Espen Stang
- Scientist
- +47 23 07 14 83
Publications 2024
Long-Term Follow-Up of Pediatric Excimer Laser-Assisted Penetrating Keratoplasty for Congenital Stromal Corneal Dystrophy
Cornea, 43 (6), 784-789
DOI 10.1097/ICO.0000000000003519, PubMed 38437155
Intercellular transfer of cancer cell invasiveness via endosome-mediated protease shedding
Nat Commun, 15 (1), 1277
DOI 10.1038/s41467-024-45558-8, PubMed 38341434
Publications 2023
Next-generation sequencing reveals mitogenome diversity in plasma extracellular vesicles from colorectal cancer patients
BMC Cancer, 23 (1), 650
DOI 10.1186/s12885-023-11092-x, PubMed 37438741
siRNA screening reveals that SNAP29 contributes to exosome release
Cell Mol Life Sci, 80 (7), 177
DOI 10.1007/s00018-023-04822-8, PubMed 37285022
Publications 2020
Hsp90 inhibition and co-incubation with pertuzumab induce internalization and degradation of trastuzumab: Implications for use of T-DM1
J Cell Mol Med, 24 (17), 10258-10262
DOI 10.1111/jcmm.15643, PubMed 32672902
Publications 2019
Protein kinase C regulates ErbB3 turnover
Exp Cell Res, 382 (2), 111473
DOI 10.1016/j.yexcr.2019.06.018, PubMed 31233741
Publications 2018
Protein kinase C mediated internalization of ErbB2 is independent of clathrin, ubiquitination and Hsp90 dissociation
Exp Cell Res, 371 (1), 139-150
DOI 10.1016/j.yexcr.2018.08.004, PubMed 30098331
Publications 2017
ErbB3 interacts with Hrs and is sorted to lysosomes for degradation
Biochim Biophys Acta Mol Cell Res, 1864 (12), 2241-2252
DOI 10.1016/j.bbamcr.2017.08.011, PubMed 28867611
Publications 2016
CTGF/CCN2 Postconditioning Increases Tolerance of Murine Hearts towards Ischemia-Reperfusion Injury
PLoS One, 11 (2), e0149000
DOI 10.1371/journal.pone.0149000, PubMed 26872261
A combination of two antibodies recognizing non-overlapping epitopes of HER2 induces kinase activity-dependent internalization of HER2
J Cell Mol Med, 20 (10), 1999-2011
DOI 10.1111/jcmm.12899, PubMed 27469139
Interaction with epsin 1 regulates the constitutive clathrin-dependent internalization of ErbB3
Biochim Biophys Acta, 1863 (6 Pt A), 1179-88
DOI 10.1016/j.bbamcr.2016.03.011, PubMed 26975582
Publications 2015
Syndecan-4 Regulates Muscle Differentiation and Is Internalized from the Plasma Membrane during Myogenesis
PLoS One, 10 (6), e0129288
DOI 10.1371/journal.pone.0129288, PubMed 26068620
Publications 2014
The Mysterious Ways of ErbB2/HER2 Trafficking
Membranes (Basel), 4 (3), 424-46
DOI 10.3390/membranes4030424, PubMed 25102001
Tartrate-resistant acid phosphatase (TRAP) co-localizes with receptor activator of NF-KB ligand (RANKL) and osteoprotegerin (OPG) in lysosomal-associated membrane protein 1 (LAMP1)-positive vesicles in rat osteoblasts and osteocytes
Histochem Cell Biol, 143 (2), 195-207
DOI 10.1007/s00418-014-1272-4, PubMed 25201349
Publications 2013
Pertuzumab counteracts the inhibitory effect of ErbB2 on degradation of ErbB3
Carcinogenesis, 34 (9), 2031-8
DOI 10.1093/carcin/bgt173, PubMed 23698633
Publications 2012
Cetuximab in combination with anti-human IgG antibodies efficiently down-regulates the EGF receptor by macropinocytosis
Exp Cell Res, 318 (20), 2578-91
DOI 10.1016/j.yexcr.2012.09.001, PubMed 22975728
Statins affect the presentation of endothelial chemokines by targeting to multivesicular bodies
PLoS One, 7 (7), e40673
DOI 10.1371/journal.pone.0040673, PubMed 22815786
Pertuzumab Increases 17-AAG-Induced Degradation of ErbB2, and This Effect Is Further Increased by Combining Pertuzumab with Trastuzumab
Pharmaceuticals (Basel), 5 (7), 674-89
DOI 10.3390/ph5070674, PubMed 24281706
The oncoprotein ErbB3 is endocytosed in the absence of added ligand in a clathrin-dependent manner
Carcinogenesis, 33 (5), 1031-9
DOI 10.1093/carcin/bgs128, PubMed 22436610
Preubiquitinated chimeric ErbB2 is constitutively endocytosed and subsequently degraded in lysosomes
Exp Cell Res, 319 (3), 32-45
DOI 10.1016/j.yexcr.2012.10.010, PubMed 23127513
Publications 2011
Nimotuzumab and cetuximab block ligand-independent EGF receptor signaling efficiently at different concentrations
J Immunother, 34 (7), 550-5
DOI 10.1097/CJI.0b013e31822a5ca6, PubMed 21760527
