Trond Stokke
Position: Senior scientist
Phone: +47 22 78 14 77
Email:


Education:
1979: B.S. (Mathematics, Physics), University of Oslo, Oslo, Norway.
1982:M.S. (Biophysics, "Fluorescence lifetimes of some dyes commonlyemployed in cell biology"), University of Oslo, Oslo, Norway.
1988: Ph.D. (Biophysics, “DNA specific dyes as probes of chromatin structure.”), University of Oslo, Oslo, Norway.
1998: Evaluated, and found to be professor-competent.

Research interests/projects:
Istudied chromatin structure during the PhD period. Later, I havestudied cell cycle regulation and apoptosis. Most of the attention hasbeen paid to the study of normal and malignant B-lymphocytes, and, morerecently, the effects of ionizing radiation on such cells.

Previous employments:
Researchscholar (83-89), post-doc (89-92), and scientist (94-03) at Institutefor Cancer Research, DNR, Oslo, Norway. Post-doc at Division ofMolecular Cytometry, UCSF, San Francisco, US (1993).

Assignments/duties:

  • Memberof the board for the Institute for Cancer Research at The NorwegianRadium Hospital (Instituttrådet ved Institutt for Kreftforskning, DNR).
  • Memberof the board for "Center for Education and Research within RadiationBiology" (SUFS, Senter for Utdanning og Forskning innen Strålebiologi)and the board for the microarray facilities.
  • Member of the scientific evaluation committee in The Norwegian Cancer Society (Den Norske Kreftforening.

Memberships:
International Society for Analytical Cytology.

 

Author network for Trond Stokke by COREMINE medical


Publications 2017

Hauge S, Naucke C, Hasvold G, Joel M, Rødland GE, Juzenas P, Stokke T, Syljuåsen RG (2017)
Combined inhibition of Wee1 and Chk1 gives synergistic DNA damage in S-phase due to distinct regulation of CDK activity and CDC45 loading
Oncotarget, 8 (7), 10966-10979
PubMed 28030798

Publications 2016

Boye E, Anda S, Rothe C, Stokke T, Grallert B (2016)
Analyzing Schizosaccharomyces pombe DNA Content by Flow Cytometry
Cold Spring Harb Protoc, 2016 (6), pdb.prot091280
PubMed 27250946

Jonsson M, Ragnum HB, Julin CH, Yeramian A, Clancy T, Frikstad KM, Seierstad T, Stokke T, Matias-Guiu X, Ree AH, Flatmark K, Lyng H (2016)
Hypoxia-independent gene expression signature associated with radiosensitisation of prostate cancer cell lines by histone deacetylase inhibition
Br J Cancer, 115 (8), 929-939
PubMed 27599042

Publications 2015

Dale Rein I, Solberg Landsverk K, Micci F, Patzke S, Stokke T (2015)
Replication-induced DNA damage after PARP inhibition causes G2 delay, and cell line-dependent apoptosis, necrosis and multinucleation
Cell Cycle, 14 (20), 3248-60
PubMed 26312527

Dale Rein I, Stokke C, Jalal M, Myklebust JH, Patzke S, Stokke T (2015)
New distinct compartments in the G2 phase of the cell cycle defined by the levels of γH2AX
Cell Cycle, 14 (20), 3261-9
PubMed 26317799

Huang R, Wang J, Zhong Y, Liu Y, Stokke T, Trope CG, Nesland JM, Suo Z (2015)
Mitochondrial DNA Deficiency in Ovarian Cancer Cells and Cancer Stem Cell-like Properties
Anticancer Res, 35 (7), 3743-53
PubMed 26124317

Håland TW, Boye E, Stokke T, Grallert B, Syljuåsen RG (2015)
Simultaneous measurement of passage through the restriction point and MCM loading in single cells
Nucleic Acids Res, 43 (22), e150
PubMed 26250117

Sternemalm J, Geimer S, Frikstad KA, Schink KO, Stokke T, Patzke S (2015)
CSPP-L Associates with the Desmosome of Polarized Epithelial Cells and Is Required for Normal Spheroid Formation
PLoS One, 10 (8), e0134789
PubMed 26241740

Publications 2014

Sternemalm J, Russnes HG, Zhao X, Risberg B, Nord S, Caldas C, Børresen-Dale AL, Stokke T, Patzke S (2014)
Nuclear CSPP1 expression defined subtypes of basal-like breast cancer
Br J Cancer, 111 (2), 326-38
PubMed 24901235

Publications 2013

Fiskvik I, Aamot HV, Delabie J, Smeland EB, Stokke T, Heim S, Holte H (2013)
Karyotyping of diffuse large B-cell lymphomas: loss of 17p is associated with poor patient outcome
Eur J Haematol, 91 (4), 332-8
PubMed 23859481

Lando M, Wilting SM, Snipstad K, Clancy T, Bierkens M, Aarnes EK, Holden M, Stokke T, Sundfør K, Holm R, Kristensen GB, Steenbergen RD, Lyng H (2013)
Identification of eight candidate target genes of the recurrent 3p12-p14 loss in cervical cancer by integrative genomic profiling
J Pathol, 230 (1), 59-69
PubMed 23335387

