Rolf I. Skotheim
Position: Group leader, Dr.philos
Phone: +47 2278 1727
Email:
Rolf Skotheim is heading the Genome biology group at the Department of molecular oncology, Institute for cancer research, Oslo university hospital-Radiumhospitalet.

Current research projects are summarised from the Genome biology group's webpage.
 

Author network for Rolf Inge Skotheim by COREMINE medical


Publications 2017

Berg KCG, Eide PW, Eilertsen IA, Johannessen B, Bruun J, Danielsen SA, Bjørnslett M, Meza-Zepeda LA, Eknæs M, Lind GE, Myklebost O, Skotheim RI, Sveen A, Lothe RA (2017)
Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies
Mol Cancer, 16 (1), 116
PubMed 28683746

Lågstad S, Zhao S, Hoff AM, Johannessen B, Christian Lingjærde O, Skotheim RI (2017)
chimeraviz: A tool for visualizing chimeric RNA
Bioinformatics (in press)
PubMed 28525538

Sveen A, Johannessen B, Tengs T, Danielsen SA, Eilertsen IA, Lind GE, Berg KCG, Leithe E, Meza-Zepeda LA, Domingo E, Myklebost O, Kerr D, Tomlinson I, Nesbakken A, Skotheim RI, Lothe RA (2017)
Multilevel genomics of colorectal cancers with microsatellite instability-clinical impact of JAK1 mutations and consensus molecular subtype 1
Genome Med, 9 (1), 46
PubMed 28539123

Zhao S, Løvf M, Carm KT, Bakken AC, Hoff AM, Skotheim RI (2017)
Novel transcription-induced fusion RNAs in prostate cancer
Oncotarget, 8 (30), 49133-49143
PubMed 28467780

Publications 2016

Cekaite L, Eide PW, Lind GE, Skotheim RI, Lothe RA (2016)
MicroRNAs as growth regulators, their function and biomarker status in colorectal cancer
Oncotarget, 7 (6), 6476-505
PubMed 26623728

Lorenz S, Barøy T, Sun J, Nome T, Vodák D, Bryne JC, Håkelien AM, Fernandez-Cuesta L, Möhlendick B, Rieder H, Szuhai K, Zaikova O, Ahlquist TC, Thomassen GO, Skotheim RI, Lothe RA, Tarpey PS, Campbell P, Flanagan A, Myklebost O, Meza-Zepeda LA (2016)
Unscrambling the genomic chaos of osteosarcoma reveals extensive transcript fusion, recurrent rearrangements and frequent novel TP53 aberrations
Oncotarget, 7 (5), 5273-88
PubMed 26672768

Moen LV, Ramberg H, Zhao S, Grytli HH, Sveen A, Berge V, Skotheim RI, Taskén KA, Skålhegg BS (2016)
Observed correlation between the expression levels of catalytic subunit, Cβ2, of cyclic adenosine monophosphate-dependent protein kinase and prostate cancer aggressiveness
Urol Oncol, 35 (3), 111.e1-111.e8
PubMed 27838142

Ramberg H, Grytli HH, Nygård S, Wang W, Ögren O, Zhao S, Løvf M, Katz B, Skotheim RI, Bjartell A, Eri LM, Berge V, Svindland A, Taskén KA (2016)
PBX3 is a putative biomarker of aggressive prostate cancer
Int J Cancer, 139 (8), 1810-20
PubMed 27273830

Smebye ML, Haugom L, Davidson B, Trope CG, Heim S, Skotheim RI, Micci F (2016)
Bilateral ovarian carcinomas differ in the expression of metastasis-related genes
Oncol Lett, 13 (1), 184-190
PubMed 28123539

Publications 2015

Brabrand S, Johannessen B, Axcrona U, Kraggerud SM, Berg KG, Bakken AC, Bruun J, Fosså SD, Lothe RA, Lehne G, Skotheim RI (2015)
Exome sequencing of bilateral testicular germ cell tumors suggests independent development lineages
Neoplasia, 17 (2), 167-74
PubMed 25748235

