Bjørnar Hassel

  • Consultant, Professor II
  • +47 22 11 91 44
 

Publications 2019

Hassel B, Rogne AG, Hope S (2019)
Intellectual Disability Associated With Pyridoxine-Responsive Epilepsies: The Need to Protect Cognitive Development
Front Psychiatry, 10, 116
DOI 10.3389/fpsyt.2019.00116, PubMed 30930802

Holmøy AKT, Johannessen CH, Hope S, van Walsem MR, Aanonsen NO, Hassel B (2019)
Uncovering health and social care needs among myotonic dystrophy patients: Utility of the Needs and Provisions Complexity Scale
Acta Neurol Scand, 139 (6), 526-532
DOI 10.1111/ane.13086, PubMed 30848487

Qureshi T, Sørensen C, Berghuis P, Jensen V, Dobszay MB, Farkas T, Dalen KT, Guo C, Hassel B, Utheim TP, Hvalby Ø, Hafting T, Harkany T, Fyhn M, Chaudhry FA (2019)
The Glutamine Transporter Slc38a1 Regulates GABAergic Neurotransmission and Synaptic Plasticity
Cereb Cortex (in press)
DOI 10.1093/cercor/bhz055, PubMed 31050701

Vohra R, Dalgaard LM, Vibaek J, Langbøl MA, Bergersen LH, Olsen NV, Hassel B, Chaudhry FA, Kolko M (2019)
Potential metabolic markers in glaucoma and their regulation in response to hypoxia
Acta Ophthalmol (in press)
DOI 10.1111/aos.14021, PubMed 30690927

Publications 2018

Hassel B, Mariussen E, Idland AV, Dahl GT, Ræder J, Frihagen F, Berg JP, Chaudhry FA, Wyller TB, Watne LO (2018)
CSF sodium at toxic levels precedes delirium in hip fracture patients
Neurotoxicology, 69, 11-16
DOI 10.1016/j.neuro.2018.08.010, PubMed 30149051

Hu QX, Ottestad-Hansen S, Holmseth S, Hassel B, Danbolt NC, Zhou Y (2018)
Expression of Glutamate Transporters in Mouse Liver, Kidney, and Intestine
J Histochem Cytochem, 66 (3), 189-202
DOI 10.1369/0022155417749828, PubMed 29303644

Morland C, Frøland AS, Pettersen MN, Storm-Mathisen J, Gundersen V, Rise F, Hassel B (2018)
Propionate enters GABAergic neurons, inhibits GABA transaminase, causes GABA accumulation and lethargy in a model of propionic acidemia
Biochem J, 475 (4), 749-758
DOI 10.1042/BCJ20170814, PubMed 29339464

Zhou Y, Dhaher R, Parent M, Hu QX, Hassel B, Yee SP, Hyder F, Gruenbaum SE, Eid T, Danbolt NC (2018)
Selective deletion of glutamine synthetase in the mouse cerebral cortex induces glial dysfunction and vascular impairment that precede epilepsy and neurodegeneration
Neurochem Int, 123, 22-33
DOI 10.1016/j.neuint.2018.07.009, PubMed 30053506

Zhou Y, Hassel B, Eid T, Danbolt NC (2018)
Axon-terminals expressing EAAT2 (GLT-1; Slc1a2) are common in the forebrain and not limited to the hippocampus
Neurochem Int, 123, 101-113
DOI 10.1016/j.neuint.2018.03.006, PubMed 29530756

Publications 2017

Dahlberg D, Struys EA, Jansen EE, Mørkrid L, Midttun Ø, Hassel B (2017)
Cyst Fluid From Cystic, Malignant Brain Tumors: A Reservoir of Nutrients, Including Growth Factor-Like Nutrients, for Tumor Cells
Neurosurgery, 80 (6), 917-924
DOI 10.1093/neuros/nyw101, PubMed 28327992

Hassel B, De Souza GA, Stensland ME, Ivanovic J, Voie Ø, Dahlberg D (2017)
The proteome of pus from human brain abscesses: host-derived neurotoxic proteins and the cell-type diversity of CNS pus
J Neurosurg, 129 (3), 829-837
DOI 10.3171/2017.4.JNS17284, PubMed 29053067

Idland AV, Wyller TB, Støen R, Dahl GT, Frihagen F, Brækhus A, Hassel B, Watne LO (2017)
Cerebrospinal Fluid Phosphate in Delirium after Hip Fracture
Dement Geriatr Cogn Dis Extra, 7 (3), 309-317
DOI 10.1159/000478723, PubMed 29118783

Publications 2016

Dingledine R, Hassel B (2016)
A New Approach for Epilepsy
Cerebrum, 2016
PubMed 27408679

Moen MN, Fjær R, Hamdani EH, Laerdahl JK, Menchini RJ, Vigeland MD, Sheng Y, Undlien DE, Hassel B, Salih MA, El Khashab HY, Selmer KK, Chaudhry FA (2016)
Pathogenic variants in KCTD7 perturb neuronal K+ fluxes and glutamine transport
Brain, 139 (Pt 12), 3109-3120
DOI 10.1093/brain/aww244, PubMed 27742667

