Øyvind S. Bruland
Position: Professor, oncologist
Phone: +47 22 93 47 67
Email:
For details on research activities, scientific publications and CV: visit www.bruland.info
The main focus of professor Bruland's research involves the development of novel targeted radiopharmaceuticals - from basic/radiochemical aspects, animal testing and early phase clinical testing in sarcoma patients, and patients with skeletal metastases.
 

Author network for Øyvind Sverre Bruland by COREMINE medical


Publications 2017

Hompland I, Bruland ØS, Hølmebakk T, Poulsen JP, Stoldt S, Hall KS, Boye K (2017)
Prediction of long-term survival in patients with metastatic gastrointestinal stromal tumor: analysis of a large, single-institution cohort
Acta Oncol, 1-7 (in press)
PubMed 28557540

Parker CC, Coleman RE, Sartor O, Vogelzang NJ, Bottomley D, Heinrich D, Helle SI, O'Sullivan JM, Fosså SD, Chodacki A, Wiechno P, Logue J, Seke M, Widmark A, Johannessen DC, Hoskin P, James ND, Solberg A, Syndikus I, Kliment J, Wedel S, Boehmer S, Dall'Oglio M, Franzén L, Bruland ØS et al. (2017)
Three-year Safety of Radium-223 Dichloride in Patients with Castration-resistant Prostate Cancer and Symptomatic Bone Metastases from Phase 3 Randomized Alpharadin in Symptomatic Prostate Cancer Trial
Eur Urol (in press)
PubMed 28705540

Publications 2016

Barøy T, Chilamakuri CS, Lorenz S, Sun J, Bruland ØS, Myklebost O, Meza-Zepeda LA (2016)
Genome Analysis of Osteosarcoma Progression Samples Identifies FGFR1 Overexpression as a Potential Treatment Target and CHM as a Candidate Tumor Suppressor Gene
PLoS One, 11 (9), e0163859
PubMed 27685995

Hompland I, Bruland ØS, Ubhayasekhera K, Bergquist J, Boye K (2016)
Clinical implications of repeated drug monitoring of imatinib in patients with metastatic gastrointestinal stromal tumour
Clin Sarcoma Res, 6, 21
PubMed 27999655

Hølmebakk T, Bjerkehagen B, Boye K, Bruland Ø, Stoldt S, Sundby Hall K (2016)
Definition and clinical significance of tumour rupture in gastrointestinal stromal tumours of the small intestine
Br J Surg, 103 (6), 684-691
PubMed 26988241

König M, Osnes TA, Lobmaier I, Bjerkehagen B, Bruland ØS, Sundby Hall K, Meling TR (2016)
Multimodal treatment of craniofacial osteosarcoma with high-grade histology. A single-center experience over 35 years
Neurosurg Rev, 40 (3), 449-460
PubMed 27858303

Parker C, Finkelstein SE, Michalski JM, O'Sullivan JM, Bruland Ø, Vogelzang NJ, Coleman RE, Nilsson S, Sartor O, Li R, Seger MA, Bottomley D (2016)
Efficacy and Safety of Radium-223 Dichloride in Symptomatic Castration-resistant Prostate Cancer Patients With or Without Baseline Opioid Use From the Phase 3 ALSYMPCA Trial
Eur Urol, 70 (5), 875-883
PubMed 27344296

Varghese M, Bruland O, Wiedswang AM, Lobmaier I, Røsok B, Benjamin RS, Hall KS (2016)
Metastatic mesenteric dedifferentiated leiomyosarcoma: a case report and a review of literature
Clin Sarcoma Res, 6, 2
PubMed 26913180

Westrøm S, Bønsdorff TB, Abbas N, Bruland ØS, Jonasdottir TJ, Mælandsmo GM, Larsen RH (2016)
Evaluation of CD146 as Target for Radioimmunotherapy against Osteosarcoma
PLoS One, 11 (10), e0165382
PubMed 27776176

Publications 2015

Anfinsen KP, Grotmol T, Bruland OS, Cathrine T, Jonasdottir TJ (2015)
Primary bone cancer in Leonbergers may be associated with a higher bodyweight during adolescence (vol 119, pg 48, 2015)
Prev. Vet. Med., 120 (2), 252

Anfinsen KP, Grotmol T, Bruland OS, Trangerud C, Jonasdottir TJ (2015)
Primary bone cancer in Leonbergers may be associated with a higher bodyweight during adolescence
Prev Vet Med, 119 (1-2), 48-53
PubMed 25732913

Berner K, Bjerkehagen B, Bruland ØS, Berner A (2015)
Extraskeletal osteosarcoma in Norway, between 1975 and 2009, and a brief review of the literature
Anticancer Res, 35 (4), 2129-40
PubMed 25862869

Berner K, Hall KS, Monge OR, Weedon-Fekjær H, Zaikova O, Bruland ØS (2015)
Prognostic factors and treatment results of high-grade osteosarcoma in norway: a scope beyond the "classical" patient
Sarcoma, 2015, 516843
PubMed 25784831

Berner K, Johannesen TB, Bruland ØS (2015)
Clinical Epidemiology of Low-Grade and Dedifferentiated Osteosarcoma in Norway during 1975 and 2009
Sarcoma, 2015, 917679
PubMed 26412976

Fauske L, Bondevik H, Bruland ØS, Ozakinci G (2015)
Negative and Positive Consequences of Cancer Treatment Experienced by Long-term Osteosarcoma Survivors: A Qualitative Study
Anticancer Res, 35 (11), 6081-90
PubMed 26504033

Fauske L, Bruland OS, Grov EK, Bondevik H (2015)
Cured of primary bone cancer, but at what cost: a qualitative study of functional impairment and lost opportunities
Sarcoma, 2015, 484196
PubMed 25949211

Hompland I, Bruland ØS (2015)
Can Imatinib Be Safely Withdrawn in Patients with Surgically Resected Metastatic GIST?
Anticancer Res, 35 (11), 5759-65
PubMed 26503996

Humm JL, Sartor O, Parker C, Bruland OS, Macklis R (2015)
Radium-223 in the treatment of osteoblastic metastases: a critical clinical review
Int J Radiat Oncol Biol Phys, 91 (5), 898-906
PubMed 25832684

