Heidi Lyng
Position: Scientist, Dr. philos
Phone: +47 22 78 1478 / 976 83 759
Email:
 

Author network for Heidi Lyng by COREMINE medical


Publications 2017

Lyng H, Malinen E (2017)
Hypoxia in cervical cancer: from biology to imaging
Clin Transl Imaging, 5 (4), 373-388
PubMed 28804704

Torheim T, Malinen E, Hole KH, Lund KV, Indahl UG, Lyng H, Kvaal K, Futsaether CM (2017)
Autodelineation of cervical cancers using multiparametric magnetic resonance imaging and machine learning
Acta Oncol, 56 (6), 806-812
PubMed 28464746

Publications 2016

Fjeldbo CS, Julin CH, Lando M, Forsberg MF, Aarnes EK, Alsner J, Kristensen GB, Malinen E, Lyng H (2016)
Integrative Analysis of DCE-MRI and Gene Expression Profiles in Construction of a Gene Classifier for Assessment of Hypoxia-Related Risk of Chemoradiotherapy Failure in Cervical Cancer
Clin Cancer Res, 22 (16), 4067-76
PubMed 27012812

Fjeldbo CS, Aarnes EK, Malinen E, Kristensen GB, Lyng H (2016)
Identification and Validation of Reference Genes for RT-qPCR Studies of Hypoxia in Squamous Cervical Cancer Patients
PLoS One, 11 (5), e0156259
PubMed 27244197

Hasvold G, Lund-Andersen C, Lando M, Patzke S, Hauge S, Suo Z, Lyng H, Syljuåsen RG (2016)
Hypoxia-induced alterations of G2 checkpoint regulators
Mol Oncol, 10 (5), 764-73
PubMed 26791779

Jonsson M, Ragnum HB, Julin CH, Yeramian A, Clancy T, Frikstad KM, Seierstad T, Stokke T, Matias-Guiu X, Ree AH, Flatmark K, Lyng H (2016)
Hypoxia-independent gene expression signature associated with radiosensitisation of prostate cancer cell lines by histone deacetylase inhibition
Br J Cancer, 115 (8), 929-939
PubMed 27599042

Torheim T, Groendahl AR, Andersen EK, Lyng H, Malinen E, Kvaal K, Futsaether CM (2016)
Cluster analysis of dynamic contrast enhanced MRI reveals tumor subregions related to locoregional relapse for cervical cancer patients
Acta Oncol, 55 (11), 1294-1298
PubMed 27564398

Wilting SM, Miok V, Jaspers A, Boon D, Sørgård H, Lando M, Snoek BC, van Wieringen WN, Meijer CJ, Lyng H, Snijders PJ, Steenbergen RD (2016)
Aberrant methylation-mediated silencing of microRNAs contributes to HPV-induced anchorage independence
Oncotarget, 7 (28), 43805-43819
PubMed 27270309

Publications 2015

Lando M, Fjeldbo CS, Wilting SM, C Snoek B, Aarnes EK, Forsberg MF, Kristensen GB, Steenbergen RD, Lyng H (2015)
Interplay between promoter methylation and chromosomal loss in gene silencing at 3p11-p14 in cervical cancer
Epigenetics, 10 (10), 970-80
PubMed 26291246

Publications 2014

Pettersen EO, Ebbesen P, Gieling RG, Williams KJ, Dubois L, Lambin P, Ward C, Meehan J, Kunkler IH, Langdon SP, Ree AH, Flatmark K, Lyng H, Calzada MJ, Peso LD, Landazuri MO, Görlach A, Flamm H, Kieninger J, Urban G, Weltin A, Singleton DC, Haider S, Buffa FM, Harris AL et al. (2014)
Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium
J Enzyme Inhib Med Chem, 30 (5), 689-721
PubMed 25347767

Ragnum HB, Vlatkovic L, Lie AK, Axcrona K, Julin CH, Frikstad KM, Hole KH, Seierstad T, Lyng H (2014)
The tumour hypoxia marker pimonidazole reflects a transcriptional programme associated with aggressive prostate cancer
Br J Cancer, 112 (2), 382-90
PubMed 25461803

