Anita Langerød's project group

TP53 and somatic genetics of breast cancer

Our research is focused on understanding the genomics of breast cancer, and in particular the role of TP53 and associated molecular networks. TP53 is a key regulator of many critical cellular processes and the gene is affected by mutation in breast cancer subtypes with poor prognosis. By integrating cancer genome profiling with single gene analysis in large series of patient samples, we aim to search for diagnostic, prognostic and predictive biomarkers of breast cancer.

Current projects and funding sources:

Elucidating the TP53 network in breast cancer (Helse Sør-Øst)
Breast Cancer Somatic Genetics Study (BASIS; EU FP7)

Contact information:

Department of Genetics, Institute for Cancer Research, Oslo University Hospital - Radiumhospitalet, Montebello, 0310 Oslo, Norway. Phone: +47 22 78 13 76, Fax: +47 22 78 13 95, Switchboard: +47 22 93 40 00. Email: anita.langerod@rr-research.no

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News & events

Untangling the development of breast cancer
Researchers announce the first comprehensive genome studies of the evolution of 21 breast cancers
May 18, 2012

Presentation of prestigious research project
Actionable Targets in Cancer Metastasis (MetAction) – from Bed to Bench to Byte to Bedside
May 16, 2012

GAP cancer conference in Oslo May 14-16
Global Academic Programs 2012
May 11, 2012

Trial lecture and disputation May 9th
Trevor Clancy
May 8, 2012

Study by Ane Hansen Kjenseth et al. featured on the cover of Journal of Biological Chemistry
May 7, 2012

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Latest publictions

Anita Langerød

Curtis C, Shah SP, Chin SF, Turashvili G, Rueda OM, Dunning MJ, Speed D, Lynch AG, Samarajiwa S, Yuan Y, Gräf S, Ha G, Haffari G, Bashashati A, Russell R, McKinney S, METABRIC Group, Co-chairs, Caldas C, Aparicio S, Writing committee, Curtis C, Shah SP, Caldas C, Aparicio S et al.
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
Nature (in press)
PubMed 22522925

Natrajan R, Mackay A, Wilkerson PM, Lambros MB, Wetterskog D, Arnedos M, Shiu KK, Geyer FC, Langerød A, Kreike B, Reyal F, Horlings HM, van de Vijver MJ, Palacios J, Weigelt B, Reis-Filho JS
Functional characterization of the 19q12 amplicon in grade III breast cancers
Breast Cancer Res, 14 (2), R53 (in press)
PubMed 22433433

Freed-Pastor WA, Mizuno H, Zhao X, Langerød A, Moon SH, Rodriguez-Barrueco R, Barsotti A, Chicas A, Li W, Polotskaia A, Bissell MJ, Osborne TF, Tian B, Lowe SW, Silva JM, Børresen-Dale AL, Levine AJ, Bargonetti J, Prives C (2012)
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway
Cell, 148 (1-2), 244-58
PubMed 22265415

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