Juzeniene A, Baturaite Z, Lagunova Z, Grigalavicius M, Porojnicu AC, Bruland ØS, Moan J (2015)
Influence of multiple UV exposures on serum cobalamin and vitamin D levels in healthy females
Scand J Public Health, 43 (3), 324-30
PubMed 25740614

Juzeniene A, Porojnicu AC, Baturaite Z, Lagunova Z, Aksnes L, Bruland ØS, Moan J (2015)
Vitamin D levels and dietary intake among patients with benign soft tissue tumors and sarcomas
Anticancer Res, 35 (2), 1171-80
PubMed 25667508

Publications 2014

Berner K, Johannesen TB, Berner A, Haugland HK, Bjerkehagen B, Bøhler PJ, Bruland ØS (2014)
Time-trends on incidence and survival in a nationwide and unselected cohort of patients with skeletal osteosarcoma
Acta Oncol, 54 (1), 25-33
PubMed 24957555

Ohnstad HO, Bruland OS, Taksdal I, Bjerkehagen B, Nenadovic M, Sæter G, Jørgensen LH, Hall KS (2014)
Response to preoperative chemotherapy in patients undergoing resection of pulmonary metastasis from soft tissue sarcoma - a predictor of outcome?
Acta Oncol, 53 (9), 1180-7
PubMed 24697744

Repetto-Llamazares A, Abbas N, Bruland ØS, Dahle J, Larsen RH (2014)
Advantage of lutetium-177 versus radioiodine immunoconjugate in targeted radionuclide therapy of b-cell tumors
Anticancer Res, 34 (7), 3263-9
PubMed 24982330

Repetto-Llamazares AH, Larsen RH, Giusti AM, Riccardi E, Bruland ØS, Selbo PK, Dahle J (2014)
177Lu-DOTA-HH1, a novel anti-CD37 radio-immunoconjugate: a study of toxicity in nude mice
PLoS One, 9 (7), e103070
PubMed 25068508

Sartor O, Coleman R, Nilsson S, Heinrich D, Helle SI, O'Sullivan JM, Fosså SD, Chodacki A, Wiechno P, Logue J, Widmark A, Johannessen DC, Hoskin P, James ND, Solberg A, Syndikus I, Vogelzang NJ, O'Bryan-Tear CG, Shan M, Bruland ØS, Parker C (2014)
Effect of radium-223 dichloride on symptomatic skeletal events in patients with castration-resistant prostate cancer and bone metastases: results from a phase 3, double-blind, randomised trial
Lancet Oncol, 15 (7), 738-46
PubMed 24836273

Switlyk MD, Bruland ØS, Skjeldal S, Hald JK, Seierstad T, Zaikova O (2014)
Radiotherapy for spinal metastases from breast cancer with emphasis on local disease control and pain response using repeated MRI
J Bone Oncol, 3 (1), 5-9
PubMed 26909292

Publications 2013

Abbas N, Heyerdahl H, Bruland ØS, Brevik EM, Dahle J (2013)
Comparing high LET 227Th- and low LET 177Lu-trastuzumab in mice with HER-2 positive SKBR-3 xenografts
Curr Radiopharm, 6 (2), 78-86
PubMed 23551110

Bjerkehagen B, Småstuen MC, Hall KS, Skjeldal S, Bruland ØS, Smeland S, Johannesen TB, Fosså SD (2013)
Incidence and mortality of second sarcomas - a population-based study
Eur J Cancer, 49 (15), 3292-302
PubMed 23787025

Dahle J, Repetto-Llamazares AH, Mollatt CS, Melhus KB, Bruland OS, Kolstad A, Larsen RH (2013)
Evaluating antigen targeting and anti-tumor activity of a new anti-CD37 radioimmunoconjugate against non-Hodgkin's lymphoma
Anticancer Res, 33 (1), 85-95
PubMed 23267131

Fløisand Y, Beiske K, Tjønnfjord GE, Heldal D, Bjerkehagen B, Revheim ME, Heim S, Bruland OS, Hall KS, Tierens A, Delabie J (2013)
Malignant phyllodes tumor and acute megakaryoblastic leukemia sharing a common clonal origin
Case Rep Hematol, 2013, 934781
PubMed 24455338

Heyerdahl H, Abbas N, Sponheim K, Mollatt C, Bruland Ø, Dahle J (2013)
Targeted alpha therapy with 227Th-trastuzumab of intraperitoneal ovarian cancer in nude mice
Curr Radiopharm, 6 (2), 106-16
PubMed 23551111

Jebsen NL, Engellau J, Engström K, Bauer HC, Monge OR, Muren LP, Eide GE, Trovik CS, Bruland OS (2013)
Patterns of local recurrence and dose fractionation of adjuvant radiation therapy in 462 patients with soft tissue sarcoma of extremity and trunk wall
Int J Radiat Oncol Biol Phys, 86 (5), 949-55
PubMed 23725998

Lagunova Z, Porojnicu AC, Aksnes L, Holick MF, Iani V, Bruland OS, Moan J (2013)
Effect of vitamin D supplementation and ultraviolet B exposure on serum 25-hydroxyvitamin D concentrations in healthy volunteers: a randomized, crossover clinical trial
Br J Dermatol, 169 (2), 434-40
PubMed 23551243

Lia K, Bruland ØS, Randem HL, Aksnes LH, Poulsen JP, Taksdal I, Sundby Hall K (2013)
Two cases with fatal outcome following total lung irradiation for metastatic bone sarcoma
J Bone Oncol, 2 (4), 174-9
PubMed 26909289

Mikalsen LT, Dhakal HP, Bruland ØS, Naume B, Borgen E, Nesland JM, Olsen DR (2013)
The clinical impact of mean vessel size and solidity in breast carcinoma patients
PLoS One, 8 (10), e75954
PubMed 24146798

Parker C, Nilsson S, Heinrich D, Helle SI, O'Sullivan JM, Fosså SD, Chodacki A, Wiechno P, Logue J, Seke M, Widmark A, Johannessen DC, Hoskin P, Bottomley D, James ND, Solberg A, Syndikus I, Kliment J, Wedel S, Boehmer S, Dall'Oglio M, Franzén L, Coleman R, Vogelzang NJ, O'Bryan-Tear CG et al. (2013)
Alpha emitter radium-223 and survival in metastatic prostate cancer
N Engl J Med, 369 (3), 213-23
PubMed 23863050

