Espen W. Remme

  • Senior researcher PhD
  • +47 23071413

Espen Remme, M.Sc, PhD, Senior Researcher, Oslo University Hospital

Espen W. Remme has a B.Eng. degree from Telemark Institute of Technology, M. Sc. Eng. degree and Ph.D in engineering cybernetics from Norwegian University of Science and Technology.

He has been working as a senior researcher at the Institute for Surgical Research and at the Intervention Centre for several years. His research is focused on cardiac mechanics, myocardial deformation, hemodynamics, diastolic function, dyssynchrony, cardiac resynchronization therapy, mathematical simulation models of the heart and cardiac motion sensors.

Espen Remme is main supervisor for 5 PhD fellows and responsible for the daily operation of the research group.

 

Publications 2019

Boe E, Smiseth OA, Storsten P, Andersen OS, Aalen J, Eriksen M, Krogh MR, Kongsgaard E, Remme EW, Skulstad H (2019)
Left ventricular end-systolic volume is a more sensitive marker of acute response to cardiac resynchronization therapy than contractility indices: insights from an experimental study
Europace, 21 (2), 347-355
DOI 10.1093/europace/euy221, PubMed 30418572

Krogh MR, Halvorsen PS, Elle OJ, Bergsland J, Remme EW (2019)
Dynamic gravity compensation does not increase detection of myocardial ischemia in combined accelerometer and gyro sensor measurements
Sci Rep, 9 (1), 2671
DOI 10.1038/s41598-018-35630-x, PubMed 30804438

Kvale KF, Bersvendsen J, Remme EW, Salles S, Aalen JM, Brekke PH, Edvardsen T, Samset E (2019)
Detection of Regional Mechanical Activation of the Left Ventricular Myocardium using High Frame Rate Ultrasound Imaging
IEEE Trans Med Imaging (in press)
DOI 10.1109/TMI.2019.2909358, PubMed 30969919

Aalen JM, Remme EW, Larsen CK, Andersen OS, Krogh M, Duchenne J, Hopp E, Ross S, Beela AS, Kongsgaard E, Bergsland J, Odland HH, Skulstad H, Opdahl A, Voigt JU, Smiseth OA (2019)
Mechanism of Abnormal Septal Motion in Left Bundle Branch Block: Role of Left Ventricular Wall Interactions and Myocardial Scar
JACC Cardiovasc Imaging (in press)
DOI 10.1016/j.jcmg.2018.11.030, PubMed 30772230

Publications 2018

Dumont KA, Kvitting JP, Karlsen JS, Remme EW, Hausken J, Lundblad R, Fiane AE, Urheim S (2018)
Validation of a Holographic Display for Quantification of Mitral Annular Dynamics by Three-Dimensional Echocardiography
J Am Soc Echocardiogr, 32 (2), 303-316.e4
DOI 10.1016/j.echo.2018.08.010, PubMed 30293779

Stokke TM, Hasselberg NE, Smedsrud MK, Sarvari SI, Haugaa KH, Smiseth OA, Edvardsen T, Remme EW (2018)
Reply: Interaction Between Longitudinal, Circumferential, and Radial Deformations and Their Contributions to Ejection Fraction
J Am Coll Cardiol, 71 (2), 257-258
DOI 10.1016/j.jacc.2017.10.090, PubMed 29325649

Stokke TM, Haugaa KH, Smiseth OA, Edvardsen T, Remme EW (2018)
Reply: Left Ventricular Twist: An Often Ignored But Crucial Determinant of Left Ventricular Function
J Am Coll Cardiol, 71 (5), 584-585
DOI 10.1016/j.jacc.2017.12.002, PubMed 29406870

Storsten P, Eriksen M, Remme EW, Boe E, Erikssen G, Smiseth OA, Skulstad H (2018)
Dysfunction of the systemic right ventricle after atrial switch: physiological implications of altered septal geometry and load
J Appl Physiol (1985), 125 (5), 1482-1489
DOI 10.1152/japplphysiol.00255.2018, PubMed 30188795

Aalen J, Storsten P, Remme EW, Sirnes PA, Gjesdal O, Larsen CK, Kongsgaard E, Boe E, Skulstad H, Hisdal J, Smiseth OA (2018)
Afterload Hypersensitivity in Patients With Left Bundle Branch Block
JACC Cardiovasc Imaging, 12 (6), 967-977
DOI 10.1016/j.jcmg.2017.11.025, PubMed 29361486

