Hakan Köksal

  • Post-doc; PhD, Msc
  • +47 22 78 23 18

HELSE SØR-ØST

Education:

2016 – Present:   Ph.D student in Department of Cellular Therapy, Oslo University Hospital, Norway

2014 – 2016       M.Sc. in Molecular Bilogy and Genetics, Bilkent University, Ankara, Turkey

2010 – 2014       B.Sc. in Molecular Bilogy and Genetics, Bilkent University, Ankara, Turkey

Research interests/projects:

  • Immunotherapy
    • Therapeutic TCRs
    • Checkpoint Inhibitors
    • Chimeric Antigen Receptors (CAR)
      • Cloning, expression and functional tests

 

Work experience

2016 (Oct) – Present      Research Member, Ph.D. candidate at Department of Cellular Therapy, OUS Radiumhospitalet, Oslo, NORWAY

2014-2016                      Research Member, M.Sc. candidate at THORLAB. Memory-like T cells transduced with tumor-specific epitope elicited pronounced cytotoxic potential. Ihsan Dogramaci Bilkent University, Molecular Biology and Genetics Department, Ankara, TURKEY.

2013-2014 Fall               Senior student at Prof. Ihsan Gursel Group. Cloning of TLR-9 and its interaction with different ligands. Ihsan Dogramaci Bilkent University, Molecular Biology and Genetics Department, Ankara, TURKEY.

June-Sept. 2013             Intern at Prof. Leo Joosten and Prof. Mihai Netea Group. ERASMUS Summer Internship Scholarship. NOD-like receptor protein-12 (NLRP12) gene polymorphism G39V in inflammatory bowel disease and Olecranon Bursitis patients` immune responses to Pseudallescheria boydii infection. Nijmegen Institute for Infection, Inflammation & Immunity, Nijmegen, NETHERLANDS.

2012-2013                      Intern at Prof. Ihsan Gursel Group. Ihsan Dogramaci Bilkent University, Molecular Biology and Genetics Department, Ankara, TURKEY.

2010-2012                      Intern at Assist. Prof. Ebru Erbay Group. TUBITAK 2209 project. Discovery of potential substrates of PKR via chemical genetic methods.  Ihsan Dogramaci Bilkent University, Molecular Biology and Genetics Department, Ankara, TURKEY.

 

 

Publications 2020

Celayir MF, Tanal M, Besler E, Koksal H (2020)
Protective Loop Ileostomy Closure Techniques: Comparison of Three Different Surgical Techniques
Cureus, 12 (10), e10977
DOI 10.7759/cureus.10977, PubMed 33094038

Dillard P, Köksal H, Maggadottir SM, Winge-Main A, Pollmann S, Menard M, Myhre MR, Mælandsmo GM, Flørenes VA, Gaudernack G, Kvalheim G, Wälchli S, Inderberg EM (2020)
Targeting Telomerase with an HLA Class II-Restricted TCR for Cancer Immunotherapy
Mol Ther (in press)
DOI 10.1016/j.ymthe.2020.11.019, PubMed 33212301

Dillard P, Lie M, Baken E, Lobert VH, Benard E, Köksal H, Inderberg EM, Wälchli S (2020)
Colorectal cysts as a validating tool for CAR therapy
BMC Biotechnol, 20 (1), 30
DOI 10.1186/s12896-020-00623-0, PubMed 32487146

Publications 2019

Josefsson SE, Beiske K, Blaker YN, Førsund MS, Holte H, Østenstad B, Kimby E, Köksal H, Wälchli S, Bai B, Smeland EB, Levy R, Kolstad A, Huse K, Myklebust JH (2019)
TIGIT and PD-1 Mark Intratumoral T Cells with Reduced Effector Function in B-cell Non-Hodgkin Lymphoma
Cancer Immunol Res, 7 (3), 355-362
DOI 10.1158/2326-6066.CIR-18-0351, PubMed 30659053

Köksal H, Dillard P, Josefsson SE, Maggadottir SM, Pollmann S, Fåne A, Blaker YN, Beiske K, Huse K, Kolstad A, Holte H, Kvalheim G, Smeland EB, Myklebust JH, Inderberg EM, Wälchli S (2019)
Preclinical development of CD37CAR T-cell therapy for treatment of B-cell lymphoma
Blood Adv, 3 (8), 1230-1243
DOI 10.1182/bloodadvances.2018029678, PubMed 30979721

Köksal H, Müller E, Inderberg EM, Bruland Ø, Wälchli S (2019)
Treating osteosarcoma with CAR T cells
Scand J Immunol, 89 (3), e12741
DOI 10.1111/sji.12741, PubMed 30549299

Publications 2018

Dillard P, Köksal H, Inderberg EM, Wälchli S (2018)
A Spheroid Killing Assay by CAR T Cells
J Vis Exp (142)
DOI 10.3791/58785, PubMed 30596389

Publications 2017

Koksal H, Walchli S (2017)
Fishing therapeutic T-cell receptors in healthy donor blood, is safety predictable?
Transl. Cancer Res., 6 3, S622-S624

Walseng E, Köksal H, Sektioglu IM, Fåne A, Skorstad G, Kvalheim G, Gaudernack G, Inderberg EM, Wälchli S (2017)
A TCR-based Chimeric Antigen Receptor
Sci Rep, 7 (1), 10713
DOI 10.1038/s41598-017-11126-y, PubMed 28878363

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