Revheim ME, Hole KH, Bruland OS, Reitan E, Bjerkehagen B, Julsrud L, Seierstad T (2013)
Multimodal functional imaging for early response assessment in GIST patients treated with imatinib
Acta Oncol, 53 (1), 143-8
PubMed 23710697

Revheim ME, Kristian A, Malinen E, Bruland ØS, Berner JM, Holm R, Joensuu H, Seierstad T (2013)
Intermittent and continuous imatinib in a human GIST xenograft model carrying KIT exon 17 resistance mutation D816H
Acta Oncol, 52 (4), 776-82
PubMed 23480638

Rusten E, Rødal J, Bruland Ø, Malinen E (2013)
Biologic targets identified from dynamic 18FDG-PET and implications for image-guided therapy
Acta Oncol, 52 (7), 1378-83
PubMed 23981046

Publications 2012

Abbas N, Bruland ØS, Brevik EM, Dahle J (2012)
Preclinical evaluation of 227Th-labeled and 177Lu-labeled trastuzumab in mice with HER-2-positive ovarian cancer xenografts
Nucl Med Commun, 33 (8), 838-47
PubMed 22643311

Micu E, Baturaite Z, Juzeniene A, Bruland ØS, Moan JE (2012)
Superficial-spreading and nodular melanomas in Norway: a comparison by body site distribution and latitude gradients
Melanoma Res, 22 (6), 460-5
PubMed 23010822

Namløs HM, Kresse SH, Müller CR, Henriksen J, Holdhus R, Sæter G, Bruland OS, Bjerkehagen B, Steen VM, Myklebost O (2012)
Global gene expression profiling of human osteosarcomas reveals metastasis-associated chemokine pattern
Sarcoma, 2012, 639038
PubMed 22518090

Nilsson S, Franzén L, Parker C, Tyrrell C, Blom R, Tennvall J, Lennernäs B, Petersson U, Johannessen DC, Sokal M, Pigott K, O'Bryan-Tear CG, Thuresson M, Bolstad B, Bruland ØS (2012)
Two-year survival follow-up of the randomized, double-blind, placebo-controlled phase II study of radium-223 chloride in patients with castration-resistant prostate cancer and bone metastases
Clin Genitourin Cancer, 11 (1), 20-6
PubMed 23021204

Nilsson S, Strang P, Aksnes AK, Franzèn L, Olivier P, Pecking A, Staffurth J, Vasanthan S, Andersson C, Bruland ØS (2012)
A randomized, dose-response, multicenter phase II study of radium-223 chloride for the palliation of painful bone metastases in patients with castration-resistant prostate cancer
Eur J Cancer, 48 (5), 678-86
PubMed 22341993

Rusten E, Rødal J, Revheim ME, Skretting A, Bruland OS, Malinen E (2012)
Quantitative dynamic ¹⁸FDG-PET and tracer kinetic analysis of soft tissue sarcomas
Acta Oncol, 52 (6), 1160-7
PubMed 23198721

Sartor O, Hoskin P, Bruland OS (2012)
Targeted radio-nuclide therapy of skeletal metastases
Cancer Treat Rev, 39 (1), 18-26
PubMed 22534284

Publications 2011

Abbas N, Heyerdahl H, Bruland OS, Borrebæk J, Nesland J, Dahle J (2011)
Experimental α-particle radioimmunotherapy of breast cancer using 227Th-labeled p-benzyl-DOTA-trastuzumab
EJNMMI Res, 1 (1), 18
PubMed 22214432

Anfinsen KP, Devesa SS, Bray F, Troisi R, Jonasdottir TJ, Bruland OS, Grotmol T (2011)
Age-period-cohort analysis of primary bone cancer incidence rates in the United States (1976-2005)
Cancer Epidemiol Biomarkers Prev, 20 (8), 1770-7
PubMed 21724855

Anfinsen KP, Grotmol T, Bruland OS, Jonasdottir TJ (2011)
Breed-specific incidence rates of canine primary bone tumors--a population based survey of dogs in Norway
Can J Vet Res, 75 (3), 209-15
PubMed 22210997

Dahle J, Abbas N, Bruland ØS, Larsen RH (2011)
Toxicity and relative biological effectiveness of alpha emitting radioimmunoconjugates
Curr Radiopharm, 4 (4), 321-8
PubMed 22202154

Mikalsen LT, Dhakal HP, Bruland OS, Nesland JM, Olsen DR (2011)
Quantification of angiogenesis in breast cancer by automated vessel identification in CD34 immunohistochemical sections
Anticancer Res, 31 (12), 4053-60
PubMed 22199261

Revheim ME, Røe K, Bruland ØS, Bach-Gansmo T, Skretting A, Seierstad T (2011)
Monitoring the effect of targeted therapies in a gastrointestinal stromal tumor xenograft using a clinical PET/CT
Mol Imaging Biol, 13 (6), 1234-40
PubMed 21161686

Sartor O, Bruland O (2011)
Stromal targeted therapies in prostate and renal cancer: new concepts and knowledge
Clin Genitourin Cancer, 9 (1), 1-2
PubMed 21925102

Sartor O, Goeckeler W, Bruland O (2011)
Stromal targeted therapy in bone metastatic prostate cancer: promise delivered
Asian J Androl, 13 (6), 783-4
PubMed 21857688

Smeland S, Bruland OS, Hjorth L, Brosjö O, Bjerkehagen B, Osterlundh G, Jakobson A, Hall KS, Monge OR, Björk O, Alvegaard TA (2011)
Results of the Scandinavian Sarcoma Group XIV protocol for classical osteosarcoma: 63 patients with a minimum follow-up of 4 years
Acta Orthop, 82 (2), 211-6
PubMed 21434784

Zaikova O, Fosså SD, Bruland OS, Giercksky KE, Sandstad B, Skjeldal S (2011)
Radiotherapy or surgery for spine metastases?
Acta Orthop, 82 (3), 365-71
PubMed 21434789