A chimeric pre-ubiquitinated EGF receptor is constitutively endocytosed in a clathrin-dependent, but kinase-independent manner
Traffic, 12 (4), 507-20
DOI 10.1111/j.1600-0854.2011.01162.x, PubMed 21226813
CIN85 regulates ubiquitination and degradative endosomal sorting of the EGF receptor
Exp Cell Res, 317 (13), 1804-16
DOI 10.1016/j.yexcr.2011.05.016, PubMed 21635887
Publications 2010
Decorin accumulation contributes to the stromal opacities found in congenital stromal corneal dystrophy
Invest Ophthalmol Vis Sci, 51 (11), 5578-82
DOI 10.1167/iovs.09-4933, PubMed 20484579
Publications 2009
Pertuzumab increases epidermal growth factor receptor down-regulation by counteracting epidermal growth factor receptor-ErbB2 heterodimerization
Mol Cancer Ther, 8 (7), 1885-92
DOI 10.1158/1535-7163.MCT-09-0291, PubMed 19584234
Internalization and intracellular sorting of the EGF receptor: a model for understanding the mechanisms of receptor trafficking
J Cell Sci, 122 (Pt 19), 3433-9
DOI 10.1242/jcs.050260, PubMed 19759283
Expression of epidermal growth factor receptor or ErbB3 facilitates geldanamycin-induced down-regulation of ErbB2
Mol Cancer Res, 7 (2), 275-84
DOI 10.1158/1541-7786.MCR-07-2183, PubMed 19208749
Publications 2008
Dysregulation of Ack1 inhibits down-regulation of the EGF receptor
Exp Cell Res, 314 (6), 1292-300
DOI 10.1016/j.yexcr.2007.12.017, PubMed 18262180
Epsin 1 is involved in recruitment of ubiquitinated EGF receptors into clathrin-coated pits
Traffic, 10 (2), 235-45
DOI 10.1111/j.1600-0854.2008.00858.x, PubMed 19054389
Geldanamycin-induced down-regulation of ErbB2 from the plasma membrane is clathrin dependent but proteasomal activity independent
Mol Cancer Res, 6 (3), 491-500
DOI 10.1158/1541-7786.MCR-07-0191, PubMed 18337455
An endosomally localized isoform of Eps15 interacts with Hrs to mediate degradation of epidermal growth factor receptor
J Cell Biol, 180 (6), 1205-18
DOI 10.1083/jcb.200708115, PubMed 18362181
Publications 2007
The Cbl-interacting protein TULA inhibits dynamin-dependent endocytosis
Exp Cell Res, 313 (8), 1696-709
DOI 10.1016/j.yexcr.2007.02.017, PubMed 17382318
Publications 2006
Activation of the epidermal growth factor (EGF) receptor induces formation of EGF receptor- and Grb2-containing clathrin-coated pits
Mol Cell Biol, 26 (2), 389-401
DOI 10.1128/MCB.26.2.389-401.2006, PubMed 16382132
EGF-induced activation of the EGF receptor does not trigger mobilization of caveolae
Traffic, 7 (11), 1518-27
DOI 10.1111/j.1600-0854.2006.00487.x, PubMed 16984407
Both clathrin-positive and -negative coats are involved in endosomal sorting of the EGF receptor
Exp Cell Res, 312 (16), 3036-48
DOI 10.1016/j.yexcr.2006.06.004, PubMed 16859684
Platelet-derived LIGHT induces inflammatory responses in endothelial cells and monocytes
Blood, 108 (3), 928-35
DOI 10.1182/blood-2005-09-010629, PubMed 16861346
Publications 2005
The inhibitory effect of ErbB2 on epidermal growth factor-induced formation of clathrin-coated pits correlates with retention of epidermal growth factor receptor-ErbB2 oligomeric complexes at the plasma membrane
Mol Biol Cell, 16 (12), 5832-42
DOI 10.1091/mbc.e05-05-0456, PubMed 16207817
Herceptin-induced inhibition of ErbB2 signaling involves reduced phosphorylation of Akt but not endocytic down-regulation of ErbB2
Int J Cancer, 116 (3), 359-67
DOI 10.1002/ijc.21015, PubMed 15800944
Publications 2004
Direct interaction of Cbl with pTyr 1045 of the EGF receptor (EGFR) is required to sort the EGFR to lysosomes for degradation
Exp Cell Res, 300 (2), 388-95
DOI 10.1016/j.yexcr.2004.07.003, PubMed 15475003
Cbl-dependent ubiquitination is required for progression of EGF receptors into clathrin-coated pits
Mol Biol Cell, 15 (8), 3591-604
DOI 10.1091/mbc.e04-01-0041, PubMed 15194809
Publications 2003
Mutants of the protein serine kinase PSKH1 disassemble the Golgi apparatus
Exp Cell Res, 291 (2), 299-312
DOI 10.1016/j.yexcr.2003.07.009, PubMed 14644153
Publications 2002
Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies
J Cell Biol, 156 (5), 843-54
DOI 10.1083/jcb.200106056, PubMed 11864992
Localizing the EGF receptor
