Publications 2013

 

Bianchini L, Birtwisle L, Saâda E, Bazin A, Long E, Roussel JF, Michiels JF, Forest F, Dani C, Myklebost O, Birtwisle-Peyrottes I, Pedeutour F. (2013) Identification of PPAP2B as a novel recurrent translocation partner gene of HMGA2 in lipomas. Genes Chromosomes Cancer doi: 10.1002/gcc.22055 PDF

Doorn J, Hugo Fernandes H, Lee B, van de Peppel J, van Leeuwen JPTM, De Vries MR, Aref Z, Quax PHA, Myklebost O, Saris D, van Blitterswijk CA, de Boer J. (2013) A small molecule approach to engineering vascularized tissue. Biomaterials  34 (12)3053-63 PDF

Stratford EW, Bostad M, Castro R, Skarpend E, Berg K, Høgset A, Myklebost O, Selbo PK (2013) Photochemical internalization of CD133-targeting immunotoxins efficiently depletes sarcoma cells with stem-like properties and reduces tumorigenicity Biochim Biophys Acta in press

Thomas D, Myklebost O, Meza-Zepeda LA (2013) Research in Well-Differentiated and Dedifferentiated Liposarcoma ESUN - A Periodical for the Sarcoma Community, Volume 10, Number 1 Link

Wang P, Gao1 Q, Suo Z, Munthe E, Solberg S, Ma L, Wang MY, Westerdaal NAC, Kvalheim G, Gaudernack G (2013) Identification and characterization of cells with cancer stem cell properties in human primary lung cancer cell lines PLoS One in press

 

 
 

Publications 2012

 

Bjørnstad LGMeza TJOtterlei MOlafsrud SMMeza-Zepeda LAFalnes PØ (2012Human ALKBH4 interacts with proteins associated with transcription PLoS One7 (11)e49045 PubMed 23145062

Chymkowitch P, Eldholm V, Lorenz S, Zimmermann C, Lindvall J, Bjørås M, Meza-Zepeda LA, Enserink JM (2012) Cdc28 kinase activity regulates the basal transcription machinery at a subset of genes. Proceedings of the National Academy of Sciences (PNAS), in press

Kresse SH, Rydbeck H, Skårn M, Namløs HM, Barragan-Polania AH, Cleton-Jansen AM, Serra M, Liestøl K, Hogendoorn PCW, Hovig, E, Myklebost;  O, Meza-Zepeda LA (2012) Integrative Analysis Reveals Relationships of Genetic and Epigenetic Alterations in Osteosarcoma. PLoS One PDF

KuijjerML, Rydbeck H, Kresse SH, Buddingh EP, Bürger H, Myklebost O, Hogendoorn PCW, Meza-Zepeda LA, Cleton-Jansen AM (2012) Identification of osteosarcoma driver genes by integrative analysis of copy number and gene expression data Genes Chromosomes Cancer 51:696-706 PDF

Namløs H, Kresse SH, Müller CR, Henriksen J, Sæter G, Bruland Ø, Holdhus R, Bjerkehagen B, Steen VM , Myklebost O (2010) Global gene expression profiling of human osteosarcomas reveals metastasis-associated chemokine pattern Sarcoma  PDF

Namløs HM, Meza-Zepeda LA, Barøy T, Østensen IHG, Kresse SH, Kuijjer ML, Serra M, Bürger H, Cleton-Jansen AM, Myklebost O (2012) Modulation of the Osteosarcoma Expression Phenotype by MicroRNAs. PLoS One in press

Ohnstad HO, Castro R, Sun J, Heintz KM, Vassilev LT, Bjerkehagen B, Kresse SH, Meza- Zepeda LA, Myklebost O (2012) Correlation of TP53 and MDM2 genotypes with response to therapy in sarcoma Cancer PDF

Reikvam DHDerrien MIslam RErofeev AGrcic VSandvik AGaustad P, Meza-Zepeda LA, Jahnsen FLSmidt HJohansen FE (2012Epithelial-microbial crosstalk in polymeric Ig receptor deficient mice
Eur J Immunol42 (11)2959-70 PubMed 22865203

Skotheim RI, Meza-Zepeda LA, Hovig E, Lønning PE, Lothe RA, Myklebost O  (2012) Genomsekvensering for persontilpasset kreftbehandling,  Tidsskr. Nor. Lægeforening 132:2406-8 PDF