Publications 2017

Andersen OS, Smiseth OA, Dokainish H, Abudiab MM, Schutt RC, Kumar A, Sato K, Harb S, Gude E, Remme EW, Andreassen AK, Ha JW, Xu J, Klein AL, Nagueh SF (2017)
Estimating Left Ventricular Filling Pressure by Echocardiography
J Am Coll Cardiol, 69 (15), 1937-1948
DOI 10.1016/j.jacc.2017.01.058, PubMed 28408024

Krogh MR, Nghiem GM, Halvorsen PS, Elle OJ, Grymyr OJ, Hoff L, Remme EW (2017)
Gravity Compensation Method for Combined Accelerometer and Gyro Sensors Used in Cardiac Motion Measurements
Ann Biomed Eng, 45 (5), 1292-1304
DOI 10.1007/s10439-017-1798-4, PubMed 28116541

Nguyen TT, Espinoza AW, Hyler S, Remme EW, D'hooge J, Hoff L (2017)
Velocity Resolution Improvement for High Temporal Resolution Ultrasonic Transducer
IEEE INT ULTRA SYM

Stokke TM, Hasselberg NE, Smedsrud MK, Sarvari SI, Haugaa KH, Smiseth OA, Edvardsen T, Remme EW (2017)
Geometry as a Confounder When Assessing Ventricular Systolic Function: Comparison Between Ejection Fraction and Strain
J Am Coll Cardiol, 70 (8), 942-954
DOI 10.1016/j.jacc.2017.06.046, PubMed 28818204

Publications 2015

Boe E, Russell K, Eek C, Eriksen M, Remme EW, Smiseth OA, Skulstad H (2015)
Non-invasive myocardial work index identifies acute coronary occlusion in patients with non-ST-segment elevation-acute coronary syndrome
Eur Heart J Cardiovasc Imaging, 16 (11), 1247-55
DOI 10.1093/ehjci/jev078, PubMed 25851329

Estensen ME, Grindheim G, Remme EW, Godang K, Henriksen T, Aukrust P, Aakhus S, Gullestad L, Ueland T (2015)
Elevated inflammatory markers in preeclamptic pregnancies, but no relation to systemic arterial stiffness
Pregnancy Hypertens, 5 (4), 325-9
DOI 10.1016/j.preghy.2015.09.003, PubMed 26597749

Grymyr OJ, Nguyen AT, Tjulkins F, Espinoza A, Remme EW, Skulstad H, Fosse E, Imenes K, Halvorsen PS (2015)
Continuous monitoring of cardiac function by 3-dimensional accelerometers in a closed-chest pig model
Interact Cardiovasc Thorac Surg, 21 (5), 573-82
DOI 10.1093/icvts/ivv191, PubMed 26254463

Hyde ER, Behar JM, Claridge S, Jackson T, Lee AW, Remme EW, Sohal M, Plank G, Razavi R, Rinaldi CA, Niederer SA (2015)
Beneficial Effect on Cardiac Resynchronization From Left Ventricular Endocardial Pacing Is Mediated by Early Access to High Conduction Velocity Tissue: Electrophysiological Simulation Study
Circ Arrhythm Electrophysiol, 8 (5), 1164-72
DOI 10.1161/CIRCEP.115.002677, PubMed 26136400

Remme EW, Niederer S, Gjesdal O, Russell K, Hyde ER, Smith N, Smiseth OA (2015)
Factors determining the magnitude of the pre-ejection leftward septal motion in left bundle branch block
Europace, 18 (12), 1905-1913
DOI 10.1093/europace/euv381, PubMed 26612883

Publications 2014

Boe E, Russell K, Remme EW, Gjesdal O, Smiseth OA, Skulstad H (2014)
Cardiac responses to left ventricular pacing in hearts with normal electrical conduction: beneficial effect of improved filling is counteracted by dyssynchrony
Am J Physiol Heart Circ Physiol, 307 (3), H370-8
DOI 10.1152/ajpheart.00089.2014, PubMed 24906920

Grymyr OJ, Remme EW, Espinoza A, Skulstad H, Elle OJ, Fosse E, Halvorsen PS (2014)
Assessment of 3D motion increases the applicability of accelerometers for monitoring left ventricular function
Interact Cardiovasc Thorac Surg, 20 (3), 329-37
DOI 10.1093/icvts/ivu404, PubMed 25472979

