Publications published since 1965 by Per O. Seglen
87 publications found
Publications 2021
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
Autophagy, 17 (1), 1-382
DOI 10.1080/15548627.2020.1797280, PubMed 33634751
Publications 2019
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Measurement of Bulk Autophagy by a Cargo Sequestration Assay
Methods Mol Biol, 1880, 307-313
DOI 10.1007/978-1-4939-8873-0_20, PubMed 30610706
Publications 2016
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Autophagy, 12 (1), 1-222
DOI 10.1080/15548627.2015.1100356, PubMed 26799652 -
A Simple Cargo Sequestration Assay for Quantitative Measurement of Nonselective Autophagy in Cultured Cells
Methods Enzymol, 587, 351-364
DOI 10.1016/bs.mie.2016.09.064, PubMed 28253965
Publications 2015
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Autophagy of cytoplasmic bulk cargo does not require LC3
Autophagy, 12 (2), 439-41
DOI 10.1080/15548627.2015.1076606, PubMed 26237084 -
Novel steps in the autophagic-lysosomal pathway
FEBS J, 282 (11), 2202-14
DOI 10.1111/febs.13268, PubMed 25779646 -
Macroautophagic cargo sequestration assays
Methods, 75, 25-36
DOI 10.1016/j.ymeth.2014.12.021, PubMed 25576638 -
Autophagic bulk sequestration of cytosolic cargo is independent of LC3, but requires GABARAPs
Exp Cell Res, 333 (1), 21-38
DOI 10.1016/j.yexcr.2015.02.003, PubMed 25684710
Publications 2013
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Modulation of intracellular calcium homeostasis blocks autophagosome formation
Autophagy, 9 (10), 1475-90
DOI 10.4161/auto.25900, PubMed 23970164 -
Autophagy proteins control goblet cell function by potentiating reactive oxygen species production
Embo J., 32 (24), 3130-3144
DOI 10.1038/emboj.2013.233
Publications 2012
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Guidelines for the use and interpretation of assays for monitoring autophagy
Autophagy, 8 (4), 445-544
DOI 10.4161/auto.19496, PubMed 22966490
Publications 2011
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Seeing is believing The impact of electron microscopy on autophagy research
Autophagy, 7 (9), 935-956
DOI 10.4161/auto.7.9.15760 -
Autophagic activity measured in whole rat hepatocytes as the accumulation of a novel BHMT fragment (p10), generated in amphisomes by the asparaginyl proteinase, legumain
Autophagy, 7 (9), 1011-27
DOI 10.4161/auto.7.9.16436, PubMed 21610319
Publications 2010
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The Norse god of autophagy
Autophagy, 6 (8), 1017-1031
DOI 10.4161/auto.6.8.13092
Publications 2009
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Sequestration assays for mammalian autophagy
Methods Enzymol, 452, 63-83
DOI 10.1016/S0076-6879(08)03605-7, PubMed 19200876 -
Phosphorylated and non-phosphorylated forms of catechol O-methyltransferase in rat liver, brain and other tissues
Biochem J, 417 (2), 535-45
DOI 10.1042/BJ20081284, PubMed 18831714
Publications 2008
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Does bafilomycin A1 block the fusion of autophagosomes with lysosomes?
Autophagy, 4 (7), 849-50
DOI 10.4161/auto.6845, PubMed 18758232
Publications 2007
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Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
Autophagy, 4 (2), 151-75
DOI 10.4161/auto.5338, PubMed 18188003 -
How shall I eat thee?