See editorial on the above paper

Skårn M, Namløs HM, Noordhuis P, Meng-Yu Wang, Meza-Zepeda LA, Myklebost O (2012) Adipocyte Differentiation of Immortalized Human Bone Marrow-Derived Stromal Cells is Modulated by microRNA-155, microRNA-221 and microRNA-222 Stem Cells and Development  21:873-83 PDF

Stratford EW, Castro R, Daffinrud J, Skårn M, Lauvrak SU, Munthe E, Myklebost O (2012) Characterization of liposarcoma cell lines for preclinical and biological studies Sarcoma 2012 doi:10.1155/2012/148614 PDF

Thomas DM, Wilhelm M, Cleton-Jansen AM, Dirksen U, Entz-Werlé N, Gelderblom H, Hassan B, Jürgens H, Koster J, Kovar H, Lankester AC, Lewis IJ, Myklebost O, Nathrath MHM, Picci P, Whelan JS, Hogendoorn PCW, Bielack SS (2012) Workshop report on the European Bone Sarcoma Networking Meeting: integration of clinical trials with tumor biology. Journal of Adolescent and Young Adult Oncology Vol 1 In press PDF

 
 

Publications 2011

 

Buddingh EP, Kuijjer ML, Duim RAJ, Bürger H, Agelopoulos K, Myklebost O, Serra M, Hogendoorn PCW, Lankester AC, Cleton-Jansen AM (2011) Metastasis suppression by tumor-infiltrating macrophages in high-grade osteosarcoma. Clin Cancer Res 2011 17:2110-2119 PDF

Hjortland GO, Meza-Zepeda LA, Beiske K, Ree AH, Tveito S, Hoifodt H, Bohler PJ, Hole KH, Myklebost O, Fodstad Ø, Smeland S, Hovig E (2011) Potential therapeutic targets revealed by genome-wide screening of metastatic cells: Case report BMC Cancer 11:455 PDF 

Kresse SH, Meza-Zepeda LA, Machado I, Llombart-Bosch A, Myklebost O (2011) Genomic validation of preclinical xenograft models of human sarcoma reveals recurrent loss of aberrations Cancer 118: 558–570 Preprint Supplementary data

Kuijjer ML, Namlos HM, Hauben EI, Machado I, Kresse SH, Serra M, Llombart-Bosch A, Hogendoorn PCW, Meza-Zepeda LA, Myklebost O, Cleton-Jansen AM (2011) mRNA expression profiles of primary high-grade central osteosarcoma are preserved in cell lines and xenografts BMC Medical Genomics, 4:66 PDF 

Müller CR (2011) Novel approaches to the treatment of high-grade sarcoma. PhD Thesis, University of Oslo ISBN 978-82-8264-004-6 No 1112 PDF

Ohnstad HO, Paulsen EB, Noordhuis P, Berg M, Lothe RA, Vassilev L, Myklebost O (2011) Pharmacological interaction of the MDM2 antagnist Nutlin-3a and cytotoxic drugs in sarcoma cell lines BMC Cancer 11:211  PDF 

Stratford EW, Castro R, Wennerstrőm AB, Holm R, Munthe E, Lauvrak S, Bjerkehagen B, Myklebost O. Combined ALDH and CD133 expression defines a stem-like cancer cell population in liposarcoma xenograft Clin Sarcoma Res 1:8 PDF

 
 

Publications 2010

 

Eide MB, Liestøl K, Lingjærde OC, Hystad M, Kresse SH, Meza-Zepeda L, Myklebost O, Aamot HV, Holte H, Smeland EB, Delabie J (2010) DNA copy number alterations reveal potential for higher grade transformation in Follicular lymphoma and confirm parallel evolution of tumor cell clones. Blood doi:10.1182/blood-2010-03-272278 PDF

Henriksen J, Stabell M, Meza-Zepeda LA, Lauvrak SAU, Kassem M, Myklebost O (2010) Identification of target genes for wild type and truncated HMGA2 in mesenchymal stem-like cells BMC Cancer, 10:329 PDF 

Kresse SH, Szuhai K, Barragan-Polania A, Rydbeck H, Cleton-Jansen AM, Myklebost O, Meza-Zepeda LA (2010) Evaluation of high-resolution microarray platforms for genomic profiling of bone tumours BMC Research Notes 3:223 PDF 