Publications 2010

Cicarma E, Juzeniene A, Porojnicu AC, Bruland ØS, Moan J (2010)
Latitude gradient for melanoma incidence by anatomic site and gender in Norway 1966-2007
J Photochem Photobiol B, 101 (2), 174-8
PubMed 20430639

Dale E, Hårsaker V, Kristoffersen DT, Bruland O, Olsen DR (2010)
CT density in lung cancer patients after radiotherapy sensitized by metoclopramide. A subgroup analysis of a randomized trial
Strahlenther Onkol, 186 (3), 163-8
PubMed 20165821

Jebsen NL, Bruland ØS, Eriksson M, Engellau J, Turesson I, Folin A, Trovik CS, Hall KS (2010)
Five-year results from a Scandinavian sarcoma group study (SSG XIII) of adjuvant chemotherapy combined with accelerated radiotherapy in high-risk soft tissue sarcoma of extremities and trunk wall
Int J Radiat Oncol Biol Phys, 81 (5), 1359-66
PubMed 20933339

Lagunova Z, Porojnicu AC, Grant WB, Bruland Ø, Moan JE (2010)
Obesity and increased risk of cancer: does decrease of serum 25-hydroxyvitamin D level with increasing body mass index explain some of the association?
Mol Nutr Food Res, 54 (8), 1127-33
PubMed 20512788

Moan J, Lagunova Z, Bruland O, Juzeniene A (2010)
Seasonal variations of cancer incidence and prognosis
Dermatoendocrinol, 2 (2), 55-7
PubMed 21547098

Revheim ME, Hole KH, Bruland OS, Haugland HK, Hall KS, Seierstad T (2010)
DW MRI for evaluation of treatment response to imatinib in a rectal gastrointestinal stromal tumour
Acta Oncol, 50 (1), 148-50
PubMed 21110775

Publications 2009

Berg A, Dahl AA, Bruland ØS, Bjøro T, Aanensen MS, Fosså SD (2009)
Definitive radiotherapy with adjuvant long-term antiandrogen treatment for locally advanced prostate cancer: health-related quality of life and hormonal changes
Prostate Cancer Prostatic Dis, 12 (3), 269-76
PubMed 19290019

Brandal P, Bjerkehagen B, Bruland OS, Skjeldal S, Bogsrud TV, Hall KS (2009)
Synchronous and metachronous skeletal osteosarcomas: the Norwegian Radium Hospital experience
Acta Oncol, 48 (8), 1165-72
PubMed 19863225

Bruland ØS, Bauer H, Alvegaard T, Smeland S (2009)
Treatment of osteosarcoma. The Scandinavian Sarcoma Group experience
Cancer Treat Res, 152, 309-18
PubMed 20213398

Bruland ØS, Høifødt H, Hall KS, Smeland S, Fodstad Ø (2009)
Bone marrow micrometastases studied by an immunomagnetic isolation procedure in extremity localized non-metastatic osteosarcoma patients
Cancer Treat Res, 152, 509-15
PubMed 20213412

Hall KS, Eriksson M, Bruland OS, Engellau J, Trovik CS (2009)
Treatment of soft tissue sarcoma of the extremity and trunk wall The Scandinavian Sarcoma Group perspective
Acta Orthop., 80, 52-59

Norum OJ, Bruland ØS, Gorunova L, Berg K (2009)
Photochemical internalization of bleomycin before external-beam radiotherapy improves locoregional control in a human sarcoma model
Int J Radiat Oncol Biol Phys, 75 (3), 878-85
PubMed 19665318

Revheim ME, Seierstad T, Berner JM, Bruland OS, Røe K, Ohnstad HO, Bjerkehagen B, Bach-Gansmo T (2009)
Establishment and characterization of a human gastrointestinal stromal tumour (GIST) xenograft in athymic nude mice
Anticancer Res, 29 (11), 4331-6
PubMed 20032375

Sande TA, Ruenes R, Lund JA, Bruland OS, Hornslien K, Bremnes R, Kaasa S (2009)
Long-term follow-up of cancer patients receiving radiotherapy for bone metastases: results from a randomised multicentre trial
Radiother Oncol, 91 (2), 261-6
PubMed 19307034

Schwarz R, Bruland O, Cassoni A, Schomberg P, Bielack S (2009)
The role of radiotherapy in oseosarcoma
Cancer Treat Res, 152, 147-64
PubMed 20213389

Smeland S, Bruland OS, Hjorth L, Brosjo O, Bjerkehagen B, Osterlundh G, Jakobson A, Hall KS, Monge OR, Bjork O, Alvegaard TA (2009)
Scandinavian experience in classical osteosarcoma Results of the SSG XIV protocol
Acta Orthop., 80, 60-66

Søvik S, Skogmo HK, Andersen EK, Bruland ØS, Olsen DR, Malinen E (2009)
DCEMRI of spontaneous canine tumors during fractionated radiotherapy: a pharmacokinetic analysis
Radiother Oncol, 93 (3), 618-24
PubMed 19747746

Publications 2008

Berg A, Bruland ØS, Fosså SD, Nesland JM, Berner A, Schirmer C, Lilleby W (2008)
Disseminated tumor cells in bone marrow following definitive radiotherapy for intermediate or high-risk prostate cancer
Prostate, 68 (15), 1607-14
PubMed 18655095

Dahle J, Bruland OS, Larsen RH (2008)
Relative biologic effects of low-dose-rate alpha-emitting 227Th-rituximab and beta-emitting 90Y-tiuexetan-ibritumomab versus external beam X-radiation
Int J Radiat Oncol Biol Phys, 72 (1), 186-92
PubMed 18722269

Erikson A, Tufto I, Bjønnum AB, Bruland ØS, Davies Cde L (2008)
The impact of enzymatic degradation on the uptake of differently sized therapeutic molecules
Anticancer Res, 28 (6A), 3557-66
PubMed 19189635

Jebsen NL, Trovik CS, Bauer HC, Rydholm A, Monge OR, Hall KS, Alvegård T, Bruland OS (2008)
Radiotherapy to improve local control regardless of surgical margin and malignancy grade in extremity and trunk wall soft tissue sarcoma: a Scandinavian sarcoma group study
Int J Radiat Oncol Biol Phys, 71 (4), 1196-203
PubMed 18207661

