Aboulghassem Shahdadfar

  • Senior Scientist; PhD

Education

  • 2007-2008: Postdoc in Tissue Engineering, Oslo University Hospital - Rikshospitalet, Norway.
  • 2003-2007: PhD in Immunology, University of Oslo, Norway.
  • 1997-2000: MSc in Immunology, University of Tromsø, Norway.
  • 1992-1996: BSc in Immunology, University of Tromsø, Norway.
  • 1979-1987: BSc in Chemistry, Ferdowsi University of Mashhad, Iran.

Affiliation

  • Center for Eye Research, Department of Ophthalmology, Oslo University Hospital - Ullevål, Norway.
  • Institute of Oral Biology, Faculty of Dentistry, University of Oslo, Norway.

Research summary
Aboulghassem Shahdadfar has a PhD in Regenerative Medicine. He has been working in the field of Tissue Engineering since 2007. His earlier researches have been centered on human articular cartilage and myocardial tissues. Later, he has focused on human ocular surface. Shahdadfar's main research interest is to reconstruct the human corneal endothelium.

Work Experience

  • 2008-present: Senior Scientist, Oslo University Hospital - Ullevål, Norway.
  • 2007-2008: Postdoctoral Research Fellow, Oslo University Hospital - Rikshospitalet, Norway.
  • 2003-2007: PhD Research Fellow, University of Oslo, Norway.
  • 2001-2003: Research Assistant (Immunology-Cell Therapy), Oslo University Hospital - Rikshospitalet, Norway.
  • 1999-2001: Research Assistant (Blood Bank), Tromsø University Hospital, Norway.
  • 1997-1999: Research Assistant (Women Clinic), Tromsø University Hospital, Norway.

Links:

 

Original articles

Yazdani M, Shahdadfar A, Jackson CJ, Utheim TP (2019)
A Hyaluronan Hydrogel Scaffold for Culture of Human Oral Mucosal Epithelial Cells in Limbal Stem-Cell Therapy
Bioengineering (Basel), 6 (4)
DOI 10.3390/bioengineering6040097, PubMed 31652804

Pathak M, Cholidis S, Haug K, Shahdadfar A, Moe MC, Nicolaissen B, Drolsum L (2012)
Clinical transplantation of ex vivo expanded autologous limbal epithelial cells using a culture medium with human serum as single supplement: a retrospective case series
Acta Ophthalmol, 91 (8), 769-75
DOI 10.1111/j.1755-3768.2012.02521.x, PubMed 22937779

Haug K, Azqueta A, Johnsen-Soriano S, Shahdadfar A, Drolsum LK, Moe MC, Røger MT, Romero FJ, Collins AR, Nicolaissen B (2012)
Donor cornea transfer from Optisol GS to organ culture storage: a two-step procedure to increase donor tissue lifespan
Acta Ophthalmol, 91 (3), 219-25
DOI 10.1111/j.1755-3768.2012.02390.x, PubMed 22429721

Shahdadfar A, Haug K, Pathak M, Drolsum L, Olstad OK, Johnsen EO, Petrovski G, Moe MC, Nicolaissen B (2012)
Ex vivo expanded autologous limbal epithelial cells on amniotic membrane using a culture medium with human serum as single supplement
Exp Eye Res, 97 (1), 1-9
DOI 10.1016/j.exer.2012.01.013, PubMed 22342952

Otto Beitnes J, Oie E, Shahdadfar A, Karlsen T, Müller RM, Aakhus S, Reinholt FP, Brinchmann JE (2012)
Intramyocardial injections of human mesenchymal stem cells following acute myocardial infarction modulate scar formation and improve left ventricular function
Cell Transplant, 21 (8), 1697-709
DOI 10.3727/096368911X627462, PubMed 22410280

Karlsen TA, Mirtaheri P, Shahdadfar A, Fløisand Y, Brinchmann JE (2011)
Effect of three-dimensional culture and incubator gas concentration on phenotype and differentiation capability of human mesenchymal stem cells
J Cell Biochem, 112 (2), 684-93
DOI 10.1002/jcb.22978, PubMed 21268090

Karlsen TA, Shahdadfar A, Brinchmann JE (2010)
Human primary articular chondrocytes, chondroblasts-like cells, and dedifferentiated chondrocytes: differences in gene, microRNA, and protein expression and phenotype
Tissue Eng Part C Methods, 17 (2), 219-27
DOI 10.1089/ten.TEC.2010.0200, PubMed 20799885