Hestenes SM, Halvorsen PS, Skulstad H, Remme EW, Espinoza A, Hyler S, Bugge JF, Fosse E, Nielsen EW, Edvardsen T (2014)
Advantages of strain echocardiography in assessment of myocardial function in severe sepsis: an experimental study
Crit Care Med, 42 (6), e432-40
DOI 10.1097/CCM.0000000000000310, PubMed 24633187

Nordbø O, Lamata P, Land S, Niederer S, Aronsen JM, Louch WE, Sjaastad I, Martens H, Gjuvsland AB, Tøndel K, Torp H, Lohezic M, Schneider JE, Remme EW, Smith N, Omholt SW, Vik JO (2014)
A computational pipeline for quantification of mouse myocardial stiffness parameters
Comput Biol Med, 53, 65-75
DOI 10.1016/j.compbiomed.2014.07.013, PubMed 25129018

Zahid W, Eek CH, Remme EW, Skulstad H, Fosse E, Edvardsen T (2014)
Early systolic lengthening may identify minimal myocardial damage in patients with non-ST-elevation acute coronary syndrome
Eur Heart J Cardiovasc Imaging, 15 (10), 1152-60
DOI 10.1093/ehjci/jeu101, PubMed 24866900

Publications 2013

Estensen ME, Remme EW, Grindheim G, Smiseth OA, Segers P, Henriksen T, Aakhus S (2013)
Increased arterial stiffness in pre-eclamptic pregnancy at term and early and late postpartum: a combined echocardiographic and tonometric study
Am J Hypertens, 26 (4), 549-56
DOI 10.1093/ajh/hps067, PubMed 23467210

Publications 2012

de Vecchi A, Nordsletten DA, Remme EW, Bellsham-Revell H, Greil G, Simpson JM, Razavi R, Smith NP (2012)
Inflow typology and ventricular geometry determine efficiency of filling in the hypoplastic left heart
Ann Thorac Surg, 94 (5), 1562-9
DOI 10.1016/j.athoracsur.2012.05.122, PubMed 22858280

Estensen ME, Grindheim G, Remme EW, Swillens A, Smiseth OA, Segers P, Henriksen T, Aakhus S (2012)
Systemic arterial response and ventriculo-arterial interaction during normal pregnancy
Am J Hypertens, 25 (6), 672-7
DOI 10.1038/ajh.2012.29, PubMed 22460202

Nguyen TT, Espinoza AW, Hyler S, Remme EW, D'hooge J, Hoff L (2012)
EFFECT OF MYOCARDIAL PERFUSION ON END-SYSTOLIC RADIAL STRAIN AT THE APEX
IEEE INT ULTRA SYM

Nguyen TT, Espinoza AW, Hyler S, Remme EW, D'hooge J, Hoff L (2012)
TRANSMURAL STRAIN DISTRIBUTION ACROSS THE CARDIAC WALL AND ITS DEPENDENCY ON MEASUREMENT SITE
IEEE INT ULTRA SYM

Opdahl A, Remme EW, Helle-Valle T, Edvardsen T, Smiseth OA (2012)
Myocardial relaxation, restoring forces, and early-diastolic load are independent determinants of left ventricular untwisting rate
Circulation, 126 (12), 1441-51
DOI 10.1161/CIRCULATIONAHA.111.080861, PubMed 22865889

Remme EW, Hoff L, Halvorsen PS, Opdahl A, Fosse E, Elle OJ (2012)
Simulation model of cardiac three dimensional accelerometer measurements
Med Eng Phys, 34 (7), 990-8
DOI 10.1016/j.medengphy.2012.04.015, PubMed 22633656

Russell K, Eriksen M, Aaberge L, Wilhelmsen N, Skulstad H, Remme EW, Haugaa KH, Opdahl A, Fjeld JG, Gjesdal O, Edvardsen T, Smiseth OA (2012)
A novel clinical method for quantification of regional left ventricular pressure-strain loop area: a non-invasive index of myocardial work
Eur Heart J, 33 (6), 724-33
DOI 10.1093/eurheartj/ehs016, PubMed 22315346

Publications 2011

Gjesdal O, Remme EW, Opdahl A, Skulstad H, Russell K, Kongsgaard E, Edvardsen T, Smiseth OA (2011)
Mechanisms of abnormal systolic motion of the interventricular septum during left bundle-branch block
Circ Cardiovasc Imaging, 4 (3), 264-73
DOI 10.1161/CIRCIMAGING.110.961417, PubMed 21393502

