Sébastien Wälchli
Position: Researcher, PhD
Phone: +47 22 78 13 16
Email:

CV

Sébastien Wälchli

Researcher

Location: Oslo Area, Norway

Industry: Hospital & Health Care

Sébastien Wälchli's Overview

Current

  • Researcher at Oslo University Hospital, Radiumhospitalet

Past

  • Post doc at Oslo University Hospital, Radiumhospitalet
  • Visiting scientist at University of Geneva
  • PhD student at Serono Pharmaceutical Institute

Education

Sébastien Wälchli's Experience

Researcher

Oslo University Hospital, Radiumhospitalet

February 2007 - Present (4 years 10 months)

T-cell receptor (TcR) based immunotherapy

Post doc

Oslo University Hospital, Radiumhospitalet

February 2003 - January 2007 (4 years)

Toxin endocytosis and related signaling

Visiting scientist

University of Geneva

Educational Institution; 5001-10,000 employees; Research industry

November 2002 - February 2003 (4 months) Geneva Area, Switzerland

Enigma Protein (ENH) characterization

PhD student

Serono Pharmaceutical Institute

September 1998 - October 2002 (4 years 2 months)

Protein Tyrosine Phosphatases (PTP) signaling

Sébastien Wälchli's Education

University of Geneva

Master degree, Molecular genetics

1996 - 1998

University of Geneva

Bachelor degree, Biological sciences

1993 - 1996

Sébastien Wälchli's Additional Information

Websites:

Groups and Associations:

Norwegian Society for Immunology: co-secretary (2010-2011) Norwegian Society for Immunology: board member (2009-2010) FYF (Young Scientist Forum) representative: 2009-present

Honors and Awards:

Inven2 Prize for 2011 (http://www.forskningsparken.no/Om-Forskningsparken/Aktuelt/Vinnerne-av-grunderpriser)

 

 

Author network for Sebastien Wälchli by COREMINE medical


Publications 2013

Gregers TF, Skånland SS, Wälchli S, Bakke O, Sandvig K (2013)
BiP Negatively Affects Ricin Transport
Toxins (Basel), 5 (5), 969-82
PubMed 23666197

Publications 2012

Abrahamsen IW, Kjellevoll S, Greve-Isdahl M, Mensali N, Wälchli S, Kumari S, Loland BF, Egeland T, Kolstad A, Olweus J (2012)
T cells raised against allogeneic HLA-A2/CD20 kill primary follicular lymphoma and acute lymphoblastic leukemia cells
Int J Cancer, 130 (8), 1821-32
PubMed 21630262

Huse K, Bakkebø M, Wälchli S, Oksvold MP, Hilden VI, Forfang L, Bredahl ML, Liestøl K, Alizadeh AA, Smeland EB, Myklebust JH (2012)
Role of Smad proteins in resistance to BMP-induced growth inhibition in B-cell lymphoma
PLoS One, 7 (10), e46117
PubMed 23049692

Zhen Y, Sørensen V, Skjerpen CS, Haugsten EM, Jin Y, Wälchli S, Olsnes S, Wiedlocha A (2012)
Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpn?1 and Kpn?1
Traffic, 13 (5), 650-64
PubMed 22321063

Publications 2011

Almåsbak H, Rian E, Hoel HJ, Pulè M, Wälchli S, Kvalheim G, Gaudernack G, Rasmussen AM (2011)
Transiently redirected T cells for adoptive transfer
Cytotherapy, 13 (5), 629-40
PubMed 21174490

Soko?owska I, Wälchli S, W?grzyn G, Sandvig K, S?omi?ska-Wojewódzka M (2011)
A single point mutation in ricin A-chain increases toxin degradation and inhibits EDEM1-dependent ER retrotranslocation
Biochem J, 436 (2), 371-85
PubMed 21388347

Wälchli S, Løset GÅ, Kumari S, Johansen JN, Yang W, Sandlie I, Olweus J (2011)
A practical approach to T-cell receptor cloning and expression
PLoS One, 6 (11), e27930
PubMed 22132171

Publications 2010

Abrahamsen IW, Stronen E, Wälchli S, Johansen JN, Kjellevoll S, Kumari S, Komada M, Gaudernack G, Tjonnfjord G, Toebes M, Schumacher TN, Lund-Johansen F, Olweus J (2010)
Targeting B cell leukemia with highly specific allogeneic T cells with a public recognition motif
Leukemia, 24 (11), 1901-9
PubMed 20844564

Yamazaki T, Wälchli S, Fujita T, Ryser S, Hoshijima M, Schlegel W, Kuroda S, Maturana AD (2010)
Splice variants of enigma homolog, differentially expressed during heart development, promote or prevent hypertrophy
Cardiovasc Res, 86 (3), 374-82
PubMed 20097676