Publications 2011

Huse K, Bakkebø M, Oksvold MP, Forfang L, Hilden VI, Stokke T, Smeland EB, Myklebust JH (2011)
Bone morphogenetic proteins inhibit CD40L/IL-21-induced Ig production in human B cells: differential effects of BMP-6 and BMP-7
Eur J Immunol, 41 (11), 3135-45
PubMed 21898381

Josefsen D, Forfang L, Dyrhaug M, Blystad AK, Stokke T, Smeland EB, Kvalheim G (2011)
Side population cells in highly enriched CD34-positive cells from peripheral blood progenitor cells identify an immature subtype of hematopoietic progenitor cells but do not predict time to engraftment in patients treated with high-dose therapy
Eur J Haematol, 87 (6), 494-502
PubMed 21752097

Knutsen JH, Rein ID, Rothe C, Stokke T, Grallert B, Boye E (2011)
Cell-cycle analysis of fission yeast cells by flow cytometry
PLoS One, 6 (2), e17175
PubMed 21386895

Landsverk KS, Patzke S, Rein ID, Stokke C, Lyng H, De Angelis PM, Stokke T (2011)
Three independent mechanisms for arrest in G2 after ionizing radiation
Cell Cycle, 10 (5), 819-29
PubMed 21325885

Ma Y, Liang D, Liu J, Axcrona K, Kvalheim G, Stokke T, Nesland JM, Suo Z (2011)
Prostate cancer cell lines under hypoxia exhibit greater stem-like properties
PLoS One, 6 (12), e29170
PubMed 22216200

Tkacz-Stachowska K, Lund-Andersen C, Velissarou A, Myklebust JH, Stokke T, Syljuåsen RG (2011)
The amount of DNA damage needed to activate the radiation-induced G2 checkpoint varies between single cells
Radiother Oncol, 101 (1), 24-7
PubMed 21722983

Publications 2010

Patzke S, Redick S, Warsame A, Murga-Zamalloa CA, Khanna H, Doxsey S, Stokke T (2010)
CSPP is a ciliary protein interacting with Nephrocystin 8 and required for cilia formation
Mol Biol Cell, 21 (15), 2555-67
PubMed 20519441

Publications 2009

Edin NJ, Olsen DR, Stokke T, Sandvik JA, Ebbesen P, Pettersen EO (2009)
Mechanisms of the elimination of low dose hyper-radiosensitivity in T-47D cells by low dose-rate priming
Int J Radiat Biol, 85 (12), 1157-65
PubMed 19995241

Lando M, Holden M, Bergersen LC, Svendsrud DH, Stokke T, Sundfør K, Glad IK, Kristensen GB, Lyng H (2009)
Gene dosage, expression, and ontology analysis identifies driver genes in the carcinogenesis and chemoradioresistance of cervical cancer
PLoS Genet, 5 (11), e1000719
PubMed 19911042

Publications 2008

Dahle J, Brunborg G, Svendsrud DH, Stokke T, Kvam E (2008)
Overexpression of human OGG1 in mammalian cells decreases ultraviolet A induced mutagenesis
Cancer Lett, 267 (1), 18-25
PubMed 18406515

Lyng H, Lando M, Brøvig RS, Svendsrud DH, Johansen M, Galteland E, Brustugun OT, Meza-Zepeda LA, Myklebost O, Kristensen GB, Hovig E, Stokke T (2008)
GeneCount: genome-wide calculation of absolute tumor DNA copy numbers from array comparative genomic hybridization data
Genome Biol, 9 (5), R86
PubMed 18500990

Publications 2007

Dahle J, Krogh C, Melhus KB, Kaalhus O, Larsen RH, Stokke T (2007)
A one-step method for determining the maximum number of bound antibodies, and the affinity and association rate constants for antibody binding
Nucl Med Commun, 28 (9), 742-7
PubMed 17667754

De Angelis PM, Stokke T, Beigi M, Flatberg G, Enger M, Haug K, Aass HC, Schjølberg A, Andresen PA, Ariansen S, Bø AS, Mjåland O, Clausen OP (2007)
Chromosomal 20q gain in the DNA diploid component of aneuploid colorectal carcinomas
Int J Cancer, 120 (12), 2734-8
PubMed 17354231

Kvinnsland Y, Stokke T, Aurlien E (2007)
Log normal distribution of cellular uptake of radioactivity
J Nucl Med, 48 (2), 327; author reply 327-8
PubMed 17268032

Melhus KB, Larsen RH, Stokke T, Kaalhus O, Selbo PK, Dahle J (2007)
Evaluation of the binding of radiolabeled rituximab to CD20-positive lymphoma cells: an in vitro feasibility study concerning low-dose-rate radioimmunotherapy with the alpha-emitter 227Th
Cancer Biother Radiopharm, 22 (4), 469-79
PubMed 17803441

Publications 2006

De Angelis PM, Svendsrud DH, Kravik KL, Stokke T (2006)
Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery
Mol Cancer, 5, 20
PubMed 16709241