Nguyen TT, Espinoza AW, Remme EW, D'hooge J, Hoff L (2011)
Transmural Myocardial Strain Distribution Measured at High Spatial and Temporal Resolution
IEEE INT ULTRA SYM, 696-699

Remme EW, Opdahl A, Smiseth OA (2011)
Mechanics of left ventricular relaxation, early diastolic lengthening, and suction investigated in a mathematical model
Am J Physiol Heart Circ Physiol, 300 (5), H1678-87
DOI 10.1152/ajpheart.00165.2010, PubMed 21317306

Russell K, Smiseth OA, Gjesdal O, Qvigstad E, Norseng PA, Sjaastad I, Opdahl A, Skulstad H, Edvardsen T, Remme EW (2011)
Mechanism of prolonged electromechanical delay in late activated myocardium during left bundle branch block
Am J Physiol Heart Circ Physiol, 301 (6), H2334-43
DOI 10.1152/ajpheart.00644.2011, PubMed 21984549

Publications 2010

Remme EW, Smiseth OA (2010)
Comments on point: Counterpoint: Left ventricular volume during diastasis is/is not the physiological in vivo equilibrium volume and is/is not related to diastolic suction
J Appl Physiol (1985), 109 (2), 612
PubMed 21312417

Russell K, Opdahl A, Remme EW, Gjesdal O, Skulstad H, Kongsgaard E, Edvardsen T, Smiseth OA (2010)
Evaluation of left ventricular dyssynchrony by onset of active myocardial force generation: a novel method that differentiates between electrical and mechanical etiologies
Circ Cardiovasc Imaging, 3 (4), 405-14
DOI 10.1161/CIRCIMAGING.109.905539, PubMed 20494943

Publications 2009

Crosby J, Hergum T, Remme EW, Torp H (2009)
The effect of including myocardial anisotropy in simulated ultrasound images of the heart
IEEE Trans Ultrason Ferroelectr Freq Control, 56 (2), 326-33
DOI 10.1109/TUFFC.2009.1041, PubMed 19251519

Halvorsen PS, Remme EW, Espinoza A, Skulstad H, Lundblad R, Bergsland J, Hoff L, Imenes K, Edvardsen T, Elle OJ, Fosse E (2009)
Automatic real-time detection of myocardial ischemia by epicardial accelerometer
J Thorac Cardiovasc Surg, 139 (4), 1026-32
DOI 10.1016/j.jtcvs.2009.05.031, PubMed 19717169

Helle-Valle T, Remme EW, Lyseggen E, Pettersen E, Vartdal T, Opdahl A, Smith HJ, Osman NF, Ihlen H, Edvardsen T, Smiseth OA (2009)
Clinical assessment of left ventricular rotation and strain: a novel approach for quantification of function in infarcted myocardium and its border zones
Am J Physiol Heart Circ Physiol, 297 (1), H257-67
DOI 10.1152/ajpheart.01116.2008, PubMed 19395547

Hergum T, Langeland S, Remme EW, Torp H (2009)
Fast ultrasound imaging simulation in K-space
IEEE Trans Ultrason Ferroelectr Freq Control, 56 (6), 1159-67
DOI 10.1109/TUFFC.2009.1158, PubMed 19574124

Lyseggen E, Vartdal T, Remme EW, Helle-Valle T, Pettersen E, Opdahl A, Edvardsen T, Smiseth OA (2009)
A novel echocardiographic marker of end systole in the ischemic left ventricle: "tug of war" sign
Am J Physiol Heart Circ Physiol, 296 (3), H645-54
DOI 10.1152/ajpheart.00313.2008, PubMed 19122168

Opdahl A, Remme EW, Helle-Valle T, Lyseggen E, Vartdal T, Pettersen E, Edvardsen T, Smiseth OA (2009)
Determinants of left ventricular early-diastolic lengthening velocity: independent contributions from left ventricular relaxation, restoring forces, and lengthening load
Circulation, 119 (19), 2578-86
DOI 10.1161/CIRCULATIONAHA.108.791681, PubMed 19414640