Publications 2009

Nygren MK, Døsen-Dahl G, Stubberud H, Wälchli S, Munthe E, Rian E (2009)
beta-catenin is involved in N-cadherin-dependent adhesion, but not in canonical Wnt signaling in E2A-PBX1-positive B acute lymphoblastic leukemia cells
Exp Hematol, 37 (2), 225-33
PubMed 19101069

Raa H, Grimmer S, Schwudke D, Bergan J, Wälchli S, Skotland T, Shevchenko A, Sandvig K (2009)
Glycosphingolipid requirements for endosome-to-Golgi transport of Shiga toxin
Traffic, 10 (7), 868-82
PubMed 19453975

Skånland SS, Wälchli S, Brech A, Sandvig K (2009)
SNX4 in complex with clathrin and dynein: implications for endosome movement
PLoS One, 4 (6), e5935
PubMed 19529763

Skånland SS, Wälchli S, Sandvig K (2009)
?-arrestins attenuate p38-mediated endosome to Golgi transport
Cell Microbiol, 11 (5), 796-807
PubMed 19159388

Stronen E, Abrahamsen IW, Gaudernack G, Wälchli S, Munthe E, Buus S, Johansen FE, Lund-Johansen F, Olweus J (2009)
Dendritic cells engineered to express defined allo-HLA peptide complexes induce antigen-specific cytotoxic T cells efficiently killing tumour cells
Scand J Immunol, 69 (4), 319-28
PubMed 19284496

Wälchli S, Aasheim HC, Skånland SS, Spilsberg B, Torgersen ML, Rosendal KR, Sandvig K (2009)
Characterization of clathrin and Syk interaction upon Shiga toxin binding
Cell Signal, 21 (7), 1161-8
PubMed 19289168

Publications 2008

Maturana AD, Wälchli S, Iwata M, Ryser S, Van Lint J, Hoshijima M, Schlegel W, Ikeda Y, Tanizawa K, Kuroda S (2008)
Enigma homolog 1 scaffolds protein kinase D1 to regulate the activity of the cardiac L-type voltage-gated calcium channel
Cardiovasc Res, 78 (3), 458-65
PubMed 18296710

Sørensen V, Zhen Y, Zakrzewska M, Haugsten EM, Wälchli S, Nilsen T, Olsnes S, Wiedlocha A (2008)
Phosphorylation of fibroblast growth factor (FGF) receptor 1 at Ser777 by p38 mitogen-activated protein kinase regulates translocation of exogenous FGF1 to the cytosol and nucleus
Mol Cell Biol, 28 (12), 4129-41
PubMed 18411303

Walchli S, Sioud M (2008)
Vector-based delivery of siRNAs: in vitro and in vivo challenges
Front Biosci, 13, 3488-93
PubMed 18508450

Wälchli S, Skånland SS, Gregers TF, Lauvrak SU, Torgersen ML, Ying M, Kuroda S, Maturana A, Sandvig K (2008)
The Mitogen-activated protein kinase p38 links Shiga Toxin-dependent signaling and trafficking
Mol Biol Cell, 19 (1), 95-104
PubMed 17959827

Publications 2007

Fujita T, Maturana AD, Ikuta J, Hamada J, Walchli S, Suzuki T, Sawa H, Wooten MW, Okajima T, Tatematsu K, Tanizawa K, Kuroda S (2007)
Axonal guidance protein FEZ1 associates with tubulin and kinesin motor protein to transport mitochondria in neurites of NGF-stimulated PC12 cells
Biochem Biophys Res Commun, 361 (3), 605-10
PubMed 17669366

Skånland SS, Wälchli S, Utskarpen A, Wandinger-Ness A, Sandvig K (2007)
Phosphoinositide-regulated retrograde transport of ricin: crosstalk between hVps34 and sorting nexins
Traffic, 8 (3), 297-309
PubMed 17319803

Torgersen ML, Wälchli S, Grimmer S, Skånland SS, Sandvig K (2007)
Protein kinase Cdelta is activated by Shiga toxin and regulates its transport
J Biol Chem, 282 (22), 16317-28
PubMed 17403690

Publications 2006

Bache KG, Stuffers S, Malerød L, Slagsvold T, Raiborg C, Lechardeur D, Wälchli S, Lukacs GL, Brech A, Stenmark H (2006)
The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor
Mol Biol Cell, 17 (6), 2513-23
PubMed 16554368

Huynh T, Wälchli S, Sioud M (2006)
Transcriptional targeting of small interfering RNAs into cancer cells
Biochem Biophys Res Commun, 350 (4), 854-9
PubMed 17034763