Shulzhenko N, Lyng H, Sanson GF, Morgun A (2014)
Ménage à trois: an evolutionary interplay between human papillomavirus, a tumor, and a woman
Trends Microbiol, 22 (6), 345-53
PubMed 24674660

Torheim T, Malinen E, Kvaal K, Lyng H, Indahl UG, Andersen EK, Futsaether CM (2014)
Classification of dynamic contrast enhanced MR images of cervical cancers using texture analysis and support vector machines
IEEE Trans Med Imaging, 33 (8), 1648-56
PubMed 24802069

Publications 2013

Andersen EK, Hole KH, Lund KV, Sundfør K, Kristensen GB, Lyng H, Malinen E (2013)
Pharmacokinetic parameters derived from dynamic contrast enhanced MRI of cervical cancers predict chemoradiotherapy outcome
Radiother Oncol, 107 (1), 117-22
PubMed 23333024

Lando M, Wilting SM, Snipstad K, Clancy T, Bierkens M, Aarnes EK, Holden M, Stokke T, Sundfør K, Holm R, Kristensen GB, Steenbergen RD, Lyng H (2013)
Identification of eight candidate target genes of the recurrent 3p12-p14 loss in cervical cancer by integrative genomic profiling
J Pathol, 230 (1), 59-69
PubMed 23335387

Mine KL, Shulzhenko N, Yambartsev A, Rochman M, Sanson GF, Lando M, Varma S, Skinner J, Volfovsky N, Deng T, Brenna SM, Carvalho CR, Ribalta JC, Bustin M, Matzinger P, Silva ID, Lyng H, Gerbase-DeLima M, Morgun A (2013)
Gene network reconstruction reveals cell cycle and antiviral genes as major drivers of cervical cancer
Nat Commun, 4, 1806
PubMed 23651994

Ragnum HB, Røe K, Holm R, Vlatkovic L, Nesland JM, Aarnes EK, Ree AH, Flatmark K, Seierstad T, Lilleby W, Lyng H (2013)
Hypoxia-independent downregulation of hypoxia-inducible factor 1 targets by androgen deprivation therapy in prostate cancer
Int J Radiat Oncol Biol Phys, 87 (4), 753-60
PubMed 24035332

Publications 2012

Halle C, Andersen E, Lando M, Aarnes EK, Hasvold G, Holden M, Syljuåsen RG, Sundfør K, Kristensen GB, Holm R, Malinen E, Lyng H (2012)
Hypoxia-induced gene expression in chemoradioresistant cervical cancer revealed by dynamic contrast-enhanced MRI
Cancer Res, 72 (20), 5285-95
PubMed 22890239

Røe K, Mikalsen LT, van der Kogel AJ, Bussink J, Lyng H, Ree AH, Marignol L, Olsen DR (2012)
Vascular responses to radiotherapy and androgen-deprivation therapy in experimental prostate cancer
Radiat Oncol, 7, 75
PubMed 22621752

Publications 2011

Andersen EK, Hole KH, Lund KV, Sundfør K, Kristensen GB, Lyng H, Malinen E (2011)
Dynamic contrast-enhanced MRI of cervical cancers: temporal percentile screening of contrast enhancement identifies parameters for prediction of chemoradioresistance
Int J Radiat Oncol Biol Phys, 82 (3), e485-92
PubMed 22014954

Andersen EK, Kristensen GB, Lyng H, Malinen E (2011)
Pharmacokinetic analysis and k-means clustering of DCEMR images for radiotherapy outcome prediction of advanced cervical cancers
Acta Oncol, 50 (6), 859-65
PubMed 21767185

Bergersen LC, Glad IK, Lyng H (2011)
Weighted lasso with data integration
Stat Appl Genet Mol Biol, 10 (1)
PubMed 23089821

Halle C, Lando M, Sundfør K, Kristensen GB, Holm R, Lyng H (2011)
Phosphorylation of EGFR measured with in situ proximity ligation assay: relationship to EGFR protein level and gene dosage in cervical cancer
Radiother Oncol, 101 (1), 152-7
PubMed 21680035

Halle C, Lando M, Svendsrud DH, Clancy T, Holden M, Sundfør K, Kristensen GB, Holm R, Lyng H (2011)
Membranous expression of ectodomain isoforms of the epidermal growth factor receptor predicts outcome after chemoradiotherapy of lymph node-negative cervical cancer
Clin Cancer Res, 17 (16), 5501-12
PubMed 21737508