Bruun J, Kolberg M, Ahlquist TC, Røyrvik EC, Nome T, Leithe E, Lind GE, Merok MA, Rognum TO, Bjørkøy G, Johansen T, Lindblom A, Sun XF, Svindland A, Liestøl K, Nesbakken A, Skotheim RI, Lothe RA (2015)
Regulator of Chromosome Condensation 2 Identifies High-Risk Patients within Both Major Phenotypes of Colorectal Cancer
Clin Cancer Res, 21 (16), 3759-70
PubMed 25910952

Hoff AM, Alagaratnam S, Zhao S, Bruun J, Andrews PW, Lothe RA, Skotheim RI (2015)
Identification of Novel Fusion Genes in Testicular Germ Cell Tumors
Cancer Res, 76 (1), 108-16
PubMed 26659575

Hoff AM, Johannessen B, Alagaratnam S, Zhao S, Nome T, Løvf M, Bakken AC, Hektoen M, Sveen A, Lothe RA, Skotheim RI (2015)
Novel RNA variants in colorectal cancers
Oncotarget, 6 (34), 36587-602
PubMed 26474385

Johannessen B, Sveen A, Skotheim RI (2015)
TIN: An R Package for Transcriptome Instability Analysis
Cancer Inform, 14, 109-12
PubMed 26448683

Kolberg M, Høland M, Lind GE, Ågesen TH, Skotheim RI, Hall KS, Mandahl N, Smeland S, Mertens F, Davidson B, Lothe RA (2015)
Protein expression of BIRC5, TK1, and TOP2A in malignant peripheral nerve sheath tumours--A prognostic test after surgical resection
Mol Oncol, 9 (6), 1129-39
PubMed 25769404

Mesquita D, Barros-Silva JD, Santos J, Skotheim RI, Lothe RA, Paulo P, Teixeira MR (2015)
Specific and redundant activities of ETV1 and ETV4 in prostate cancer aggressiveness revealed by co-overexpression cellular contexts
Oncotarget, 6 (7), 5217-36
PubMed 25595908

Munkley J, Oltean S, Vodák D, Wilson BT, Livermore KE, Zhou Y, Star E, Floros VI, Johannessen B, Knight B, McCullagh P, McGrath J, Crundwell M, Skotheim RI, Robson CN, Leung HY, Harries LW, Rajan P, Mills IG, Elliott DJ (2015)
The androgen receptor controls expression of the cancer-associated sTn antigen and cell adhesion through induction of ST6GalNAc1 in prostate cancer
Oncotarget, 6 (33), 34358-74
PubMed 26452038

Rounge TB, Furu K, Skotheim RI, Haugen TB, Grotmol T, Enerly E (2015)
Profiling of the small RNA populations in human testicular germ cell tumors shows global loss of piRNAs
Mol Cancer, 14, 153
PubMed 26265322

Sveen A, Kilpinen S, Ruusulehto A, Lothe RA, Skotheim RI (2015)
Aberrant RNA splicing in cancer; expression changes and driver mutations of splicing factor genes
Oncogene, 35 (19), 2413-27
PubMed 26300000

Publications 2014

Løvf M, Nome T, Bruun J, Eknaes M, Bakken AC, Mpindi JP, Kilpinen S, Rognum TO, Nesbakken A, Kallioniemi O, Lothe RA, Skotheim RI (2014)
A novel transcript, VNN1-AB, as a biomarker for colorectal cancer
Int J Cancer, 135 (9), 2077-84
PubMed 24687856

Nome T, Hoff AM, Bakken AC, Rognum TO, Nesbakken A, Skotheim RI (2014)
High frequency of fusion transcripts involving TCF7L2 in colorectal cancer: novel fusion partner and splice variants
PLoS One, 9 (3), e91264
PubMed 24608966

Oppelt A, Haugsten EM, Zech T, Danielsen HE, Sveen A, Lobert VH, Skotheim RI, Wesche J (2014)
PIKfyve, MTMR3 and their product PtdIns5P regulate cancer cell migration and invasion through activation of Rac1
Biochem J, 461 (3), 383-90
PubMed 24840251