Porojnicu AC, Bruland OS, Aksnes L, Grant WB, Moan J (2008)
Sun beds and cod liver oil as vitamin D sources
J Photochem Photobiol B, 91 (2-3), 125-31
PubMed 18417354

Søvik A, Kippenes Skogmo H, Bruland ØS, Rune Olsen D, Malinen E (2008)
DCEMRI monitoring of canine tumors during fractionated radiotherapy
Acta Oncol, 47 (7), 1249-56
PubMed 18618342

Vågane R, Bruland ØS, Fosså SD, Olsen DR (2008)
Radiological and functional assessment of radiation-induced pulmonary damage following breast irradiation
Acta Oncol, 47 (2), 248-54
PubMed 18210300

Publications 2007

Aksnes LH, Bruland ØS (2007)
Some musculo-skeletal sequelae in cancer survivors
Acta Oncol, 46 (4), 490-6
PubMed 17497316

Berg A, Berner A, Lilleby W, Bruland ØS, Fosså SD, Nesland JM, Kvalheim G (2007)
Impact of disseminated tumor cells in bone marrow at diagnosis in patients with nonmetastatic prostate cancer treated by definitive radiotherapy
Int J Cancer, 120 (8), 1603-9
PubMed 17230512

Berg A, Lilleby W, Bruland OS, Fosså SD (2007)
10-year survival and quality of life in patients with high-risk pN0 prostate cancer following definitive radiotherapy
Int J Radiat Oncol Biol Phys, 69 (4), 1074-83
PubMed 17703896

Dahle J, Borrebaek J, Jonasdottir TJ, Hjelmerud AK, Melhus KB, Bruland ØS, Press OW, Larsen RH (2007)
Targeted cancer therapy with a novel low-dose rate alpha-emitting radioimmunoconjugate
Blood, 110 (6), 2049-56
PubMed 17536011

Larsen RH, Borrebaek J, Dahle J, Melhus KB, Krogh C, Valan MH, Bruland OS (2007)
Preparation of TH227-labeled radioimmunoconjugates, assessment of serum stability and antigen binding ability
Cancer Biother Radiopharm, 22 (3), 431-7
PubMed 17651051

Nilsson S, Franzén L, Parker C, Tyrrell C, Blom R, Tennvall J, Lennernäs B, Petersson U, Johannessen DC, Sokal M, Pigott K, Yachnin J, Garkavij M, Strang P, Harmenberg J, Bolstad B, Bruland OS (2007)
Bone-targeted radium-223 in symptomatic, hormone-refractory prostate cancer: a randomised, multicentre, placebo-controlled phase II study
Lancet Oncol, 8 (7), 587-94
PubMed 17544845

Olsen DR, Bruland OS, Frykholm G, Norderhaug IN (2007)
Proton therapy - a systematic review of clinical effectiveness
Radiother Oncol, 83 (2), 123-32
PubMed 17499374

Porojnicu AC, Robsahm TE, Dahlback A, Berg JP, Christiani D, Bruland OS, Moan J (2007)
Seasonal and geographical variations in lung cancer prognosis in Norway. Does Vitamin D from the sun play a role?
Lung Cancer, 55 (3), 263-70
PubMed 17207891

Søvik A, Malinen E, Skogmo HK, Bentzen SM, Bruland OS, Olsen DR (2007)
Radiotherapy adapted to spatial and temporal variability in tumor hypoxia
Int J Radiat Oncol Biol Phys, 68 (5), 1496-504
PubMed 17674980

Publications 2006

Aksnes LH, Hall KS, Folleraas G, Stenwig AE, Bjerkehagen B, Taksdal I, Winderen M, Bruland OS, Saeter G (2006)
Management of high-grade bone sarcomas over two decades: the Norwegian Radium Hospital experience
Acta Oncol, 45 (1), 38-46
PubMed 16464794

Bruland ØS (2006)
[Jumping after the Swedes]
Tidsskr Nor Laegeforen, 126 (5), 637
PubMed 16505887

Bruland ØS, Nilsson S, Fisher DR, Larsen RH (2006)
High-linear energy transfer irradiation targeted to skeletal metastases by the alpha-emitter 223Ra: adjuvant or alternative to conventional modalities?
Clin Cancer Res, 12 (20 Pt 2), 6250s-6257s
PubMed 17062709

Dahle J, Borrebaek J, Melhus KB, Bruland OS, Salberg G, Olsen DR, Larsen RH (2006)
Initial evaluation of (227)Th-p-benzyl-DOTA-rituximab for low-dose rate alpha-particle radioimmunotherapy
Nucl Med Biol, 33 (2), 271-9
PubMed 16546683

Jonasdottir TJ, Fisher DR, Borrebaek J, Bruland OS, Larsen RH (2006)
First in vivo evaluation of liposome-encapsulated 223Ra as a potential alpha-particle-emitting cancer therapeutic agent
Anticancer Res, 26 (4B), 2841-8
PubMed 16886603

Kaasa S, Brenne E, Lund JA, Fayers P, Falkmer U, Holmberg M, Lagerlund M, Bruland O (2006)
Prospective randomised multicenter trial on single fraction radiotherapy (8 Gy x 1) versus multiple fractions (3 Gy x 10) in the treatment of painful bone metastases
Radiother Oncol, 79 (3), 278-84
PubMed 16793154

Larsen RH, Saxtorph H, Skydsgaard M, Borrebaek J, Jonasdottir TJ, Bruland OS, Klastrup S, Harling R, Ramdahl T (2006)
Radiotoxicity of the alpha-emitting bone-seeker 223Ra injected intravenously into mice: histology, clinical chemistry and hematology
In Vivo, 20 (3), 325-31
PubMed 16724665

Lipton A, Berenson JR, Body JJ, Boyce BF, Bruland OS, Carducci MA, Cleeland CS, Clohisy DR, Coleman RE, Cook RJ, Guise TA, Pearse RN, Powles TJ, Rogers MJ, Roodman GD, Smith MR, Suva LJ, Vessella RL, Weilbaecher KN, King L (2006)
Advances in treating metastatic bone cancer: summary statement for the First Cambridge Conference
Clin Cancer Res, 12 (20 Pt 2), 6209s-6212s
PubMed 17062702