Autophagy, 3 (5), 413-6
DOI 10.4161/auto.4377, PubMed 17568180 -
Methods for monitoring autophagy from yeast to human
Autophagy, 3 (3), 181-206
DOI 10.4161/auto.3678, PubMed 17224625 -
Proteomic analysis of membrane-associated proteins from rat liver autophagosomes
Autophagy, 3 (4), 300-22
DOI 10.4161/auto.3910, PubMed 17377489
Publications 2005
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Pancreatic trypsin activates human promatrix metalloproteinase-2
J Mol Biol, 350 (4), 682-98
DOI 10.1016/j.jmb.2005.05.018, PubMed 15950241 -
Stimulation of hepatocytic AMP-activated protein kinase by okadaic acid and other autophagy-suppressive toxins
Biochem J, 386 (Pt 2), 237-44
DOI 10.1042/BJ20040609, PubMed 15461583 -
Comigration of two autophagosome-associated dehydrogenases on two-dimensional polyacrylamide gels
Autophagy, 1 (3), 157-62
DOI 10.4161/auto.1.3.2037, PubMed 16874067
Publications 2004
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Toxin-induced tail phosphorylation of hepatocellular S6 kinase: evidence for a dual involvement of the AMP-activated protein kinase in S6 kinase regulation
Toxicol Sci, 82 (2), 628-37
DOI 10.1093/toxsci/kfh273, PubMed 15342961 -
Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway
Dev Cell, 7 (2), 179-92
DOI 10.1016/j.devcel.2004.07.005, PubMed 15296715
Publications 2003
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Okadaic acid-induced, naringin-sensitive phosphorylation of glycine N-methyltransferase in isolated rat hepatocytes
Biochem J, 373 (Pt 2), 505-13
DOI 10.1042/BJ20030502, PubMed 12697024
Publications 2002
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Naringin-sensitive phosphorylation of plectin, a cytoskeletal cross-linking protein, in isolated rat hepatocytes
J Biol Chem, 277 (38), 34826-35
DOI 10.1074/jbc.M205028200, PubMed 12095991
Publications 2001
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Effects of the diarrhetic shellfish toxin, okadaic acid, on cytoskeletal elements, viability and functionality of rat liver and intestinal cells
Toxicon, 39 (2-3), 349-62
DOI 10.1016/s0041-0101(00)00137-9, PubMed 10978754 -
Effects of inhibitors of the vacuolar proton pump on hepatic heterophagy and autophagy
Biochim Biophys Acta, 1510 (1-2), 243-57
DOI 10.1016/s0005-2736(00)00354-0, PubMed 11342162
Publications 2000
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Prevention of toxin-induced cytoskeletal disruption and apoptotic liver cell death by the grapefruit flavonoid, naringin
Cell Death Differ, 7 (8), 739-46
DOI 10.1038/sj.cdd.4400705, PubMed 10918448 -
Ultrastructural characterization of the delimiting membranes of isolated autophagosomes and amphisomes by freeze-fracture electron microscopy
Eur J Cell Biol, 79 (12), 871-82
DOI 10.1078/0171-9335-00125, PubMed 11152279 -
Autophagosome-associated variant isoforms of cytosolic enzymes
Biochem J, 352 Pt 3 (Pt 3), 773-81
DOI 10.1042/0264-6021:3520773, PubMed 11104685
Publications 1998
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Isolation and characterization of rat liver amphisomes. Evidence for fusion of autophagosomes with both early and late endosomes
J Biol Chem, 273 (34), 21883-92
DOI 10.1074/jbc.273.34.21883, PubMed 9705327 -
Inhibition of hepatocytic autophagy by adenosine, adenosine analogs and AMP
Biol Chem, 379 (11), 1341-7
DOI 10.1515/bchm.1998.379.11.1341, PubMed 9865607 -
Regional selective neuronal degeneration after protein phosphatase inhibition in hippocampal slice cultures: evidence for a MAP kinase-dependent mechanism
J Neurosci, 18 (18), 7296-305
DOI 10.1523/JNEUROSCI.18-18-07296.1998, PubMed 9736650 -
Inhibition of hepatocytic autophagy by adenosine, aminoimidazole-4-carboxamide riboside, and N6-mercaptopurine riboside. Evidence for involvement of amp-activated protein kinase
J Biol Chem, 273 (37), 23758-63
DOI 10.1074/jbc.273.37.23758, PubMed 9726984 -
Citation rates and journal impact factors are not suitable for evaluation of research
Acta Orthop Scand, 69 (3), 224-9
DOI 10.3109/17453679809000920, PubMed 9703393 -
Purification and characterization of autophagosomes from rat hepatocytes
Biochem J, 335 ( Pt 2) (Pt 2), 217-24
DOI 10.1042/bj3350217, PubMed 9761717
Publications 1997