Nat Cell Biol, 4 (2), E22; author reply E22-3
DOI 10.1038/ncb0202-e22a, PubMed 11835048
Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes
Nat Cell Biol, 4 (5), 394-8
DOI 10.1038/ncb791, PubMed 11988743
Inhibitors of COP-mediated transport and cholera toxin action inhibit simian virus 40 infection
Mol Biol Cell, 13 (5), 1750-64
DOI 10.1091/mbc.01-12-0592, PubMed 12006667
Cholesterol is important in control of EGF receptor kinase activity but EGF receptors are not concentrated in caveolae
J Cell Sci, 115 (Pt 6), 1331-40
DOI 10.1242/jcs.115.6.1331, PubMed 11884532
Publications 2001
Heterodimerization of the epidermal-growth-factor (EGF) receptor and ErbB2 and the affinity of EGF binding are regulated by different mechanisms
Biochem J, 356 (Pt 1), 87-96
DOI 10.1042/0264-6021:3560087, PubMed 11336639
Hrs recruits clathrin to early endosomes
EMBO J, 20 (17), 5008-21
DOI 10.1093/emboj/20.17.5008, PubMed 11532964
FYVE and coiled-coil domains determine the specific localisation of Hrs to early endosomes
J Cell Sci, 114 (Pt 12), 2255-63
DOI 10.1242/jcs.114.12.2255, PubMed 11493665
Publications 2000
Polyubiquitination of the epidermal growth factor receptor occurs at the plasma membrane upon ligand-induced activation
J Biol Chem, 275 (18), 13940-7
DOI 10.1074/jbc.275.18.13940, PubMed 10788520
Publications 1999
Characterization of a peptide-loading compartment by monoclonal antibodies
J Immunol Methods, 230 (1-2), 87-97
DOI 10.1016/s0022-1759(99)00125-8, PubMed 10594356
Molecular characterization of caveolin association with the Golgi complex: identification of a cis-Golgi targeting domain in the caveolin molecule
J Cell Biol, 145 (7), 1443-59
DOI 10.1083/jcb.145.7.1443, PubMed 10385524
Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains
Nat Cell Biol, 1 (2), 98-105
DOI 10.1038/10067, PubMed 10559881
Polarized transport of MHC class II molecules in Madin-Darby canine kidney cells is directed by a leucine-based signal in the cytoplasmic tail of the beta-chain
J Immunol, 163 (5), 2540-8
PubMed 10452991
Publications 1998
Major histocompatibility complex class II-dependent antigen presentation by human intestinal endothelial cells
Gastroenterology, 114 (4), 649-56
DOI 10.1016/s0016-5085(98)70578-5, PubMed 9516385
A lipid associated with the antiphospholipid syndrome regulates endosome structure and function
Nature, 392 (6672), 193-7
DOI 10.1038/32440, PubMed 9515966
High-affinity binding of epidermal growth factor (EGF) to EGF receptor is disrupted by overexpression of mutant dynamin (K44A)
J Biol Chem, 273 (27), 16639-42
DOI 10.1074/jbc.273.27.16639, PubMed 9642213
Endocytosed epidermal growth factor (EGF) receptors contribute to the EGF-mediated growth arrest in A431 cells by inducing a sustained increase in p21/CIP1
Exp Cell Res, 243 (1), 161-72
DOI 10.1006/excr.1998.4127, PubMed 9716460
DR/CLIP (class II-associated invariant chain peptides) and DR/peptide complexes colocalize in prelysosomes in human B lymphoblastoid cells
J Immunol, 160 (10), 4696-707
PubMed 9590215
Publications 1997
Caveolin-3 associates with developing T-tubules during muscle differentiation
J Cell Biol, 136 (1), 137-54
DOI 10.1083/jcb.136.1.137, PubMed 9008709
Involvement of the transmembrane protein p23 in biosynthetic protein transport
J Cell Biol, 139 (5), 1119-35
DOI 10.1083/jcb.139.5.1119, PubMed 9382861
Sorting of MHC class II molecules and the associated invariant chain (Ii) in polarized MDCK cells
J Cell Sci, 110 ( Pt 5), 597-609
DOI 10.1242/jcs.110.5.597, PubMed 9092942
MHC class II-associated invariant chain-induced enlarged endosomal structures: a morphological study
Exp Cell Res, 235 (1), 79-92
DOI 10.1006/excr.1997.3617, PubMed 9281355
Major histocompatibility complex class I molecules mediate association of SV40 with caveolae
Mol Biol Cell, 8 (1), 47-57
DOI 10.1091/mbc.8.1.47, PubMed 9017594
Publications 1996
Characterization of a lysozyme-major histocompatibility complex class II molecule-loading compartment as a specialized recycling endosome in murine B lymphocytes
J Biol Chem, 271 (44), 27360-5
DOI 10.1074/jbc.271.44.27360, PubMed 8910313
Chernobyl - System accident or human error?