Lyng H, Brøvig RS, Svendsrud DH, Holm R, Kaalhus O, Knutstad K, Oksefjell H, Sundfør K, Kristensen GB, Stokke T (2006)
Gene expressions and copy numbers associated with metastatic phenotypes of uterine cervical cancer
BMC Genomics, 7, 268
PubMed 17054779

Patzke S, Stokke T, Aasheim HC (2006)
CSPP and CSPP-L associate with centrosomes and microtubules and differently affect microtubule organization
J Cell Physiol, 209 (1), 199-210
PubMed 16826565

Ree AH, Stokke T, Bratland A, Patzke S, Nome RV, Folkvord S, Meza-Zepeda LA, Flatmark K, Fodstad O, Andersson Y (2006)
DNA damage responses in cell cycle G2 phase and mitosis--tracking and targeting
Anticancer Res, 26 (3A), 1909-16
PubMed 16827124

Shahzidi S, Stokke T, Soltani H, Nesland JM, Peng Q (2006)
Induction of apoptosis by hexaminolevulinate-mediated photodynamic therapy in human colon carcinoma cell line 320DM
J Environ Pathol Toxicol Oncol, 25 (1-2), 159-71
PubMed 16566715

Sivertsen EA, Galteland E, Mu D, Holte H, Meza-Zepeda L, Myklebost O, Patzke S, Smeland EB, Stokke T (2006)
Gain of chromosome 6p is an infrequent cause of increased PIM1 expression in B-cell non-Hodgkin's lymphomas
Leukemia, 20 (3), 539-42
PubMed 16437153

Publications 2005

Dahle J, Kvam E, Stokke T (2005)
Bystander effects in UV-induced genomic instability: antioxidants inhibit delayed mutagenesis induced by ultraviolet A and B radiation
J Carcinog, 4, 11
PubMed 16091149

Dahle J, Kaalhus O, Stokke T, Kvam E (2005)
Bystander effects may modulate ultraviolet A and B radiation-induced delayed mutagenesis
Radiat Res, 163 (3), 289-95
PubMed 15733036

Dahle J, Noordhuis P, Stokke T, Svendsrud DH, Kvam E (2005)
Multiplex polymerase chain reaction analysis of UV-A- and UV-B-induced delayed and early mutations in V79 Chinese hamster cells
Photochem Photobiol, 81 (1), 114-9
PubMed 15453821

Galteland E, Sivertsen EA, Svendsrud DH, Smedshammer L, Kresse SH, Meza-Zepeda LA, Myklebost O, Suo Z, Mu D, Deangelis PM, Stokke T (2005)
Translocation t(14;18) and gain of chromosome 18/BCL2: effects on BCL2 expression and apoptosis in B-cell non-Hodgkin's lymphomas
Leukemia, 19 (12), 2313-23
PubMed 16193090

Graff P, Amellem O, Seim J, Stokke T, Pettersen EO (2005)
The role of p27 in controlling the oxygen-dependent checkpoint of mammalian cells in late G1
Anticancer Res, 25 (3B), 2259-67
PubMed 16158973

Lund T, Stokke T, Olsen ØE, Fodstad Ø (2005)
Garlic arrests MDA-MB-435 cancer cells in mitosis, phosphorylates the proapoptotic BH3-only protein BimEL and induces apoptosis
Br J Cancer, 92 (9), 1773-81
PubMed 15827557

Lyng H, Landsverk KS, Kristiansen E, DeAngelis PM, Ree AH, Myklebost O, Hovig E, Stokke T (2005)
Response of malignant B lymphocytes to ionizing radiation: gene expression and genotype
Int J Cancer, 115 (6), 935-42
PubMed 15723354

Patzke S, Hauge H, Sioud M, Finne EF, Sivertsen EA, Delabie J, Stokke T, Aasheim HC (2005)
Identification of a novel centrosome/microtubule-associated coiled-coil protein involved in cell-cycle progression and spindle organization
Oncogene, 24 (7), 1159-73
PubMed 15580290

Publications 2004

de Angelis PM, Fjell B, Kravik KL, Haug T, Tunheim SH, Reichelt W, Beigi M, Clausen OP, Galteland E, Stokke T (2004)
Molecular characterizations of derivatives of HCT116 colorectal cancer cells that are resistant to the chemotherapeutic agent 5-fluorouracil
Int J Oncol, 24 (5), 1279-88
PubMed 15067352

Graff P, Seim J, Amellem Ø, Arakawa H, Nakamura Y, Andersson KK, Stokke T, Pettersen EO (2004)
Counteraction of pRb-dependent protection after extreme hypoxia by elevated ribonucleotide reductase
Cell Prolif, 37 (5), 367-83
PubMed 15377335

Landsverk KS, Lyng H, Stokke T (2004)
The response of malignant B lymphocytes to ionizing radiation: cell cycle arrest, apoptosis and protection against the cytotoxic effects of the mitotic inhibitor nocodazole
Radiat Res, 162 (4), 405-15
PubMed 15447042

Lyng H, Badiee A, Svendsrud DH, Hovig E, Myklebost O, Stokke T (2004)
Profound influence of microarray scanner characteristics on gene expression ratios: analysis and procedure for correction
BMC Genomics, 5 (1), 10
PubMed 15018648

