
| Sébastien Wälchli | |
| Position: | Researcher, PhD |
| Phone: | +47 22 78 13 16 |
| Email: | |
CV
Sébastien Wälchli
Researcher
Location: Oslo Area, Norway
Industry: Hospital & Health Care
Sébastien Wälchli's Overview
Current
- Researcher at Oslo University Hospital, Radiumhospitalet
Past
- Post doc at Oslo University Hospital, Radiumhospitalet
- Visiting scientist at University of Geneva
- PhD student at Serono Pharmaceutical Institute
Education
- University of Geneva
- University of Geneva
- List of publications (PubMed)
Sébastien Wälchli's Experience
Researcher
Oslo University Hospital, Radiumhospitalet
February 2007 - Present (4 years 10 months)
T-cell receptor (TcR) based immunotherapy
Post doc
Oslo University Hospital, Radiumhospitalet
February 2003 - January 2007 (4 years)
Toxin endocytosis and related signaling
Visiting scientist
Educational Institution; 5001-10,000 employees; Research industry
November 2002 - February 2003 (4 months) Geneva Area, Switzerland
Enigma Protein (ENH) characterization
PhD student
Serono Pharmaceutical Institute
September 1998 - October 2002 (4 years 2 months)
Protein Tyrosine Phosphatases (PTP) signaling
Sébastien Wälchli's Education
University of Geneva
Master degree, Molecular genetics
1996 - 1998
University of Geneva
Bachelor degree, Biological sciences
1993 - 1996
Sébastien Wälchli's Additional Information
Websites:
Groups and Associations:
Norwegian Society for Immunology: co-secretary (2010-2011) Norwegian Society for Immunology: board member (2009-2010) FYF (Young Scientist Forum) representative: 2009-present
Honors and Awards:
Inven2 Prize for 2011 (http://www.forskningsparken.no/Om-Forskningsparken/Aktuelt/Vinnerne-av-grunderpriser)
Author network for Sebastien Wälchli by COREMINE medical
Publications 2013
BiP Negatively Affects Ricin Transport
Toxins (Basel), 5 (5), 969-82
PubMed 23666197
Publications 2012
T cells raised against allogeneic HLA-A2/CD20 kill primary follicular lymphoma and acute lymphoblastic leukemia cells
Int J Cancer, 130 (8), 1821-32
PubMed 21630262
Role of Smad proteins in resistance to BMP-induced growth inhibition in B-cell lymphoma
PLoS One, 7 (10), e46117
PubMed 23049692
Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpn?1 and Kpn?1
Traffic, 13 (5), 650-64
PubMed 22321063
Publications 2011
Transiently redirected T cells for adoptive transfer
Cytotherapy, 13 (5), 629-40
PubMed 21174490
A single point mutation in ricin A-chain increases toxin degradation and inhibits EDEM1-dependent ER retrotranslocation
Biochem J, 436 (2), 371-85
PubMed 21388347
A practical approach to T-cell receptor cloning and expression
PLoS One, 6 (11), e27930
PubMed 22132171
Publications 2010
Targeting B cell leukemia with highly specific allogeneic T cells with a public recognition motif
Leukemia, 24 (11), 1901-9
PubMed 20844564
Splice variants of enigma homolog, differentially expressed during heart development, promote or prevent hypertrophy
Cardiovasc Res, 86 (3), 374-82
PubMed 20097676
Publications 2009
beta-catenin is involved in N-cadherin-dependent adhesion, but not in canonical Wnt signaling in E2A-PBX1-positive B acute lymphoblastic leukemia cells
Exp Hematol, 37 (2), 225-33
PubMed 19101069
Glycosphingolipid requirements for endosome-to-Golgi transport of Shiga toxin
Traffic, 10 (7), 868-82
PubMed 19453975
SNX4 in complex with clathrin and dynein: implications for endosome movement
PLoS One, 4 (6), e5935
PubMed 19529763
?-arrestins attenuate p38-mediated endosome to Golgi transport
Cell Microbiol, 11 (5), 796-807
PubMed 19159388
Dendritic cells engineered to express defined allo-HLA peptide complexes induce antigen-specific cytotoxic T cells efficiently killing tumour cells
Scand J Immunol, 69 (4), 319-28
PubMed 19284496
Characterization of clathrin and Syk interaction upon Shiga toxin binding
Cell Signal, 21 (7), 1161-8
PubMed 19289168
Publications 2008
