Zhenhe Suo
- Researcher, professor; PhD
- +47 22 78 24 35
Publications 2019
Anti-senescence role of heterozygous fumarate hydratase gene knockout in rat lung fibroblasts in vitro
Aging (Albany NY), 11 (2), 573-589
DOI 10.18632/aging.101761, PubMed 30668541
Author Correction: PBX3 is targeted by multiple miRNAs and is essential for liver tumour-initiating cells
Nat Commun, 10 (1), 2259
DOI 10.1038/s41467-019-10052-z, PubMed 31113949
High level of lncRNA H19 expression is associated with shorter survival in esophageal squamous cell cancer patients
Pathol Res Pract, 215 (11), 152638
DOI 10.1016/j.prp.2019.152638, PubMed 31551175
PDHA1 Gene Knockout In Human Esophageal Squamous Cancer Cells Resulted In Greater Warburg Effect And Aggressive Features In Vitro And In Vivo
Onco Targets Ther, 12, 9899-9913
DOI 10.2147/OTT.S226851, PubMed 31819487
USP7: Novel Drug Target in Cancer Therapy
Front Pharmacol, 10, 427
DOI 10.3389/fphar.2019.00427, PubMed 31114498
Potent 5-Cyano-6-phenyl-pyrimidin-Based Derivatives Targeting DCN1-UBE2M Interaction
J Med Chem, 62 (11), 5382-5403
DOI 10.1021/acs.jmedchem.9b00003, PubMed 31157974
Potent and specific MTH1 inhibitors targeting gastric cancer
Cell Death Dis, 10 (6), 434
DOI 10.1038/s41419-019-1665-3, PubMed 31164636
Publications 2018
Clinical Significance of Retinoic Acid Receptor Beta Promoter Methylation in Prostate Cancer: A Meta-Analysis
Cell Physiol Biochem, 45 (6), 2497-2505
DOI 10.1159/000488268, PubMed 29554659
Identification of an early diagnostic biomarker of lung adenocarcinoma based on co-expression similarity and construction of a diagnostic model
J Transl Med, 16 (1), 205
DOI 10.1186/s12967-018-1577-5, PubMed 30029648
A Diaper Pad for Diaper-Based Urine Collection and Colorimetric Screening of Urinary Biomarkers
Ann Biomed Eng, 46 (5), 717-725
DOI 10.1007/s10439-018-1996-8, PubMed 29464459
High SRPX2 protein expression predicts unfavorable clinical outcome in patients with prostate cancer
Onco Targets Ther, 11, 3149-3157
DOI 10.2147/OTT.S158820, PubMed 29881288
Publications 2017
MtDNA depletion influences the transition of CD44 subtypes in human prostate cancer DU145 cells
Tumour Biol, 39 (8), 1010428317713671
DOI 10.1177/1010428317713671, PubMed 28789597
Mitochondrial pyruvate carrier function determines cell stemness and metabolic reprogramming in cancer cells
Oncotarget, 8 (28), 46363-46380
DOI 10.18632/oncotarget.18199, PubMed 28624784
Metabolic reprogramming is associated with flavopiridol resistance in prostate cancer DU145 cells
Sci Rep, 7 (1), 5081
DOI 10.1038/s41598-017-05086-6, PubMed 28698547
Correction: MtDNA depleted PC3 cells exhibit Warburg effect and cancer stem cell features
Oncotarget, 8 (4), 7208-7213
DOI 10.18632/oncotarget.14800, PubMed 28179591
Mitochondrial pyruvate carrier function is negatively linked to Warburg phenotype in vitro and malignant features in esophageal squamous cell carcinomas
Oncotarget, 8 (1), 1058-1073
DOI 10.18632/oncotarget.13717, PubMed 27911865
AQP4 Association with Amyloid Deposition and Astrocyte Pathology in the Tg-ArcSwe Mouse Model of Alzheimer's Disease