Lyng H, Beigi M, Svendsrud DH, Brustugun OT, Stokke T, Kristensen GB, Sundfør K, Skjønsberg A, De Angelis PM (2004)
Intratumor chromosomal heterogeneity in advanced carcinomas of the uterine cervix
Int J Cancer, 111 (3), 358-66
PubMed 15221962

Ree AH, Bratland A, Nome RV, Stokke T, Fodstad O, Andersson Y (2004)
Inhibitory targeting of checkpoint kinase signaling overrides radiation-induced cell cycle gene regulation: a therapeutic strategy in tumor cell radiosensitization?
Radiother Oncol, 72 (3), 305-10
PubMed 15450729

Publications 2003

Hellum M, Høgset A, Engesaeter BO, Prasmickaite L, Stokke T, Wheeler C, Berg K (2003)
Photochemically enhanced gene delivery with cationic lipid formulations
Photochem Photobiol Sci, 2 (4), 407-11
PubMed 12760539

Ree AH, Bratland A, Nome RV, Stokke T, Fodstad Ø (2003)
Repression of mRNA for the PLK cell cycle gene after DNA damage requires BRCA1
Oncogene, 22 (55), 8952-5
PubMed 14654792

Seim J, Graff P, Amellem O, Landsverk KS, Stokke T, Pettersen EO (2003)
Hypoxia-induced irreversible S-phase arrest involves down-regulation of cyclin A
Cell Prolif, 36 (6), 321-32
PubMed 14710850

Publications 2002

Galteland E, Smedshammer L, Suo Z, DeAngelis P, Stokke T (2002)
Proliferation-dependent expression and phosphorylation of pRB in B cell non-Hodgkin's lymphomas: dependence on RB1 copy number
Leukemia, 16 (8), 1549-55
PubMed 12145697

Jenssen TK, Kuo WP, Stokke T, Hovig E (2002)
Associations between gene expressions in breast cancer and patient survival
Hum Genet, 111 (4-5), 411-20
PubMed 12384785

Moan J, Ma LW, Stokke T (2002)
Transfer of protoporphyrin IX between cells
Photochem Photobiol, 76 (5), 526-9
PubMed 12462648

Myklebust JH, Blomhoff HK, Rusten LS, Stokke T, Smeland EB (2002)
Activation of phosphatidylinositol 3-kinase is important for erythropoietin-induced erythropoiesis from CD34(+) hematopoietic progenitor cells
Exp Hematol, 30 (9), 990-1000
PubMed 12225790

Myklebust JH, Blomhoff HK, Rusten LS, Stokke T, Smeland EB (2002)
Activation of phosphatidylinositol 3-kinase is important for erythropoietin-induced erythropoiesis from CD34(+) hematopoietic progenitor cells
Exp. Hematol., 30 (9), PII S0301-475X(02)00868-8-1000

Rosenwald A, Wright G, Chan WC, Connors JM, Campo E, Fisher RI, Gascoyne RD, Muller-Hermelink HK, Smeland EB, Giltnane JM, Hurt EM, Zhao H, Averett L, Yang L, Wilson WH, Jaffe ES, Simon R, Klausner RD, Powell J, Duffey PL, Longo DL, Greiner TC, Weisenburger DD, Sanger WG, Dave BJ et al. (2002)
The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma
N Engl J Med, 346 (25), 1937-47
PubMed 12075054

Steen HB, Stokke T (2002)
Dye exclusion artifact in flow cytometers
Cytometry, 47 (3), 200-5
PubMed 11891725

Publications 2001

De Angelis PM, Stokke T, Beigi M, Mjåland O, Clausen OP (2001)
Prognostic significance of recurrent chromosomal aberrations detected by comparative genomic hybridization in sporadic colorectal cancer
Int J Colorectal Dis, 16 (1), 38-45
PubMed 11317696

Kvinnsland Y, Stokke T, Aurlien E (2001)
Radioimmunotherapy with alpha-particle emitters: microdosimetry of cells with a heterogeneous antigen expression and with various diameters of cells and nuclei
Radiat Res, 155 (2), 288-96
PubMed 11175663

Stokke T, DeAngelis P, Smedshammer L, Galteland E, Steen HB, Smeland EB, Delabie J, Holte H (2001)
Loss of chromosome 11q21-23.1 and 17p and gain of chromosome 6p are independent prognostic indicators in B-cell non-Hodgkin's lymphoma
Br J Cancer, 85 (12), 1900-13
PubMed 11747333

Publications 2000

Juul MH, Rivedal E, Stokke T, Sanner T (2000)
Quantitative determination of gap junction intercellular communication using flow cytometric measurement of fluorescent dye transfer
Cell Adhes Commun, 7 (6), 501-12
PubMed 11051460

Kolpakova E, Frengen E, Stokke T, Olsnes S (2000)
Organization, chromosomal localization and promoter analysis of the gene encoding human acidic fibroblast growth factor intracellular binding protein
Biochem J, 352 Pt 3, 629-35
PubMed 11104667

