Ingvild Sørum Leikfoss
- Research coordinator/senior engineer PhD, MSc
- +47 230 79021
Address: Oslo University Hospital, Research Unit for Neuroscience, Domus Medica II, 2nd floor, L-260, Gaustadalleen 34, 0372 Oslo
Ingvild Sørum Leikfoss has a PhD degree in Molecular Immunology from the University of Oslo from 2015, with the following title “Characterization of multiple sclerosis susceptibility genes”. She has a Master of Science degree in Molecular Biology and Immunology from the Department of Molecular Biosciences. The focus of her master thesis was in vitro characterization of the binding between Immunoglobulin G and different Fc receptors from both humans and mice.
Project title: " Characterization of multiple sclerosis susceptibility genes - Genetic and molecular studies in T cells".
The main objective was to understand the biological implications for the single nucleotide polymorphisms in the CLEC16A gene that show genome-wide significant associations with MS. In addition, using molecular and immunological methods, the aim has been to characterize the function of CLEC16A in human immune cell lines.
Main supervisor: Tone Berge (MSc, PhD)
Co-supervisors: Hanne F Harbo (MD, PhD) and Anne Spurkland (MD, PhD, Professor at the Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo).
• Molecular biology
• Cultivation and transfection of cell lines (Jurkat T cells, Raji B cells)
• Isolation and cultivation of primary, human T - and B- cells
• Western blotting
• Flow cytometry
• Image stream
• RNA and DNA isolation
• Quantitative real-time PCR
The multiple sclerosis susceptibility genes TAGAP and IL2RA are regulated by vitamin D in CD4+ T cells
Genes Immun, 17 (2), 118-27
Genome-wide DNA methylation profiles indicate CD8+ T cell hypermethylation in multiple sclerosis
PLoS One, 10 (3), e0117403
Multiple Sclerosis Risk Allele in CLEC16A Acts as an Expression Quantitative Trait Locus for CLEC16A and SOCS1 in CD4+ T Cells
PLoS One, 10 (7), e0132957
Retinoic acid enhances the levels of IL-10 in TLR-stimulated B cells from patients with relapsing-remitting multiple sclerosis
J Neuroimmunol, 278, 11-8
From Identification to Characterization of the Multiple Sclerosis Susceptibility Gene CLEC16A
Int J Mol Sci, 14 (3), 4476-97
Anti-carcinoembryonic antigen single-chain variable fragment antibody variants bind mouse and human neonatal Fc receptor with different affinities that reveal distinct cross-species differences in serum half-life
J Biol Chem, 287 (27), 22927-37
Multiple sclerosis-associated single-nucleotide polymorphisms in CLEC16A correlate with reduced SOCS1 and DEXI expression in the thymus
Genes Immun, 14 (1), 62-6