Lie HC, Finset A (2021)
From Observation to Action: Developing and Pilot-Testing a Communication Tool for Follow-up Consultations with Adolescent Cancer Survivors
J Adolesc Young Adult Oncol, 11 (4), 419-426
DOI 10.1089/jayao.2021.0123, PubMed 34910892

Myrdal OH, Aaløkken TM, Diep PP, Ruud E, Brinch L, Fosså K, Mangseth H, Kongerud J, Sikkeland LI, Lund MB (2021)
Late-Onset, Noninfectious Pulmonary Complications following Allogeneic Hematopoietic Stem Cell Transplantation: A Nationwide Cohort Study of Long-Term Survivors
Respiration, 101 (6), 544-552
DOI 10.1159/000520824, PubMed 34937032

Puhr A, Ruud E, Anderson V, Due-Tønnessen BJ, Skarbø AB, Finset A, Andersson S (2021)
Executive Function and Psychosocial Adjustment in Adolescent Survivors of Pediatric Brain Tumor
Dev Neuropsychol, 46 (2), 149-168
DOI 10.1080/87565641.2021.1900191, PubMed 33783291

Publications 2020

Berlanga P, Pasqualini C, Pötschger U, Sangüesa C, Castellani MR, Cañete A, Luksch R, Elliot M, Schreier G, Kropf M, Morgenstern D, Papadakis V, Ash S, Ruud E, Brock P, Wieczorek A, Kogner P, Trahair T, Ambros P, Boterberg T, Castel V, Valteau-Couanet D, Ladenstein R (2020)
Central nervous system relapse in high-risk stage 4 neuroblastoma: The HR-NBL1/SIOPEN trial experience
Eur J Cancer, 144, 1-8
DOI 10.1016/j.ejca.2020.10.020, PubMed 33316634

Del Risco Kollerud R, Cannon-Albright LA, Haugnes HS, Ruud E, Thoresen M, Nafstad P, Blaasaas KG, Naess Ø, Claussen B (2020)
Childhood central nervous system tumors and leukemia: Incidence and familial risk. A comparative population-based study in Utah and Norway
Pediatr Blood Cancer, 67 (8), e28408
DOI 10.1002/pbc.28408, PubMed 32437093

Holmes K, Pötschger U, Pearson ADJ, Sarnacki S, Cecchetto G, Gomez-Chacon J, Squire R, Freud E, Bysiek A, Matthyssens LE, Metzelder M, Monclair T, Stenman J, Rygl M, Rasmussen L, Joseph JM, Irtan S, Avanzini S, Godzinski J, Björnland K, Elliott M, Luksch R, Castel V, Ash S, Balwierz W et al. (2020)
Influence of Surgical Excision on the Survival of Patients With Stage 4 High-Risk Neuroblastoma: A Report From the HR-NBL1/SIOPEN Study
J Clin Oncol, 38 (25), 2902-2915
DOI 10.1200/JCO.19.03117, PubMed 32639845

Jarvis KB, Lind A, LeBlanc M, Ruud E (2020)
Observed reduction in the diagnosis of acute lymphoblastic leukaemia in children during the COVID-19 pandemic
Acta Paediatr, 110 (2), 596-597
DOI 10.1111/apa.15576, PubMed 32959407

Jarvis KB, Nielsen RL, Gupta R, Hede FD, Huttunen P, Jónsson ÓG, Rank CU, Ranta S, Saks K, Trakymiene SS, Tuckuviene R, Tulstrup M, INVENT consortium, Ruud E, Schmiegelow K, LeBlanc M (2020)
Polygenic risk score-analysis of thromboembolism in patients with acute lymphoblastic leukemia
Thromb Res, 196, 15-20
DOI 10.1016/j.thromres.2020.08.015, PubMed 32818716

Ladenstein R, Pötschger U, Valteau-Couanet D, Luksch R, Castel V, Ash S, Laureys G, Brock P, Michon JM, Owens C, Trahair T, Chi Fung Chan G, Ruud E, Schroeder H, Beck-Popovic M, Schreier G, Loibner H, Ambros P, Holmes K, Castellani MR, Gaze MN, Garaventa A, Pearson ADJ, Lode HN (2020)
Investigation of the Role of Dinutuximab Beta-Based Immunotherapy in the SIOPEN High-Risk Neuroblastoma 1 Trial (HR-NBL1)
Cancers (Basel), 12 (2)
DOI 10.3390/cancers12020309, PubMed 32013055

Massey RJ, Diep PP, Ruud E, Burman MM, Kvaslerud AB, Brinch L, Aakhus S, Gullestad LL, Beitnes JO (2020)
Left Ventricular Systolic Function in Long-Term Survivors of Allogeneic Hematopoietic Stem Cell Transplantation
JACC CardioOncol, 2 (3), 460-471
DOI 10.1016/j.jaccao.2020.06.011, PubMed 34396253