Stokke T, Galteland E, Holte H, Smedshammer L, Suo Z, Smeland EB, Børresen-Dale AL, DeAngelis P, Steen HB (2000)
Oncogenic aberrations in the p53 pathway are associated with a high S phase fraction and poor patient survival in B-cell Non-Hodgkin's lymphoma
Int J Cancer, 89 (4), 313-24
PubMed 10956404

Torheim NK, Boye E, Løbner-Olesen A, Stokke T, Skarstad K (2000)
The Escherichia coli SeqA protein destabilizes mutant DnaA204 protein
Mol Microbiol, 37 (3), 629-38
PubMed 10931356

Publications 1999

Carlson CR, Grallert B, Stokke T, Boye E (1999)
Regulation of the start of DNA replication in Schizosaccharomyces pombe
J Cell Sci, 112 ( Pt 6), 939-46
PubMed 10036243

De Angelis PM, Clausen OP, Schjølberg A, Stokke T (1999)
Chromosomal gains and losses in primary colorectal carcinomas detected by CGH and their associations with tumour DNA ploidy, genotypes and phenotypes
Br J Cancer, 80 (3-4), 526-35
PubMed 10408863

Galteland E, Holte H, Stokke T (1999)
c-MYC, RB-1, TP53, and centromere 8 and 17 copy number in B-cell non-Hodgkin's lymphomas assessed by dual-color fluorescence in situ hybridization
Cytometry, 38 (2), 53-60
PubMed 10323217

Holte H, Suo Z, Smeland EB, Kvaløy S, Langholm R, Stokke T (1999)
Prognostic value of lymphoma-specific S-phase fraction compared with that of other cell proliferation markers
Acta Oncol, 38 (4), 495-503
PubMed 10418718

Josefsen D, Myklebust JH, Lynch DH, Stokke T, Blomhoff HK, Smeland EB (1999)
Fas ligand promotes cell survival of immature human bone marrow CD34+CD38- hematopoietic progenitor cells by suppressing apoptosis
Exp Hematol, 27 (9), 1451-9
PubMed 10480436

Noodt BB, Berg K, Stokke T, Peng Q, Nesland JM (1999)
Different apoptotic pathways are induced from various intracellular sites by tetraphenylporphyrins and light
Br J Cancer, 79 (1), 72-81
PubMed 10408696

Publications 1998

Amellem O, Sandvik JA, Stokke T, Pettersen EO (1998)
The retinoblastoma protein-associated cell cycle arrest in S-phase under moderate hypoxia is disrupted in cells expressing HPV18 E7 oncoprotein
Br J Cancer, 77 (6), 862-72
PubMed 9528826

Bernander R, Stokke T, Boye E (1998)
Flow cytometry of bacterial cells: comparison between different flow cytometers and different DNA stains
Cytometry, 31 (1), 29-36
PubMed 9450522

Danielsen T, Hvidsten M, Stokke T, Solberg K, Rofstad EK (1998)
Hypoxia induces p53 accumulation in the S-phase and accumulation of hypophosphorylated retinoblastoma protein in all cell cycle phases of human melanoma cells
Br J Cancer, 78 (12), 1547-58
PubMed 9862563

De Angelis PM, Stokke T, Thorstensen L, Lothe RA, Clausen OP (1998)
Apoptosis and expression of Bax, Bcl-x, and Bcl-2 apoptotic regulatory proteins in colorectal carcinomas, and association with p53 genotype/phenotype
Mol Pathol, 51 (5), 254-61
PubMed 10193519

Moan J, Bech O, Gaullier JM, Stokke T, Steen HB, Ma LW, Berg K (1998)
Protoporphyrin IX accumulation in cells treated with 5-aminolevulinic acid: dependence on cell density, cell size and cell cycle
Int J Cancer, 75 (1), 134-9
PubMed 9426701

Stokke T, Holte H, Smedshammer L, Smeland EB, Kaalhus O, Steen HB (1998)
Proliferation and apoptosis in malignant and normal cells in B-cell non-Hodgkin's lymphomas
Br J Cancer, 77 (11), 1832-8
PubMed 9667654

Stokke T, Smeland EB, Kvaløy S, Holte H (1998)
Tumour cell proliferation, but not apoptosis, predicts survival in B-cell non-Hodgkin's lymphomas
Br J Cancer, 77 (11), 1839-41
PubMed 9667655

Stokke T, Solberg K, DeAngelis P, Steen HB (1998)
Propidium iodide quenches the fluorescence of TdT-incorporated FITC-labeled dUTP in apoptotic cells
Cytometry, 33 (4), 428-34
PubMed 9845437

Publications 1997

Amellem O, Stokke T, Sandvik JA, Smedshammer L, Pettersen EO (1997)
Hypoxia-induced apoptosis in human cells with normal p53 status and function, without any alteration in the nuclear protein level
Exp Cell Res, 232 (2), 361-70
PubMed 9168813

Carlson CR, Grallert B, Bernander R, Stokke T, Boye E (1997)
Measurement of nuclear DNA content in fission yeast by flow cytometry
Yeast, 13 (14), 1329-35
PubMed 9392077

