Genetic variation and ROS metabolism and signalling pathways in relation to response to treatment with radiation and chemotherapy.

Both radiation treatment and chemotherapy exert their therapeutic effect through the generation of reactive oxygen species (ROS). Ionising radiation stimulates hydrolyses of water and also generates a number of reactive oxygen species. ROS react often irreversible with cellular macromolecules like DNA, proteins and lipids. Genotype profiling of patients before administering therapy for breast cancer may help identify individuals with potentially severe side effects of given treatment. The patients genotyped in this project have received radiation therapy (RT) or chemotherapy, either as a sole mean of treatment or complimentary to surgery for their breast cancer. In retrospect, the women were evaluated for side effects of the treatment. By combining this information with their genotype profile we hope to find markers that can be used to design successful therapy strategies in the clinics.

Figure. Members of the ROS generating and signaling pathways, detoxifying enzymes and DNA repair. (click to enlarge) — **Figure.** Members of the ROS generating and signaling pathways, detoxifying enzymes and DNA repair. *(click to enlarge)*

Key member: Hege Edvardsen