J Alzheimers Dis, 57 (1), 157-169
DOI 10.3233/JAD-160957, PubMed 28222512
Pyruvate dehydrogenase expression is negatively associated with cell stemness and worse clinical outcome in prostate cancers
Oncotarget, 8 (8), 13344-13356
DOI 10.18632/oncotarget.14527, PubMed 28076853
Publications 2016
Hypoxia-induced alterations of G2 checkpoint regulators
Mol Oncol, 10 (5), 764-73
DOI 10.1016/j.molonc.2015.12.015, PubMed 26791779
Aldehyde Dehydrogenase-1 Expression Predicts Unfavorable Outcomes in Patients with Esophageal Squamous Cell Carcinoma
Anticancer Res, 36 (1), 343-9
PubMed 26722063
MPC1 and MPC2 expressions are associated with favorable clinical outcomes in prostate cancer
BMC Cancer, 16 (1), 894
DOI 10.1186/s12885-016-2941-6, PubMed 27852261
Establishment of mitochondrial pyruvate carrier 1 (MPC1) gene knockout mice with preliminary gene function analyses
Oncotarget, 7 (48), 79981-79994
DOI 10.18632/oncotarget.13210, PubMed 27835892
MtDNA depleted PC3 cells exhibit Warburg effect and cancer stem cell features
Oncotarget, 7 (26), 40297-40313
DOI 10.18632/oncotarget.9610, PubMed 27248169
Decreased expression of pyruvate dehydrogenase A1 predicts an unfavorable prognosis in ovarian carcinoma
Am J Cancer Res, 6 (9), 2076-2087
PubMed 27725912
PDHA1 gene knockout in prostate cancer cells results in metabolic reprogramming towards greater glutamine dependence
Oncotarget, 7 (33), 53837-53852
DOI 10.18632/oncotarget.10782, PubMed 27462778
Prognostic and clinicopathological significance of Cacna2d1 expression in epithelial ovarian cancers: a retrospective study
Am J Cancer Res, 6 (9), 2088-2097
PubMed 27725913
Generation of TALEN-mediated FH knockout rat model
Oncotarget, 7 (38), 61656-61669
DOI 10.18632/oncotarget.11429, PubMed 27556703
Publications 2015
PDGFR-α and CD117 Expression Pattern in Esophageal Carcinomas
Anticancer Res, 35 (7), 3793-9
PubMed 26124324
Nuclear, cytoplasmic, and stromal expression of ZEB1 in squamous and small cell carcinoma of the esophagus
APMIS, 123 (12), 1040-7
DOI 10.1111/apm.12473, PubMed 26547370
PBX3 is targeted by multiple miRNAs and is essential for liver tumour-initiating cells
Nat Commun, 6, 8271
DOI 10.1038/ncomms9271, PubMed 26420065
The expression of aldehyde dehydrogenase 1 (ALDH1) in ovarian carcinomas and its clinicopathological associations: a retrospective study
BMC Cancer, 15, 502
DOI 10.1186/s12885-015-1513-5, PubMed 26148881
Mitochondrial DNA Deficiency in Ovarian Cancer Cells and Cancer Stem Cell-like Properties
Anticancer Res, 35 (7), 3743-53
PubMed 26124317
Expression of zinc finger E-box-binding homeobox factor 1 in epithelial ovarian cancer: A clinicopathological analysis of 238 patients
Mol Clin Oncol, 4 (1), 18-22
DOI 10.3892/mco.2015.662, PubMed 26870350
Age-dependent sex hormone-binding globulin expression in male rat
Ultrastruct Pathol, 39 (2), 121-30
DOI 10.3109/01913123.2015.1009222, PubMed 25879298
Hypoxia increases the expression of enamel genes and cytokines in an ameloblast-derived cell line
Eur J Oral Sci, 123 (5), 335-340
DOI 10.1111/eos.12201, PubMed 26193448
Circulating and tumor-infiltrating Tim-3 in patients with colorectal cancer