Massey RJ, Diep PP, Ruud E, Burman MM, Kvaslerud AB, Brinch L, Aakhus S, Gullestad LL, Beitnes JO (2020)
Left Ventricular Systolic Function in Long-Term Survivors of Allogeneic Hematopoietic Stem Cell Transplantation
JACC CardioOncol, 2 (3), 460-471
DOI 10.1016/j.jaccao.2020.06.011, PublikaID 352

Mateos MK, Tulstrup M, Quinn MC, Tuckuviene R, Marshall GM, Gupta R, Mayoh C, Wolthers BO, Barbaro PM, Ruud E, Sutton R, Huttunen P, Revesz T, Trakymiene SS, Barbaric D, Tedgård U, Giles JE, Alvaro F, Jonsson OG, Mechinaud F, Saks K, Catchpoole D, Kotecha RS, Dalla-Pozza L, Chenevix-Trench G et al. (2020)
Genome-Wide Association Meta-Analysis of Single-Nucleotide Polymorphisms and Symptomatic Venous Thromboembolism during Therapy for Acute Lymphoblastic Leukemia and Lymphoma in Caucasian Children
Cancers (Basel), 12 (5)
DOI 10.3390/cancers12051285, PubMed 32438682

Mellblom AV, Kiserud CE, Rueegg CS, Ruud E, Loge JH, Fosså SD, Lie HC (2020)
Self-reported late effects and long-term follow-up care among 1889 long-term Norwegian Childhood, Adolescent, and Young Adult Cancer Survivors (the NOR-CAYACS study)
Support Care Cancer, 29 (6), 2947-2957
DOI 10.1007/s00520-020-05790-6, PubMed 33011832

Myrdal OH, Diep PP, Ruud E, Brinch L, Massey RJ, Edvardsen E, Kongerud J, Lund MB, Sikkeland LI (2020)
Determinants of cardiorespiratory fitness in very long-term survivors of allogeneic hematopoietic stem cell transplantation: a national cohort study
Support Care Cancer, 29 (4), 1959-1967
DOI 10.1007/s00520-020-05644-1, PubMed 32827056

Tuckuviene R, Bjerg CL, Jonsson OG, Langstrom S, Rank CU, Ranta S, Saks K, Trakymiene SS, Ruud E (2020)
Pulmonary embolism in acute lymphoblastic leukemia - An observational study of 1685 patients treated according to the NOPHO ALL2008 protocol
Res Pract Thromb Haemost, 4 (5), 866-871
DOI 10.1002/rth2.12356, PubMed 32685896

Ålykkja A, Ruud E, Larsen MH, Vatne TM, Lie HC (2020)
Available, but not always accessible: A nationwide, qualitative study of multidisciplinary healthcare providers' experiences with follow-up care after paediatric brain tumour
Eur J Cancer Care (Engl), 30 (2), e13375
DOI 10.1111/ecc.13375, PubMed 33236388

Publications 2019

Dahl AA, Fosså SD, Lie HC, Loge JH, Reinertsen KV, Ruud E, Kiserud CE (2019)
Employment Status and Work Ability in Long-Term Young Adult Cancer Survivors
J Adolesc Young Adult Oncol, 8 (3), 304-311
DOI 10.1089/jayao.2018.0109, PubMed 30900929

Del Risco Kollerud R, Ruud E, Haugnes HS, Cannon-Albright LA, Thoresen M, Nafstad P, Vlatkovic L, Blaasaas KG, Næss Ø, Claussen B (2019)
Family history of cancer and risk of paediatric and young adult's testicular cancer: A Norwegian cohort study
Br J Cancer, 120 (10), 1007-1014
DOI 10.1038/s41416-019-0445-2, PubMed 30967648

Jarvis KB, LeBlanc M, Tulstrup M, Nielsen RL, Albertsen BK, Gupta R, Huttunen P, Jónsson ÓG, Rank CU, Ranta S, Ruud E, Saks K, Trakymiene SS, Tuckuviene R, Schmiegelow K (2019)
Candidate single nucleotide polymorphisms and thromboembolism in acute lymphoblastic leukemia - A NOPHO ALL2008 study
Thromb Res, 184, 92-98
DOI 10.1016/j.thromres.2019.11.002, PubMed 31715544

Jarvis KB, Tveiterås M, de Lange C, Ruud E (2019)
Central venous line-related thromboembolism is common in children with non-high-risk acute lymphoblastic leukaemia
Acta Paediatr, 108 (6), 1167-1168
DOI 10.1111/apa.14757, PubMed 30786076

Lie HC, Rueegg CS, Fosså SD, Loge JH, Ruud E, Kiserud CE (2019)
Limited evidence of non-response bias despite modest response rate in a nationwide survey of long-term cancer survivors-results from the NOR-CAYACS study
J Cancer Surviv, 13 (3), 353-363
DOI 10.1007/s11764-019-00757-x, PubMed 30993649