Smebye ML, Sveen A, Haugom L, Davidson B, Tropé CG, Lothe RA, Heim S, Skotheim RI, Micci F (2014)
Chromosome 19 rearrangements in ovarian carcinomas: zinc finger genes are particularly targeted
Genes Chromosomes Cancer, 53 (7), 558-67
PubMed 24634323

Sveen A, Johannessen B, Teixeira MR, Lothe RA, Skotheim RI (2014)
Transcriptome instability as a molecular pan-cancer characteristic of carcinomas
BMC Genomics, 15, 672
PubMed 25109687

Vedeld HM, Skotheim RI, Lothe RA, Lind GE (2014)
The recently suggested intestinal cancer stem cell marker DCLK1 is an epigenetic biomarker for colorectal cancer
Epigenetics, 9 (3), 346-50
PubMed 24384857

Publications 2013

Alagaratnam S, Harrison N, Bakken AC, Hoff AM, Jones M, Sveen A, Moore HD, Andrews PW, Lothe RA, Skotheim RI (2013)
Transforming pluripotency: an exon-level study of malignancy-specific transcripts in human embryonal carcinoma and embryonic stem cells
Stem Cells Dev, 22 (7), 1136-46
PubMed 23137282

Avery S, Hirst AJ, Baker D, Lim CY, Alagaratnam S, Skotheim RI, Lothe RA, Pera MF, Colman A, Robson P, Andrews PW, Knowles BB (2013)
BCL-XL mediates the strong selective advantage of a 20q11.21 amplification commonly found in human embryonic stem cell cultures
Stem Cell Reports, 1 (5), 379-86
PubMed 24286026

Barros-Silva JD, Paulo P, Bakken AC, Cerveira N, Løvf M, Henrique R, Jerónimo C, Lothe RA, Skotheim RI, Teixeira MR (2013)
Novel 5' fusion partners of ETV1 and ETV4 in prostate cancer
Neoplasia, 15 (7), 720-6
PubMed 23814484

Chung CC, Kanetsky PA, Wang Z, Hildebrandt MA, Koster R, Skotheim RI, Kratz CP, Turnbull C, Cortessis VK, Bakken AC, Bishop DT, Cook MB, Erickson RL, Fosså SD, Jacobs KB, Korde LA, Kraggerud SM, Lothe RA, Loud JT, Rahman N, Skinner EC, Thomas DC, Wu X, Yeager M, Schumacher FR et al. (2013)
Meta-analysis identifies four new loci associated with testicular germ cell tumor
Nat Genet, 45 (6), 680-5
PubMed 23666239

Kraggerud SM, Hoei-Hansen CE, Alagaratnam S, Skotheim RI, Abeler VM, Rajpert-De Meyts E, Lothe RA (2013)
Molecular characteristics of malignant ovarian germ cell tumors and comparison with testicular counterparts: implications for pathogenesis
Endocr Rev, 34 (3), 339-76
PubMed 23575763

Løvf M, Thomassen GO, Mertens F, Cerveira N, Teixeira MR, Lothe RA, Skotheim RI (2013)
Assessment of fusion gene status in sarcomas using a custom made fusion gene microarray
PLoS One, 8 (8), e70649
PubMed 23967081

Nome T, Thomassen GO, Bruun J, Ahlquist T, Bakken AC, Hoff AM, Rognum T, Nesbakken A, Lorenz S, Sun J, Barros-Silva JD, Lind GE, Myklebost O, Teixeira MR, Meza-Zepeda LA, Lothe RA, Skotheim RI (2013)
Common fusion transcripts identified in colorectal cancer cell lines by high-throughput RNA sequencing
Transl Oncol, 6 (5), 546-53
PubMed 24151535

