Tommy Aleksander Karlsen

  • Post doc; PhD

Publications 2021

Frerker N, Karlsen TA, Lilledahl MB, Brorson SH, Tibballs JE, Brinchmann JE (2021)
Scaffold-Free Engineering of Human Cartilage Implants
Cartilage, 13 (1_suppl), 1237S-1249S
DOI 10.1177/19476035211007923, PubMed 33858229

Hanousková B, Vávrová G, Ambrož M, Boušová I, Karlsen TA, Skálová L, Matoušková P (2021)
MicroRNAs mediated regulation of glutathione peroxidase 7 expression and its changes during adipogenesis
Biochim Biophys Acta Gene Regul Mech, 1864 (10), 194734
DOI 10.1016/j.bbagrm.2021.194734, PubMed 34339889

Publications 2019

Al-Modawi RN, Brinchmann JE, Karlsen TA (2019)
Multi-pathway Protective Effects of MicroRNAs on Human Chondrocytes in an In Vitro Model of Osteoarthritis
Mol Ther Nucleic Acids, 17, 776-790
DOI 10.1016/j.omtn.2019.07.011, PubMed 31446120

Bogdanova M, Zabirnyk A, Malashicheva A, Enayati KZ, Karlsen TA, Kaljusto ML, Kvitting JP, Dissen E, Sullivan GJ, Kostareva A, Stensløkken KO, Rutkovskiy A, Vaage J (2019)
Interstitial cells in calcified aortic valves have reduced differentiation potential and stem cell-like properties
Sci Rep, 9 (1), 12934
DOI 10.1038/s41598-019-49016-0, PubMed 31506459

Idaszek J, Costantini M, Karlsen TA, Jaroszewicz J, Colosi C, Testa S, Fornetti E, Bernardini S, Seta M, Kasarełło K, Wrzesień R, Cannata S, Barbetta A, Gargioli C, Brinchman JE, Święszkowski W (2019)
3D bioprinting of hydrogel constructs with cell and material gradients for the regeneration of full-thickness chondral defect using a microfluidic printing head
Biofabrication, 11 (4), 044101
DOI 10.1088/1758-5090/ab2622, PubMed 31151123

Karlsen TA, Sundaram AYM, Brinchmann JE (2019)
Single-Cell RNA Sequencing of In Vitro Expanded Chondrocytes: MSC-Like Cells With No Evidence of Distinct Subsets
Cartilage, 13 (2_suppl), 774S-784S
DOI 10.1177/1947603519847746, PubMed 31072202

Karlsen TA, Aae TF, Brinchmann JE (2019)
Robust profiling of microRNAs and isomiRs in human plasma exosomes across 46 individuals
Sci Rep, 9 (1), 19999
DOI 10.1038/s41598-019-56593-7, PubMed 31882820

Suliman S, Ali HRW, Karlsen TA, Amiaud J, Mohamed-Ahmed S, Layrolle P, Costea DE, Brinchmann JE, Mustafa K (2019)
Impact of humanised isolation and culture conditions on stemness and osteogenic potential of bone marrow derived mesenchymal stromal cells
Sci Rep, 9 (1), 16031
DOI 10.1038/s41598-019-52442-9, PubMed 31690774

Publications 2018

Karlsen TA, Brinchmann JE (2018)
Expression of inflammatory cytokines in mesenchymal stromal cells is sensitive to culture conditions and simple cell manipulations
Exp Cell Res, 374 (1), 122-127
DOI 10.1016/j.yexcr.2018.11.014, PubMed 30496759

Publications 2016

Karlsen TA, de Souza GA, Ødegaard B, Engebretsen L, Brinchmann JE (2016)
microRNA-140 Inhibits Inflammation and Stimulates Chondrogenesis in a Model of Interleukin 1β-induced Osteoarthritis
Mol Ther Nucleic Acids, 5 (10), e373
DOI 10.1038/mtna.2016.64, PubMed 27727249

Publications 2013

Fernandes AM, Herlofsen SR, Karlsen TA, Küchler AM, Fløisand Y, Brinchmann JE (2013)
Similar properties of chondrocytes from osteoarthritis joints and mesenchymal stem cells from healthy donors for tissue engineering of articular cartilage
PLoS One, 8 (5), e62994
DOI 10.1371/journal.pone.0062994, PubMed 23671648

Karlsen TA, Brinchmann JE (2013)
Liposome delivery of microRNA-145 to mesenchymal stem cells leads to immunological off-target effects mediated by RIG-I
Mol Ther, 21 (6), 1169-81
DOI 10.1038/mt.2013.55, PubMed 23568258

Karlsen TA, Jakobsen RB, Mikkelsen TS, Brinchmann JE (2013)
microRNA-140 targets RALA and regulates chondrogenic differentiation of human mesenchymal stem cells by translational enhancement of SOX9 and ACAN
Stem Cells Dev, 23 (3), 290-304
DOI 10.1089/scd.2013.0209, PubMed 24063364

Publications 2011

Karlsen TA, Mirtaheri P, Shahdadfar A, Fløisand Y, Brinchmann JE (2011)
Effect of three-dimensional culture and incubator gas concentration on phenotype and differentiation capability of human mesenchymal stem cells
J Cell Biochem, 112 (2), 684-93
DOI 10.1002/jcb.22978, PubMed 21268090

Publications 2010

Karlsen TA, Shahdadfar A, Brinchmann JE (2010)
Human primary articular chondrocytes, chondroblasts-like cells, and dedifferentiated chondrocytes: differences in gene, microRNA, and protein expression and phenotype
Tissue Eng Part C Methods, 17 (2), 219-27
DOI 10.1089/ten.TEC.2010.0200, PubMed 20799885

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