Elin Bergseng
Position: Research Fellow
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Author network for Elin Bergseng by COREMINE medical


Publications 2017

Gunnarsen KS, Høydahl LS, Risnes LF, Dahal-Koirala S, Neumann RS, Bergseng E, Frigstad T, Frick R, du Pré MF, Dalhus B, Lundin KE, Qiao SW, Sollid LM, Sandlie I, Løset GÅ (2017)
A TCRα framework-centered codon shapes a biased T cell repertoire through direct MHC and CDR3β interactions
JCI Insight, 2 (17) (in press)
PubMed 28878121

Nguyen TB, Jayaraman P, Bergseng E, Madhusudhan MS, Kim CY, Sollid LM (2017)
Unraveling the structural basis for the unusually rich association of human leukocyte antigen DQ2.5 with class-II-associated invariant chain peptides
J Biol Chem, 292 (22), 9218-9228
PubMed 28364043

Publications 2016

Christophersen A, Risnes LF, Bergseng E, Lundin KE, Sollid LM, Qiao SW (2016)
Healthy HLA-DQ2.5+ Subjects Lack Regulatory and Memory T Cells Specific for Immunodominant Gluten Epitopes of Celiac Disease
J Immunol, 196 (6), 2819-26
PubMed 26895834

Dørum S, Steinsbø Ø, Bergseng E, Arntzen MØ, de Souza GA, Sollid LM (2016)
Gluten-specific antibodies of celiac disease gut plasma cells recognize long proteolytic fragments that typically harbor T-cell epitopes
Sci Rep, 6, 25565
PubMed 27146306

Publications 2015

Sollid LM, Iversen R, Steinsbø Ø, Qiao SW, Bergseng E, Dørum S, du Pré MF, Stamnaes J, Christophersen A, Cardoso I, Hnida K, Chen X, Snir O, Lundin KE (2015)
Small bowel, celiac disease and adaptive immunity
Dig Dis, 33 (2), 115-21
PubMed 25925911

Publications 2014

Bergseng E, Dørum S, Arntzen MØ, Nielsen M, Nygård S, Buus S, de Souza GA, Sollid LM (2014)
Different binding motifs of the celiac disease-associated HLA molecules DQ2.5, DQ2.2, and DQ7.5 revealed by relative quantitative proteomics of endogenous peptide repertoires
Immunogenetics, 67 (2), 73-84
PubMed 25502872

Christophersen A, Ráki M, Bergseng E, Lundin KE, Jahnsen J, Sollid LM, Qiao SW (2014)
Tetramer-visualized gluten-specific CD4+ T cells in blood as a potential diagnostic marker for coeliac disease without oral gluten challenge
United European Gastroenterol J, 2 (4), 268-78
PubMed 25083284

Dørum S, Bodd M, Fallang LE, Bergseng E, Christophersen A, Johannesen MK, Qiao SW, Stamnaes J, de Souza GA, Sollid LM (2014)
HLA-DQ molecules as affinity matrix for identification of gluten T cell epitopes
J Immunol, 193 (9), 4497-506
PubMed 25261484

Publications 2013

Bodd M, Ráki M, Bergseng E, Jahnsen J, Lundin KE, Sollid LM (2013)
Direct cloning and tetramer staining to measure the frequency of intestinal gluten-reactive T cells in celiac disease
Eur J Immunol, 43 (10), 2605-12
PubMed 23775608

Publications 2012

Bodd M, Tollefsen S, Bergseng E, Lundin KE, Sollid LM (2012)
Evidence that HLA-DQ9 confers risk to celiac disease by presence of DQ9-restricted gluten-specific T cells
Hum Immunol, 73 (4), 376-81
PubMed 22342873

Publications 2011

Brottveit M, Ráki M, Bergseng E, Fallang LE, Simonsen B, Løvik A, Larsen S, Løberg EM, Jahnsen FL, Sollid LM, Lundin KE (2011)
Assessing possible celiac disease by an HLA-DQ2-gliadin Tetramer Test
Am J Gastroenterol, 106 (7), 1318-24
PubMed 21364548