Radiat. Prot. Dosim., 68 (3-4), 197-201
DOI 10.1093/oxfordjournals.rpd.a031864
Publications 1995
Invariant chain induces a delayed transport from early to late endosomes
J Biol Chem, 270 (6), 2741-6
DOI 10.1074/jbc.270.6.2741, PubMed 7852345
Publications 1993
Receptor-mediated endocytosis of ricin in rat liver endothelial cells. An immunocytochemical study
Eur J Cell Biol, 60 (1), 154-62
PubMed 8462592
The ultrastructural localization of metallothionein in cadmium exposed rat liver
Histochem J, 25 (12), 857-64
PubMed 8113097
Cell surface HLA-DR-invariant chain complexes are targeted to endosomes by rapid internalization
Proc Natl Acad Sci U S A, 90 (18), 8581-5
DOI 10.1073/pnas.90.18.8581, PubMed 8397411
Transfer of retinol-binding protein from HepG2 human hepatoma cells to cocultured rat stellate cells
Proc Natl Acad Sci U S A, 90 (8), 3616-20
DOI 10.1073/pnas.90.8.3616, PubMed 8386378
Publications 1992
Endocytosis and intracellular processing of tissue-type plasminogen activator by rat liver cells in vivo
Biochem J, 282 ( Pt 3) (Pt 3), 841-51
DOI 10.1042/bj2820841, PubMed 1554369
Evidence for carbohydrate-independent endocytosis of tissue-type plasminogen activator by liver cells
Biochem J, 285 ( Pt 3) (Pt 3), 799-804
DOI 10.1042/bj2850799, PubMed 1323274
Publications 1991
Endocytosis of the recombinant tissue plasminogen activator alteplase by hepatic endothelial cells
Arzneimittelforschung, 41 (2), 182-6
PubMed 1904231
An immunocytochemical study of receptor-mediated endocytosis in rat liver cells: with special reference to sinusoidal endothelial cells
[E. Stang], Oslo, 1 b. (flere pag.)
BIBSYS 911429131
HEPATIC ENDOCYTOSIS OF TISSUE-TYPE PLASMINOGEN-ACTIVATOR WITH SPECIAL REFERENCE TO THE SINUSOIDAL CELLS
CELLS OF THE HEPATIC SINUSOID, VOL 3, 542-545
Pharmacokinetics and hepatic catabolism of tissue-type plasminogen activator
Arzneimittelforschung, 41 (12), 1310-9
PubMed 1815534
Publications 1990
Intracellular transport of endocytosed proteins in rat liver endothelial cells
Biochem J, 270 (1), 205-11
DOI 10.1042/bj2700205, PubMed 2396981
Internalization of retinol-binding protein in parenchymal and stellate cells of rat liver
J Lipid Res, 31 (7), 1229-39
PubMed 2401856
Endocytosis mediated by the mannose receptor in liver endothelial cells. An immunocytochemical study
Eur J Cell Biol, 52 (1), 67-76
PubMed 2387309
Publications 1988
MODIFICATION OF THE LKB 7800 SERIES KNIFEMAKER FOR SYMMETRICAL BREAKING OF CRYO KNIVES
J. Microsc.-Oxf., 149, 77-79
DOI 10.1111/j.1365-2818.1988.tb04564.x
Publications 1985
Kalkkroppdannelse i Diphyllobothrium dendriticum (Cestoda): En ultrastrukturell og røntgenmikroanalytisk undersøkelse
E. Stang, Oslo, 138 s.
BIBSYS 961217022