Terhi Kärpänen
Position: Researcher, PhD
Phone: +47 22 78 1309
Email:
 

Publications 2017

Karpanen T, Padberg Y, van de Pavert SA, Dierkes C, Morooka N, Peterson-Maduro J, van de Hoek G, Adrian M, Mochizuki N, Sekiguchi K, Kiefer F, Schulte D, Schulte-Merker S (2017)
An Evolutionarily Conserved Role for Polydom/Svep1 During Lymphatic Vessel Formation
Circ Res, 120 (8), 1263-1275
PubMed 28179432

Publications 2015

Karpanen T, Olweus J (2015)
T-cell receptor gene therapy--ready to go viral?
Mol Oncol, 9 (10), 2019-42
PubMed 26548533

Publications 2013

Helker CS, Schuermann A, Karpanen T, Zeuschner D, Belting HG, Affolter M, Schulte-Merker S, Herzog W (2013)
The zebrafish common cardinal veins develop by a novel mechanism: lumen ensheathment
Development, 140 (13), 2776-86
PubMed 23698350

Publications 2011

Bos FL, Caunt M, Peterson-Maduro J, Planas-Paz L, Kowalski J, Karpanen T, van Impel A, Tong R, Ernst JA, Korving J, van Es JH, Lammert E, Duckers HJ, Schulte-Merker S (2011)
CCBE1 is essential for mammalian lymphatic vascular development and enhances the lymphangiogenic effect of vascular endothelial growth factor-C in vivo
Circ Res, 109 (5), 486-91
PubMed 21778431

Karpanen T, Schulte-Merker S (2011)
Zebrafish provides a novel model for lymphatic vascular research
Methods Cell Biol, 105, 223-38
PubMed 21951532

Zheng W, Tammela T, Yamamoto M, Anisimov A, Holopainen T, Kaijalainen S, Karpanen T, Lehti K, Ylä-Herttuala S, Alitalo K (2011)
Notch restricts lymphatic vessel sprouting induced by vascular endothelial growth factor
Blood, 118 (4), 1154-62
PubMed 21566091

Publications 2010

Nykänen AI, Sandelin H, Krebs R, Keränen MA, Tuuminen R, Kärpänen T, Wu Y, Pytowski B, Koskinen PK, Ylä-Herttuala S, Alitalo K, Lemström KB (2010)
Targeting lymphatic vessel activation and CCL21 production by vascular endothelial growth factor receptor-3 inhibition has novel immunomodulatory and antiarteriosclerotic effects in cardiac allografts
Circulation, 121 (12), 1413-22
PubMed 20231530

Pedrioli DM, Karpanen T, Dabouras V, Jurisic G, van de Hoek G, Shin JW, Marino D, Kälin RE, Leidel S, Cinelli P, Schulte-Merker S, Brändli AW, Detmar M (2010)
miR-31 functions as a negative regulator of lymphatic vascular lineage-specific differentiation in vitro and vascular development in vivo
Mol Cell Biol, 30 (14), 3620-34
PubMed 20479124

Publications 2008

Karpanen T, Alitalo K (2008)
VEGF-D: a modifier of embryonic lymphangiogenesis
Blood, 112 (5), 1547-8
PubMed 18725566

Karpanen T, Alitalo K (2008)
Molecular biology and pathology of lymphangiogenesis
Annu Rev Pathol, 3, 367-97
PubMed 18039141

Karpanen T, Bry M, Ollila HM, Seppänen-Laakso T, Liimatta E, Leskinen H, Kivelä R, Helkamaa T, Merentie M, Jeltsch M, Paavonen K, Andersson LC, Mervaala E, Hassinen IE, Ylä-Herttuala S, Oresic M, Alitalo K (2008)
Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy
Circ Res, 103 (9), 1018-26
PubMed 18757827

Publications 2007

Keskitalo S, Tammela T, Lyytikka J, Karpanen T, Jeltsch M, Markkanen J, Yla-Herttuala S, Alitalo K (2007)
Enhanced capillary formation stimulated by a chimeric vascular endothelial growth factor/vascular endothelial growth factor-C silk domain fusion protein
Circ Res, 100 (10), 1460-7
PubMed 17478734

Publications 2006

Jeltsch M, Karpanen T, Strandin T, Aho K, Lankinen H, Alitalo K (2006)
Vascular endothelial growth factor (VEGF)/VEGF-C mosaic molecules reveal specificity determinants and feature novel receptor binding patterns
J Biol Chem, 281 (17), 12187-95
PubMed 16505489

Karpanen T, Wirzenius M, Mäkinen T, Veikkola T, Haisma HJ, Achen MG, Stacker SA, Pytowski B, Ylä-Herttuala S, Alitalo K (2006)
Lymphangiogenic growth factor responsiveness is modulated by postnatal lymphatic vessel maturation
Am J Pathol, 169 (2), 708-18
PubMed 16877368

Kärpänen T, Heckman CA, Keskitalo S, Jeltsch M, Ollila H, Neufeld G, Tamagnone L, Alitalo K (2006)
Functional interaction of VEGF-C and VEGF-D with neuropilin receptors
FASEB J, 20 (9), 1462-72
PubMed 16816121

Publications 2005

Karpanen T, Mäkinen T (2005)
Regulation of lymphangiogenesis--from cell fate determination to vessel remodeling
Exp Cell Res, 312 (5), 575-83
PubMed 16343484

Publications 2004

He Y, Karpanen T, Alitalo K (2004)
Role of lymphangiogenic factors in tumor metastasis
Biochim Biophys Acta, 1654 (1), 3-12
PubMed 14984763

Laakkonen P, Akerman ME, Biliran H, Yang M, Ferrer F, Karpanen T, Hoffman RM, Ruoslahti E (2004)
Antitumor activity of a homing peptide that targets tumor lymphatics and tumor cells
Proc Natl Acad Sci U S A, 101 (25), 9381-6
PubMed 15197262

Petrova TV, Karpanen T, Norrmén C, Mellor R, Tamakoshi T, Finegold D, Ferrell R, Kerjaschki D, Mortimer P, Ylä-Herttuala S, Miura N, Alitalo K (2004)
Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis
Nat Med, 10 (9), 974-81
PubMed 15322537

Uutela M, Wirzenius M, Paavonen K, Rajantie I, He Y, Karpanen T, Lohela M, Wiig H, Salven P, Pajusola K, Eriksson U, Alitalo K (2004)
PDGF-D induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis
Blood, 104 (10), 3198-204
PubMed 15271796

Publications 2002

He Y, Kozaki K, Karpanen T, Koshikawa K, Yla-Herttuala S, Takahashi T, Alitalo K (2002)
Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling
J Natl Cancer Inst, 94 (11), 819-25
PubMed 12048269

Mattila MM, Ruohola JK, Karpanen T, Jackson DG, Alitalo K, Härkönen PL (2002)
VEGF-C induced lymphangiogenesis is associated with lymph node metastasis in orthotopic MCF-7 tumors
Int J Cancer, 98 (6), 946-51
PubMed 11948478

Zhou Y, McMaster M, Woo K, Janatpour M, Perry J, Karpanen T, Alitalo K, Damsky C, Fisher SJ (2002)
Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome
Am J Pathol, 160 (4), 1405-23
PubMed 11943725