Schumacher FR, Wang Z, Skotheim RI, Koster R, Chung CC, Hildebrandt MA, Kratz CP, Bakken AC, Bishop DT, Cook MB, Erickson RL, Fosså SD, Greene MH, Jacobs KB, Kanetsky PA, Kolonel LN, Loud JT, Korde LA, Le Marchand L, Lewinger JP, Lothe RA, Pike MC, Rahman N, Rubertone MV, Schwartz SM et al. (2013)
Testicular germ cell tumor susceptibility associated with the UCK2 locus on chromosome 1q23
Hum Mol Genet, 22 (13), 2748-53
PubMed 23462292

Sveen A, Nesbakken A, Ågesen TH, Guren MG, Tveit KM, Skotheim RI, Lothe RA (2013)
Anticipating the clinical use of prognostic gene expression-based tests for colon cancer stage II and III: is Godot finally arriving?
Clin Cancer Res, 19 (24), 6669-77
PubMed 24166914

Publications 2012

Agesen TH, Sveen A, Merok MA, Lind GE, Nesbakken A, Skotheim RI, Lothe RA (2012)
ColoGuideEx: a robust gene classifier specific for stage II colorectal cancer prognosis
Gut, 61 (11), 1560-7
PubMed 22213796

Camões MJ, Paulo P, Ribeiro FR, Barros-Silva JD, Almeida M, Costa VL, Cerveira N, Skotheim RI, Lothe RA, Henrique R, Jerónimo C, Teixeira MR (2012)
Potential downstream target genes of aberrant ETS transcription factors are differentially affected in Ewing's sarcoma and prostate carcinoma
PLoS One, 7 (11), e49819
PubMed 23185447

Cekaite L, Rantala JK, Bruun J, Guriby M, Agesen TH, Danielsen SA, Lind GE, Nesbakken A, Kallioniemi O, Lothe RA, Skotheim RI (2012)
MiR-9, -31, and -182 deregulation promote proliferation and tumor cell survival in colon cancer
Neoplasia, 14 (9), 868-79
PubMed 23019418

Celestino R, Sigstad E, Løvf M, Thomassen GO, Grøholt KK, Jørgensen LH, Berner A, Castro P, Lothe RA, Bjøro T, Sobrinho-Simões M, Soares P, Skotheim RI (2012)
Survey of 548 oncogenic fusion transcripts in thyroid tumors supports the importance of the already established thyroid fusions genes
Genes Chromosomes Cancer, 51 (12), 1154-64
PubMed 22961909

Matheu A, Collado M, Wise C, Manterola L, Cekaite L, Tye AJ, Canamero M, Bujanda L, Schedl A, Cheah KS, Skotheim RI, Lothe RA, López de Munain A, Briscoe J, Serrano M, Lovell-Badge R (2012)
Oncogenicity of the developmental transcription factor Sox9
Cancer Res, 72 (5), 1301-15
PubMed 22246670

Nyquist KB, Panagopoulos I, Thorsen J, Haugom L, Gorunova L, Bjerkehagen B, Fosså A, Guriby M, Nome T, Lothe RA, Skotheim RI, Heim S, Micci F (2012)
Whole-transcriptome sequencing identifies novel IRF2BP2-CDX1 fusion gene brought about by translocation t(1;5)(q42;q32) in mesenchymal chondrosarcoma
PLoS One, 7 (11), e49705
PubMed 23185413

Paulo P, Ribeiro FR, Santos J, Mesquita D, Almeida M, Barros-Silva JD, Itkonen H, Henrique R, Jerónimo C, Sveen A, Mills IG, Skotheim RI, Lothe RA, Teixeira MR (2012)
Molecular subtyping of primary prostate cancer reveals specific and shared target genes of different ETS rearrangements
Neoplasia, 14 (7), 600-11
PubMed 22904677

Skotheim RI, Meza-Zepeda LA, Hovig E, Lønning PE, Lothe RA, Myklebost O (2012)
[Genome sequencing for personalized cancer treatment]
Tidsskr Nor Laegeforen, 132 (21), 2406-8
PubMed 23160594