Lauvrak SU, Wälchli S, Iversen TG, Slagsvold HH, Torgersen ML, Spilsberg B, Sandvig K (2006)
Shiga toxin regulates its entry in a Syk-dependent manner
Mol Biol Cell, 17 (3), 1096-109
PubMed 16371508

Slominska-Wojewodzka M, Gregers TF, Wälchli S, Sandvig K (2006)
EDEM is involved in retrotranslocation of ricin from the endoplasmic reticulum to the cytosol
Mol Biol Cell, 17 (4), 1664-75
PubMed 16452630

Utskarpen A, Slagsvold HH, Iversen TG, Wälchli S, Sandvig K (2006)
Transport of ricin from endosomes to the Golgi apparatus is regulated by Rab6A and Rab6A'
Traffic, 7 (6), 663-72
PubMed 16683916

Publications 2005

Grimmer S, Ying M, Wälchli S, van Deurs B, Sandvig K (2005)
Golgi vesiculation induced by cholesterol occurs by a dynamin- and cPLA2-dependent mechanism
Traffic, 6 (2), 144-56
PubMed 15634214

Hetz C, Russelakis-Carneiro M, Wälchli S, Carboni S, Vial-Knecht E, Maundrell K, Castilla J, Soto C (2005)
The disulfide isomerase Grp58 is a protective factor against prion neurotoxicity
J Neurosci, 25 (11), 2793-802
PubMed 15772339

Sioud M, Wälchli S (2005)
Strategies for the design of random siRNA libraries and the selection of anti-GFP siRNAs
Methods Mol Biol, 309, 83-91
PubMed 15990399

Spilsberg B, Sandvig K, Wälchli S (2005)
Reconstitution of active diphtheria toxin based on a hexahistidine tagged version of the B-fragment produced to high yields in bacteria
Toxicon, 46 (8), 900-6
PubMed 16260019

Wälchli S, Espanel X, Hooft van Huijsduijnen R (2005)
Sap-1/PTPRH activity is regulated by reversible dimerization
Biochem Biophys Res Commun, 331 (2), 497-502
PubMed 15850787

Publications 2004

Sozio MS, Mathis MA, Young JA, Wälchli S, Pitcher LA, Wrage PC, Bartók B, Campbell A, Watts JD, Aebersold R, Hooft van Huijsduijnen R, van Oers NS (2004)
PTPH1 is a predominant protein-tyrosine phosphatase capable of interacting with and dephosphorylating the T cell receptor zeta subunit
J Biol Chem, 279 (9), 7760-9
PubMed 14672952

Wälchli S, Espanel X, Harrenga A, Rossi M, Cesareni G, Hooft van Huijsduijnen R (2004)
Probing protein-tyrosine phosphatase substrate specificity using a phosphotyrosine-containing phage library
J Biol Chem, 279 (1), 311-8
PubMed 14578355

Publications 2003

Espanel X, Wälchli S, Rückle T, Harrenga A, Huguenin-Reggiani M, Hooft van Huijsduijnen R (2003)
Mapping of synergistic components of weakly interacting protein-protein motifs using arrays of paired peptides
J Biol Chem, 278 (17), 15162-7
PubMed 12551909

Pasquali C, Curchod ML, Wälchli S, Espanel X, Guerrier M, Arigoni F, Strous G, Hooft van Huijsduijnen R (2003)
Identification of protein tyrosine phosphatases with specificity for the ligand-activated growth hormone receptor
Mol Endocrinol, 17 (11), 2228-39
PubMed 12907755

Publications 2002

Hooft van Huijsduijnen R, Wälchli S, Ibberson M, Harrenga A (2002)
Protein tyrosine phosphatases as drug targets: PTP1B and beyond
Expert Opin Ther Targets, 6 (6), 637-47
PubMed 12472377

Publications 2001

Espanel X, Wälchli S, Gobert RP, El Alama M, Curchod ML, Gullu-Isler N, Hooft van Huijsduijnen R (2001)
Pulling strings below the surface: hormone receptor signaling through inhibition of protein tyrosine phosphatases
Endocrine, 15 (1), 19-28
PubMed 11572321

Publications 2000

Wälchli S, Colinge J, Hooft van Huijsduijnen R (2000)
MetaBlasts: tracing protein tyrosine phosphatase gene family roots from Man to Drosophila melanogaster and Caenorhabditis elegans genomes
Gene, 253 (2), 137-43
PubMed 10940550

Wälchli S, Curchod ML, Gobert RP, Arkinstall S, Hooft van Huijsduijnen R (2000)
Identification of tyrosine phosphatases that dephosphorylate the insulin receptor. A brute force approach based on "substrate-trapping" mutants
J Biol Chem, 275 (13), 9792-6
PubMed 10734133