Landsverk KS, Patzke S, Rein ID, Stokke C, Lyng H, De Angelis PM, Stokke T (2011)
Three independent mechanisms for arrest in G2 after ionizing radiation
Cell Cycle, 10 (5), 819-29
PubMed 21325885

Publications 2009

Holm R, Ali T, Svendsrud DH, Nesland JM, Kristensen GB, Lyng H (2009)
Expression of 14-3-3sigma in cervical squamous cell carcinomas: relationship with clinical outcome
Oncol Rep, 22 (1), 11-5
PubMed 19513498

Lando M, Holden M, Bergersen LC, Svendsrud DH, Stokke T, Sundfør K, Glad IK, Kristensen GB, Lyng H (2009)
Gene dosage, expression, and ontology analysis identifies driver genes in the carcinogenesis and chemoradioresistance of cervical cancer
PLoS Genet, 5 (11), e1000719
PubMed 19911042

Publications 2008

Ferkingstad E, Frigessi A, Lyng H (2008)
Indirect genomic effects on survival from gene expression data
Genome Biol, 9 (3), R58
PubMed 18358079

Holm R, Kraus I, Skomedal H, Langerød A, Kristensen GB, Lyng H (2008)
Human papillomavirus DNA and e6/e7 mRNA status in relation to survival of patients treated for cervical squamous cell carcinoma
Open Virol J, 2, 74-81
PubMed 19440467

Lyng H, Lando M, Brøvig RS, Svendsrud DH, Johansen M, Galteland E, Brustugun OT, Meza-Zepeda LA, Myklebost O, Kristensen GB, Hovig E, Stokke T (2008)
GeneCount: genome-wide calculation of absolute tumor DNA copy numbers from array comparative genomic hybridization data
Genome Biol, 9 (5), R86
PubMed 18500990

Nygaard V, Liu F, Holden M, Kuo WP, Trimarchi J, Ohno-Machado L, Cepko CL, Frigessi A, Glad IK, Wiel MA, Hovig E, Lyng H (2008)
Validation of oligoarrays for quantitative exploration of the transcriptome
BMC Genomics, 9, 258
PubMed 18513391

Publications 2007

Lyng H, Sitter B, Bathen TF, Jensen LR, Sundfør K, Kristensen GB, Gribbestad IS (2007)
Metabolic mapping by use of high-resolution magic angle spinning 1H MR spectroscopy for assessment of apoptosis in cervical carcinomas
BMC Cancer, 7, 11
PubMed 17233882

Publications 2006

Lyng H, Brøvig RS, Svendsrud DH, Holm R, Kaalhus O, Knutstad K, Oksefjell H, Sundfør K, Kristensen GB, Stokke T (2006)
Gene expressions and copy numbers associated with metastatic phenotypes of uterine cervical cancer
BMC Genomics, 7, 268
PubMed 17054779

Publications 2005

Frigessi A, van de Wiel MA, Holden M, Svendsrud DH, Glad IK, Lyng H (2005)
Genome-wide estimation of transcript concentrations from spotted cDNA microarray data
Nucleic Acids Res, 33 (17), e143
PubMed 16204447

Lyng H, Landsverk KS, Kristiansen E, DeAngelis PM, Ree AH, Myklebost O, Hovig E, Stokke T (2005)
Response of malignant B lymphocytes to ionizing radiation: gene expression and genotype
Int J Cancer, 115 (6), 935-42
PubMed 15723354

Scheel I, Aldrin M, Glad IK, Sørum R, Lyng H, Frigessi A (2005)
The influence of missing value imputation on detection of differentially expressed genes from microarray data
Bioinformatics, 21 (23), 4272-9
PubMed 16216830

Publications 2004

Landsverk KS, Lyng H, Stokke T (2004)
The response of malignant B lymphocytes to ionizing radiation: cell cycle arrest, apoptosis and protection against the cytotoxic effects of the mitotic inhibitor nocodazole
Radiat Res, 162 (4), 405-15
PubMed 15447042