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Why the impact factor of journals should not be used for evaluating research
BMJ, 314 (7079), 498-502
DOI 10.1136/bmj.314.7079.497, PubMed 9056804 -
DNA ploidy and autophagic protein degradation as determinants of hepatocellular growth and survival
Cell Biol Toxicol, 13 (4-5), 301-15
DOI 10.1023/a:1007487425047, PubMed 9298250 -
Citations and journal impact factors: questionable indicators of research quality
Allergy, 52 (11), 1050-6
DOI 10.1111/j.1398-9995.1997.tb00175.x, PubMed 9404555 -
A novel method for the study of autophagy: destruction of hepatocytic lysosomes, but not autophagosomes, by the photosensitizing porphyrin tetra(4-sulphonatophenyl)porphine
Biochem J, 321 ( Pt 1) (Pt 1), 217-25
DOI 10.1042/bj3210217, PubMed 9003422 -
Differences between fluid-phase endocytosis (pinocytosis) and receptor-mediated endocytosis in isolated rat hepatocytes
Eur J Cell Biol, 73 (1), 28-39
PubMed 9174669
Publications 1996
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Role of cAMP in the regulation of hepatocytic autophagy
Eur J Biochem, 236 (1), 163-70
DOI 10.1111/j.1432-1033.1996.00163.x, PubMed 8617261 -
Structural aspects of autophagy
Adv Exp Med Biol, 389, 103-11
DOI 10.1007/978-1-4613-0335-0_12, PubMed 8860999
Publications 1995
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Disruption of the cytokeratin cytoskeleton and inhibition of hepatocytic autophagy by okadaic acid
Exp Cell Res, 218 (2), 522-30
DOI 10.1006/excr.1995.1187, PubMed 7540986 -
Ultrastructural and immunocytochemical characterization of autophagic vacuoles in isolated hepatocytes: effects of vinblastine and asparagine on vacuole distributions
Exp Cell Res, 221 (2), 504-19
DOI 10.1006/excr.1995.1402, PubMed 7493651 -
Vanadate inhibition of hepatocytic autophagy. Calcium-modulated and osmolality-modulated antagonism by asparagine
Eur J Biochem, 230 (1), 17-24
DOI 10.1111/j.1432-1033.1995.0017i.x, PubMed 7601097 -
Protection by naringin and some other flavonoids of hepatocytic autophagy and endocytosis against inhibition by okadaic acid
J Biol Chem, 270 (11), 5830-8
DOI 10.1074/jbc.270.11.5830, PubMed 7890712 -
Inhibition of asialoglycoprotein endocytosis and degradation in rat hepatocytes by protein phosphatase inhibitors
Biochem J, 311 ( Pt 1) (Pt 1), 317-26
DOI 10.1042/bj3110317, PubMed 7575471 -
Inhibition of autophagy and multiple steps in asialoglycoprotein endocytosis by inhibitors of tyrosine protein kinases (tyrphostins)
J Biol Chem, 270 (21), 12823-31
DOI 10.1074/jbc.270.21.12823, PubMed 7759538
Publications 1994
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Separation of lysosomes and autophagosomes by means of glycyl-phenylalanine-naphthylamide, a lysosome-disrupting cathepsin-C substrate
Eur J Biochem, 221 (1), 595-602
DOI 10.1111/j.1432-1033.1994.tb18771.x, PubMed 8168547 -
[The impact factor as an instrument of allocation. Not accepted by the journals in Scandinavia]
Lakartidningen, 91 (8), 744-5
PubMed 8189977 -
Effect of 4-acetylaminofluorene and other tumour promoters on hepatocellular growth and binucleation
Carcinogenesis, 15 (2), 371-9
DOI 10.1093/carcin/15.2.371, PubMed 7508825 -
Flow cytometric investigation of a possible precursor--product relationship between oval cells and parenchymal cells in the rat liver
Carcinogenesis, 15 (1), 53-9
DOI 10.1093/carcin/15.1.53, PubMed 8293549 -
The fraction of cells in G1 with bound retinoblastoma protein increases with the duration of the cell cycle
Cell Prolif, 27 (2), 95-104
DOI 10.1111/j.1365-2184.1994.tb01408.x, PubMed 10465029 -
Ploidy-dependent growth and binucleation in cultured rat hepatocytes
Exp Cell Res, 214 (2), 551-60
DOI 10.1006/excr.1994.1293, PubMed 7925649
Publications 1993
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Binucleation and polyploidization patterns in developmental and regenerative rat liver growth
Cell Prolif, 26 (6), 557-65
DOI 10.1111/j.1365-2184.1993.tb00033.x, PubMed 9116122 -
Dependence of hepatocytic autophagy on intracellularly sequestered calcium
J Biol Chem, 268 (35), 26107-12
PubMed 8253727 -
Inhibition of hepatocytic autophagy by okadaic acid and other protein phosphatase inhibitors
Eur J Biochem, 215 (1), 113-22
DOI 10.1111/j.1432-1033.1993.tb18013.x, PubMed 8393787 -
