Vibeke Marie Almaas
- Consultant Cardiologist, MD, PhD
- +47 230 74145
Vibeke Almaas successfully defended her PhD thesis "Obstructive hypertrophic cardiomyopathy. Pathophysiology and clinical management" in October 2015. Her supervisors were Professor Emeritus Jan Peder Amlie, MD, PhD, University of Oslo and Professor Svend Aakhus, MD, PhD, Norwegian University of Science and Technology.
She found that a type of scarring in the heart muscle, interstitial fibrosis, in patients with hypertrophic cardiomyopathy (HCM), is associated with severe cardiac arrhythmia and that a newly developed cardiac ultrasound examination can identify patients at increased risk. Together with Scandinavian colleagues, Vibeke M. Almaas has shown that PTSMA is a safe and effective treatment for obstructive HCM patients.
In the period 2001-2009, over a hundred HCM patients were referred to Department of Cardiology, Rikshospitalet, Oslo University Hospital, for PTSMA; a catheter-based method of applying a myocardial infarction to the thickened heart partition, or myectomy; a heart operation where the thickened part of the heart partition is removed. Obstructive HCM patients have thickened cardiac wall that prevents blood from flowing freely into the main artery. These patients may be offered PTSMA or myectomy. A treatment team with experience in HCM assessed whether conditions were suitable for PTSMA or whether surgical correction and myectomy were needed. Before and after PTSMA / myectomy, patients were examined, among other things, with 48-hour cardiac rhythm recording, cardiac ultrasound and magnetic resonance (MRI) of the heart. The heart muscle tissue removed by myectomy was examined microscopically. PTSMA-treated patients were included in a Scandinavian database where long-term follow-up after PTSMA was recorded.
In her thesis Almaas and her colleagues showed that the catheter-based method PTSMA can be safely performed at centers with experienced invasive cardiologists and that interstitial fibrosis, scarring associated with severe arrhythmia, is not so readily seen in cardiac MRI examination, but scarring leads to reduced function of the heart muscle which can be identified by a fast and simple heart ultrasound method.
Pregnancy and Progression of Cardiomyopathy in Women With LMNA Genotype-Positive
J Am Heart Assoc, 11 (8), e024960
Lumican accumulates with fibrillar collagen in fibrosis in hypertrophic cardiomyopathy
ESC Heart Fail (in press)
Left Ventricular Dysfunction in Arrhythmogenic Cardiomyopathy: Association With Exercise Exposure, Genetic Basis, and Prognosis
J Am Heart Assoc, 10 (8), e018680
Sex differences in disease progression and arrhythmic risk in patients with arrhythmogenic cardiomyopathy
Europace, 23 (7), 1084-1091
The extracellular matrix glycoprotein ADAMTSL2 is increased in heart failure and inhibits TGFβ signalling in cardiac fibroblasts
Sci Rep, 11 (1), 19757
Effect of impaired cardiac conduction after alcohol septal ablation on clinical outcomes: insights from the Euro-ASA registry
Eur Heart J Qual Care Clin Outcomes, 5 (3), 252-258
Low Molecular Mass Myocardial Hyaluronan in Human Hypertrophic Cardiomyopathy
Cells, 8 (2)
Effect of Institutional Experience on Outcomes of Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy
Can J Cardiol, 34 (1), 16-22
The systolic paradox in hypertrophic cardiomyopathy
Open Heart, 4 (1), e000571
Outcome of Alcohol Septal Ablation in Mildly Symptomatic Patients With Hypertrophic Obstructive Cardiomyopathy: A Long-Term Follow-Up Study Based on the Euro-Alcohol Septal Ablation Registry
J Am Heart Assoc, 6 (5)
Strain echocardiography is related to fibrosis and ventricular arrhythmias in hypertrophic cardiomyopathy
Eur Heart J Cardiovasc Imaging, 17 (6), 613-21
Influence of Septal Thickness on the Clinical Outcome After Alcohol Septal Alation in Hypertrophic Cardiomyopathy
Circ Cardiovasc Interv, 9 (6)
Long-term clinical outcome after alcohol septal ablation for obstructive hypertrophic cardiomyopathy: results from the Euro-ASA registry
Eur Heart J, 37 (19), 1517-23
Familial globotriaosylceramide-associated cardiomyopathy mimicking Fabry disease
Heart, 100 (22), 1793-8
Increased amount of interstitial fibrosis predicts ventricular arrhythmias, and is associated with reduced myocardial septal function in patients with obstructive hypertrophic cardiomyopathy
Europace, 15 (9), 1319-27
Noninvasive assessment of myocardial fibrosis in patients with obstructive hypertrophic cardiomyopathy
Heart, 100 (8), 631-8
Long-term outcome of percutaneous transluminal septal myocardial ablation in hypertrophic obstructive cardiomyopathy: a Scandinavian multicenter study
Circ Cardiovasc Interv, 4 (3), 256-65
Diagnosing and prioritizing uncertainties according to their relevance for policy: the case of transgene silencing
Sci Total Environ, 390 (1), 23-34
Management of suspected pulmonary embolism (PE) by D-dimer and multi-slice computed tomography in outpatients: an outcome study
J Thromb Haemost, 3 (9), 1926-32
Holdninger til personvern: rapport fra fokusgrupper om elektroniske spor og personvern
In Rapport, Rådet, Oslo, 1, februar 2004, 28 bl.
Når det piper i telefonen...: en analyse av mobiltelefonens betydning for by- og bygdeungdom
V. Almaas, [Trondheim], 93,  bl.