Oncotarget, 6 (24), 20592-603
DOI 10.18632/oncotarget.4112, PubMed 26008981
ILs-3, 6 and 11 increase, but ILs-10 and 24 decrease stemness of human prostate cancer cells in vitro
Oncotarget, 6 (40), 42687-703
DOI 10.18632/oncotarget.5883, PubMed 26528857
Decreased Expression of PDHE1α Predicts Worse Clinical Outcome in Esophageal Squamous Cell Carcinoma
Anticancer Res, 35 (10), 5533-8
PubMed 26408721
Application of mitochondrial pyruvate carrier blocker UK5099 creates metabolic reprogram and greater stem-like properties in LnCap prostate cancer cells in vitro
Oncotarget, 6 (35), 37758-69
DOI 10.18632/oncotarget.5386, PubMed 26413751
Publications 2014
CD117 expression in fibroblasts-like stromal cells indicates unfavorable clinical outcomes in ovarian carcinoma patients
PLoS One, 9 (11), e112209
DOI 10.1371/journal.pone.0112209, PubMed 25380303
Aldehyde dehydrogenase-1 predicts favorable prognosis in patients with vulvar squamous cell carcinoma
Anticancer Res, 34 (2), 859-65
PubMed 24511023
Publications 2013
CD117 expression in operable oesophageal squamous cell carcinomas predicts worse clinical outcome
Histopathology, 62 (7), 1028-37
DOI 10.1111/his.12111, PubMed 23570416
[Influence of EphA2 siRNA transfection on the biological behavior of human ovarian carcinoma cell]
Sichuan Da Xue Xue Bao Yi Xue Ban, 44 (6), 877-81
PubMed 24490493
Sex hormone-binding globulin (SHBG) expression in ovarian carcinomas and its clinicopathological associations
PLoS One, 8 (12), e83238
DOI 10.1371/journal.pone.0083238, PubMed 24386165
Notch1 is a 5-fluorouracil resistant and poor survival marker in human esophagus squamous cell carcinomas
PLoS One, 8 (2), e56141
DOI 10.1371/journal.pone.0056141, PubMed 23409141
Dendritic and lymphocytic cell infiltration in prostate carcinoma
Histol Histopathol, 28 (12), 1621-8
DOI 10.14670/HH-28.1621, PubMed 23729368
Blocking mtDNA replication upregulates the expression of stemness-related genes in prostate cancer cell lines
Ultrastruct Pathol, 37 (4), 258-66
DOI 10.3109/01913123.2013.770112, PubMed 23634795
SHBG is an important factor in stemness induction of cells by DHT in vitro and associated with poor clinical features of prostate carcinomas
PLoS One, 8 (7), e70558
DOI 10.1371/journal.pone.0070558, PubMed 23936228
Lamin A/C cleavage by caspase-6 activation is crucial for apoptotic induction by photodynamic therapy with hexaminolevulinate in human B-cell lymphoma cells
Cancer Lett, 339 (1), 25-32
DOI 10.1016/j.canlet.2013.07.026, PubMed 23916608
Identification and characterization of cells with cancer stem cell properties in human primary lung cancer cell lines
PLoS One, 8 (3), e57020
DOI 10.1371/journal.pone.0057020, PubMed 23469181
In vitro and in vivo properties of CD133 expressing cells from human lung cancer cell lines
Exp Hematol Oncol, 2 (1), 16
DOI 10.1186/2162-3619-2-16, PubMed 23738757
The prevalence and risk factors of OAB in middle-aged and old people in China
Neurourol Urodyn, 33 (4), 387-91
DOI 10.1002/nau.22429, PubMed 23765684
Publications 2012