Enigma homolog 1 scaffolds protein kinase D1 to regulate the activity of the cardiac L-type voltage-gated calcium channel
Cardiovasc Res, 78 (3), 458-65
PubMed 18296710
Phosphorylation of fibroblast growth factor (FGF) receptor 1 at Ser777 by p38 mitogen-activated protein kinase regulates translocation of exogenous FGF1 to the cytosol and nucleus
Mol Cell Biol, 28 (12), 4129-41
PubMed 18411303
Vector-based delivery of siRNAs: in vitro and in vivo challenges
Front Biosci, 13, 3488-93
PubMed 18508450
The Mitogen-activated protein kinase p38 links Shiga Toxin-dependent signaling and trafficking
Mol Biol Cell, 19 (1), 95-104
PubMed 17959827
Publications 2007
Axonal guidance protein FEZ1 associates with tubulin and kinesin motor protein to transport mitochondria in neurites of NGF-stimulated PC12 cells
Biochem Biophys Res Commun, 361 (3), 605-10
PubMed 17669366
Phosphoinositide-regulated retrograde transport of ricin: crosstalk between hVps34 and sorting nexins
Traffic, 8 (3), 297-309
PubMed 17319803
Protein kinase Cdelta is activated by Shiga toxin and regulates its transport
J Biol Chem, 282 (22), 16317-28
PubMed 17403690
Publications 2006
The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor
Mol Biol Cell, 17 (6), 2513-23
PubMed 16554368
Transcriptional targeting of small interfering RNAs into cancer cells
Biochem Biophys Res Commun, 350 (4), 854-9
PubMed 17034763
Shiga toxin regulates its entry in a Syk-dependent manner
Mol Biol Cell, 17 (3), 1096-109
PubMed 16371508
EDEM is involved in retrotranslocation of ricin from the endoplasmic reticulum to the cytosol
Mol Biol Cell, 17 (4), 1664-75
PubMed 16452630
Transport of ricin from endosomes to the Golgi apparatus is regulated by Rab6A and Rab6A'
Traffic, 7 (6), 663-72
PubMed 16683916
Publications 2005
Golgi vesiculation induced by cholesterol occurs by a dynamin- and cPLA2-dependent mechanism
Traffic, 6 (2), 144-56
PubMed 15634214
The disulfide isomerase Grp58 is a protective factor against prion neurotoxicity
J Neurosci, 25 (11), 2793-802
PubMed 15772339
Strategies for the design of random siRNA libraries and the selection of anti-GFP siRNAs
Methods Mol Biol, 309, 83-91
PubMed 15990399
Reconstitution of active diphtheria toxin based on a hexahistidine tagged version of the B-fragment produced to high yields in bacteria
Toxicon, 46 (8), 900-6
PubMed 16260019
Sap-1/PTPRH activity is regulated by reversible dimerization
Biochem Biophys Res Commun, 331 (2), 497-502
PubMed 15850787
Publications 2004
PTPH1 is a predominant protein-tyrosine phosphatase capable of interacting with and dephosphorylating the T cell receptor zeta subunit
J Biol Chem, 279 (9), 7760-9
PubMed 14672952
Probing protein-tyrosine phosphatase substrate specificity using a phosphotyrosine-containing phage library
J Biol Chem, 279 (1), 311-8
PubMed 14578355
Publications 2003
Mapping of synergistic components of weakly interacting protein-protein motifs using arrays of paired peptides
J Biol Chem, 278 (17), 15162-7
PubMed 12551909
Identification of protein tyrosine phosphatases with specificity for the ligand-activated growth hormone receptor
Mol Endocrinol, 17 (11), 2228-39
PubMed 12907755
Publications 2002
Protein tyrosine phosphatases as drug targets: PTP1B and beyond
Expert Opin Ther Targets, 6 (6), 637-47
PubMed 12472377
Publications 2001
Pulling strings below the surface: hormone receptor signaling through inhibition of protein tyrosine phosphatases
Endocrine, 15 (1), 19-28
PubMed 11572321
Publications 2000
MetaBlasts: tracing protein tyrosine phosphatase gene family roots from Man to Drosophila melanogaster and Caenorhabditis elegans genomes
Gene, 253 (2), 137-43
PubMed 10940550
Identification of tyrosine phosphatases that dephosphorylate the insulin receptor. A brute force approach based on "substrate-trapping" mutants
J Biol Chem, 275 (13), 9792-6
PubMed 10734133




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