Sveen A, Bakken AC, Ågesen TH, Lind GE, Nesbakken A, Nordgård O, Brackmann S, Rognum TO, Lothe RA, Skotheim RI (2012)
The exon-level biomarker SLC39A14 has organ-confined cancer-specificity in colorectal cancer
Int J Cancer, 131 (6), 1479-85
PubMed 22173985

Sveen A, Ågesen TH, Nesbakken A, Meling GI, Rognum TO, Liestøl K, Skotheim RI, Lothe RA (2012)
ColoGuidePro: a prognostic 7-gene expression signature for stage III colorectal cancer patients
Clin Cancer Res, 18 (21), 6001-10
PubMed 22991413

Publications 2011

Alagaratnam S, Lind GE, Kraggerud SM, Lothe RA, Skotheim RI (2011)
The testicular germ cell tumour transcriptome
Int J Androl, 34 (4 Pt 2), e133-50; discussion e150-1
PubMed 21651573

Danielsen SA, Cekaite L, Ågesen TH, Sveen A, Nesbakken A, Thiis-Evensen E, Skotheim RI, Lind GE, Lothe RA (2011)
Phospholipase C isozymes are deregulated in colorectal cancer--insights gained from gene set enrichment analysis of the transcriptome
PLoS One, 6 (9), e24419
PubMed 21909432

Lind GE, Danielsen SA, Ahlquist T, Merok MA, Andresen K, Skotheim RI, Hektoen M, Rognum TO, Meling GI, Hoff G, Bretthauer M, Thiis-Evensen E, Nesbakken A, Lothe RA (2011)
Identification of an epigenetic biomarker panel with high sensitivity and specificity for colorectal cancer and adenomas
Mol Cancer, 10, 85
PubMed 21777459

Løvf M, Thomassen GO, Bakken AC, Celestino R, Fioretos T, Lind GE, Lothe RA, Skotheim RI (2011)
Fusion gene microarray reveals cancer type-specificity among fusion genes
Genes Chromosomes Cancer, 50 (5), 348-57
PubMed 21305644

Paulo P, Barros-Silva JD, Ribeiro FR, Ramalho-Carvalho J, Jerónimo C, Henrique R, Lind GE, Skotheim RI, Lothe RA, Teixeira MR (2011)
FLI1 is a novel ETS transcription factor involved in gene fusions in prostate cancer
Genes Chromosomes Cancer, 51 (3), 240-9
PubMed 22081504

Ribeiro FR, Paulo P, Costa VL, Barros-Silva JD, Ramalho-Carvalho J, Jerónimo C, Henrique R, Lind GE, Skotheim RI, Lothe RA, Teixeira MR (2011)
Cysteine-rich secretory protein-3 (CRISP3) is strongly up-regulated in prostate carcinomas with the TMPRSS2-ERG fusion gene
PLoS One, 6 (7), e22317
PubMed 21814574

Sagona AP, Nezis IP, Bache KG, Haglund K, Bakken AC, Skotheim RI, Stenmark H (2011)
A tumor-associated mutation of FYVE-CENT prevents its interaction with Beclin 1 and interferes with cytokinesis
PLoS One, 6 (3), e17086
PubMed 21455500

Sveen A, Agesen TH, Nesbakken A, Rognum TO, Lothe RA, Skotheim RI (2011)
Transcriptome instability in colorectal cancer identified by exon microarray analyses: Associations with splicing factor expression levels and patient survival
Genome Med, 3 (5), 32
PubMed 21619627

Ågesen TH, Berg M, Clancy T, Thiis-Evensen E, Cekaite L, Lind GE, Nesland JM, Bakka A, Mala T, Hauss HJ, Fetveit T, Vatn MH, Hovig E, Nesbakken A, Lothe RA, Skotheim RI (2011)
CLC and IFNAR1 are differentially expressed and a global immunity score is distinct between early- and late-onset colorectal cancer
Genes Immun, 12 (8), 653-62
PubMed 21716316