The hypoxic microenvironment upgrades stem-like properties of ovarian cancer cells
BMC Cancer, 12, 201
DOI 10.1186/1471-2407-12-201, PubMed 22642602
Synergistic effect of SCF and G-CSF on stem-like properties in prostate cancer cell lines
Tumour Biol, 33 (4), 967-78
DOI 10.1007/s13277-012-0325-3, PubMed 22252524
Publications 2011
Antitumour activity of oral E7080, a novel inhibitor of multiple tyrosine kinases, in human sarcoma xenografts
Int J Cancer, 129 (3), 742-50
DOI 10.1002/ijc.25922, PubMed 21225632
[Expression and prognostic significance of EphA2 and EphrinA-1 in ovarian serous carcinomas]
Sichuan Da Xue Xue Bao Yi Xue Ban, 42 (2), 179-84
PubMed 21500549
Altered characteristics of cancer stem/initiating cells in a breast cancer cell line treated with persistent 5-FU chemotherapy
Exp Ther Med, 2 (5), 821-826
DOI 10.3892/etm.2011.279, PubMed 22977582
CD44(+)/CD24(-) cells are transit progenitors and do not determine the molecular subtypes and clinical parameters in breast carcinomas
Ultrastruct Pathol, 35 (2), 72-8
DOI 10.3109/01913123.2010.544843, PubMed 21299347
Prostate cancer cell lines under hypoxia exhibit greater stem-like properties
PLoS One, 6 (12), e29170
DOI 10.1371/journal.pone.0029170, PubMed 22216200
Growth of hepatocellular carcinoma in the regenerating liver
Liver Transpl, 17 (7), 866-74
DOI 10.1002/lt.22325, PubMed 21542129
The prognostic value of 14-3-3 isoforms in vulvar squamous cell carcinoma cases: 14-3-3β and ε are independent prognostic factors for these tumors
PLoS One, 6 (9), e24843
DOI 10.1371/journal.pone.0024843, PubMed 21935479
Publications 2010
Aldehyde dehydrogenase (ALDH) activity does not select for cells with enhanced aggressive properties in malignant melanoma
PLoS One, 5 (5), e10731
DOI 10.1371/journal.pone.0010731, PubMed 20505780
Human malignant melanoma harbours a large fraction of highly clonogenic cells that do not express markers associated with cancer stem cells
Pigment Cell Melanoma Res, 23 (3), 449-51
DOI 10.1111/j.1755-148X.2010.00690.x, PubMed 20236249
Decreased expression of GST pi is correlated with a poor prognosis in human esophageal squamous carcinoma
BMC Cancer, 10, 352
DOI 10.1186/1471-2407-10-352, PubMed 20602752
Overexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in vulvar squamous cell carcinomas are associated with malignant features and aggressive cancer phenotypes
BMC Cancer, 10, 233
DOI 10.1186/1471-2407-10-233, PubMed 20500813
Publications 2009
Expression of TIP30 tumor suppressor gene is down-regulated in human colorectal carcinoma
Dig Dis Sci, 55 (8), 2219-26
DOI 10.1007/s10620-009-0992-0, PubMed 19798571
Down-regulation of the apoptosis-inducing factor or Bcl-2 inhibitor of transcription by RNA interference can alleviate TAp63gamma-induced apoptosis in esophageal squamous carcinoma EC9706 cells
Int J Oncol, 35 (2), 359-67
DOI 10.3892/ijo_00000347, PubMed 19578750
Identification of cancer stem-like side population cells in ovarian cancer cell line OVCAR-3
Ultrastruct Pathol, 33 (4), 175-81
DOI 10.1080/01913120903086072, PubMed 19728235
Adenocarcinomas on the rise--does it influence survival from oesophageal cancer?