De Angelis PM, Stokke T, Clausen OP (1997)
NO38 expression and nucleolar counts are correlated with cellular DNA content but not with proliferation parameters in colorectal carcinomas
Mol Pathol, 50 (4), 201-8
PubMed 9350304

Kraggerud SM, Jacobsen KD, Berner A, Stokke T, Holm R, Smedshammer L, Børresen-Dale AL, Fosså SD (1997)
A comparison of different modes for the detection of p53 protein accumulation. A study of bladder cancer
Pathol Res Pract, 193 (7), 471-8
PubMed 9342752

Noodt BB, Berg K, Stokke T, Peng Q, Nesland JM (1997)
Different pathways to apoptosis induced by tetraphenylporphine derivatives and light in V79 cells
P SOC PHOTO-OPT INS, 3191, 107-113

Stokke T, Smedshammer L, Jonassen TS, Blomhoff HK, Skarstad K, Steen HB (1997)
Uncoupling of the order of the S and M phases: effects of staurosporine on human cell cycle kinases
Cell Prolif, 30 (5), 197-218
PubMed 9420612

Publications 1996

Amellem O, Stokke T, Sandvik JA, Pettersen EO (1996)
The retinoblastoma gene product is reversibly dephosphorylated and bound in the nucleus in S and G2 phases during hypoxic stress
Exp Cell Res, 227 (1), 106-15
PubMed 8806457

Boye E, Stokke T, Kleckner N, Skarstad K (1996)
Coordinating DNA replication initiation with cell growth: differential roles for DnaA and SeqA proteins
Proc Natl Acad Sci U S A, 93 (22), 12206-11
PubMed 8901558

Jacobsen FW, Veiby OP, Stokke T, Jacobsen SE (1996)
TNF-alpha bidirectionally modulates the viability of primitive murine hematopoietic progenitor cells in vitro
J Immunol, 157 (3), 1193-9
PubMed 8757625

Noodt BB, Berg K, Stokke T, Peng Q, Nesland JM (1996)
Apoptosis and necrosis induced with light and 5-aminolaevulinic acid-derived protoporphyrin IX
Br J Cancer, 74 (1), 22-9
PubMed 8679453

Røsok O, Odeberg J, Rode M, Stokke T, Funderud S, Smeland E, Lundeberg J (1996)
Solid-phase method for differential display of genes expressed in hematopoietic stem cells
Biotechniques, 21 (1), 114-21
PubMed 8816245

Publications 1995

Bånrud H, Stokke T, Moan J, Berg K (1995)
S phase arrest and induction of multinucleated cells after exposure to ultraviolet radiation
Carcinogenesis, 16 (5), 1087-94
PubMed 7767969

De Angelis P, Stokke T, Smedshammer L, Lothe RA, Lehne G, Chen Y, Clausen OP (1995)
P-glycoprotein is not expressed in a majority of colorectal carcinomas and is not regulated by mutant p53 in vivo
Br J Cancer, 72 (2), 307-11
PubMed 7640210

Jacobsen FW, Stokke T, Jacobsen SE (1995)
Transforming growth factor-beta potently inhibits the viability-promoting activity of stem cell factor and other cytokines and induces apoptosis of primitive murine hematopoietic progenitor cells
Blood, 86 (8), 2957-66
PubMed 7579388

Lømo J, Blomhoff HK, Beiske K, Stokke T, Smeland EB (1995)
TGF-beta 1 and cyclic AMP promote apoptosis in resting human B lymphocytes
J Immunol, 154 (4), 1634-43
PubMed 7836748

Stokke T, Collins C, Kuo WL, Kowbel D, Shadravan F, Tanner M, Kallioniemi A, Kallioniemi OP, Pinkel D, Deaven L (1995)
A physical map of chromosome 20 established using fluorescence in situ hybridization and digital image analysis
Genomics, 26 (1), 134-7
PubMed 7782072

Publications 1994

Christoffersen J, Smeland EB, Stokke T, Taskén K, Andersson KB, Blomhoff HK (1994)
Retinoblastoma protein is rapidly dephosphorylated by elevated cyclic adenosine monophosphate levels in human B-lymphoid cells
Cancer Res, 54 (8), 2245-50
PubMed 8174134

Gerlyng P, Grotmol T, Stokke T, Erikstein B, Seglen PO (1994)
Flow cytometric investigation of a possible precursor--product relationship between oval cells and parenchymal cells in the rat liver
Carcinogenesis, 15 (1), 53-9
PubMed 8293549

Gray JW, Collins C, Henderson IC, Isola J, Kallioniemi A, Kallioniemi OP, Nakamura H, Pinkel D, Stokke T, Tanner M (1994)
Molecular cytogenetics of human breast cancer
Cold Spring Harb Symp Quant Biol, 59, 645-52
PubMed 7587125

Jonassen TS, Seglen PO, Stokke T (1994)
The fraction of cells in G1 with bound retinoblastoma protein increases with the duration of the cell cycle
Cell Prolif, 27 (2), 95-104
PubMed 10465029

