Germ cell tumors of the ovary

Germ cell tumors of the ovary arises from the germ cells. They are infrequent, accounting for less the 5 % of ovarian malignancies. They are heterogenous, and the most common types are dysgerminomas, endodermal sinus tumor, and immature teratomas. Choriocarcinomas, embryonal carcinomas and gonadoblastomas are also described. Generally good prognosis with >85 % 5-year survival. Average age at diagnosis about 25

Material

• Retrospective study
• Paraffin embedded tissue sections
• 49 cases of malignant ovarian germ cell tumors
• 20 dysgerminomas
• 17 immature teratomas
• 10 endodermal sinus tumor
  
• 1 embryonal carcinoma
• 1 chorio carcinoma
  

A subgroup of 25 cases from this material are also included in a planned study on comparison of DNA ploidy and number of chromosomal copy numbers performed by comparative genomic hybridization

FIGO stage
I: 33, II: 6, III: 7 and IV: 3
Follow up > 10 years

Methods

• DNA ploidy analysis performed by image cytometry.
• Comparative genomic hybridization.
  

Preliminary results
Main findings:

• Most cases were non-diploid 2/3
• None of the patients with diploid, FIGO stage I, IT subtype got recurrence of disease
  

Publications