Scand J Surg, 98 (4), 214-20
DOI 10.1177/145749690909800404, PubMed 20218417
Expression of HIWI in human esophageal squamous cell carcinoma is significantly associated with poorer prognosis
BMC Cancer, 9, 426
DOI 10.1186/1471-2407-9-426, PubMed 19995427
Differentiation effect of pyruvate and uridine on cultured U937-rho degrees cells
Ultrastruct Pathol, 33 (4), 160-4
DOI 10.1080/01913120902889187, PubMed 19728232
MUC-1-/ESA+ progenitor cells in normal, benign and malignant human breast epithelial cells
Histol Histopathol, 24 (11), 1381-90
DOI 10.14670/HH-24.1381, PubMed 19760587
[Quantity and distribution of CD44+/CD24- cells in breast cancer tissue and the cell lines]
Zhonghua Bing Li Xue Za Zhi, 38 (7), 441-4
PubMed 19781189
Oct3/4 and Sox2 are significantly associated with an unfavorable clinical outcome in human esophageal squamous cell carcinoma
Anticancer Res, 29 (4), 1233-41
PubMed 19414369
Publications 2008
FAP-alpha and uPA show different expression patterns in premalignant and malignant esophageal lesions
Ultrastruct Pathol, 32 (3), 89-96
DOI 10.1080/01913120802034934, PubMed 18570153
Seprase, dipeptidyl peptidase IV and urokinase-type plasminogen activator expression in dysplasia and invasive squamous cell carcinoma of the esophagus. A study of 229 cases from Anyang Tumor Hospital, Henan Province, China
Oncology, 75 (1-2), 49-59
DOI 10.1159/000151741, PubMed 18787344
Dipeptidyl peptidase IV expression in cancer and stromal cells of human esophageal squamous cell carcinomas, adenocarcinomas and squamous cell carcinoma cell lines
APMIS, 116 (9), 823-31
DOI 10.1111/j.1600-0463.2008.01029.x, PubMed 19024603
Expressions of EphA2 and EphrinA-1 in early squamous cell cervical carcinomas and their relation to prognosis
Int J Med Sci, 5 (3), 121-6
DOI 10.7150/ijms.5.121, PubMed 18566674
The clinicopathological and prognostic impact of 14-3-3 sigma expression on vulvar squamous cell carcinomas
BMC Cancer, 8, 308
DOI 10.1186/1471-2407-8-308, PubMed 18950492
[Correlation of DPPIV expression with clinicopathological features and prognosis in epithelial ovarian carcinoma]
Zhonghua Zhong Liu Za Zhi, 30 (11), 848-52
PubMed 19173831
Publications 2007
VP-16 resistance in the NCI-H460 human lung cancer cell line is significantly associated with glucose-regulated protein78 (GRP78) induction
Anticancer Res, 27 (4B), 2359-64
PubMed 17695526
The EPH receptor Bs (EPHBs) promoters are unmethylated in colon and ovarian cancers
Epigenetics, 2 (4), 237-43
DOI 10.4161/epi.2.4.5406, PubMed 18281782
DNA methylation profiling of ovarian carcinomas and their in vitro models identifies HOXA9, HOXB5, SCGB3A1, and CRABP1 as novel targets
Mol Cancer, 6, 45
DOI 10.1186/1476-4598-6-45, PubMed 17623056
Expression of seprase in effusions from patients with epithelial ovarian carcinoma
Chin Med J (Engl), 120 (8), 663-8
PubMed 17517181
Publications 2006
Chromosome 2q24.2 is lost in sporadic but not in BRCA1-associated ovarian carcinomas
Pathology, 38 (2), 145-51
DOI 10.1080/00313020600561526, PubMed 16680901
Activation of EDTA-resistant gelatinases in malignant human tumors
Cancer Res, 66 (20), 9977-85
DOI 10.1158/0008-5472.CAN-06-1499, PubMed 17047060
[Expressions of estrogen receptor subtypes in epithelial ovarian carcinomas]
Sichuan Da Xue Xue Bao Yi Xue Ban, 37 (4), 606-10
PubMed 16909613