Publications 2010

Bodd M, Ráki M, Tollefsen S, Fallang LE, Bergseng E, Lundin KE, Sollid LM (2010)
HLA-DQ2-restricted gluten-reactive T cells produce IL-21 but not IL-17 or IL-22
Mucosal Immunol, 3 (6), 594-601
PubMed 20571486

Publications 2009

Bethune MT, Crespo-Bosque M, Bergseng E, Mazumdar K, Doyle L, Sestak K, Sollid LM, Khosla C (2009)
Noninflammatory gluten peptide analogs as biomarkers for celiac sprue
Chem Biol, 16 (8), 868-81
PubMed 19716477

Fallang LE, Bergseng E, Hotta K, Berg-Larsen A, Kim CY, Sollid LM (2009)
Differences in the risk of celiac disease associated with HLA-DQ2.5 or HLA-DQ2.2 are related to sustained gluten antigen presentation
Nat Immunol, 10 (10), 1096-101
PubMed 19718029

Publications 2008

Bergseng E, Sidney J, Sette A, Sollid LM (2008)
Analysis of the binding of gluten T-cell epitopes to various human leukocyte antigen class II molecules
Hum Immunol, 69 (2), 94-100
PubMed 18361933

Fallang LE, Roh S, Holm A, Bergseng E, Yoon T, Fleckenstein B, Bandyopadhyay A, Mellins ED, Sollid LM (2008)
Complexes of two cohorts of CLIP peptides and HLA-DQ2 of the autoimmune DR3-DQ2 haplotype are poor substrates for HLA-DM
J Immunol, 181 (8), 5451-5461
PubMed 18832702

Jüse U, Fleckenstein B, Bergseng E, Sollid LM (2008)
Soluble HLA-DQ2 expressed in S2 cells copurifies with a high affinity insect cell derived protein
Immunogenetics, 61 (2), 81-9
PubMed 18987854

Publications 2007

Ráki M, Fallang LE, Brottveit M, Bergseng E, Quarsten H, Lundin KE, Sollid LM (2007)
Tetramer visualization of gut-homing gluten-specific T cells in the peripheral blood of celiac disease patients
Proc Natl Acad Sci U S A, 104 (8), 2831-6
PubMed 17307878

Xia J, Bergseng E, Fleckenstein B, Siegel M, Kim CY, Khosla C, Sollid LM (2007)
Cyclic and dimeric gluten peptide analogues inhibiting DQ2-mediated antigen presentation in celiac disease
Bioorg Med Chem, 15 (20), 6565-73
PubMed 17681795

Publications 2006

Xia J, Siegel M, Bergseng E, Sollid LM, Khosla C (2006)
Inhibition of HLA-DQ2-mediated antigen presentation by analogues of a high affinity 33-residue peptide from alpha2-gliadin
J Am Chem Soc, 128 (6), 1859-67
PubMed 16464085

Publications 2005

Bergseng E, Xia J, Kim CY, Khosla C, Sollid LM (2005)
Main chain hydrogen bond interactions in the binding of proline-rich gluten peptides to the celiac disease-associated HLA-DQ2 molecule
J Biol Chem, 280 (23), 21791-6
PubMed 15826953

Qiao SW, Bergseng E, Molberg O, Jung G, Fleckenstein B, Sollid LM (2005)
Refining the rules of gliadin T cell epitope binding to the disease-associated DQ2 molecule in celiac disease: importance of proline spacing and glutamine deamidation
J Immunol, 175 (1), 254-61
PubMed 15972656

Publications 2004

Kim CY, Quarsten H, Bergseng E, Khosla C, Sollid LM (2004)
Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease
Proc Natl Acad Sci U S A, 101 (12), 4175-9
PubMed 15020763

Qiao SW, Bergseng E, Molberg Ø, Xia J, Fleckenstein B, Khosla C, Sollid LM (2004)
Antigen presentation to celiac lesion-derived T cells of a 33-mer gliadin peptide naturally formed by gastrointestinal digestion
J Immunol, 173 (3), 1757-62
PubMed 15265905