OUH - Contacts

Hakan Köksal

PhD student; Msc
+47 22 78 23 18

HELSE SØR-ØST

Education:

2016 – Present: Ph.D student in Department of Cellular Therapy, Oslo University Hospital, Norway

2014 – 2016 M.Sc. in Molecular Bilogy and Genetics, Bilkent University, Ankara, Turkey

2010 – 2014 B.Sc. in Molecular Bilogy and Genetics, Bilkent University, Ankara, Turkey

Research interests/projects:

Immunotherapy

Therapeutic TCRs
Checkpoint Inhibitors
Chimeric Antigen Receptors (CAR)

Cloning, expression and functional tests

Work experience

2016 (Oct) – Present Research Member, Ph.D. candidate at Department of Cellular Therapy, OUS Radiumhospitalet, Oslo, NORWAY

2014-2016 Research Member, M.Sc. candidate at THORLAB. Memory-like T cells transduced with tumor-specific epitope elicited pronounced cytotoxic potential. Ihsan Dogramaci Bilkent University, Molecular Biology and Genetics Department, Ankara, TURKEY.

2013-2014 Fall Senior student at Prof. Ihsan Gursel Group. Cloning of TLR-9 and its interaction with different ligands. Ihsan Dogramaci Bilkent University, Molecular Biology and Genetics Department, Ankara, TURKEY.

June-Sept. 2013 Intern at Prof. Leo Joosten and Prof. Mihai Netea Group. ERASMUS Summer Internship Scholarship. NOD-like receptor protein-12 (NLRP12) gene polymorphism G39V in inflammatory bowel disease and Olecranon Bursitis patients` immune responses to Pseudallescheria boydii infection. Nijmegen Institute for Infection, Inflammation & Immunity, Nijmegen, NETHERLANDS.

2012-2013 Intern at Prof. Ihsan Gursel Group. Ihsan Dogramaci Bilkent University, Molecular Biology and Genetics Department, Ankara, TURKEY.

2010-2012 Intern at Assist. Prof. Ebru Erbay Group. TUBITAK 2209 project. Discovery of potential substrates of PKR via chemical genetic methods. Ihsan Dogramaci Bilkent University, Molecular Biology and Genetics Department, Ankara, TURKEY.

Original articles

Köksal H, Dillard P, Josefsson SE, Maggadottir SM, Pollmann S, Fåne A, Blaker YN, Beiske K, Huse K, Kolstad A, Holte H, Kvalheim G, Smeland EB, Myklebust JH, Inderberg EM, Wälchli S (2019)
Preclinical development of CD37CAR T-cell therapy for treatment of B-cell lymphoma
Blood Adv, 3 (8), 1230-1243
DOI 10.1182/bloodadvances.2018029678, PubMed 30979721

Josefsson SE, Beiske K, Blaker YN, Førsund MS, Holte H, Østenstad B, Kimby E, Köksal H, Wälchli S, Bai B, Smeland EB, Levy R, Kolstad A, Huse K, Myklebust JH (2019)
TIGIT and PD-1 Mark Intratumoral T Cells with Reduced Effector Function in B-cell Non-Hodgkin Lymphoma
Cancer Immunol Res, 7 (3), 355-362
DOI 10.1158/2326-6066.CIR-18-0351, PubMed 30659053

Dillard P, Köksal H, Inderberg EM, Wälchli S (2018)
A Spheroid Killing Assay by CAR T Cells
J Vis Exp (142)
DOI 10.3791/58785, PubMed 30596389

Walseng E, Köksal H, Sektioglu IM, Fåne A, Skorstad G, Kvalheim G, Gaudernack G, Inderberg EM, Wälchli S (2017)
A TCR-based Chimeric Antigen Receptor
Sci Rep, 7 (1), 10713
DOI 10.1038/s41598-017-11126-y, PubMed 28878363

Ozguven BY, Tuncel D, Polat N, Sakiz D, Kabukcuoglu F, Koksal H, Kaya H (2015)
Solid-pseudopapillary neoplasm of the pancreas: Clinicopathologic and immunohistochemical analysis of nine cases
Indian J Pathol Microbiol, 58 (3), 292-5
DOI 10.4103/0377-4929.162833, PubMed 26275248

Demir U, Yazıcı P, Bostancı Ö, Kaya C, Köksal H, Işıl G, Bozdağ E, Mihmanlı M (2014)
Timing of cholecystectomy in biliary pancreatitis treatment
Ulus Cerrahi Derg, 30 (1), 10-3
DOI 10.5152/UCD.2014.2401, PubMed 25931883

Köksal H, Rahman A, Burma O, Halifeoğlu I, Bayar MK (2008)
The effects of low dose N-acetylcysteine (NAC) as an adjunct to cardioplegia in coronary artery bypass surgery
Anadolu Kardiyol Derg, 8 (6), 437-43
PubMed 19103540

Köksal H, Yildirim S, Celayir F, Cipe G, Baykan A, Mihmanli M, Akgün I (2005)
[A critical overview of surgical treatment methods of colorectal injuries]
Ulus Travma Acil Cerrahi Derg, 11 (2), 121-7
PubMed 15877242

Yildirim S, Köksal H, Celayir F, Erdem L, Oner M, Baykan A (2004)
Colonic interposition vs. gastric pull-up after total esophagectomy
J Gastrointest Surg, 8 (6), 675-8
DOI 10.1016/j.gassur.2004.03.007, PubMed 15358327

Yildirim S, Tok H, Köksal H, Erdem L, Baykan A (2002)
Allopurinol plus pentoxifilline in hepatic ischaemia/reperfusion injury
Asian J Surg, 25 (2), 149-53
DOI 10.1016/S1015-9584(09)60164-0, PubMed 12376236

Review articles

Köksal H, Müller E, Inderberg EM, Bruland Ø, Wälchli S (2019)
Treating osteosarcoma with CAR T cells
Scand J Immunol, 89 (3), e12741
DOI 10.1111/sji.12741, PubMed 30549299