Puhr A, Ruud E, Anderson V, Due-Tønnessen BJ, Skarbø AB, Finset A, Andersson S (2019)
Social attainment in physically well-functioning long-term survivors of pediatric brain tumour; the role of executive dysfunction, fatigue, and psychological and emotional symptoms
Neuropsychol Rehabil, 31 (1), 129-153
DOI 10.1080/09602011.2019.1677480, PubMed 31603026

Richartz N, Duthil E, Ford A, Naderi EH, Bhagwat S, Gilljam KM, Burman MM, Ruud E, Blomhoff HK, Skah S (2019)
Targeting cyclooxygenase by indomethacin decelerates progression of acute lymphoblastic leukemia in a xenograft model
Blood Adv, 3 (21), 3181-3190
DOI 10.1182/bloodadvances.2019000473, PubMed 31698450

Publications 2018

Berbegall AP, Bogen D, Pötschger U, Beiske K, Bown N, Combaret V, Defferrari R, Jeison M, Mazzocco K, Varesio L, Vicha A, Ash S, Castel V, Coze C, Ladenstein R, Owens C, Papadakis V, Ruud E, Amann G, Sementa AR, Navarro S, Ambros PF, Noguera R, Ambros IM (2018)
Heterogeneous MYCN amplification in neuroblastoma: a SIOP Europe Neuroblastoma Study
Br J Cancer, 118 (11), 1502-1512
DOI 10.1038/s41416-018-0098-6, PubMed 29755120

Byrne J, Grabow D, Campbell H, O'Brien K, Bielack S, Am Zehnhoff-Dinnesen A, Calaminus G, Kremer L, Langer T, van den Heuvel-Eibrink MM, van Dulmen-den Broeder E, Baust K, Bautz A, Beck JD, Berger C, Binder H, Borgmann-Staudt A, Broer L, Cario H, Casagranda L, Clemens E, Deuster D, de Vries A, Dirksen U, Winther JF et al. (2018)
PanCareLIFE: The scientific basis for a European project to improve long-term care regarding fertility, ototoxicity and health-related quality of life after cancer occurring among children and adolescents
Eur J Cancer, 103, 227-237
DOI 10.1016/j.ejca.2018.08.007, PubMed 30273888

Del Risco Kollerud R, Blaasaas KG, Claussen B, Nafstad P, Cannon-Albright LA, Ruud E, Wesenberg F, Næss Ø (2018)
Family history of cancer and the risk of childhood solid tumours: a Norwegian nationwide register-based cohort study
Br J Cancer, 118 (6), 905-912
DOI 10.1038/bjc.2017.493, PubMed 29462129

Diep PP, Melberg HO, Brinch L, Buechner J, Fløisand Y, Gedde-Dahl T, Loge JH, Tjønnfjord GE, Ruud E (2018)
Cost-utility of allogeneic hematopoietic stem cell transplantation in Norway
Bone Marrow Transplant, 53 (5), 657-660
DOI 10.1038/s41409-018-0091-y, PubMed 29358600

Ladenstein R, Pötschger U, Valteau-Couanet D, Luksch R, Castel V, Yaniv I, Laureys G, Brock P, Michon JM, Owens C, Trahair T, Chan GCF, Ruud E, Schroeder H, Beck Popovic M, Schreier G, Loibner H, Ambros P, Holmes K, Castellani MR, Gaze MN, Garaventa A, Pearson ADJ, Lode HN (2018)
Interleukin 2 with anti-GD2 antibody ch14.18/CHO (dinutuximab beta) in patients with high-risk neuroblastoma (HR-NBL1/SIOPEN): a multicentre, randomised, phase 3 trial
Lancet Oncol, 19 (12), 1617-1629
DOI 10.1016/S1470-2045(18)30578-3, PubMed 30442501

Morgenstern DA, Pötschger U, Moreno L, Papadakis V, Owens C, Ash S, Pasqualini C, Luksch R, Garaventa A, Canete A, Elliot M, Wieczorek A, Laureys G, Kogner P, Malis J, Ruud E, Beck-Popovic M, Schleiermacher G, Valteau-Couanet D, Ladenstein R (2018)
Risk stratification of high-risk metastatic neuroblastoma: A report from the HR-NBL-1/SIOPEN study
Pediatr Blood Cancer, 65 (11), e27363
DOI 10.1002/pbc.27363, PubMed 30015396

Myrdal OH, Kanellopoulos A, Christensen JR, Ruud E, Edvardsen E, Kongerud J, Sikkeland LI, Lund MB (2018)
Risk factors for impaired pulmonary function and cardiorespiratory fitness in very long-term adult survivors of childhood acute lymphoblastic leukemia after treatment with chemotherapy only
Acta Oncol, 57 (5), 658-664
DOI 10.1080/0284186X.2017.1423177, PubMed 29303026

