Courses

3 December 2012
Principles of Stem Cell Biology
A one-day lecture course on what stem cells are, how they behave, how they are regulated and how they can be used clinically.
Where: Seminar room 1, B2.U001, Rikshospitalet

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Primo  April, 2012
Stem Cell differentiation: MicroRNA and transcription factors as determinants of cell phenotypes
A 40-60 h (10 day) module consisting of lectures, guest lectures, research seminars, group work (including the use of Mir@nt@n-based informatics) and practical course.

Objective
To describe microRNA and transcription factor (TF) interaction as a key regulatory system in the determination of cell phenotype through regulation of marker gene expression. To describe how microRNA signatures of cell phenotypes are determinant for normal organ functioning and pathophysiology. Contact info: j.o.gordeladze@medisin.uio.no, professor, PhD.

Lectures by Jan Oxholm Gordeladze
1. Introduction to the course: MicroRNAs, synthesis and function (1 lecture)
2. MicroRNAs and transcription factors in stem cell renewal and differentiation, strategies of how to search for phenotype-specific microRNA signatures, microRNAs in exosomes (cell-cell microRNA communication), introduction to practical courses (5 lectures)

Guest lectures (speakers, not all confirmed)
1. Joel Glover - Stem cells, self renewal and differentiation potential
2. Enikö Sonkoly - MicroRNAs as disease markers: focus on the immune system and inflammation
3. Jörg Haier - MicroRNAs and cancer: predictors and modifiers of chemo- and radiotherapy in different tumour types
4. TBD - MicroRNAs as determinants of β-cell function and lipid metabolism

Lunch seminars
These will be seminars featuring results obtained during the practical laboratory work sessions and bioinformatics sessions within a given scientific context (performed by the PhD-students)

Practical laboratory course and bioinformatics analyses
The objective is to provide practical information on how microRNA and transcription factors interact in differentiating stem cells, how to use a microRNA species as a disease marker. Furthermore, the different databases (including Mir@nt@n)) will be used as part of the strategy to identify important microRNA vs transcription factor networks. Lastly, the students will get some hands on experience related to the analyses of microRNA and transcription factor expression as well as traditional staining techniques identifying osteoblasts, chondrocytes and adipocytes differentiated from mesenchymal stem cells or fat tissue derived stem cells.

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26 October 2011
Principles of Stem Cell Biology
A one-day lecture course on what stem cells are, how they behave, how they are regulated and how they can be used clinically.

Where: Domus Odontologica, Auditorium GA02 A1.1001, University of Oslo

Program

Litterature:
http://www.uio.no/studier/emner/medisin/med/MF9410/h10/reading-list.html

Presentations

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12 - 16 September 2011
Epigenetics, Development and Disease
The Objective of the course is to introduce the concept of epigenetics as a key mechanism of regulation of gene expression steering development and cell fate, and which can be affected in disease. The course consists of formal lectures on epigenetics and stem cells, guest lectures on epigenetics and early embryo development, live-style and epigenetics, epigenetics and cancer, and nuclear receptors. Lectures are supplemented with lunch research seminars by the guest lecturers, group work and a practical course during which students carry out a chromatin immunoprecipitation (ChIP) assay.

Center's Lunch Seminars for the week of September 12-16, 2011
Place: Domus Medica, room 2180

Tue 13 sep., 13:15-14:00 - Dr. Leonardo Meza-Zepeda, OUS-Radiumhospitalet
Epigenetics and disease

Thu 15 sep., 13:15-14:00 - Dr. Robert Feil, University of Montpellier, France
Epigenetic regulation of germ line development

Fri 16 sep., 12:15-13:00 - Professor John C. Mathers, Institute for Ageing and Health, University of Newcastle, UK