Vibeke Marie Almaas

  • Consultant Cardiologist, MD, PhD
  • +47 230 74145

Vibeke Almaas successfully defended her PhD thesis "Obstructive hypertrophic cardiomyopathy. Pathophysiology and clinical management" in October 2015. Her supervisors were Professor Emeritus Jan Peder Amlie, MD, PhD, University of Oslo and Professor Svend Aakhus, MD, PhD, Norwegian University of Science and Technology.

She found that a type of scarring in the heart muscle, interstitial fibrosis, in patients with hypertrophic cardiomyopathy (HCM), is associated with severe cardiac arrhythmia and that a newly developed cardiac ultrasound examination can identify patients at increased risk. Together with Scandinavian colleagues, Vibeke M. Almaas has shown that PTSMA is a safe and effective treatment for obstructive HCM patients.

In the period 2001-2009, over a hundred HCM patients were referred to Department of Cardiology, Rikshospitalet, Oslo University Hospital, for PTSMA; a catheter-based method of applying a myocardial infarction to the thickened heart partition, or myectomy; a heart operation where the thickened part of the heart partition is removed. Obstructive HCM patients have thickened cardiac wall that prevents blood from flowing freely into the main artery. These patients may be offered PTSMA or myectomy. A treatment team with experience in HCM assessed whether conditions were suitable for PTSMA or whether surgical correction and myectomy were needed. Before and after PTSMA / myectomy, patients were examined, among other things, with 48-hour cardiac rhythm recording, cardiac ultrasound and magnetic resonance (MRI) of the heart. The heart muscle tissue removed by myectomy was examined microscopically. PTSMA-treated patients were included in a Scandinavian database where long-term follow-up after PTSMA was recorded.

In her thesis Almaas and her colleagues showed that the catheter-based method PTSMA can be safely performed at centers with experienced invasive cardiologists and that interstitial fibrosis, scarring associated with severe arrhythmia, is not so readily seen in cardiac MRI examination, but scarring leads to reduced function of the heart muscle which can be identified by a fast and simple heart ultrasound method.

 

Publications 2019

Jensen MK, Faber L, Liebregts M, Januska J, Krejci J, Bartel T, Cooper RM, Dabrowski M, Hansen PR, Almaas VM, Seggewiss H, Horstkotte D, Adlova R, Berg JT, Bundgaard H, Veselka J (2019)
Effect of impaired cardiac conduction after alcohol septal ablation on clinical outcomes: insights from the Euro-ASA registry
Eur Heart J Qual Care Clin Outcomes, 5 (3), 252-258
DOI 10.1093/ehjqcco/qcy049, PubMed 30304395

Lorén CE, Dahl CP, Do L, Almaas VM, Geiran OR, Mörner S, Hellman U (2019)
Low Molecular Mass Myocardial Hyaluronan in Human Hypertrophic Cardiomyopathy
Cells, 8 (2)
DOI 10.3390/cells8020097, PubMed 30699940

Publications 2018

Veselka J, Faber L, Jensen MK, Cooper R, Januska J, Krejci J, Bartel T, Dabrowski M, Hansen PR, Almaas VM, Seggewiss H, Horstkotte D, Adlova R, Bundgaard H, Ten Berg J, Liebregts M (2018)
Effect of Institutional Experience on Outcomes of Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy
Can J Cardiol, 34 (1), 16-22
DOI 10.1016/j.cjca.2017.10.020, PubMed 29275877

Publications 2017

Haland TF, Hasselberg NE, Almaas VM, Dejgaard LA, Saberniak J, Leren IS, Berge KE, Haugaa KH, Edvardsen T (2017)
The systolic paradox in hypertrophic cardiomyopathy
Open Heart, 4 (1), e000571
DOI 10.1136/openhrt-2016-000571, PubMed 28674623

Veselka J, Faber L, Liebregts M, Cooper R, Januska J, Krejci J, Bartel T, Dabrowski M, Hansen PR, Almaas VM, Seggewiss H, Horstkotte D, Adlova R, Bundgaard H, Ten Berg J, Stables RH, Jensen MK (2017)
Outcome of Alcohol Septal Ablation in Mildly Symptomatic Patients With Hypertrophic Obstructive Cardiomyopathy: A Long-Term Follow-Up Study Based on the Euro-Alcohol Septal Ablation Registry
J Am Heart Assoc, 6 (5)
DOI 10.1161/JAHA.117.005735, PubMed 28512112