Pathak M, Diep PP, Lai X, Brinch L, Ruud E, Drolsum L (2018)
Ocular findings and ocular graft-versus-host disease after allogeneic stem cell transplantation without total body irradiation
Bone Marrow Transplant, 53 (7), 863-872
DOI 10.1038/s41409-018-0090-z, PubMed 29382955

Puhr A, Ruud E, Anderson V, Due-Tønnesen BJ, Skarbø AB, Finset A, Andersson S (2018)
Self-Reported Executive Dysfunction, Fatigue, and Psychological and Emotional Symptoms in Physically Well-Functioning Long-Term Survivors of Pediatric Brain Tumor
Dev Neuropsychol, 44 (1), 88-103
DOI 10.1080/87565641.2018.1540007, PubMed 30395731

Rank CU, Toft N, Tuckuviene R, Grell K, Nielsen OJ, Frandsen TL, Marquart HVH, Albertsen BK, Tedgård U, Hallböök H, Ruud E, Jarvis KB, Quist-Paulsen P, Huttunen P, Wartiovaara-Kautto U, Jónsson ÓG, Trakymiene SS, Griškevičius L, Saks K, Punab M, Schmiegelow K (2018)
Thromboembolism in acute lymphoblastic leukemia: results of NOPHO ALL2008 protocol treatment in patients aged 1 to 45 years
Blood, 131 (22), 2475-2484
DOI 10.1182/blood-2018-01-827949, PubMed 29661787

Skah S, Richartz N, Duthil E, Gilljam KM, Bindesbøll C, Naderi EH, Eriksen AB, Ruud E, Dirdal MM, Simonsen A, Blomhoff HK (2018)
cAMP-mediated autophagy inhibits DNA damage-induced death of leukemia cells independent of p53
Oncotarget, 9 (54), 30434-30449
DOI 10.18632/oncotarget.25758, PubMed 30100998

Wolthers BO, Mogensen PR, Frandsen TL, Abrahamsson J, Behrendtz M, Heyman M, Lohi O, Norén-Nyström U, Ruud E, Schmiegelow K (2018)
Insulin-dependent diabetes: A chronic complication to acute pancreatitis in childhood acute lymphoblastic leukemia
Pediatr Blood Cancer, 66 (1), e27437
DOI 10.1002/pbc.27437, PubMed 30216644

Publications 2017

Ladenstein R, Pötschger U, Pearson ADJ, Brock P, Luksch R, Castel V, Yaniv I, Papadakis V, Laureys G, Malis J, Balwierz W, Ruud E, Kogner P, Schroeder H, de Lacerda AF, Beck-Popovic M, Bician P, Garami M, Trahair T, Canete A, Ambros PF, Holmes K, Gaze M, Schreier G, Garaventa A et al. (2017)
Busulfan and melphalan versus carboplatin, etoposide, and melphalan as high-dose chemotherapy for high-risk neuroblastoma (HR-NBL1/SIOPEN): an international, randomised, multi-arm, open-label, phase 3 trial
Lancet Oncol, 18 (4), 500-514
DOI 10.1016/S1470-2045(17)30070-0, PubMed 28259608

Lie HC, Mellblom AV, Brekke M, Finset A, Fosså SD, Kiserud CE, Ruud E, Loge JH (2017)
Experiences with late effects-related care and preferences for long-term follow-up care among adult survivors of childhood lymphoma
Support Care Cancer, 25 (8), 2445-2454
DOI 10.1007/s00520-017-3651-6, PubMed 28236146

Mellblom AV, Ruud E, Loge JH, Lie HC (2017)
Do negative emotions expressed during follow-up consultations with adolescent survivors of childhood cancer reflect late effects?
Patient Educ Couns, 100 (11), 2098-2101
DOI 10.1016/j.pec.2017.06.008, PubMed 28641990

Publications 2016

Christiansen JR, Massey R, Dalen H, Kanellopoulos A, Hamre H, Fosså SD, Ruud E, Kiserud CE, Aakhus S (2016)
Utility of Global Longitudinal Strain by Echocardiography to Detect Left Ventricular Dysfunction in Long-Term Adult Survivors of Childhood Lymphoma and Acute Lymphoblastic Leukemia
Am J Cardiol, 118 (3), 446-52
DOI 10.1016/j.amjcard.2016.05.021, PubMed 27296561

Christiansen JR, Massey R, Dalen H, Kanellopoulos A, Hamre H, Ruud E, Kiserud CE, Fosså SD, Aakhus S (2016)
Right ventricular function in long-term adult survivors of childhood lymphoma and acute lymphoblastic leukaemia
Eur Heart J Cardiovasc Imaging, 17 (7), 735-41
DOI 10.1093/ehjci/jew018, PubMed 26917232

