Atrial switch operation in patients with transposition of the great arteries (TGA), leads to leftward shift and changes the geometry of the interventricular septum. This mechanistic study demonstrates that septal dysfunction contributes to failure of the systemic RV after atrial switch in TGA patients. Medical therapy that counteracts septal flattening may improve function of the systemic RV. First author of the study is PhD fellow Petter Storsten.
Storsten P, Eriksen M, Remme EW, Boe E, Erikssen G, Smiseth OA, Skulstad H
Dysfunction of the Systemic Right Ventricle After Atrial Switch: Physiological Implications of Altered Septal Geometry and Load.
J Appl Physiol. 2018 Sep 6.