Kresse SH, Ohnstad HO, Bjerkehagen B, Myklebost O, Meza-Zepeda LA (2010) DNA Copy Number Changes in Human Malignant Fibrous Histiocytomas by Array Comparative Genomic Hybridisation PloS One Nov 9;5:e15378 PDF

Mayordomo E, Machado I, Giner F, Kresse SH, Myklebost O, Carda C, Navarro S, Llombart-Bosch (2010) A Histopathology, immunohistochemistry and xenotransplant in Osteosarcoma: a tissue microarray study. Applied Immunohistochemistry and Molecular Morphology doi: 10.1097/PAI.0b013e3181daace3 PDF

Ottaviano L, Schaefer KL, Gajewski M, Huckenbeck W, Baldus S, Rogel U, Mackintosh C, de Alava E, Myklebost O, Kresse SH, Meza-Zepeda LA, Serra M, Cleton-Jansen AM, Hogendoorn PCW, Buerger H, Gabbert HE, Poremba C (2010) Molecular characterization of commonly used cell lines for bone tumor research. A trans-European EuroBoNet effort. Genes Chromosomes Cancer 49:40-51 PubMed

Müller CR, Namløs H, Smeland S, Sæter G, Bjerkehagen B, Bjerner J, Holden M, Bruland Ø, Myklebost O (2010) Characterization of Treatment Response to Interferon-a in Osteosarcoma Xenografts. J Cancer Sci Ther 2:33-42 PDF

Skårn M, Namløs HM, Noordhuis PMeng-Yu Wang, Meza-Zepeda LA, Myklebost O (2010) Adipocyte Differentiation of Immortalized Human Bone Marrow-Derived Stromal Cells is Modulated by microRNA-155, microRNA-221 and microRNA-222 Stem Cells and Development PDF ahead of print

Tenstad E, Tourovskaia A, Folch A, Myklebost O, Rian E (2010) Extensive adipogenic and osteogenic differentiation of patterned human mesenchymal stem cells in a microfluidic device. Lab on a Chip  DOI:10.1039/B926738G PDF see special mention 
Cover page   

 
 

Publications 2009

 

Kresse SH, Ohnstad HO, Paulsen EB, Bjerkehagen B, Szuhai K, Serra M, Schaefer K-L, Myklebost O, Meza-Zepeda LA (2009) LSAMP, a novel candidate tumor suppressor gene in human osteosarcomas identified by array comparative genomic hybridization. Genes Chromosomes Cancer 48 (8)679-93 PubMed 19441093

Lehne G, Grasmo-Wendler UH, Berner JM, Meza-Zepeda LA, Adamsen BL, Flack A, Reiner A, Clausen OPF, Hovig E, Myklebost O (2009). Upregulation of stem cell genes in multidrug resistant K562 leukem ia cells. Leukemia Research  33 (10)1379-85 PubMed 19394083

Revheim ME, Seierstad T, Berner JM, Bruland OS, Roe K, Ohnstad HO, Bjerkehagen B, Bach-Gansmo T. 2009. Establishment and characterization of a human gastrointestinal stromal tumour (GIST) xenograft in athymic nude mice. Anticancer Res 29:4331-6

Våtsveen TK, Tian E, Kresse SH, Meza-Zepeda LA, Gabrea A, Glebov O, Dai HY, Sundan A, Kuehl WM, Børset M (2009) OH-2, a hyperdiploid myeloma cell line without an IGH translocation, has a complex translocation juxtaposing MYC near MAFB and the IGK locus. Leukemia Research 33:1670 PubMed 19395026

 
 

Publications 2008

 

Kresse SH, Skårn M, Ohnstad HO, Namløs HM, Bjerkehagen B, Wang J, Myklebost O and Meza-Zepeda LA. (2008) DNA copy number changes in malignant peripheral nerve sheath tumors by array comparative genomic hybridization. Molecular Cancer 7:48 PDF

Larsen E, Kleppa L, Meza TJ, Meza-Zepeda LA, Rada C, Castellanos CG, Lien GF, Nesse GJ, Neuberger MS, Laerdahl JK, Doughty RW, Klungland A (2008) Early-onset lymphoma and extensive embryonic apoptosis in two domain-specific Fen1 mice mutants Cancer Res 68:4571-9 PDF