Morland C, Pettersen MN, Hassel B (2016)
Hyperosmolar sodium chloride is toxic to cultured neurons and causes reduction of glucose metabolism and ATP levels, an increase in glutamate uptake, and a reduction in cytosolic calcium
Neurotoxicology, 54, 34-43
DOI 10.1016/j.neuro.2016.03.005, PubMed 26994581

Watne LO, Idland AV, Fekkes D, Raeder J, Frihagen F, Ranhoff AH, Chaudhry FA, Engedal K, Wyller TB, Hassel B (2016)
Increased CSF levels of aromatic amino acids in hip fracture patients with delirium suggests higher monoaminergic activity
BMC Geriatr, 16, 149
DOI 10.1186/s12877-016-0324-0, PubMed 27484129

Publications 2015

Dahlberg D, Ivanovic J, Hassel B (2015)
Toxic levels of ammonia in human brain abscess
J Neurosurg, 124 (3), 854-60
DOI 10.3171/2015.1.JNS142582, PubMed 26274996

Dahlberg D, Ivanovic J, Mariussen E, Hassel B (2015)
High extracellular levels of potassium and trace metals in human brain abscess
Neurochem Int, 82, 28-32
DOI 10.1016/j.neuint.2015.02.003, PubMed 25684071

Dahlberg D, Mariussen E, Goverud IL, Tønjum T, Mæhlen J, Antal EA, Hassel B (2015)
Staphylococcal α-hemolysin is neurotoxic and causes lysis of brain cells in vivo and in vitro
Neurotoxicology, 48, 61-7
DOI 10.1016/j.neuro.2015.03.001, PubMed 25757835

Hassel B, Elsais A, Frøland AS, Taubøll E, Gjerstad L, Quan Y, Dingledine R, Rise F (2015)
Uptake and metabolism of fructose by rat neocortical cells in vivo and by isolated nerve terminals in vitro
J Neurochem, 133 (4), 572-81
DOI 10.1111/jnc.13079, PubMed 25708447

Solyga VM, Western E, Solheim H, Hassel B, Kerty E (2015)
[Posterior cortical atrophy]
Tidsskr Nor Laegeforen, 135 (10), 949-52
DOI 10.4045/tidsskr.14.1127, PubMed 26037756

Publications 2014

Dahlberg D, Ivanovic J, Hassel B (2014)
High extracellular concentration of excitatory amino acids glutamate and aspartate in human brain abscess
Neurochem Int, 69, 41-7
DOI 10.1016/j.neuint.2014.03.001, PubMed 24632003

Hassel B, Dahlberg D, Mariussen E, Goverud IL, Antal EA, Tønjum T, Maehlen J (2014)
Brain infection with Staphylococcus aureus leads to high extracellular levels of glutamate, aspartate, γ-aminobutyric acid, and zinc
J Neurosci Res, 92 (12), 1792-800
DOI 10.1002/jnr.23444, PubMed 25043715

Publications 2013

Hassel B (2013)
Tetanus: pathophysiology, treatment, and the possibility of using botulinum toxin against tetanus-induced rigidity and spasms
Toxins (Basel), 5 (1), 73-83
DOI 10.3390/toxins5010073, PubMed 23299659

Publications 2012

Hassel B (2012)
[A description of early hydrocephalus with macrocephaly, cerebral palsy, epilepsy, intellectual disability, and growth retardation by Norwegian novelist Amalie Skram (1846-1905)]
Tidsskr Nor Laegeforen, 132 (23-24), 2632-5
DOI 10.4045/tidsskr.12.0912, PubMed 23338097

Zhou Y, Holmseth S, Guo C, Hassel B, Höfner G, Huitfeldt HS, Wanner KT, Danbolt NC (2012)
Deletion of the γ-aminobutyric acid transporter 2 (GAT2 and SLC6A13) gene in mice leads to changes in liver and brain taurine contents
J Biol Chem, 287 (42), 35733-46
DOI 10.1074/jbc.M112.368175, PubMed 22896705

Publications 2010

Hassel B, Taubøll E, Shaw R, Gjerstad L, Dingledine R (2010)
Region-specific changes in gene expression in rat brain after chronic treatment with levetiracetam or phenytoin
Epilepsia, 51 (9), 1714-20
DOI 10.1111/j.1528-1167.2010.02545.x, PubMed 20345932

Publications 2008

Hassel B, Solyga V, Lossius A (2008)
High-affinity choline uptake and acetylcholine-metabolizing enzymes in CNS white matter. A quantitative study
Neurochem Int, 53 (6-8), 193-8
DOI 10.1016/j.neuint.2008.06.008, PubMed 18674580

Herrman H, Braekhus A, Aaserud O, Aukrust P, Stubhaug A, Hassel B (2008)
Early treatment of tetanus-induced trismus with botulinum toxin A
Anesth Analg, 106 (5), 1591
DOI 10.1213/ANE.0b013e31816a30f0, PubMed 18420892