Gunnes MW, Lie RT, Bjørge T, Ghaderi S, Ruud E, Syse A, Moster D (2016)
Reproduction and marriage among male survivors of cancer in childhood, adolescence and young adulthood: a national cohort study
Br J Cancer, 114 (3), 348-56
DOI 10.1038/bjc.2015.455, PubMed 26794280

Gunnes MW, Lie RT, Bjørge T, Ghaderi S, Syse A, Ruud E, Wesenberg F, Moster D (2016)
Suicide and violent deaths in survivors of cancer in childhood, adolescence and young adulthood-A national cohort study
Int J Cancer, 140 (3), 575-580
DOI 10.1002/ijc.30474, PubMed 27750385

Gunnes MW, Lie RT, Bjørge T, Syse A, Ruud E, Wesenberg F, Moster D (2016)
Economic independence in survivors of cancer diagnosed at a young age: A Norwegian national cohort study
Cancer, 122 (24), 3873-3882
DOI 10.1002/cncr.30253, PubMed 27518040

Korsvold L, Lie HC, Mellblom AV, Ruud E, Loge JH, Finset A (2016)
Tailoring the delivery of cancer diagnosis to adolescent and young adult patients displaying strong emotions: An observational study of two cases
Int J Qual Stud Health Well-being, 11, 30763
DOI 10.3402/qhw.v11.30763, PubMed 27125477

Korsvold L, Mellblom AV, Finset A, Ruud E, Lie HC (2016)
A content analysis of emotional concerns expressed at the time of receiving a cancer diagnosis: An observational study of consultations with adolescent and young adult patients and their family members
Eur J Oncol Nurs, 26, 1-8
DOI 10.1016/j.ejon.2016.10.005, PubMed 28069147

Korsvold L, Mellblom AV, Lie HC, Ruud E, Loge JH, Finset A (2016)
Patient-provider communication about the emotional cues and concerns of adolescent and young adult patients and their family members when receiving a diagnosis of cancer
Patient Educ Couns, 99 (10), 1576-83
DOI 10.1016/j.pec.2016.03.028, PubMed 27139576

Tuckuviene R, Ranta S, Albertsen BK, Andersson NG, Bendtsen MD, Frisk T, Gunnes MW, Helgestad J, Heyman MM, Jonsson OG, Mäkipernaa A, Pruunsild K, Tedgård U, Trakymiene SS, Ruud E (2016)
Prospective study of thromboembolism in 1038 children with acute lymphoblastic leukemia: a Nordic Society of Pediatric Hematology and Oncology (NOPHO) study
J Thromb Haemost, 14 (3), 485-94
DOI 10.1111/jth.13236, PubMed 26707629

Publications 2015

Christiansen JR, Kanellopoulos A, Lund MB, Massey R, Dalen H, Kiserud CE, Ruud E, Aakhus S (2015)
Impaired exercise capacity and left ventricular function in long-term adult survivors of childhood acute lymphoblastic leukemia
Pediatr Blood Cancer, 62 (8), 1437-43
DOI 10.1002/pbc.25492, PubMed 25832752

Ghaderi S, Engeland A, Gunnes MW, Moster D, Ruud E, Syse A, Wesenberg F, Bjørge T (2015)
Educational attainment among long-term survivors of cancer in childhood and adolescence: a Norwegian population-based cohort study
J Cancer Surviv, 10 (1), 87-95
DOI 10.1007/s11764-015-0453-z, PubMed 25929213

Kanellopoulos A, Andersson S, Zeller B, Tamnes CK, Fjell AM, Walhovd KB, Westlye LT, Fosså SD, Ruud E (2015)
Neurocognitive Outcome in Very Long-Term Survivors of Childhood Acute Lymphoblastic Leukemia After Treatment with Chemotherapy Only
Pediatr Blood Cancer, 63 (1), 133-8
DOI 10.1002/pbc.25690, PubMed 26312396

Lie HC, Loge JH, Fosså SD, Hamre HM, Hess SL, Mellblom AV, Ruud E, Finset A (2015)
Providing information about late effects after childhood cancer: lymphoma survivors' preferences for what, how and when
Patient Educ Couns, 98 (5), 604-11
DOI 10.1016/j.pec.2015.01.016, PubMed 25704291

Mellblom AV, Korsvold L, Finset A, Loge J, Ruud E, Lie HC (2015)
Providing Information About Late Effects During Routine Follow-Up Consultations Between Pediatric Oncologists and Adolescent Survivors: A Video-Based, Observational Study
J Adolesc Young Adult Oncol, 4 (4), 200-8
DOI 10.1089/jayao.2015.0037, PubMed 26697269

Mellblom AV, Korsvold L, Ruud E, Lie HC, Loge JH, Finset A (2015)
Sequences of talk about emotional concerns in follow-up consultations with adolescent childhood cancer survivors
Patient Educ Couns, 99 (1), 77-84
DOI 10.1016/j.pec.2015.07.021, PubMed 26265504

