Munthe group

Ludvig A. Munthe heads a research team that studies how dysregulated interactions between Th cells and B cells predisposes for B cell cancer. They define how Th cells support and maintain B cell cancer in mice and humans.

Ludvig A. Munthe

About the group

The team investigate how Th cells can induce B cell lymphoma by chronically stimulating B cells in mice (J Exp Med, 2007). Work in animal models has been extended to humans by studying patients with chronic lymphocytic leukemia (CLL). We have demonstrated that CLL cells are patent antigen presenting cells and that they can collaborate with Th cells (Cell Rep 2013). Moreover, we discovered that patients had a high frequency of Th cells that were specific for CLL cells and stimulated CLL cell proliferation both in vitro and in vivo.

We also have interest in Idiotype networks (1)(2), Id specific Th cells and collaborations with Id+B cells (3)(4), see also the Bogen group presentation. This in mice as well as in humans, both in autoimmunity and in B cell cancer.

Projects

We are now extending the studies mentioned above to define the cytokines and inflammatory microenvironment in CLL. Moreover, we are studying the effect of EBV, identifying signaling aberrations for drug discovery (collaboration with NCMM), and are establishing ex vivo culture systems. We are now extending this work to acute lymphoctic leukemia (ALL) and myeloma.

Selected publications

Tags: USA
Published Jan. 6, 2014 1:21 AM - Last modified Mar. 22, 2017 10:36 AM

Contact

  • Department of Immunology, Oslo University Hospital Rikshospitalet and University of Oslo, PO Box 4950 Nydalen, Oslo 0424, Norway.

 

Group leader