Malinen E, Søvik A, Hristov D, Bruland ØS, Olsen DR (2006)
Adapting radiotherapy to hypoxic tumours
Phys Med Biol, 51 (19), 4903-21
PubMed 16985278

Søvik A, Malinen E, Bruland ØS, Bentzen SM, Olsen DR (2006)
Optimization of tumour control probability in hypoxic tumours by radiation dose redistribution: a modelling study
Phys Med Biol, 52 (2), 499-513
PubMed 17202629

Publications 2005

Bruland OS, Høifødt H, Saeter G, Smeland S, Fodstad O (2005)
Hematogenous micrometastases in osteosarcoma patients
Clin Cancer Res, 11 (13), 4666-73
PubMed 16000559

Brustugun OT, Reed W, Poulsen JP, Bruland OS (2005)
Primary osteosarcoma of the breast
Acta Oncol, 44 (7), 767-70
PubMed 16227171

Dale E, Hellebust TP, Bruland ØS, Olsen DR (2005)
Comparative analyses of the dynamic properties of the bladder wall studied by repetitive pelvic CT scans of patients and cryo-sections of cadavers
Br J Radiol, 78 (930), 528-32
PubMed 15900058

Eikenes L, Tari M, Tufto I, Bruland OS, de Lange Davies C (2005)
Hyaluronidase induces a transcapillary pressure gradient and improves the distribution and uptake of liposomal doxorubicin (Caelyx) in human osteosarcoma xenografts
Br J Cancer, 93 (1), 81-8
PubMed 15942637

Henriksen G, Bruland OS, Larsen RH (2005)
Preparation and preclinical assessment of folate-conjugated, radiolabelled antibodies
Anticancer Res, 25 (1A), 9-15
PubMed 15816513

Nilsson S, Larsen RH, Fosså SD, Balteskard L, Borch KW, Westlin JE, Salberg G, Bruland OS (2005)
First clinical experience with alpha-emitting radium-223 in the treatment of skeletal metastases
Clin Cancer Res, 11 (12), 4451-9
PubMed 15958630

Norum J, Bruland ØS, Spanne O, Bergmo T, Green T, Olsen DR, Olsen JH, Sjåeng EE, Burkow T (2005)
Telemedicine in radiotherapy: a study exploring remote treatment planning, supervision and economics
J Telemed Telecare, 11 (5), 245-50
PubMed 16035967

Onda M, Bruland ØS, Pastan I (2005)
TP-3 immunotoxins improve antitumor activity in mice with osteosarcoma
Clin Orthop Relat Res (430), 142-8
PubMed 15662316

Publications 2004

Bruheim S, Bruland OS, Breistol K, Maelandsmo GM, Fodstad O (2004)
Human osteosarcoma xenografts and their sensitivity to chemotherapy
Pathol Oncol Res, 10 (3), 133-41
PubMed 15448748

Eikenes L, Bruland ØS, Brekken C, Davies Cde L (2004)
Collagenase increases the transcapillary pressure gradient and improves the uptake and distribution of monoclonal antibodies in human osteosarcoma xenografts
Cancer Res, 64 (14), 4768-73
PubMed 15256445

Henriksen G, Bruland OS, Larsen RH (2004)
Thorium and actinium polyphosphonate compounds as bone-seeking alpha particle-emitting agents
Anticancer Res, 24 (1), 101-5
PubMed 15015582

Henriksen G, Schoultz BW, Michaelsen TE, Bruland ØS, Larsen RH (2004)
Sterically stabilized liposomes as a carrier for alpha-emitting radium and actinium radionuclides
Nucl Med Biol, 31 (4), 441-9
PubMed 15093814

Publications 2003

Dale E, Hellebust TP, Bruland ØS, Olsen DR (2003)
Comparative analyses of the dynamic properties of the rectum studied by cryo-sections of human cadavers and pelvic CT scans of patients
Br J Radiol, 76 (902), 104-8
PubMed 12642278

Henriksen G, Fisher DR, Roeske JC, Bruland ØS, Larsen RH (2003)
Targeting of osseous sites with alpha-emitting 223Ra: comparison with the beta-emitter 89Sr in mice
J Nucl Med, 44 (2), 252-9
PubMed 12571218

Olstad OK, Gautvik VT, Reppe S, Rian E, Jemtland R, Ohlsson C, Bruland OS, Gautvik KM (2003)
Molecular heterogeneity in human osteosarcoma demonstrated by enriched mRNAs isolated by directional tag PCR subtraction cloning
Anticancer Res, 23 (3B), 2201-16
PubMed 12894494

Publications 2002

Anderson PM, Wiseman GA, Dispenzieri A, Arndt CA, Hartmann LC, Smithson WA, Mullan BP, Bruland OS (2002)
High-dose samarium-153 ethylene diamine tetramethylene phosphonate: low toxicity of skeletal irradiation in patients with osteosarcoma and bone metastases
J Clin Oncol, 20 (1), 189-96
PubMed 11773169

Aurlien E, Kvinnsland Y, Larsen RH, Bruland ØS (2002)
Radiation doses to non-Hodgkin's lymphoma cells and normal bone marrow exposed in vitro. Comparison of an alpha-emitting radioimmunoconjugate and external gamma-irradiation
Int J Radiat Biol, 78 (2), 133-42
PubMed 11779363

Henriksen G, Breistøl K, Bruland ØS, Fodstad Ø, Larsen RH (2002)
Significant antitumor effect from bone-seeking, alpha-particle-emitting (223)Ra demonstrated in an experimental skeletal metastases model
Cancer Res, 62 (11), 3120-5
PubMed 12036923

Kvinnsland Y, Bruland O, Moe L, Skretting A (2002)
A method for measurement of the uptake patterns of two beta-emitting radionuclides in the same tissue section with a digital silicon detector: application to a study of 89SrCl2 and 153Sm-EDTMP in a dog with spontaneous osteosarcoma
Eur J Nucl Med Mol Imaging, 29 (2), 191-7
PubMed 11926381

Ree AH, Bratland A, Kroes RA, Aasheim HC, Flørenes VA, Moskal JR, Fodstad O, Bruland OS, Maelandsmo GM (2002)
Clinical and cell line specific expression profiles of a human gene identified in experimental central nervous system metastases
Anticancer Res, 22 (4), 1949-57
PubMed 12174869