Reduced autophagic activity in primary rat hepatocellular carcinoma and ascites hepatoma cells
Carcinogenesis, 14 (12), 2501-5
DOI 10.1093/carcin/14.12.2501, PubMed 8269618 -
Evidence for acidity of prelysosomal autophagic/endocytic vacuoles (amphisomes)
Biochem J, 291 ( Pt 1) (Pt 1), 115-21
DOI 10.1042/bj2910115, PubMed 8471030
Publications 1992
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Reduced proliferative activity of polyploid cells in primary hepatocellular carcinoma
Carcinogenesis, 13 (10), 1795-801
DOI 10.1093/carcin/13.10.1795, PubMed 1330342 -
Analytical methods for the study of liver cell proliferation
Cytometry, 13 (4), 404-15
DOI 10.1002/cyto.990130411, PubMed 1382009 -
Prelysosomal and lysosomal connections between autophagy and endocytosis
Biochem J, 283 ( Pt 2) (Pt 2), 361-9
DOI 10.1042/bj2830361, PubMed 1575680 -
Protein kinase-dependent effects of okadaic acid on hepatocytic autophagy and cytoskeletal integrity
Biochem J, 284 ( Pt 3) (Pt 3), 633-6
DOI 10.1042/bj2840633, PubMed 1320371 -
Autophagy and other vacuolar protein degradation mechanisms
Experientia, 48 (2), 158-72
DOI 10.1007/BF01923509, PubMed 1740188
Publications 1991
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Effects of adrenergic agonists and antagonists on autophagic activity in isolated rat liver cells
Biomed Biochim Acta, 50 (4-6), 383-7
PubMed 1801702 -
Role of cyclic nucleotides in the control of hepatic autophagy
Biomed Biochim Acta, 50 (4-6), 389-92
PubMed 1666282 -
Inhibition of autophagic-lysosomal delivery and autophagic lactolysis by asparagine
J Cell Biol, 113 (6), 1305-12
DOI 10.1083/jcb.113.6.1305, PubMed 1904444 -
Diploid growth pattern of hepatocellular tumours induced by various carcinogenic treatments
Carcinogenesis, 12 (2), 325-7
DOI 10.1093/carcin/12.2.325, PubMed 1847321 -
Hepatocytic autophagy
Biomed Biochim Acta, 50 (4-6), 373-81
PubMed 1666281
Publications 1990
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Effects of the tumor promoter 2-acetylaminofluorene and of 4-acetylaminofluorene on rat liver growth
Bull Cancer, 77 (5), 461-6
PubMed 2400817 -
Cell biology of hepatocarcinogenesis
Crit Rev Oncog, 1 (4), 437-66
PubMed 1964598 -
Growth-related alterations during liver carcinogenesis: effect of promoters
Environ Health Perspect, 88, 197-205
DOI 10.1289/ehp.9088197, PubMed 2272315 -
Non-selective autophagy
Semin Cell Biol, 1 (6), 441-8
PubMed 2103895 -
Liver tumor promoters stimulate growth of transplanted hepatocellular carcinomas
Hepatology, 12 (2), 295-300
DOI 10.1002/hep.1840120217, PubMed 2167869
Publications 1989
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Experimental characterization of the autophagic-lysosomal pathway in isolated rat hepatocytes
Biochem Soc Symp, 55, 129-43
PubMed 2619764 -
Diploid nature of hepatocellular tumours developing from transplanted preneoplastic liver cells
Br J Cancer, 59 (2), 198-205
DOI 10.1038/bjc.1989.41, PubMed 2930686 -
Neuroendocrine dysdifferentiation and bombesin production in carcinogen-induced hepatocellular rat tumours
Carcinogenesis, 10 (1), 21-5
DOI 10.1093/carcin/10.1.21, PubMed 2910524
Publications 1988
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Prelysosomal convergence of autophagic and endocytic pathways
Biochem Biophys Res Commun, 151 (1), 40-7
DOI 10.1016/0006-291x(88)90556-6, PubMed 3126737 -
Changes in ploidy distributions in human liver carcinogenesis
J Natl Cancer Inst, 80 (18), 1480-5
DOI 10.1093/jnci/80.18.1480, PubMed 2846856 -
The polyploidizing growth pattern of normal rat liver is replaced by divisional, diploid growth in hepatocellular nodules and carcinomas
Carcinogenesis, 9 (6), 939-45
DOI 10.1093/carcin/9.6.939, PubMed 3370757 -
2-Acetylaminofluorene promotion of liver carcinogenesis by a non-cytotoxic mechanism
Carcinogenesis, 9 (4), 581-7
DOI 10.1093/carcin/9.4.581, PubMed 2895691
Publications 1987
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Sugar uptake by fluid-phase pinocytosis and diffusion in isolated rat hepatocytes
Biochem J, 243 (3), 655-60
DOI 10.1042/bj2430655, PubMed 3663095
Publications 1973
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Glycogen synthesis in isolated parenchymal rat liver cells
FEBS Lett, 30 (1), 25-28
DOI 10.1016/0014-5793(73)80611-8, PubMed 11947054