Publications 2007

Bough KJ, Paquet M, Paré JF, Hassel B, Smith Y, Hall RA, Dingledine R (2007)
Evidence against enhanced glutamate transport in the anticonvulsant mechanism of the ketogenic diet
Epilepsy Res, 74 (2-3), 232-6
DOI 10.1016/j.eplepsyres.2007.03.002, PubMed 17416486

Hassel B, Tessler S, Faull RL, Emson PC (2007)
Glutamate uptake is reduced in prefrontal cortex in Huntington's disease
Neurochem Res, 33 (2), 232-7
DOI 10.1007/s11064-007-9463-1, PubMed 17726644

Henjum S, Hassel B (2007)
High-affinity glycine and glutamate transport in pig forebrain white and gray matter: a quantitative study
Neurochem Int, 50 (5), 696-702
DOI 10.1016/j.neuint.2007.01.002, PubMed 17316904

Morland C, Henjum S, Iversen EG, Skrede KK, Hassel B (2007)
Evidence for a higher glycolytic than oxidative metabolic activity in white matter of rat brain
Neurochem Int, 50 (5), 703-9
DOI 10.1016/j.neuint.2007.01.003, PubMed 17316901

Nguyen NH, Gonzalez SV, Hassel B (2007)
Formation of glycerol from glucose in rat brain and cultured brain cells. Augmentation with kainate or ischemia
J Neurochem, 101 (6), 1694-700
DOI 10.1111/j.1471-4159.2006.04433.x, PubMed 17286586

Nguyen NH, Morland C, Gonzalez SV, Rise F, Storm-Mathisen J, Gundersen V, Hassel B (2007)
Propionate increases neuronal histone acetylation, but is metabolized oxidatively by glia. Relevance for propionic acidemia
J Neurochem, 101 (3), 806-14
DOI 10.1111/j.1471-4159.2006.04397.x, PubMed 17286595

Publications 2006

Bough KJ, Wetherington J, Hassel B, Pare JF, Gawryluk JW, Greene JG, Shaw R, Smith Y, Geiger JD, Dingledine RJ (2006)
Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet
Ann Neurol, 60 (2), 223-35
DOI 10.1002/ana.20899, PubMed 16807920

Hassel B (2006)
Nicotinic mechanisms contribute to soman-induced symptoms and lethality
Neurotoxicology, 27 (4), 501-7
DOI 10.1016/j.neuro.2006.01.007, PubMed 16500708

Henjum S, Hassel B (2006)
High-affinity GABA uptake and GABA-metabolizing enzymes in pig forebrain white matter: a quantitative study
Neurochem Int, 50 (2), 365-70
DOI 10.1016/j.neuint.2006.09.004, PubMed 17069932

Nguyen N, Gonzalez SV, Rise F, Hassel B (2006)
Cerebral metabolism of glucose and pyruvate in soman poisoning. A 13C nuclear magnetic resonance spectroscopic study
Neurotoxicology, 28 (1), 13-8
DOI 10.1016/j.neuro.2006.09.007, PubMed 17087995

Publications 2005

Gonzalez SV, Nguyen NH, Rise F, Hassel B (2005)
Brain metabolism of exogenous pyruvate
J Neurochem, 95 (1), 284-93
DOI 10.1111/j.1471-4159.2005.03365.x, PubMed 16181432

Publications 2004

Morland C, Boldingh KA, Iversen EG, Hassel B (2004)
Valproate is neuroprotective against malonate toxicity in rat striatum: an association with augmentation of high-affinity glutamate uptake
J Cereb Blood Flow Metab, 24 (11), 1226-34
DOI 10.1097/01.WCB.0000138666.25305.A7, PubMed 15545916

Publications 2003

Hassel B, Boldingh KA, Narvesen C, Iversen EG, Skrede KK (2003)
Glutamate transport, glutamine synthetase and phosphate-activated glutaminase in rat CNS white matter. A quantitative study
J Neurochem, 87 (1), 230-7
DOI 10.1046/j.1471-4159.2003.01984.x, PubMed 12969269

Nguyen NH, Bråthe A, Hassel B (2003)
Neuronal uptake and metabolism of glycerol and the neuronal expression of mitochondrial glycerol-3-phosphate dehydrogenase
J Neurochem, 85 (4), 831-42
DOI 10.1046/j.1471-4159.2003.01762.x, PubMed 12716415

Publications 2002

Hassel B, Bråthe A, Petersen D (2002)
Cerebral dicarboxylate transport and metabolism studied with isotopically labelled fumarate, malate and malonate
J Neurochem, 82 (2), 410-9
DOI 10.1046/j.1471-4159.2002.00986.x, PubMed 12124442

Hassel B, Sonnewald U (2002)
Effects of potassium and glutamine on metabolism of glucose in astrocytes
Neurochem Res, 27 (1-2), 167-71
DOI 10.1023/A:1014827327690, PubMed 11926271

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