Kallioniemi A, Kallioniemi OP, Piper J, Tanner M, Stokke T, Chen L, Smith HS, Pinkel D, Gray JW, Waldman FM (1994)
Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization
Proc Natl Acad Sci U S A, 91 (6), 2156-60
PubMed 8134364

Kvam E, Stokke T (1994)
Sites of photodynamically induced DNA repair in human cells
Photochem Photobiol, 59 (4), 437-40
PubMed 7912836

Rasmussen AM, Blomhoff HK, Stokke T, Horejsi V, Smeland EB (1994)
Cross-linking of CD53 promotes activation of resting human B lymphocytes
J Immunol, 153 (11), 4997-5007
PubMed 7963560

Tanner MM, Tirkkonen M, Kallioniemi A, Collins C, Stokke T, Karhu R, Kowbel D, Shadravan F, Hintz M, Kuo WL (1994)
Increased copy number at 20q13 in breast cancer: defining the critical region and exclusion of candidate genes
Cancer Res, 54 (16), 4257-60
PubMed 8044767

Wold S, Skarstad K, Steen HB, Stokke T, Boye E (1994)
The initiation mass for DNA replication in Escherichia coli K-12 is dependent on growth rate
EMBO J, 13 (9), 2097-102
PubMed 8187762

Publications 1993

Deangelis P, Stokke T, Smedshammer L, Lothe R, Meling G, Rofstad M, Chen Y, Clausen O (1993)
P53 expression is associated with a high-degree of tumor DNA aneuploidy and incidence of p53 gene mutation, and is localized to the aneuploid component in colorectal carcinomas
Int J Oncol, 3 (2), 305-12
PubMed 21573365

Gerlyng P, Abyholm A, Grotmol T, Erikstein B, Huitfeldt HS, Stokke T, Seglen PO (1993)
Binucleation and polyploidization patterns in developmental and regenerative rat liver growth
Cell Prolif, 26 (6), 557-65
PubMed 9116122

Stokke T, Erikstein BK, Smedshammer L, Boye E, Steen HB (1993)
The retinoblastoma gene product is bound in the nucleus in early G1 phase
Exp Cell Res, 204 (1), 147-55
PubMed 8416792

Publications 1992

Gerlyng P, Grotmol T, Erikstein B, Stokke T, Seglen PO (1992)
Reduced proliferative activity of polyploid cells in primary hepatocellular carcinoma
Carcinogenesis, 13 (10), 1795-801
PubMed 1330342

Gerlyng P, Stokke T, Huitfeldt HS, Stenersen T, Danielsen HE, Grotmol T, Seglen PO (1992)
Analytical methods for the study of liver cell proliferation
Cytometry, 13 (4), 404-15
PubMed 1382009

Kvam E, Stokke T, Moan J, Steen HB (1992)
Plateau distributions of DNA fragment lengths produced by extended light exposure of extranuclear photosensitizers in human cells
Nucleic Acids Res, 20 (24), 6687-93
PubMed 1480490

Stokke T, Holte H, Smeland EB, Lie SO, Steen HB (1992)
Differential chromatin structure-dependent binding of 7-aminoactinomycin D in normal and malignant bone marrow hematopoietic cells
Cancer Res, 52 (18), 5007-12
PubMed 1516056

Publications 1991

Erikstein BK, Schwarze P, Blomhoff HK, Funderud S, Stokke T, Smeland EB (1991)
Use of size fractionation of in vitro-activated human B lymphocytes for studies of cell cycle-dependent growth regulation
Scand J Immunol, 33 (1), 51-60
PubMed 1899949

Lømo J, Smeland EB, Stokke T, Holte H, Funderud S, Blomhoff HK (1991)
Differential effects of interferon-gamma and low molecular weight BCGF on growth of human B lymphocytes; interferon-gamma prolongs the increased c-MYC mRNA levels after activation
Scand J Immunol, 33 (4), 365-73
PubMed 1902001

Rofstad EK, Wahl A, Hystad ME, Nesland JM, Stokke T (1991)
Establishment in monolayer culture and characterization of four human melanoma cell lines
Virchows Arch B Cell Pathol Incl Mol Pathol, 60 (3), 189-97
PubMed 1679270

Stokke T, Erikstein B, Holte H, Funderud S, Steen HB (1991)
Cell cycle-specific expression and nuclear binding of DNA polymerase alpha
Mol Cell Biol, 11 (6), 3384-9
PubMed 2038340

Stokke T, Holte H, Erikstein B, Davies CL, Funderud S, Steen HB (1991)
Simultaneous assessment of chromatin structure, DNA content, and antigen expression by dual wavelength excitation flow cytometry
Cytometry, 12 (2), 172-8
PubMed 1710961

Publications 1990

Funderud S, Erikstein B, Asheim HC, Nustad K, Stokke T, Blomhoff HK, Holte H, Smeland EB (1990)
Functional properties of CD19+ B lymphocytes positively selected from buffy coats by immunomagnetic separation
Eur J Immunol, 20 (1), 201-6
PubMed 1689662

