Cell Reports Medicine paper: Study detailing in-depth pharmacogenomic analysis of tumor heterogeneity
Kushtrim Kryeziu, leader of the "Functional precision oncology" project group at the Department Molecular Oncology, is first author on a recent article in Cell Reports Medicine, entitled "Patient-derived organoids from metastatic colorectal cancer mirror tumor heterogeneity and predict patient survival and drug sensitivity".
"This study is a milestone for our organoid lab," says Dr. Kushtrim Kryeziu, announcing the establishment of a living biobank comprising 213 patient-derived organoids from colorectal cancer liver metastases.
"Created in close collaboration with researchers at our department and various clinical departments at OUS, the study details an in-depth pharmacogenomic analysis of tumor heterogeneity."
The study reports the pharmacogenomic analysis in context of tumor heterogeneity. Molecular fidelity is confirmed in tumor-organoid pairs. The authors demonstrate that distinct morphological phenotypes correlate with specific molecular traits and drug responses. Multimodal organoid analysis captures intra- and inter-patient CRC heterogeneity and can predict patient survival and guide personalized therapeutic interventions.
Links:
Kryeziu project group - Functional precision oncology
The paper
Kryeziu K, Klokkerud SK, Totland MZ, Moosavi SH, Reims HM, Bergsland CH, Eilertsen IA, Smeby J, Lassen K, Lundesgaard KK, Syversveen T, Brændengen M, Nesbakken A, Guren TK, Yaqub S, Sveen A, Lothe RA (2026)
Patient-derived organoids from metastatic colorectal cancer mirror tumor heterogeneity and predict patient survival and drug sensitivity
Cell Rep Med, 102840 (in press)
DOI 10.1016/j.xcrm.2026.102840, PubMed 42208542