Seetha V. Balasingham
Position: Research scientist, PhD
Phone: +47 23079019
Email:

Studies of components that are involved in genome maintenance of two major bacterial pathogens; Mycobacterium tuberculosis and Neisseria meningitidis, to understand the precise roles of these components in bacterial adaptation, fitness for survival and pathogenesis, as well as for immune escape and drug resistance development.

 

Author network for Seetha V. Balasingham by COREMINE medical


Publications 2017

Hovland E, Beyene GT, Frye SA, Homberset H, Balasingham SV, Gómez-Muñoz M, Derrick JP, Tønjum T, Ambur OH (2017)
DprA from Neisseria meningitidis: properties and role in natural competence for transformation
Microbiology (in press)
PubMed 28696187

Publications 2016

Beyene GT, Balasingham SV, Frye SA, Namouchi A, Homberset H, Kalayou S, Riaz T, Tønjum T (2016)
Characterization of the Neisseria meningitidis Helicase RecG
PLoS One, 11 (10), e0164588
PubMed 27736945

Namouchi A, Gómez-Muñoz M, Frye SA, Moen LV, Rognes T, Tønjum T, Balasingham SV (2016)
The Mycobacterium tuberculosis transcriptional landscape under genotoxic stress
BMC Genomics, 17 (1), 791
PubMed 27724857

Publications 2015

Frye SA, Lång E, Beyene GT, Balasingham SV, Homberset H, Rowe AD, Ambur OH, Tønjum T (2015)
The Inner Membrane Protein PilG Interacts with DNA and the Secretin PilQ in Transformation
PLoS One, 10 (8), e0134954
PubMed 26248334

Publications 2013

Zegeye ED, Balasingham SV, Laerdahl JK, Homberset H, Kristiansen PE, Tønjum T (2013)
Effects of conserved residues and naturally occurring mutations on Mycobacterium tuberculosis RecG helicase activity
Microbiology, 160 (Pt 1), 217-27
PubMed 24169816

Publications 2012

Balasingham SV, Zegeye ED, Homberset H, Rossi ML, Laerdahl JK, Bohr VA, Tønjum T (2012)
Enzymatic activities and DNA substrate specificity of Mycobacterium tuberculosis DNA helicase XPB
PLoS One, 7 (5), e36960
PubMed 22615856

Zegeye ED, Balasingham SV, Laerdahl JK, Homberset H, Tønjum T (2012)
Mycobacterium tuberculosis RecG binds and unwinds model DNA substrates with a preference for Holliday junctions
Microbiology, 158 (Pt 8), 1982-93
PubMed 22628485

Publications 2011

Yang M, Aamodt RM, Dalhus B, Balasingham S, Helle I, Andersen P, Tønjum T, Alseth I, Rognes T, Bjørås M (2011)
The ada operon of Mycobacterium tuberculosis encodes two DNA methyltransferases for inducible repair of DNA alkylation damage
DNA Repair (Amst), 10 (6), 595-602
PubMed 21570366

Publications 2009

Ambur OH, Davidsen T, Frye SA, Balasingham SV, Lagesen K, Rognes T, Tønjum T (2009)
Genome dynamics in major bacterial pathogens
FEMS Microbiol Rev, 33 (3), 453-70
PubMed 19396949

Balasingham SV, Davidsen T, Szpinda I, Frye SA, Tønjum T (2009)
Molecular diagnostics in tuberculosis: basis and implications for therapy
Mol Diagn Ther, 13 (3), 137-51
PubMed 19650669

Olsen I, Balasingham SV, Davidsen T, Debebe E, Rødland EA, van Soolingen D, Kremer K, Alseth I, Tønjum T (2009)
Characterization of the major formamidopyrimidine-DNA glycosylase homolog in Mycobacterium tuberculosis and its linkage to variable tandem repeats
FEMS Immunol Med Microbiol, 56 (2), 151-61
PubMed 19496823

Publications 2007

Assalkhou R, Balasingham S, Collins RF, Frye SA, Davidsen T, Benam AV, Bjørås M, Derrick JP, Tønjum T (2007)
The outer membrane secretin PilQ from Neisseria meningitidis binds DNA
Microbiology, 153 (Pt 5), 1593-603
PubMed 17464074

Balasingham SV, Collins RF, Assalkhou R, Homberset H, Frye SA, Derrick JP, Tønjum T (2007)
Interactions between the lipoprotein PilP and the secretin PilQ in Neisseria meningitidis
J Bacteriol, 189 (15), 5716-27
PubMed 17526700

Publications 2006

Golovanov AP, Balasingham S, Tzitzilonis C, Goult BT, Lian LY, Homberset H, Tønjum T, Derrick JP (2006)
The solution structure of a domain from the Neisseria meningitidis lipoprotein PilP reveals a new beta-sandwich fold
J Mol Biol, 364 (2), 186-95
PubMed 17007878

Golovanov AP, Balasingham S, Tzitzilonis C, Goult BT, Lian LY, Homberset H, Tønjum T, Derrick JP (2006)
Assignment of 1H, 13C, and 15N resonances for the PilP pilot protein from Neisseria meningitidis
J Biomol NMR, 36 Suppl 1, 68
PubMed 16933020

Publications 2005

Collins RF, Frye SA, Balasingham S, Ford RC, Tønjum T, Derrick JP (2005)
Interaction with type IV pili induces structural changes in the bacterial outer membrane secretin PilQ
J Biol Chem, 280 (19), 18923-30
PubMed 15753075