Remme EW, Hoff L, Halvorsen PS, Naerum E, Skulstad H, Fleischer LA, Elle OJ, Fosse E (2009)
Validation of cardiac accelerometer sensor measurements
Physiol Meas, 30 (12), 1429-44
DOI 10.1088/0967-3334/30/12/010, PubMed 19907074

Remme EW, Lyseggen E, Helle-Valle T, Pettersen E, Ragnarsson A, Ihlen H, Edvardsen T, Smiseth OA, Opdahl A, Vartdal T, Ljosland M (2009)
Response to Letter Regarding Article, "Mechanisms of Preejection and Postejection Velocity Spikes in Left Ventricular Myocardium: Interaction Between Wall Deformation and Valve Events"
Circulation, 119 (6), E205

Smiseth OA, Russell K, Remme EW (2009)
Pacing in heart failure patients with narrow QRS: is there more to gain than resynchronization?
Circulation, 120 (17), 1651-3
DOI 10.1161/CIRCULATIONAHA.109.900381, PubMed 19822804

Publications 2008

Crosby J, Amundsen BH, Hergum T, Remme EW, Langeland S, Torp H (2008)
3-D speckle tracking for assessment of regional left ventricular function
Ultrasound Med Biol, 35 (3), 458-71
DOI 10.1016/j.ultrasmedbio.2008.09.011, PubMed 19056164

Opdahl A, Helle-Valle T, Remme EW, Vartdal T, Pettersen E, Lunde K, Edvardsen T, Smiseth OA (2008)
Apical rotation by speckle tracking echocardiography: a simplified bedside index of left ventricular twist
J Am Soc Echocardiogr, 21 (10), 1121-8
DOI 10.1016/j.echo.2008.06.012, PubMed 18760568

Orderud F, Kiss G, Langeland S, Remme EW, Torp HG, Rabben SI (2008)
Combining Edge Detection With Speckle-Tracking for Cardiac Strain Assessment in 3D echocardiography
ULTRASON, 1959-+

Remme EW, Lyseggen E, Helle-Valle T, Opdahl A, Pettersen E, Vartdal T, Ragnarsson A, Ljosland M, Ihlen H, Edvardsen T, Smiseth OA (2008)
Mechanisms of preejection and postejection velocity spikes in left ventricular myocardium: interaction between wall deformation and valve events
Circulation, 118 (4), 373-80
DOI 10.1161/CIRCULATIONAHA.107.748491, PubMed 18606917

Publications 2007

Remme EW, Smiseth OA (2007)
Characteristic strain pattern of moderately ischemic myocardium investigated in a finite element simulation model
LECT NOTES COMPUT SC, 4466, 330-+

Publications 2005

Remme EW, Augenstein KF, Young AA, Hunter PJ (2005)
Parameter distribution models for estimation of population based left ventricular deformation using sparse fiducial markers
IEEE Trans Med Imaging, 24 (3), 381-8
DOI 10.1109/TMI.2004.842458, PubMed 15754988

Smiseth OA, Remme EW (2005)
Regional left ventricular electric and mechanical activation and relaxation
J Am Coll Cardiol, 47 (1), 173-4
DOI 10.1016/j.jacc.2005.10.039, PubMed 16386682

Publications 2004

Remme EW, Hunter PJ, Smiseth O, Stevens C, Rabben SI, Skulstad H, Angelsen BB (2004)
Development of an in vivo method for determining material properties of passive myocardium
J Biomech, 37 (5), 669-78
DOI 10.1016/j.jbiomech.2003.09.023, PubMed 15046996

Remme EW, Young AA, Augenstein KF, Cowan B, Hunter PJ (2004)
Extraction and quantification of left ventricular deformation modes
IEEE Trans Biomed Eng, 51 (11), 1923-31
DOI 10.1109/TBME.2004.834283, PubMed 15536894

Publications 2003

Stevens C, Remme E, LeGrice I, Hunter P (2003)
Ventricular mechanics in diastole: material parameter sensitivity
J Biomech, 36 (5), 737-48
PubMed 12695004

Publications 2000

Segers P, Carlier S, Pasquet A, Rabben SI, Hellevik LR, Remme E, De Backer T, De Sutter J, Thomas JD, Verdonck P (2000)
Individualizing the aorto-radial pressure transfer function: feasibility of a model-based approach
Am J Physiol Heart Circ Physiol, 279 (2), H542-9
DOI 10.1152/ajpheart.2000.279.2.H542, PubMed 10924052

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