Oslo University Hospital prize to Harald Stenmark

Harald Stenmark received the first "Excellent Researcher Award" from the Director of Oslo University Hospital on April 26th 2013. Read more

Viola Lobert defended her PhD thesis

Viola Lobert successfully defended her PhD thesis on 19 October 2012. More

Antonia Sagona defended her PhD thesis

Antonia Sagona successfully defended her PhD thesis on 22 March 2012. More

Kaisa Haglund awarded prestigious grant

In December 2011, project leader Kaisa Haglund in Harald Stenmark´s group was awarded a prestigious career grant ("utvidet forskerstipend") from Helse Sør-Øst for the proposal "Mechanisms of cytokinesis in development and carcinogenesis". The grant amounts to NOK 2 million per year and runs from April 2012 to March 2016.

Rusten and Stenmark with review in Nature Cell Biology

In a recent issue of Nature Cell Biology, Tor Erik Rusten, Thomas Vaccari and Harald Stenmark discuss the role of ESCRT proteins in developmental processes. Read more

Camilla Raiborg receives the Mørk legacy prize 2011

Camilla Raiborg receives the Mørk Legacy Prize 2011 for her outstanding research on mechanisms of downregulation of growth factor receptors. Read more

Abrahamsen and Stenmark discuss growth signalling in Science

In the Nov 4 2011 issue of Science, Hilde Abrahamsen and Harald Stenmark discuss recent progress in our understanding of how amino acids are sensed by a cellular machinery that promotes growth. Read more

Cover story in Traffic about ESCRTs

Lene Malerød and Nina Marie Pedersen have recently published an article about ESCRT proteins that has been dedicated the cover in the September 2011 issue of Traffic. Read more

Cover story in "Physiology"

An illustration from the review article ""Cell polarity and migration: Emerging role of the endosomal sorting machinery", by Viola H. Lobert and Harald Stenmark, was chosen for the cover of the June 2011 issue of "Physiology". Read more

Novel cancer biomarker is a cytokinesis regulator

Guro E.Lind has identified a novel biomarker for early detection of colorectal cancer, and Camilla Raiborg has shown that the gene product is a regulator of cytokinesis. Read more.

Raiborg and Stenmark with Perspective in Science

Camilla Raiborg and Harald Stenmark have recently contributed a Perspective in Science about recent developments in our understanding of how the final stage of cell division - cytokinesis - is regulated. Read more

Ioannis Nezis identifies mechanistic link between autophagy and programmed cell death

Viola Lobert discovers functional importance of integrin degradation

Sir Hans Krebs Medal to Harald Stenmark

Kaisa Haglund identifies new regulator of cytokinesis

Findings in Nature Cell Biology paper discussed on "forskning.no"

A recent Nature Cell Biology paper by PhD student Antonia Sagona and co-workers was recently discussed in the Norwegian research web portal forskning.no.

New functional mechanism revealed for a tumour suppressor

PhD student Antonia Sagona and her co-workers in Harald Stenmark's group have uncovered a new functional mechanism for a known tumour suppressor, class III phosphoinositide 3-kinase. The article was published in the April 2010 issue of Nature Cell Biology.

Cover story in "Histochemistry and Cell Biology"

Catherine Sem Wegner and her colleagues in Andreas Brech´s project group have published a paper that was chosen for the cover of "Histochemistry and Cell Biology". Read more

Poster prize to PhD student Sigrid Bratlie Thoresen

Sigrid Bratlie Thoresen received the 2nd prize for best poster at the Winter Meeting of the Norwegian Biochemical Society in January 2010. Read more

Doctoral dissertation Ingrid Roxrud

Ingrid Roxrud defended her PhD thesis entitled “Endocytic trafficking of membrane proteins. Mechanisms in human disease” on November 6th 2009. Read more

Rab review in Nature Reviews in Molecular Cell Biology

Harald Stenmark has recently published a review about Rab GTPases in Nature Reviews in Molecular Cell Biology (impact factor 35.4). The review covers the functions of Rab GTPases in vesicle traffic, and their roles in preventing diseases, including cancer. Link to the article.

Stenmark group member of ESF project

The Stenmark group participates in the European Science Foundation (ESF) project on "Tracking of phosphoinositide pools", which recently was approved for funding. This is a project under the EuroMEMBRANE programme under the EUROCORES scheme of ESF. The focus of this project is the elucidation of dynamic processes in phosphoinositide signalling during cell migration and changes in cell-cell contacts. The other principal investigators of this project are Matthias Wymann (Basel, coordinator), Carsten Schultz (Heidelberg), Dorus Gadella (Amsterdam) and Karl-Eric Magnusson (Linköping). The project will last from September 2009 to December 2012.