Lybæk H, Meza-Zepeda LA, Kresse SH, Høysæter T, Steen VM, Houge G. (2008) Array-CGH fine mapping of minor and cryptic chromosome-CGH detected genomic imbalances in 80 out of 590 patients abnormal development. Eur j Hum Genet 16:1318-28

Lyng H, Lando M, Brøvig RS, Svendsrud DH, Johansen M, Galteland E, Brustugun OT, Meza-Zepeda LA, Myklebost O, Kristensen GB, Hovig E, Stokke T (2008) GeneCount: Genome-wide calculation of absolute tumor DNA copy numbers from array CGH data Genome Biology 2008, 9:R86 PDF

Meza-Zepeda LA, Noer A, Dahl JA, Micci F, Myklebost O, Collas P (2008) High-resolution analysis of genetic stability of human adipose tissue stem cells cultured to senescence. J Cell Mol Med 12:553-63 PDF

Nakajima GPatino-Garcia ABruheim SXi YSan Julian MLecanda FSierrasesumaga L, Müller CFodstad OJu J(2008)
CDH11 expression is associated with survival in patients with osteosarcoma Cancer Genomics Proteomics, 5 (1)37-42
PubMed 18359978

Roman E, Meza-Zepeda LA, Kresse SH, Myklebost O, Vasstrand EN, Ibrahim SO (2008) Chromosomal aberrations in head and neck squamous cell carcinomas in Norwegian and Sudanese populations by array comparative genomic hybridization. Oncol Rep 20:825-43 PDF

Varghese M, Olstorn H, Sandberg C, Vik-Mo EO, Noordhuis P, Nistér M, Berg-Johnsen J, Moe MC, Langmoen IA (2008) A comparison between stem cells from the adult human brain and from brain tumors. Neurosurgery. 2008 Dec;63(6):1022-33; discussion 1033-4

 
 

Publications 2007

 

Kleivi K, Lind GE, Diep CB, Meling GI, Brandal LT, Nesland JM, Myklebost O, Rognum TO, Giercksky KE, Skotheim RI, Lothe RA (2007) Gene expression profiles of primary colorectal carcinomas, liver metastases, and carcinomatoses. Molecular Cancer 6:2 PDF

Müller CR, Paulsen EB, Noordhuis P, Peudeutour F, Sæter G, Myklebost O (2007) Potential For Treatment Of Liposarcomas With The MDM2 Antagonist Nutlin-3a In J Cancer 121: 199-205 PDF

Princy Francis, Heidi Maria Namløs, Christoph Müller, Patrik Edén, Josefin Fernebro, Jeanne-Marie Berner, Bodil Bjerkehagen, Måns Åkerman, Pär-Ola Bendahl, Anna Isinger, Anders Rydholm, Ola Myklebost and Mef Nilbert (2007) Diagnostic and prognostic gene expression signatures in 177 soft tissue sarcomas: hypoxia-induced transcription profile signifies metastatic potential BMC Genomics 2007, 8:73 PDF

Cekaite L, Peng Q, Reiner A, Shahzidi S, Tveito S, Furre IE, Hovig E (2007) Mapping of oxidative stress responses of human tumor cells following photodynamic therapy using hexaminolevulinate BMC Genomics 8:273 PDF

 
 

Publications 2006

 
Berner JM, Müller CR, Holden M, Wang J, Hovig E, Myklebost O (2006) Sampling effects on gene expression data from a human tumor xenograft Scand J Lab Animal Science 33:17-30 PDF

Meza-Zepeda LA, Kresse SH, Barragan-Polania AHB, Bjerkehagen B, Ohnstad HO, Namløs HM, Wang J, Kristiansen BE, Myklebost O (2006) Array CGH unveils distinct DNA copy number differences between leiomyosarcomas and gastrointestinal stromal tumours Cancer Research 66:8984-93

Sivertsen EA, Galteland E, Mu D, Holte H, Meza-Zepeda L, Myklebost O, Patzke S, Smeland EB, Stokke T (2006) gain of chromosome 6p is an infrequent cause of increased PIM1 expression in B-cell non-Hodgkin’s lymphomas. Leukaemia 20:539-542

The MAQC Consortium [including Myklebost O] (2006) The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements Nature Biotech Vol 24: pp1151 - 1161

Tovar C, Rosinski J, Filipovic Z, Higgins B, Kolinsky K, Hilton H, Zhao X, Vu BT, Qing W, Packman K, Myklebost O, Heimbrook DC, Vassilev LT (2006) Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy Proc Natl Acad Sci USA 103:188-1893 PDF See Editorial in PNAS.