Monclair T, Ruud E, Holmstrom H, Aagenaes I, Asplin M, Beiske K (2015)
Extra-adrenal composite phaeochromocytoma/neuroblastoma in a 15-month-old child
J. Pediatr. Surg. Case Rep., 3 (8), 348-350
DOI 10.1016/j.epsc.2015.06.014

Monclair T, Ruud E, Holmstrøm HA, Aagenæs I, Asplin Marius, Beiske K (2015)
Extra-adrenal composite phaechromocytoma/neuroblastoma in a 15-month-old child
Journal of Pediatric Surgery CASE REPORTS, 3, 348-350
PublikaID 226

Naderi EH, Skah S, Ugland H, Myklebost O, Sandnes DL, Torgersen ML, Josefsen D, Ruud E, Naderi S, Blomhoff HK (2015)
Bone marrow stroma-derived PGE2 protects BCP-ALL cells from DNA damage-induced p53 accumulation and cell death
Mol Cancer, 14 (1), 14
DOI 10.1186/s12943-014-0278-9, PubMed 25623255

Ruud E (2015)
[Cured, but not quite well]
Tidsskr Nor Laegeforen, 135 (5), 410
DOI 10.4045/tidsskr.14.1265, PubMed 25761013

Tamnes CK, Zeller B, Amlien IK, Kanellopoulos A, Andersson S, Due-Tønnessen P, Ruud E, Walhovd KB, Fjell AM (2015)
Cortical surface area and thickness in adult survivors of pediatric acute lymphoblastic leukemia
Pediatr Blood Cancer, 62 (6), 1027-34
DOI 10.1002/pbc.25386, PubMed 25597852

Wilberg P, Kanellopoulos A, Ruud E, Hjermstad MJ, Fosså SD, Herlofson BB (2015)
Dental abnormalities after chemotherapy in long-term survivors of childhood acute lymphoblastic leukemia 7-40 years after diagnosis
Support Care Cancer, 24 (4), 1497-506
DOI 10.1007/s00520-015-2940-1, PubMed 26361760

Publications 2014

Henriksen LT, Harila-Saari A, Ruud E, Abrahamsson J, Pruunsild K, Vaitkeviciene G, Jónsson ÓG, Schmiegelow K, Heyman M, Schrøder H, Albertsen BK, Nordic Society of Paediatric Haematology and Oncology (NOPHO) group (2014)
PEG-asparaginase allergy in children with acute lymphoblastic leukemia in the NOPHO ALL2008 protocol
Pediatr Blood Cancer, 62 (3), 427-33
DOI 10.1002/pbc.25319, PubMed 25418987

Mellblom AV, Finset A, Korsvold L, Loge JH, Ruud E, Lie HC (2014)
Emotional concerns in follow-up consultations between paediatric oncologists and adolescent survivors: a video-based observational study
Psychooncology, 23 (12), 1365-72
DOI 10.1002/pon.3568, PubMed 24798739

Ranta S, Tuckuviene R, Mäkipernaa A, Albertsen BK, Frisk T, Tedgård U, Jónsson ÓG, Pruunsild K, Gretenkort Andersson N, Winther Gunnes M, Saulyte Trakymiene S, Frandsen T, Heyman M, Ruud E, Helgestad J (2014)
Cerebral sinus venous thromboses in children with acute lymphoblastic leukaemia - a multicentre study from the Nordic Society of Paediatric Haematology and Oncology
Br J Haematol, 168 (4), 547-52
DOI 10.1111/bjh.13162, PubMed 25288392

Zeller B, Loge JH, Kanellopoulos A, Hamre H, Wyller VB, Ruud E (2014)
Chronic fatigue in long-term survivors of childhood lymphomas and leukemia: persistence and associated clinical factors
J Pediatr Hematol Oncol, 36 (6), 438-44
DOI 10.1097/MPH.0000000000000051, PubMed 24276036

Publications 2013

Ghaderi S, Engeland A, Moster D, Ruud E, Syse A, Wesenberg F, Bjørge T (2013)
Increased uptake of social security benefits among long-term survivors of cancer in childhood, adolescence and young adulthood: a Norwegian population-based cohort study
Br J Cancer, 108 (7), 1525-33
DOI 10.1038/bjc.2013.107, PubMed 23481179

Ghaderi S, Lie RT, Moster D, Ruud E, Syse A, Wesenberg F, Bjorge T (2013)
Cancer in childhood, adolescence, and young adults: a population-based study of changes in risk of cancer death during four decades in Norway (vol 23, pg 1297, 2012)
Cancer Causes Control, 24 (12), 2253-2256
DOI 10.1007/s10552-013-0297-7