Kvam E, Stokke T, Moan J (1990)
The lengths of DNA fragments light-induced in the presence of a photosensitizer localized at the nuclear membrane of human cells
Biochim Biophys Acta, 1049 (1), 33-7
PubMed 2141534

Rofstad EK, Wahl A, Stokke T, Nesland JM (1990)
Establishment and characterization of six human melanoma xenograft lines
APMIS, 98 (10), 945-53
PubMed 2245014

Smeland EB, Holte H, Kiil Blomhoff H, Asheim HC, Stokke T, Torjesen P, Funderud S (1990)
Inhibition of polyphosphoinositide breakdown and c-myc induction accompanying inhibition of human B-cell activation by two monoclonal antibodies against the leucocyte common antigen (CD45)
Scand J Immunol, 31 (5), 583-91
PubMed 1693226

Stokke T, Holte H, Davies CD, Steen HB, Lie SO (1990)
Quenching of Hoechst 33258 fluorescence in erythroid precursors
Cytometry, 11 (6), 686-90
PubMed 1696537

Publications 1989

Holte H, Blomhoff HK, Beiske K, Funderud S, Torjesen P, Gaudernack G, Stokke T, Smeland EB (1989)
Intracellular events associated with inhibition of B cell activation by monoclonal antibodies to HLA class II antigens
Eur J Immunol, 19 (7), 1221-5
PubMed 2547623

Holte H, de Lange Davies C, Beiske K, Stokke T, Marton PF, Smeland EB, Høie J, Kvaløy S (1989)
Ki67 and 4F2 antigen expression as well as DNA synthesis predict survival at relapse/tumour progression in low-grade B-cell lymphoma
Int J Cancer, 44 (6), 975-80
PubMed 2606582

Holte H, Stokke T, Smeland E, Watt R, Blomhoff HK, Kaalhus O, Ohlsson R (1989)
Levels of myc protein, as analyzed by flow cytometry, correlate with cell growth potential in malignant B-cell lymphomas
Int J Cancer, 43 (1), 164-70
PubMed 2642893

Publications 1988

Blomhoff HK, Blomhoff R, Stokke T, deLange Davies C, Brevik K, Smeland EB, Funderud S, Godal T (1988)
cAMP-mediated growth inhibition of a B-lymphoid precursor cell line Reh is associated with an early transient delay in G2/M, followed by an accumulation of cells in G1
J Cell Physiol, 137 (3), 583-7
PubMed 2848044

Jacobsen PB, Stokke T, Solesvik O, Steen HB (1988)
Temperature-induced chromatin changes in ethanol-fixed cells
J Histochem Cytochem, 36 (12), 1495-501
PubMed 2461412

Stokke T (1988)
Re: L. F. Pearlman et al., interaction of three second-generation anthracyclines with polynucleotides, RNA, DNA, and nucleosomes. Cancer Res., 46:341-346, 1986
Cancer Res, 48 (23), 6962-5
PubMed 2460232

STOKKE T (1988)
INTERACTION OF 3 2ND-GENERATION ANTHRACYCLINES WITH POLYNUCLEOTIDES, RNA, DNA, AND NUCLEOSOMES
Cancer Res., 48 (23), 6962-6963

Stokke T, Holte H, Steen HB (1988)
In vitro and in vivo activation of B-lymphocytes: a flow cytometric study of chromatin structure employing 7-aminoactinomycin D
Cancer Res, 48 (23), 6708-14
PubMed 3263191

Publications 1987

DORNISH JM, PETTERSEN EO, STOKKE T (1987)
THE EFFECT OF BENZALDEHYDE ON TERBIUM FLUORESCENCE ENHANCEMENT IN HUMAN NHIK 3025 CELLS TREATED WITH CIS-DICHLORODIAMMINEPLATINUM(II)
INORG CHIM A-BIOINOR, 137 (1-2), 105-107

Fosse E, Mollnes TE, Aasen AO, Trumpy JH, Stokke T (1987)
Complement activation following multiple injuries
Acta Chir Scand, 153 (5-6), 325-30
PubMed 3499041

Stokke T, Steen HB (1987)
Distinction of leucocyte classes based on chromatin-structure-dependent DNA-binding of 7-aminoactinomycin D
Cytometry, 8 (6), 576-83
PubMed 2448092

Publications 1986

Steen HB, Stokke T (1986)
Fluorescence spectra of cells stained with a DNA-specific dye, measured by flow cytometry
Cytometry, 7 (1), 104-6
PubMed 2419053

Stokke T, Steen HB (1986)
Binding of Hoechst 33258 to chromatin in situ
Cytometry, 7 (3), 227-34
PubMed 2423306

Stokke T, Steen HB (1986)
Fluorescence spectra of Hoechst 33258 bound to chromatin
Biochim Biophys Acta, 868 (1), 17-23
PubMed 2428400

Publications 1985

Stokke T, Steen HB (1985)
Neither adriamycin nor actinomycin D displaces Tb3+ from DNA
Biochim Biophys Acta, 825 (4), 416-8
PubMed 4016123

Stokke T, Steen HB (1985)
Multiple binding modes for Hoechst 33258 to DNA
J Histochem Cytochem, 33 (4), 333-8
PubMed 2579998