 
 

Publications 2005

 

Bjerkehagen B, Myklebost O (2005) Diagnostisk Molekylærbiologi: Ben- og bløtvevsvulster. Tidsskr. Nor. Lægeforening 125: 3286-9 PDF

Dietze A, Peng Q, Selbo PK, Kaalhus O, Müller C, Bown S, Berg K (2005) Enhanced photodynamic destruction of a transplantable fibrosarcoma using photochemical internalisation of gelonin. Br J Cancer 6:2004-9 

Galteland E, Sivertsen EA, Svendsrud DH, Smedshammer L, Kresse SH, Meza-Zepeda LA, Myklebost O, Suo Z, Mu D, Deangelis PM, Stokke T. (2006) Translocation t(14;18) and gain of chromosome 18/BCL2: effects on BCL2 expression and apoptosis in B-cell non-Hodgkin's lymphomas. Leukemia 19:2313-2323

Kresse SH, Berner JM, Meza-Zepeda LA, Gregory SG, W-L Kuo, Gray JW, Forus A Myklebost O (2005) Mapping and characterisation of the amplicon near APOA2 in 1q23 in human sarcomas Mol Cancer 2005, 4:39 PDF

Lyng H, Landsverk KS, Kristiansen E, DeAngelis P, Ree AH, Myklebost O, Hovig E, Stokke T. (2005) The response of malignant B lymphocytes to ionizing radiation: mRNA expression and genotypes. Int J Cancer 115:935-42

Dahle J, Noordhuis P, Stokke T, Svendsrud DH, Kvam E (2005) Multiplex polymerase chain reaction analysis of UV-A- and UV-B-induced delayed and early mutations in V79 Chinese hamster cells Photochem Photobiol. 81:114-9 

Nygaard V, Holden M, Loland A, Langaas M, Myklebost O, Hovig E (2005) Limitations of mRNA amplification from small-size cell samples BMC Genomics 6:147 PDF

Ågesen TH, Flørenes VA, Molenaar WM, Lind GE, Berner JM, Plaat BEC, Komdeur R, Myklebost O,van den Berg E, Lothe RA (2005) Expression patterns of cell cycle components in sporadic and neurofibromatosis type 1 related malignantperipheral nerve sheath tumors. J Neuropathol Exp Neurol 64:74-81

 
 

Publications 2004

 

Cekaite L, Haug O, Myklebost O, Aldrin M, Østenstad B, Holden M, Frigessi A, Hovig E, Sioud M (2004) Analysis of the humoral immune response to immunoselected phagedisplayed peptides by a microarray-based method. Proteomics 4:2572-2582

Lyng H, Baidee A, Svendsrud DH, Hovig E, Myklebost O, Stokke T (2004) Profound influence of non-linearity in microarray scanners on gene expression ratios: Analysis and procedure for correction. BMC Genomics 5:10. PDF

Myklebost O (2004) Putting Norway on the gene-therapy map. Letter to the Editor of Nature 429:129. PDF

Nilbert M, Meza-Zepeda LA, Francis P, Berner JM, Namløs HM, Myklebost O (2004) Lessons from genetic profiling in soft tissue sarcomas. Acta Orth. Scand. 75 (Suppl 313) 35-50 PDF

Nilsson M, Meza-Zepeda L, Mertens M, Forus A, Myklebost O, Mandahl N.Chromosomal distribution of amplified chromosome 1 sequences in softtissue and bone tumors". Int J Cancer 109:363-9 PDF

Trøen G, Nygaard V, Jenssen TK, Ikonomou IM, Tierens A, Matutes E, Gruszka-Westwood A, Catovsky D, Myklebost O, Lauritzsen G, Hovig E, Delabie J (2004) Constitutive expression of the AP-1 transcription factors c-jun, junD, junB and c-fos and the marginal zone B-cell transcription factor Notch2 in splenic marginal zone lymphoma. Journal of Molecular Diagnostics in press

Wang J, Meza-Zepeda LA, Kresse SH, Myklebost O (2004) M-CGH: Analysing microarray-based CGH experiments. BMC Bioinformatics 5:74 PDF


 
 
  Publications 2003 
  Publications 2002 
  Publications 2001 
  Publications 1983-2000