Saeter G, Hall KS, Bruland ØS, Solheim ØP, Høie J, Follerås G, Helgerud P, Stenwig AE, Bjerkehagen B, Talle K, Taksdal I, Winderen M (2002)
[Bone and soft tissue sarcomas treated at the Norwegian Radium Hospital 1980-99]
Tidsskr Nor Laegeforen, 122 (21), 2089-94
PubMed 12555642

Publications 2001

Hassfjell S, Ingebrigtsen K, Bruland ØS (2001)
Synthesis, purification and biodistribution of (205)Bi-DOTMP, visualizing bone deposition patterns with autoradiography
Nucl Med Biol, 28 (4), 425-33
PubMed 11395316

Kvinnsland Y, Skretting A, Bruland OS (2001)
Radionuclide therapy with bone-seeking compounds: Monte Carlo calculations of dose-volume histograms for bone marrow in trabecular bone
Phys Med Biol, 46 (4), 1149-61
PubMed 11324957

Onda M, Olafsen T, Tsutsumi Y, Bruland OS, Pastan I (2001)
Cytotoxicity of antiosteosarcoma recombinant immunotoxins composed of TP-3 Fv fragments and a truncated Pseudomonas exotoxin A
J Immunother, 24 (2), 144-50
PubMed 11265772

Publications 2000

Aurlien E, Larsen RH, Akabani G, Olsen DR, Zalutsky MR, Bruland OS (2000)
Exposure of human osteosarcoma and bone marrow cells to tumour-targeted alpha-particles and gamma-irradiation: analysis of cell survival and microdosimetry
Int J Radiat Biol, 76 (8), 1129-41
PubMed 10947126

Aurlien E, Larsen RH, Kvalheim G, Bruland OS (2000)
Demonstration of highly specific toxicity of the alpha-emitting radioimmunoconjugate(211)At-rituximab against non-Hodgkin's lymphoma cells
Br J Cancer, 83 (10), 1375-9
PubMed 11044364

Braendengen M, Bruland OS, Olsen DR (2000)
[Radiotherapy of skeletal metastases]
Tidsskr Nor Laegeforen, 120 (16), 1870-4
PubMed 10925615

Pihl A, Bruland OS (2000)
Oral presentations in science and medicine. An art in decline?
Anticancer Res, 20 (5A), 2795-9
PubMed 11062686

Publications 1999

Jemtland R, Rian E, Olstad OK, Haug E, Bruland OS, Bucht E, Gautvik KM (1999)
Two human osteoblast-like osteosarcoma cell lines show distinct expression and differential regulation of parathyroid hormone-related protein
J Bone Miner Res, 14 (6), 904-14
PubMed 10352098

Larsen RH, Murud KM, Akabani G, Hoff P, Bruland OS, Zalutsky MR (1999)
211At- and 131I-labeled bisphosphonates with high in vivo stability and bone accumulation
J Nucl Med, 40 (7), 1197-203
PubMed 10405142

Murud KM, Larsen RH, Bruland OS, Hoff P (1999)
Influence of pretreatment with 3-amino-1-hydroxypropylidene-1,1-bisphosphonate (APB) on organ uptake of 211At and 125I-labeled amidobisphosphonates in mice
Nucl Med Biol, 26 (7), 791-4
PubMed 10628558

Olafsen T, Munthe Lund CK, Bruland OS, Sandlie I, Michaelsen TE (1999)
Complement-mediated lysis of cultured osteosarcoma cell lines using chimeric mouse/human TP-1 IgG1 and IgG3 antibodies
Cancer Immunol Immunother, 48 (7), 411-8
PubMed 10501855

Ree AH, Tvermyr M, Engebraaten O, Rooman M, Røsok O, Hovig E, Meza-Zepeda LA, Bruland OS, Fodstad O (1999)
Expression of a novel factor in human breast cancer cells with metastatic potential
Cancer Res, 59 (18), 4675-80
PubMed 10493524

Tanum G, Bruland OS, Hjelle D, Reitan JB (1999)
[Patient treatment in radiation accidents]
Tidsskr Nor Laegeforen, 119 (10), 1446-50
PubMed 10354753

Aas M, Moe L, Gamlem H, Skretting A, Ottesen N, Bruland OS (1999)
Internal radionuclide therapy of primary osteosarcoma in dogs, using 153Sm-ethylene-diamino-tetramethylene-phosphonate (EDTMP)
Clin Cancer Res, 5 (10 Suppl), 3148s-3152s
PubMed 10541356

Publications 1998

Hassfjell SP, Skretting A, Bruland OS, Hoff P (1998)
Predicting detectability in radioguided surgery: a study based on physical characterization of the probe and on tissue uptake ratios of 125I-, 153Sm- and 165Er-labelled radiopharmaceuticals
Nucl Med Commun, 19 (3), 207-17
PubMed 9625495

Larsen RH, Bruland OS (1998)
Intratumour injection of immunoglobulins labelled with the alpha-particle emitter 211At: analyses of tumour retention, microdistribution and growth delay
Br J Cancer, 77 (7), 1115-22
PubMed 9569048

Lopes JM, Hannisdal E, Bjerkehagen B, Bruland OS, Danielsen HE, Pettersen EO, Sobrinho-Simões M, Nesland JM (1998)
Synovial sarcoma. Evaluation of prognosis with emphasis on the study of DNA ploidy and proliferation (PCNA and Ki-67) markers
Anal Cell Pathol, 16 (1), 45-62
PubMed 9584899

Olafsen T, Rasmussen IB, Norderhaug L, Bruland OS, Sandlie I (1998)
IgM secretory tailpiece drives multimerisation of bivalent scFv fragments in eukaryotic cells
Immunotechnology, 4 (2), 141-53
PubMed 9853955

Olsen DR, Bruland OS (1998)
Radiotherapy in Scandinavia
Acta Oncol, 37 (6), 553-60
PubMed 9860313

Publications 1997

Bruland OS, Pihl A (1997)
On the current management of osteosarcoma. A critical evaluation and a proposal for a modified treatment strategy
Eur J Cancer, 33 (11), 1725-31
PubMed 9470825