Hamre H, Zeller B, Kanellopoulos A, Kiserud CE, Aakhus S, Lund MB, Loge JH, Fossa SD, Ruud E (2013)
High Prevalence of Chronic Fatigue in Adult Long-Term Survivors of Acute Lymphoblastic Leukemia and Lymphoma During Childhood and Adolescence
J. Adolesc. Young Adult Oncol., 2 (1), 2-9
DOI 10.1089/jayao.2012.0015

Hamre H, Zeller B, Kanellopoulos A, Ruud E, Fosså SD, Loge JH, Aukrust P, Halvorsen B, Mollnes TE, Kiserud CE (2013)
Serum cytokines and chronic fatigue in adults surviving after childhood leukemia and lymphoma
Brain Behav Immun, 30, 80-7
DOI 10.1016/j.bbi.2013.01.006, PubMed 23333795

Kanellopoulos A, Hamre HM, Dahl AA, Fosså SD, Ruud E (2013)
Factors associated with poor quality of life in survivors of childhood acute lymphoblastic leukemia and lymphoma
Pediatr Blood Cancer, 60 (5), 849-55
DOI 10.1002/pbc.24375, PubMed 23335116

Naderi EH, Ugland HK, Diep PP, Josefsen D, Ruud E, Naderi S, Blomhoff HK (2013)
Selective inhibition of cell death in malignant vs normal B-cell precursors: implications for cAMP in development and treatment of BCP-ALL
Blood, 121 (10), 1805-13
DOI 10.1182/blood-2012-08-452698, PubMed 23299313

Zeller B, Ruud E, Havard Loge J, Kanellopoulos A, Hamre H, Godang K, Bruun Wyller V (2013)
Chronic fatigue in adult survivors of childhood cancer: associated symptoms, neuroendocrine markers, and autonomic cardiovascular responses
Psychosomatics, 55 (6), 621-9
DOI 10.1016/j.psym.2013.12.005, PubMed 24656688

Zeller B, Tamnes CK, Kanellopoulos A, Amlien IK, Andersson S, Due-Tønnessen P, Fjell AM, Walhovd KB, Westlye LT, Ruud E (2013)
Reduced neuroanatomic volumes in long-term survivors of childhood acute lymphoblastic leukemia
J Clin Oncol, 31 (17), 2078-85
DOI 10.1200/JCO.2012.47.4031, PubMed 23589559

Zeller B, Tamnes CK, Kanellopoulos A, Amlien IK, Andersson S, Due-Tønnessen P, Fjell AM, Walhovd KB, Westlye LT, Ruud E (2013)
Response to A.A.M. van der Veldt et al
J Clin Oncol, 32 (8), 852-3
DOI 10.1200/JCO.2013.52.5725, PubMed 24220558

Publications 2012

Ghaderi S, Lie RT, Moster D, Ruud E, Syse A, Wesenberg F, Bjørge T (2012)
Cancer in childhood, adolescence, and young adults: a population-based study of changes in risk of cancer death during four decades in Norway
Cancer Causes Control, 23 (8), 1297-305
DOI 10.1007/s10552-012-0007-x, PubMed 22706693

Ruud E, Kanellopoulos A, Zeller B, Widing E, Tjønnfjord GE, Fosså SD (2012)
Patient knowledge of late effects of acute lymphoblastic leukaemia
Tidsskr Nor Laegeforen, 132 (18), 2052-5
DOI 10.4045/tidsskr.12.0153, PubMed 23038194

Publications 2011

Hamre H, Kiserud CE, Ruud E, Thorsby PM, Fosså SD (2011)
Gonadal function and parenthood 20 years after treatment for childhood lymphoma: a cross-sectional study
Pediatr Blood Cancer, 59 (2), 271-7
DOI 10.1002/pbc.23363, PubMed 22021108

Publications 2010

Bodd TL, Van Ghelue M, Eiklid K, Ruud E, Møller P, Mæhle L (2010)
Fanconi anaemia, BRCA2 and familial considerations - follow up on a previous case report
Acta Paediatr, 99 (11), 1741-3
DOI 10.1111/j.1651-2227.2010.01929.x, PubMed 20608899

Ladenstein R, Valteau-Couanet D, Brock P, Yaniv I, Castel V, Laureys G, Malis J, Papadakis V, Lacerda A, Ruud E, Kogner P, Garami M, Balwierz W, Schroeder H, Beck-Popovic M, Schreier G, Machin D, Pötschger U, Pearson A (2010)
Randomized Trial of prophylactic granulocyte colony-stimulating factor during rapid COJEC induction in pediatric patients with high-risk neuroblastoma: the European HR-NBL1/SIOPEN study
J Clin Oncol, 28 (21), 3516-24
DOI 10.1200/JCO.2009.27.3524, PubMed 20567002