Cover story in Traffic

An electron micrograph from an article by Sanne Stuffers and co-workers in Andreas Brech's project group was chosen for the cover of the July 2009 issue of Traffic. Read more

Advanced Grant from the European Research Council

Harald Stenmark has received a grant of 2.27 million EURO from the European Research Council for the project "The PI3K-III complex: Function in cell regulation and tumour suppression". Read more

Review in Nature about ESCRTs

Camilla Raiborg and Harald Stenmark have published a review about ESCRT proteins in endosomal protein sorting in the journal Nature. Read more

Poster prize to Ingrid Roxrud

PhD student Ingrid Roxrud received prize for best poster at the 2009 Winter meeting of the Norwegian Biochemical Society.

Comment in Cell about ESCRT functions

Lene Malerød and Harald Stenmark have written a Comment about recent developments in our understanding of how ESCRT proteins mediate membrane deformation. The Comment was published in Cell.

Camilla Raiborg figure on the cover of the 2009 edition of Experimental Cell Research

A figure from the paper "Differential functions of Hrs and ESCRT proteins in endocytic membrane trafficking" by Camilla Raiborg and co-workers, published in March 2008, has been selected for the cover of the whole 2009 edition of Experimental Cell Research.

Trial lecture and doctoral dissertation - Sanne Stuffers

See announcement.

Tor Erik Rusten receives Dr. Mørk's prize for excellent cancer research

Tor Erik Rusten, leader of the project "phosphatidylinositol signalling & disease" received Dr. Ragnar Mørk's prize for outstanding cancer research. Read more

Mediating protein aggregation in the brain

New findings by Ioannis Nezis and co-workers in Andreas Brech's project group reveal a protein required for formation of protein aggregates in the brains of fruit flies. The paper was published in the Journal of Cell Biology. Read more.

New protein involved in growth factor receptor downregulation discovered

A new ubiquitin-binding protein that mediates sorting of endocytosed growth factor receptors from endosomes to lysosomes has been discovered by PhD student Ingrid Roxrud and other scientists from Harald Stenmark's group at the Institute for Cancer Research, as reported in the 24 March issue of the Journal of Cell Biology. Read more.

Autophagy article from Tor Erik Rusten and co-workers highlighted in Cell

A recent paper from Tor Erik Rusten and co-workers, showing that ESCRT proteins and the phosphoinositide 5-kinase Fab1 are required for completion of autophagy, has been dedicated an editorial in the "Leading Edge" section of Cell. Read more.

Cover article from Anne Simonsen and co-workers highlighted in Science

A recent cover article in Autophagy from Anne Simonsen, Andreas Brech and Pauline Isakson at the Institute for Cancer Research, in collaboration with Kim Finley's group at the Salk Institute in San Diego, has been dedicated an editorial under "Editor's Choice" in Science.

Trial lecture and disputation, 07.12 2007

Karine Lindmo

Siv. ing. Karine Lindmo from Harald Stenmark's group at the Department of Biochemistry at the Institute for Cancer Research defended her thesis - entitled "Regulation and function of autophagy in Drosophila melanogaster" on December 7th 2007 at 12:15 in Auditorium 2, Kristine Bonnevies hus, Blindern, UiO.

Her trial lecture - on the subject "Signalling mechanisms controlling autophagy. The role of TOR and Atg1" - was held at 10:15 the same day.

Ragnar Mørk prize to Anne Simonsen

Project leader Anne Simonsen received the Dr. Ragnar Mørk legazy prize for excellent cancer research on 23 Nov 2007. Read more.

Cancer researchers shed light on inherited brain damage

Scientists at the Centre for Cancer Biomedicine (CCB) have been studying the so-called ESCRT proteins, a group of cellular proteins that appear to prevent normal cells from turning into cancer cells. Important findings from these studies have recently been published in the high-impact journals Current Biology and Journal of Cell Biology. An article showing evidence that faulty autophagic degradation of protein aggregates is the cause of brain damage in certain patients is presented on the cover of the November 5th issue of JCB. Read more

Escorting receptors for degradation

In a recent paper in Traffic, Lene Malerød, a postdoc in Stenmark’s lab, shows that the ESCRT-II complex is required for degradation of ubiquitinated epidermal growth factor receptor and chemokine receptors. This provides new insight into how growth factor and chemokine receptors are transported intracellularly and identifies a novel potential tumour suppressor complex.

Poster awards for PhD students from the Institute for Cancer Research

Lina Rodahl was one of two PhD students from our institute to receive poster awards at the annual meeting of the Norwegian Biochemical Society.

"Centre for Cancer Biomedicine" - new centre of excellence

The "Centre for Cancer Biomedicine", headed by Harald Stenmark, was on 21 December 2006 appointed Centre of Excellence by the Research Council of Norway.

Dec 22, 2006

Crystal structure of GLUE complexed to ubiquitin published in Nature Structural & Molecular Biology

T. Slagsvold

Thomas Slagsvold, a postdoc in Harald Stenmark’s lab has previously identified a novel ubiquitin- and phosphoinositide binding domain, called GLUE. This identification was in collaboration with Rein Aasland at the University of Bergen and Soichi Wakatuki’s group at the Structural Biology Research Center in Ibaraki, Japan. In a continued collaboration with Wakatsuki’s group the crystal structure of the GLUE domain complexed to ubiquitin has now been solved. The structure is published in a recent issue of the prestigious journal "Nature Structural & Molecular Biology" (impact factor 12,19).