Publications 2010

Berg M, Agesen TH, Thiis-Evensen E, INFAC-study group, Merok MA, Teixeira MR, Vatn MH, Nesbakken A, Skotheim RI, Lothe RA (2010)
Distinct high resolution genome profiles of early onset and late onset colorectal cancer integrated with gene expression data identify candidate susceptibility loci
Mol Cancer, 9, 100
PubMed 20459617

Brekke HR, Ribeiro FR, Kolberg M, Agesen TH, Lind GE, Eknaes M, Hall KS, Bjerkehagen B, van den Berg E, Teixeira MR, Mandahl N, Smeland S, Mertens F, Skotheim RI, Lothe RA (2010)
Genomic changes in chromosomes 10, 16, and X in malignant peripheral nerve sheath tumors identify a high-risk patient group
J Clin Oncol, 28 (9), 1573-82
PubMed 20159821

Burum-Auensen E, Skotheim RI, Schjølberg AR, Røislien J, Lothe RA, Clausen OP (2010)
Spindle proteins are differentially expressed in the various histological subtypes of testicular germ cell tumors
J Carcinog, 9, 1
PubMed 20411023

Costa VL, Henrique R, Danielsen SA, Duarte-Pereira S, Eknaes M, Skotheim RI, Rodrigues A, Magalhães JS, Oliveira J, Lothe RA, Teixeira MR, Jerónimo C, Lind GE (2010)
Three epigenetic biomarkers, GDF15, TMEFF2, and VIM, accurately predict bladder cancer from DNA-based analyses of urine samples
Clin Cancer Res, 16 (23), 5842-51
PubMed 20975101

Micci F, Skotheim RI, Haugom L, Weimer J, Eibak AM, Abeler VM, Trope CG, Arnold N, Lothe RA, Heim S (2010)
Array-CGH analysis of microdissected chromosome 19 markers in ovarian carcinoma identifies candidate target genes
Genes Chromosomes Cancer, 49 (11), 1046-53
PubMed 20725991

Sagona AP, Nezis IP, Pedersen NM, Liestøl K, Poulton J, Rusten TE, Skotheim RI, Raiborg C, Stenmark H (2010)
PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody
Nat Cell Biol, 12 (4), 362-71
PubMed 20208530

Publications 2009

Brekke HR, Kolberg M, Skotheim RI, Hall KS, Bjerkehagen B, Risberg B, Domanski HA, Mandahl N, Liestøl K, Smeland S, Danielsen HE, Mertens F, Lothe RA (2009)
Identification of p53 as a strong predictor of survival for patients with malignant peripheral nerve sheath tumors
Neuro Oncol, 11 (5), 514-28
PubMed 19182148

Godmann M, Gashaw I, Eildermann K, Schweyer S, Bergmann M, Skotheim RI, Behr R (2009)
The pluripotency transcription factor Krüppel-like factor 4 is strongly expressed in intratubular germ cell neoplasia unclassified and seminoma
Mol Hum Reprod, 15 (8), 479-88
PubMed 19505997

Micci F, Weimer J, Haugom L, Skotheim RI, Grunewald R, Abeler VM, Silins I, Lothe RA, Trope CG, Arnold N, Heim S (2009)
Reverse painting of microdissected chromosome 19 markers in ovarian carcinoma identifies a complex rearrangement map
Genes Chromosomes Cancer, 48 (2), 184-93
PubMed 18973136

Skotheim RI, Thomassen GO, Eken M, Lind GE, Micci F, Ribeiro FR, Cerveira N, Teixeira MR, Heim S, Rognes T, Lothe RA (2009)
A universal assay for detection of oncogenic fusion transcripts by oligo microarray analysis
Mol Cancer, 8, 5
PubMed 19152679

Publications 2008

Ahlquist T, Lind GE, Costa VL, Meling GI, Vatn M, Hoff GS, Rognum TO, Skotheim RI, Thiis-Evensen E, Lothe RA (2008)
Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers
Mol Cancer, 7, 94
PubMed 19117505

