The research group of Vessela N. Kristensen

Cancer Genome Variation

”If it were not for the great variability
among individuals medicine might as
well be science and not an art”

Sir William Osler, 1892

The tumor initiation, progression and clinical presentation are directly dependent on its genetic and biochemical environment – the entire body. Our group is working on different projects related to how genetic variation affects occurrence of somatic alterations, gene expression patterns and genome wide copy number alterations in human breast and ovarian tumors. Understanding inherited genetic variability and how it affects crucial biological pathways is likely to lead to new successful prevention and treatment strategies.

The research in the group is focusing on constitutive variation such as single nucleotide polymorphisms (SNPs) and copy number variations (CNVs) in relation to:

Susceptibility
Clinical presentation
Treatment response and adverse side effects of treatment
Gene regulation and proximal phenotypes (RNA expression and metabolic profiles)

Link to list of our research projects

The group:

From left to right: Daniel Nebdal, Grethe I. Grenaker Alnæs, Jovana Jovanovic, Vessela N. Kristensen, Thomas Fleischer, Miriam Ragle Aure, Hege Edvardsen, Fatemeh Kaveh, Elen Møller, Helene Røtterud, Andliena Tahiri and Shakila Jabeen.

Vessela N. Kristensen
Grethe I. Grenaker Alnæs
Hege Edvardsen
Silje Nordgard
Margarethe Biong
Miriam Ragle Aure
Fatemeh Kaveh
Jovana Jovanovic
Thomas Fleischer
Elen Møller

Group contact information:

Professor Vessela N. Kristensen, Email: Vessela.N.Kristensen@rr-research.no
Department of Genetics, Institute for Cancer Research,
Oslo University Hospital Radiumhospitalet, N-0310 Oslo, Norway
Phone: +47 22 78 13 75, Fax: +47 22 78 13 95, Switchboard: +47 22 93 40 00

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Situated at:

Radiumhospitalet

News & events

Visiting Master student
Nov 15, 2011

Group project nominated to Project of the month by the Norwegian Cancer Society
Aug 11, 2010

Visiting collaborator at Mount Sinai School of Medicine
Mar 22, 2010

New group member
Mar 22, 2010

Espen Enerly goes to the Cancer Registry of Norway
Mar 22, 2010

More news

Latest publications

Vessela N. Kristensen

Lambrechts D, Truong T, Justenhoven C, Humphreys MK, Wang J, Hopper JL, Dite GS, Apicella C, Southey MC, Schmidt MK, Broeks A, Cornelissen S, Hien RV, Sawyer E, Tomlinson I, Kerin M, Miller N, Milne RL, Zamora MP, Pérez JI, Benítez J, Hamann U, Ko YD, Brüning T, The GENICA Network et al.
11q13 is a Susceptibility Locus for Hormone Receptor Positive Breast Cancer
Hum Mutat (in press)
PubMed 22461340

Vachon CM, Scott CG, Fasching PA, Hall P, Tamimi RM, Li J, Stone J, Apicella C, Odefrey F, Gierach GL, Jud SM, Heusinger K, Beckmann MW, Pollan M, Fernandez-Navarro P, Gonzalez-Neira A, Benítez J, van Gils CH, Lokate MA, Onland-Moret NC, Peeters PH, Brown J, Leyland J, Varghese JS, Easton DF et al.
Common Breast Cancer Susceptibility Variants in LSP1 and RAD51L1 Are Associated with Mammographic Density Measures that Predict Breast Cancer Risk
Cancer Epidemiol Biomarkers Prev (in press)
PubMed 22454379

Ghoussaini M, Fletcher O, Michailidou K, Turnbull C, Schmidt MK, Dicks E, Dennis J, Wang Q, Humphreys MK, Luccarini C, Baynes C, Conroy D, Maranian M, Ahmed S, Driver K, Johnson N, Orr N, dos Santos Silva I, Waisfisz Q, Meijers-Heijboer H, Uitterlinden AG, Rivadeneira F, Netherlands Collaborative Group on Hereditary Breast and Ovarian Cancer (HEBON), Hall P, Czene K et al. (2012)
Genome-wide association analysis identifies three new breast cancer susceptibility loci
Nat Genet, 44 (3), 312-8
PubMed 22267197

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