New growth-regulatory enzyme identified

Tor-Erik Rusten

Tor Erik Rusten, a postdoc in Harald Stenmark’s group has recently used the fruit fly Drosophila melanogaster to study the function of a novel enzyme, Fab1, that catalyzes phosphorylation of a specific phospholipid to yield the reaction product known as PtdIns(3,5)P2. In a paper published in Molecular Biology of the Cell (impact factor 6.52) Rusten and co-workers show that Fab1 is essential for viability.

New mechanism for increased levels of metastatic chemokine receptors revealed

Th. Slagsvold

Thomas Slagsvold, a postdoctoral fellow in Harald Stenmark’s group, has recently published in EMBO Journal (impact factor 10,053) a paper that sheds light on how the cellular levels of the chemokine receptor CXCR4 are increased in cancers. This issue is of considerable interest because enhanced expression of CXCR4 has been strongly associated with metastasis of breast cancer cells to lung tissue.

The Stenmark group and two other groups at the Radium Hospital receive FUGE grants

The Stenmark group recently received a FUGE grant together with Terje Johansen's group in Tromsø on the project "Protein aggregation and degradation in aging and disease".

Aug 1, 2006

Radium hospital researchers involved in new centre for research-based innovation

The Stenmark group is one of several groups at the Norwegian Radium Hospital involved in the new centre for Stem Cell Based Tumour Therapy.

Aug 5, 2006

Breaking news on how ubiquitin regulates intracellular transport

Camilla Raiborg

Camilla Raiborg, a postdoc of the Norwegian Cancer Society working in Harald Stenmark's group at the Department of Biochemistry of the Institute for Cancer Research, has recently published two articles together with international collaborators that reveal how the small protein ubiquitin regulates intracellular trafficking.

Feb 6, 2006

King's gold medal to Kristi Grønvold Bache for excellent thesis

Kristi Grønvold Bache

The University of Oslo rewards the most outstanding doctoral theses from the major faculties every year. The winners are distributed the King's gold medal. From the medical faculty, Kristi Grønvold Bache from Harald Stenmark's group has won the prestigous prize for her thesis entitled "The function of ubiquitin-binding protein complexes in endocytic downregulation of growth factor receptors" this year. She will receive the gold medal on the annual University party on September 2nd.

Paper from the Stenmark group on the front page of "Journal of Cell Science"

The Stenmark group has recently published an article about the protein "Alix", which is given the front page illustration in the June 15th issue of Journal of Cell Science.
The article - entitled "Alix regulates cortical actin and the spatial distribution of endosomes" has also been given an editorial comment.

Jun 14, 2005

Kristi Grønvold Bache has defended her thesis "The function of ubiquitin-binding protein complexes in endocytic downregulation of growth factor receptors"

Kristi Grønvold Bache from Harald Stenmark's group at the Department of Biochemistry has defended her thesis "The function of ubiquitin-binding protein complexes in endocytic downregulation of growth factor receptors". The disputation took place on March 11th in the Auditorium at the Norwegian National Hospital in Oslo.

The results presented in the thesis represent a first step towards understanding the molecular mechanisms of endocytic downregulation of growth factor receptors and provide novel links between this pathway and growth regulation and cancer.

Visit the web page of Harald Stenmark's group to read more about the subjects covered in the thesis.

Camilla Raiborg has defended her thesis "Hrs makes receptors silent. A key to endosomal protein sorting"

Camilla Raiborg from Harald Stenmark's group at the Department of Biochemistry has defended her thesis "Hrs makes receptors silent. A key to endosomal protein sorting". The disputation took place March 15th in the Auditorium at the Norwegian Radium Hospital.

The common denominator in the thesis is the Hrs and during the project several components were shown to cooperate with Hrs in the sorting process: clathrin, STAM, Eps15, AIP4 etc.

Read the complete statement from the evaluation committe here

Visit the web page of Harald Stenmark's group to read more about the subjects covered in the thesis.

Mar 17, 2005

Important autophagy findings commented in Nature

Tor Erik Rusten and co-workers in Harald Stenmark's group has recently provided new insights into how autophagy is regulated in the cell. Their findings - published in the August edition Developmental Cell - has stirred considerable attention, and two commentary articles has been written in "News and view" in Nature, and in "Nature Reviews Molecular Cell Biology".

Click on the links below to read the commentaries.

"Regulated self-cannibalism", by Daniel J. Klionsky Nature 431, 31-32 (2004)
"Breakdown recovery", by Arianne Heinrichs Nature Reviews Molecular Cell Biology 5, (2004)

See also: Paper from Stenmark's group accepted in "Developmental Cell".

Sep 15, 2004

Paper from Stenmark's group accepted in "Developmental Cell".

Harald Stenmark's group has published an article in the August edition of "Developmental Cell".
This journal has a very high impact factor, and only the most outstanding research is accepted. The group's discoveries has stirred considerable attention.

Aug 9, 2004

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