Alagaratnam S, Hardy JR, Lothe RA, Skotheim RI, Byrne JA (2008)
TPD52, a candidate gene from genomic studies, is overexpressed in testicular germ cell tumours
Mol Cell Endocrinol, 306 (1-2), 75-80
PubMed 19041365

Kilpinen S, Autio R, Ojala K, Iljin K, Bucher E, Sara H, Pisto T, Saarela M, Skotheim RI, Björkman M, Mpindi JP, Haapa-Paananen S, Vainio P, Edgren H, Wolf M, Astola J, Nees M, Hautaniemi S, Kallioniemi O (2008)
Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues
Genome Biol, 9 (9), R139
PubMed 18803840

Lind GE, Ahlquist T, Kolberg M, Berg M, Eknaes M, Alonso MA, Kallioniemi A, Meling GI, Skotheim RI, Rognum TO, Thiis-Evensen E, Lothe RA (2008)
Hypermethylated MAL gene - a silent marker of early colon tumorigenesis
J Transl Med, 6, 13
PubMed 18346269

Publications 2007

Almstrup K, Leffers H, Lothe RA, Skakkebaek NE, Sonne SB, Nielsen JE, Rajpert-De Meyts E, Skotheim RI (2007)
Improved gene expression signature of testicular carcinoma in situ
Int J Androl, 30 (4), 292-302; discussion 303
PubMed 17488342

Kleivi K, Lind GE, Diep CB, Meling GI, Brandal LT, Nesland JM, Myklebost O, Rognum TO, Giercksky KE, Skotheim RI, Lothe RA (2007)
Gene expression profiles of primary colorectal carcinomas, liver metastases, and carcinomatoses
Mol Cancer, 6, 2
PubMed 17201907

Lind GE, Skotheim RI, Lothe RA (2007)
The epigenome of testicular germ cell tumors
APMIS, 115 (10), 1147-60
PubMed 18042148

Skotheim RI, Nees M (2007)
Alternative splicing in cancer: noise, functional, or systematic?
Int J Biochem Cell Biol, 39 (7-8), 1432-49
PubMed 17416541

Publications 2006

Iljin K, Wolf M, Edgren H, Gupta S, Kilpinen S, Skotheim RI, Peltola M, Smit F, Verhaegh G, Schalken J, Nees M, Kallioniemi O (2006)
TMPRSS2 fusions with oncogenic ETS factors in prostate cancer involve unbalanced genomic rearrangements and are associated with HDAC1 and epigenetic reprogramming
Cancer Res, 66 (21), 10242-6
PubMed 17079440

Lind GE, Skotheim RI, Fraga MF, Abeler VM, Esteller M, Lothe RA (2006)
Novel epigenetically deregulated genes in testicular cancer include homeobox genes and SCGB3A1 (HIN-1)
J Pathol, 210 (4), 441-9
PubMed 17029216

Lothe RA, Skotheim RI, Kallioniemi O, Esteller M (2006)
To the Readers and Future Authors of Critical Reviews in Oncogenesis
Critical Reviews in Oncogenesis, 12 (1-2), 1-2
PublikaID 27

Skotheim RI, Autio R, Lind GE, Kraggerud SM, Andrews PW, Monni O, Kallioniemi O, Lothe RA (2006)
Novel genomic aberrations in testicular germ cell tumors by array-CGH, and associated gene expression changes
Cell Oncol, 28 (5-6), 315-26
PubMed 17167184

von Eyben FE, Jacobsen GK, Skotheim RI, von der Maase H, Rorth M (2006)
Precursor lesions in testis and dysgenetic gonads
Hum Pathol, 37 (6), 773; author reply 774
PubMed 16733221

Publications 2005

Hofer MD, Browne TJ, He L, Skotheim RI, Lothe RA, Rubin MA (2005)
Identification of two molecular groups of seminomas by using expression and tissue microarrays
Clin Cancer Res, 11 (16), 5722-9
PubMed 16115909