Ekstrøm PO, Giercksky KE, Andersen A, Bruland OS, Slørdal L (1997)
Intratumoral differences in methotrexate levels within human osteosarcoma xenografts studied by microdialysis
Life Sci, 61 (19), PL275-80
PubMed 9364204

Hassfjell SP, Bruland OS, Hoff P (1997)
212Bi-DOTMP: an alpha particle emitting bone-seeking agent for targeted radiotherapy
Nucl Med Biol, 24 (3), 231-7
PubMed 9228657

Lopes JM, Bruland OS, Bjerkehagen B, Silva MC, Holm R, Pettersen EO, Solheim OP, Sobrinho-Simões M, Nesland JM (1997)
Synovial sarcoma: immunohistochemical expression of P-glycoprotein and glutathione S transferase-pi and clinical drug resistance
Pathol Res Pract, 193 (1), 21-36
PubMed 9112270

Publications 1996

Bruland OS, Skretting A, Solheim OP, Aas M (1996)
Targeted radiotherapy of osteosarcoma using 153 Sm-EDTMP. A new promising approach
Acta Oncol, 35 (3), 381-4
PubMed 8679270

Gordeladze JO, Lund HW, Jablonski G, Bruland OS (1996)
Diverse expression of G-proteins in human sarcoma cell lines with different osteogenic potential: evidence for the involvement of Gi2 in cell proliferation
J Cell Biochem, 60 (1), 95-106
PubMed 8825419

Moe L, Boysen M, Aas M, Lønaas L, Gamlem H, Bruland OS (1996)
Maxillectomy and targeted radionuclide therapy with 153Sm-EDTMP in a recurrent canine osteosarcoma
J Small Anim Pract, 37 (5), 241-6
PubMed 8736231

Olafsen T, Bruland OS, Zalutsky MR, Sandlie I (1996)
Abundant tyrosine residues in the antigen binding site in anti-osteosarcoma monoclonal antibodies TP-1 and TP-3: Application to radiolabeling
Acta Oncol, 35 (3), 297-301
PubMed 8679259

Saeter G, Bruland OS, Follerås G, Boysen M, Høie J (1996)
Extremity and non-extremity high-grade osteosarcoma -- the Norwegian Radium Hospital experience during the modern chemotherapy era
Acta Oncol, 35 Suppl 8, 129-34
PubMed 9073059

Publications 1995

Bruland OS (1995)
Cancer therapy with radiolabeled antibodies. An overview
Acta Oncol, 34 (8), 1085-94
PubMed 8608033

Larsen RH, Hoff P, Vergote IB, Bruland OS, Aas M, De Vos L, Nustad K (1995)
Alpha-particle radiotherapy with 211At-labeled monodisperse polymer particles, 211At-labeled IgG proteins, and free 211At in a murine intraperitoneal tumor model
Gynecol Oncol, 57 (1), 9-15
PubMed 7705707

Olafsen T, Bruland OS, Zalutsky MR, Sandlie I (1995)
Cloning and sequencing of V genes from anti-osteosarcoma monoclonal antibodies TP-1 and TP-3: location of lysine residues and implications for radiolabeling
Nucl Med Biol, 22 (6), 765-71
PubMed 8535337

Publications 1994

Bruland OS, Fodstad O, Aas M, Solheim OP, Høie J, Skretting A, Winderen M, Michaelsen T, Pihl A (1994)
Immunoscintigraphy of bone sarcomas--results in 5 patients
Eur J Cancer, 30A (10), 1484-9
PubMed 7833107

Larsen RH, Bruland OS, Hoff P, Alstad J, Lindmo T, Rofstad EK (1994)
Inactivation of human osteosarcoma cells in vitro by 211At-TP-3 monoclonal antibody: comparison with astatine-211-labeled bovine serum albumin, free astatine-211 and external-beam X rays
Radiat Res, 139 (2), 178-84
PubMed 8052693

Larsen RH, Bruland OS, Hoff P, Alstad J, Rofstad EK (1994)
Analysis of the therapeutic gain in the treatment of human osteosarcoma microcolonies in vitro with 211At-labelled monoclonal antibody
Br J Cancer, 69 (6), 1000-5
PubMed 8198960

Page RL, Garg PK, Garg S, Archer GE, Bruland OS, Zalutsky MR (1994)
PET imaging of osteosarcoma in dogs using a fluorine-18-labeled monoclonal antibody Fab fragment
J Nucl Med, 35 (9), 1506-13
PubMed 8071702

Publications 1993

Andreassen A, Oyjord T, Hovig E, Holm R, Flørenes VA, Nesland JM, Myklebost O, Høie J, Bruland OS, Børresen AL (1993)
p53 abnormalities in different subtypes of human sarcomas
Cancer Res, 53 (3), 468-71
PubMed 8425179

Publications 1992

Flørenes VA, Aamdal S, Myklebost O, Maelandsmo GM, Bruland OS, Fodstad O (1992)
Levels of nm23 messenger RNA in metastatic malignant melanomas: inverse correlation to disease progression
Cancer Res, 52 (21), 6088-91
PubMed 1356624

Haines DM, Bruland OS, Matte G, Wilkinson AA, Meric SM, Fowler JD (1992)
Immunoscintigraphic detection of primary and metastatic spontaneous canine osteosarcoma with F(ab')2 fragments of osteosarcoma-associated monoclonal antibody TP-1
Anticancer Res, 12 (6B), 2151-7
PubMed 1295462

Publications 1990

Fjeld JG, Bruland OS, Benestad HB, Schjerven L, Stigbrand T, Nustad K (1990)
Radioimmunotargeting of human tumour cells in immunocompetent animals
Br J Cancer, 62 (4), 573-8
PubMed 2223574

Publications 1989

Haines DM, Bruland OS (1989)
Immunohistochemical detection of osteosarcoma-associated antigen in canine osteosarcoma
Anticancer Res, 9 (4), 903-7
PubMed 2684000

Publications 1988

Bruland OS, Fodstad O, Stenwig AE, Pihl A (1988)
Expression and characteristics of a novel human osteosarcoma-associated cell surface antigen
Cancer Res, 48 (18), 5302-9
PubMed 2457439