Induction of hypoxia-inducible factor-1alpha overexpression by cobalt chloride enhances cellular resistance to photodynamic therapy
Cancer Lett, 244 (2), 182-9
DOI 10.1016/j.canlet.2005.12.010, PubMed 16427735
Subcellular localization pattern of protoporphyrin IX is an important determinant for its photodynamic efficiency of human carcinoma and normal cell lines
J Photochem Photobiol B, 84 (3), 213-20
DOI 10.1016/j.jphotobiol.2006.03.006, PubMed 16709459
The prognostic impact of EphB2/B4 expression on patients with advanced ovarian carcinoma
Gynecol Oncol, 102 (1), 15-21
DOI 10.1016/j.ygyno.2005.11.034, PubMed 16499955
Publications 2005
The clinical significance of EphA2 and Ephrin A-1 in epithelial ovarian carcinomas
Gynecol Oncol, 99 (2), 278-86
DOI 10.1016/j.ygyno.2005.06.036, PubMed 16061279
[Correlation between methylation of 5'-CpG islands and inactivation of FHIT gene in cervical cancer]
Ai Zheng, 24 (1), 7-11
PubMed 15642192
Predictive value of EphA2 and EphrinA-1 expression in oesophageal squamous cell carcinoma
Anticancer Res, 25 (4), 2943-50
PubMed 16080548
Publications 2004
Malignant mesothelioma
Ultrastruct Pathol, 28 (4), 179-80
DOI 10.1080/01913120490518051, PubMed 15693629
Real-time PCR quantification of c-erbB-2 gene is an alternative for FISH in the clinical management of breast carcinoma patients
Int J Surg Pathol, 12 (4), 311-8
DOI 10.1177/106689690401200404, PubMed 15494857
Papillary serous carcinoma of the ovary: an ultrastructural and immunohistochemical study
Ultrastruct Pathol, 28 (3), 141-7
DOI 10.1080/01913120490475716, PubMed 15471427
Prognostic significance of dysadherin expression in cervical squamous cell carcinoma
Pathol Oncol Res, 10 (4), 212-8
DOI 10.1007/bf03033763, PubMed 15619642
Prognostic value of EphA2 and EphrinA-1 in squamous cell cervical carcinoma
Gynecol Oncol, 94 (2), 312-9
DOI 10.1016/j.ygyno.2004.05.019, PubMed 15297167
Expression of Ephb2 and Ephb4 in breast carcinoma
Pathol Oncol Res, 10 (1), 26-33
DOI 10.1007/bf02893405, PubMed 15029258
Publications 2003
Electron microscopy in diagnosis of spindle cell tumors
Semin Diagn Pathol, 20 (1), 5-12
DOI 10.1053/sdia.2003.50006, PubMed 12693671
5'-CpG island methylation of the FHIT gene is associated with reduced protein expression and higher clinical stage in cervical carcinomas
Ultrastruct Pathol, 27 (6), 417-22
DOI 10.1080/01913120390250329, PubMed 14660280
Publications 2002
Type 1 protein tyrosine kinases in breast carcinoma: a review
Ultrastruct Pathol, 26 (3), 125-35
DOI 10.1080/01913120290076784, PubMed 12184370
Barrett's esophagus: intestinal metaplasia or phenotypic shift of undifferentiated elements in the stem cells
Ultrastruct Pathol, 26 (2), 53-4
DOI 10.1080/01913120252959218, PubMed 12036092
EGFR family expression in breast carcinomas. c-erbB-2 and c-erbB-4 receptors have different effects on survival
J Pathol, 196 (1), 17-25
DOI 10.1002/path.1003, PubMed 11748637
The expression of EGFR family ligands in breast carcinomas
Int J Surg Pathol, 10 (2), 91-9
DOI 10.1177/106689690201000202, PubMed 12075402
Cytologic screening for esophageal cancer in a high-risk population in Anyang County, China
Acta Cytol, 46 (3), 445-52
DOI 10.1159/000326859, PubMed 12040635
Publications 1991
Case for the panel. Cytoplasmic structures in the cells of esophageal squamous cell carcinomas
Ultrastruct Pathol, 15 (3), 309-10
DOI 10.3109/01913129109021893, PubMed 1871903