Jakobsen RB, Shahdadfar A, Reinholt FP, Brinchmann JE (2009)
Chondrogenesis in a hyaluronic acid scaffold: comparison between chondrocytes and MSC from bone marrow and adipose tissue
Knee Surg Sports Traumatol Arthrosc, 18 (10), 1407-16
DOI 10.1007/s00167-009-1017-4, PubMed 20020100

Duggal S, Frønsdal KB, Szöke K, Shahdadfar A, Melvik JE, Brinchmann JE (2009)
Phenotype and gene expression of human mesenchymal stem cells in alginate scaffolds
Tissue Eng Part A, 15 (7), 1763-73
DOI 10.1089/ten.tea.2008.0306, PubMed 19115828

Shahdadfar A, Løken S, Dahl JA, Tunheim SH, Collas P, Reinholt FP, Engebretsen L, Brinchmann JE (2008)
Persistence of collagen type II synthesis and secretion in rapidly proliferating human articular chondrocytes in vitro
Tissue Eng Part A, 14 (12), 1999-2007
DOI 10.1089/ten.tea.2007.0344, PubMed 18636947

Løken S, Jakobsen RB, Arøen A, Heir S, Shahdadfar A, Brinchmann JE, Engebretsen L, Reinholt FP (2008)
Bone marrow mesenchymal stem cells in a hyaluronan scaffold for treatment of an osteochondral defect in a rabbit model
Knee Surg Sports Traumatol Arthrosc, 16 (10), 896-903
DOI 10.1007/s00167-008-0566-2, PubMed 18592218

Pedersen ME, Fortunati D, Nielsen M, Brorson SH, Lekva T, Nissen-Meyer LS, Gautvik VT, Shahdadfar A, Gautvik KM, Jemtland R (2008)
Calmodulin-dependent kinase 1beta is expressed in the epiphyseal growth plate and regulates proliferation of mouse calvarial osteoblasts in vitro
Bone, 43 (4), 700-7
DOI 10.1016/j.bone.2008.06.006, PubMed 18620088

Dahl JA, Duggal S, Coulston N, Millar D, Melki J, Shahdadfar A, Brinchmann JE, Collas P (2008)
Genetic and epigenetic instability of human bone marrow mesenchymal stem cells expanded in autologous serum or fetal bovine serum
Int J Dev Biol, 52 (8), 1033-42
DOI 10.1387/ijdb.082663jd, PubMed 18956336

Boquest AC, Shahdadfar A, Brinchmann JE, Collas P (2006)
Isolation of stromal stem cells from human adipose tissue
Methods Mol Biol, 325, 35-46
DOI 10.1385/1-59745-005-7:35, PubMed 16761717

Shahdadfar A, Frønsdal K, Haug T, Reinholt FP, Brinchmann JE (2005)
In vitro expansion of human mesenchymal stem cells: choice of serum is a determinant of cell proliferation, differentiation, gene expression, and transcriptome stability
Stem Cells, 23 (9), 1357-66
DOI 10.1634/stemcells.2005-0094, PubMed 16081661

Boquest AC, Shahdadfar A, Frønsdal K, Sigurjonsson O, Tunheim SH, Collas P, Brinchmann JE (2005)
Isolation and transcription profiling of purified uncultured human stromal stem cells: alteration of gene expression after in vitro cell culture
Mol Biol Cell, 16 (3), 1131-41
DOI 10.1091/mbc.e04-10-0949, PubMed 15635089

Review articles

Yazdani M, Elgstøen KBP, Rootwelt H, Shahdadfar A, Utheim ØA, Utheim TP (2019)
Tear Metabolomics in Dry Eye Disease: A Review
Int J Mol Sci, 20 (15)
DOI 10.3390/ijms20153755, PubMed 31374809

Yazdani M, Shahdadfar A, Jackson CJ, Utheim TP (2019)
Hyaluronan-Based Hydrogel Scaffolds for Limbal Stem Cell Transplantation: A Review
Cells, 8 (3)
DOI 10.3390/cells8030245, PubMed 30875861

Navaratnam J, Utheim TP, Rajasekhar VK, Shahdadfar A (2015)
Substrates for Expansion of Corneal Endothelial Cells towards Bioengineering of Human Corneal Endothelium
J Funct Biomater, 6 (3), 917-45
DOI 10.3390/jfb6030917, PubMed 26378588

Other articles

Jakobsen RB, Shahdadfar A, Reinholt FP, Brinchmann JE (2014)
Chondrogenesis in a hyaluronic acid scaffold: comparison between chondrocytes and MSC from bone marrow and adipose tissue (vol 18, pg 1407, 2010)
Knee Surg. Sports Traumatol. Arthrosc., 22 (7), 1711-1714

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