Publications 2016

Haland TF, Almaas VM, Hasselberg NE, Saberniak J, Leren IS, Hopp E, Edvardsen T, Haugaa KH (2016)
Strain echocardiography is related to fibrosis and ventricular arrhythmias in hypertrophic cardiomyopathy
Eur Heart J Cardiovasc Imaging, 17 (6), 613-21
DOI 10.1093/ehjci/jew005, PubMed 26873460

Jensen MK, Jacobsson L, Almaas V, van Buuren F, Hansen PR, Hansen TF, Aakhus S, Eriksson MJ, Bundgaard H, Faber L (2016)
Influence of Septal Thickness on the Clinical Outcome After Alcohol Septal Alation in Hypertrophic Cardiomyopathy
Circ Cardiovasc Interv, 9 (6)
DOI 10.1161/CIRCINTERVENTIONS.115.003214, PubMed 27217377

Veselka J, Jensen MK, Liebregts M, Januska J, Krejci J, Bartel T, Dabrowski M, Hansen PR, Almaas VM, Seggewiss H, Horstkotte D, Tomasov P, Adlova R, Bundgaard H, Steggerda R, Ten Berg J, Faber L (2016)
Long-term clinical outcome after alcohol septal ablation for obstructive hypertrophic cardiomyopathy: results from the Euro-ASA registry
Eur Heart J, 37 (19), 1517-23
DOI 10.1093/eurheartj/ehv693, PubMed 26746632

Publications 2014

Apelland T, Gude E, Strøm EH, Gullestad L, Eiklid KL, Månsson JE, Reinholt FP, Houge G, Dahl CP, Almaas VM, Heiberg A (2014)
Familial globotriaosylceramide-associated cardiomyopathy mimicking Fabry disease
Heart, 100 (22), 1793-8
DOI 10.1136/heartjnl-2014-305616, PubMed 25031264

Publications 2013

Almaas VM, Haugaa KH, Strøm EH, Scott H, Dahl CP, Leren TP, Geiran OR, Endresen K, Edvardsen T, Aakhus S, Amlie JP (2013)
Increased amount of interstitial fibrosis predicts ventricular arrhythmias, and is associated with reduced myocardial septal function in patients with obstructive hypertrophic cardiomyopathy
Europace, 15 (9), 1319-27
DOI 10.1093/europace/eut028, PubMed 23426552

Almaas VM, Haugaa KH, Strøm EH, Scott H, Smith HJ, Dahl CP, Geiran OR, Endresen K, Aakhus S, Amlie JP, Edvardsen T (2013)
Noninvasive assessment of myocardial fibrosis in patients with obstructive hypertrophic cardiomyopathy
Heart, 100 (8), 631-8
DOI 10.1136/heartjnl-2013-304923, PubMed 24368281

Publications 2011

Jensen MK, Almaas VM, Jacobsson L, Hansen PR, Havndrup O, Aakhus S, Svane B, Hansen TF, Køber L, Endresen K, Eriksson MJ, Jørgensen E, Amlie JP, Gadler F, Bundgaard H (2011)
Long-term outcome of percutaneous transluminal septal myocardial ablation in hypertrophic obstructive cardiomyopathy: a Scandinavian multicenter study
Circ Cardiovasc Interv, 4 (3), 256-65
DOI 10.1161/CIRCINTERVENTIONS.110.959718, PubMed 21540441

Publications 2007

Krayer von Krauss MP, Kaiser M, Almaas V, van der Sluijs J, Kloprogge P (2007)
Diagnosing and prioritizing uncertainties according to their relevance for policy: the case of transgene silencing
Sci Total Environ, 390 (1), 23-34
DOI 10.1016/j.scitotenv.2007.09.028, PubMed 17988720

Publications 2005

Ghanima W, Almaas V, Aballi S, Dörje C, Nielssen BE, Holmen LO, Almaas R, Abdelnoor M, Sandset PM (2005)
Management of suspected pulmonary embolism (PE) by D-dimer and multi-slice computed tomography in outpatients: an outcome study
J Thromb Haemost, 3 (9), 1926-32
DOI 10.1111/j.1538-7836.2005.01544.x, PubMed 16102097

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