Publications 2009

De Bernardi B, Gerrard M, Boni L, Rubie H, Cañete A, Di Cataldo A, Castel V, Forjaz de Lacerda A, Ladenstein R, Ruud E, Brichard B, Couturier J, Ellershaw C, Munzer C, Bruzzi P, Michon J, Pearson AD (2009)
Excellent outcome with reduced treatment for infants with disseminated neuroblastoma without MYCN gene amplification
J Clin Oncol, 27 (7), 1034-40
DOI 10.1200/JCO.2008.17.5877, PubMed 19171711

Naderi EH, Findley HW, Ruud E, Blomhoff HK, Naderi S (2009)
Activation of cAMP signaling inhibits DNA damage-induced apoptosis in BCP-ALL cells through abrogation of p53 accumulation
Blood, 114 (3), 608-18
DOI 10.1182/blood-2009-02-204883, PubMed 19451550

Publications 2008

Ruud E, Holmstrøm H, Bergan S, Wesenberg F (2008)
Oral anticoagulation with warfarin is significantly influenced by steroids and CYP2C9 polymorphisms in children with cancer
Pediatr Blood Cancer, 50 (3), 710-3
DOI 10.1002/pbc.21133, PubMed 17226852

Publications 2006

Ruud E (2006)
Central line-associated venous thromboembolism in children with cancer: prevalence, prevention and outcome
In Series of dissertations submitted to the Faculty of Medicine, University of Oslo, Unipub, Oslo, no. 433, 1 b. (flere pag.)
BIBSYS 061836486, ISBN 82-8072-679-9

Ruud E, Holmstrøm H, Brosstad F, Wesenberg F (2006)
Children with acute lymphoblastic leukaemia have high plasma levels of total homocysteine at time of diagnosis
Scand J Clin Lab Invest, 66 (1), 67-78
DOI 10.1080/00365510500453003, PubMed 16464788

Ruud E, Holmstrøm H, De Lange C, Hogstad EM, Wesenberg F (2006)
Low-dose warfarin for the prevention of central line-associated thromboses in children with malignancies--a randomized, controlled study
Acta Paediatr, 95 (9), 1053-9
DOI 10.1080/08035250600729092, PubMed 16938749

Ruud E, Holmstrøm H, de Lange C, Natvig S, Albertsen BK, Wesenberg F (2006)
Thrombotic effects of asparaginase in two acute lymphoblastic leukemia protocols (NOPHO ALL-1992 versus NOPHO ALL-2000): a single-institution study
Pediatr Hematol Oncol, 23 (3), 207-16
DOI 10.1080/08880010500506701, PubMed 16517537

Ruud E, Holmstrøm H, Hopp E, Wesenberg F (2006)
Central line-associated venous late effects in children without prior history of thrombosis
Acta Paediatr, 95 (9), 1060-5
DOI 10.1080/08035250500499457, PubMed 16938750

Publications 2005

Ruud E, Holmstrøm H, Brosstad F, Wesenberg F (2005)
Diagnostic value of family histories of thrombosis to identify children with thrombophilia
Pediatr Hematol Oncol, 22 (6), 453-62
DOI 10.1080/08880010591002224, PubMed 16169812

Publications 2003

Ruud E, Holmstrøm H, Thaulow E (2003)
[Fontan circulation is associated with thrombosis]
Tidsskr Nor Laegeforen, 123 (10), 1342-4
PubMed 12806673

Ruud E, Holmstrøm H, Aagenaes I, Hafsahl G, Handeland M, Kyte A, Brosstad F (2003)
Successful thrombolysis by prolonged low-dose alteplase in catheter-directed infusion
Acta Paediatr, 92 (8), 973-6
DOI 10.1080/08035250310004270, PubMed 12948076

Ruud E, Thaulow E, Früh A, Lindberg H, Lie SO (2003)
Unexpected medical coincidences require systematic and careful strategies: an example
Arch Dis Child, 88 (5), 435-7
DOI 10.1136/adc.88.5.435, PubMed 12716720

Publications 2002

Ruud E, Holmstrøm H, Natvig S, Wesenberg F (2002)
Prevalence of thrombophilia and central venous catheter-associated neck vein thrombosis in 41 children with cancer--a prospective study
Med Pediatr Oncol, 38 (6), 405-10
DOI 10.1002/mpo.10062, PubMed 11984801

Ruud E, Natvig S, Holmstrøm H, Wesenberg F (2002)
Low prevalence of femoral venous thrombosis after cardiac catheterizations in children: a prospective study
Cardiol Young, 12 (6), 513-8
DOI 10.1017/s1047951102000938, PubMed 12635998

Publications 2001

Ruud E, Wesenberg F (2001)
Microcephalus, medulloblastoma and excessive toxicity from chemotherapy: an unusual presentation of Fanconi anaemia
Acta Paediatr, 90 (5), 580-3
DOI 10.1080/080352501750197764, PubMed 11430722

Publications 1997

Ruud E, Holt J (1997)
[Phimosis can be treated with local steroids]
Tidsskr Nor Laegeforen, 117 (4), 513-4
PubMed 9148449