Lind GE, Skotheim RI, Fraga MF, Abeler VM, Henrique R, Saatcioglu F, Esteller M, Teixeira MR, Lothe RA (2005)
The loss of NKX3.1 expression in testicular--and prostate--cancers is not caused by promoter hypermethylation
Mol Cancer, 4 (1), 8
PubMed 15691383

Skotheim RI, Lind GE, Monni O, Nesland JM, Abeler VM, Fosså SD, Duale N, Brunborg G, Kallioniemi O, Andrews PW, Lothe RA (2005)
Differentiation of human embryonal carcinomas in vitro and in vivo reveals expression profiles relevant to normal development
Cancer Res, 65 (13), 5588-98
PubMed 15994931

von Eyben FE, Jacobsen GK, Skotheim RI (2005)
Microinvasive germ cell tumor of the testis
Virchows Arch, 447 (3), 610-25
PubMed 15968545

Publications 2003

Kraggerud SM, Lee MP, Skotheim RI, Stenwig AE, Fosså SD, Feinberg AP, Lothe RA (2003)
Lack of parental origin specificity of altered alleles at 11p15 in testicular germ cell tumors
Cancer Genet Cytogenet, 147 (1), 1-8
PubMed 14580764

Skotheim RI, Abeler VM, Nesland JM, Fosså SD, Holm R, Wagner U, Flørenes VA, Aass N, Kallioniemi OP, Lothe RA (2003)
Candidate genes for testicular cancer evaluated by in situ protein expression analyses on tissue microarrays
Neoplasia, 5 (5), 397-404
PubMed 14670177

Skotheim RI, Kallioniemi A, Bjerkhagen B, Mertens F, Brekke HR, Monni O, Mousses S, Mandahl N, Soeter G, Nesland JM, Smeland S, Kallioniemi OP, Lothe RA (2003)
Topoisomerase-II alpha is upregulated in malignant peripheral nerve sheath tumors and associated with clinical outcome
J Clin Oncol, 21 (24), 4586-91
PubMed 14673046

Skotheim RI, Korkmaz KS, Klokk TI, Abeler VM, Korkmaz CG, Nesland JM, Fosså SD, Lothe RA, Saatcioglu F (2003)
NKX3.1 expression is lost in testicular germ cell tumors
Am J Pathol, 163 (6), 2149-54
PubMed 14633588

Skotheim RI, Lothe RA (2003)
The testicular germ cell tumour genome
APMIS, 111 (1), 136-50; discussion 50-1
PubMed 12752254

Publications 2002

Kraggerud SM, Skotheim RI, Szymanska J, Eknaes M, Fosså SD, Stenwig AE, Peltomäki P, Lothe RA (2002)
Genome profiles of familial/bilateral and sporadic testicular germ cell tumors
Genes Chromosomes Cancer, 34 (2), 168-74
PubMed 11979550

Skotheim RI, Monni O, Mousses S, Fosså SD, Kallioniemi OP, Lothe RA, Kallioniemi A (2002)
New insights into testicular germ cell tumorigenesis from gene expression profiling
Cancer Res, 62 (8), 2359-64
PubMed 11956097

Smith-Sørensen B, Lind GE, Skotheim RI, Fosså SD, Fodstad Ø, Stenwig AE, Jakobsen KS, Lothe RA (2002)
Frequent promoter hypermethylation of the O6-Methylguanine-DNA Methyltransferase (MGMT) gene in testicular cancer
Oncogene, 21 (57), 8878-84
PubMed 12483540

Publications 2001

Skotheim RI, Diep CB, Kraggerud SM, Jakobsen KS, Lothe RA (2001)
Evaluation of loss of heterozygosity/allelic imbalance scoring in tumor DNA
Cancer Genet Cytogenet, 127 (1), 64-70
PubMed 11408068

Skotheim RI, Kraggerud SM, Fosså SD, Stenwig AE, Gedde-Dahl T, Danielsen HE, Jakobsen KS, Lothe RA (2001)
Familial/bilateral and sporadic testicular germ cell tumors show frequent genetic changes at loci with suggestive linkage evidence
Neoplasia, 3 (3), 196-203
PubMed 11494113