Lyng H, Badiee A, Svendsrud DH, Hovig E, Myklebost O, Stokke T (2004)
Profound influence of microarray scanner characteristics on gene expression ratios: analysis and procedure for correction
BMC Genomics, 5 (1), 10
PubMed 15018648

Lyng H, Beigi M, Svendsrud DH, Brustugun OT, Stokke T, Kristensen GB, Sundfør K, Skjønsberg A, De Angelis PM (2004)
Intratumor chromosomal heterogeneity in advanced carcinomas of the uterine cervix
Int J Cancer, 111 (3), 358-66
PubMed 15221962

Publications 2001

Lyng H, Sundfor K, Rofstad EK (2001)
Serial changes in tumor oxygenation during the early phase of radiation therapy in cervical cancer - Are we quantitating hypoxia change? Response
Int. J. Radiat. Oncol. Biol. Phys., 49 (1), 285-289

Lyng H, Vorren AO, Sundfør K, Taksdal I, Lien HH, Kaalhus O, Rofstad EK (2001)
Intra- and intertumor heterogeneity in blood perfusion of human cervical cancer before treatment and after radiotherapy
Int J Cancer, 96 (3), 182-90
PubMed 11410887

Lyng H, Vorren AO, Sundfør K, Taksdal I, Lien HH, Kaalhus O, Rofstad EK (2001)
Assessment of tumor oxygenation in human cervical carcinoma by use of dynamic Gd-DTPA-enhanced MR imaging
J Magn Reson Imaging, 14 (6), 750-6
PubMed 11747032

Måseide K, Lyng H, Rofstad EK (2001)
Microvessel oxyhemoglobin saturation does not reflect tissue oxygen tension in human melanoma xenografts
Microvasc Res, 61 (2), 199-202
PubMed 11254399

Publications 2000

Bjørnaes I, Lyng H, Dahle GA, Kaalhus O, Rofstad EK (2000)
Intratumor heterogeneity in perfusion in human melanoma xenografts measured by contrast-enhanced magnetic resonance imaging
Magn Reson Imaging, 18 (8), 997-1002
PubMed 11121704

Lyng H, Haraldseth O, Rofstad EK (2000)
Measurement of cell density and necrotic fraction in human melanoma xenografts by diffusion weighted magnetic resonance imaging
Magn Reson Med, 43 (6), 828-36
PubMed 10861877

Lyng H, Sundfør K, Rofstad EK (2000)
Changes in tumor oxygen tension during radiotherapy of uterine cervical cancer: relationships to changes in vascular density, cell density, and frequency of mitosis and apoptosis
Int J Radiat Oncol Biol Phys, 46 (4), 935-46
PubMed 10705016

Lyng H, Sundfør K, Tropé C, Rofstad EK (2000)
Disease control of uterine cervical cancer: relationships to tumor oxygen tension, vascular density, cell density, and frequency of mitosis and apoptosis measured before treatment and during radiotherapy
Clin Cancer Res, 6 (3), 1104-12
PubMed 10741740

Rofstad EK, Sundfør K, Lyng H, Tropé CG (2000)
Hypoxia-induced treatment failure in advanced squamous cell carcinoma of the uterine cervix is primarily due to hypoxia-induced radiation resistance rather than hypoxia-induced metastasis
Br J Cancer, 83 (3), 354-9
PubMed 10917551

Sundfør K, Lyng H, Tropé CG, Rofstad EK (2000)
Treatment outcome in advanced squamous cell carcinoma of the uterine cervix: relationships to pretreatment tumor oxygenation and vascularization
Radiother Oncol, 54 (2), 101-7
PubMed 10699471

Publications 1999

Lyng H, Tanum G, Evensen JF, Rofstad EK (1999)
Changes in oxygen tension during radiotherapy of head and neck tumours
Acta Oncol, 38 (8), 1037-42
PubMed 10665759

Olsen G, Lyng H, Tufto I, Solberg K, Bjørnaes I, Rofstad EK (1999)
Measurement of proliferation activity in human melanoma xenografts by magnetic resonance imaging
Magn Reson Imaging, 17 (3), 393-402
PubMed 10195582

Publications 1998

Lyng H, Dahle GA, Kaalhus O, Skretting A, Rofstad EK (1998)
Measurement of perfusion rate in human melanoma xenografts by contrast-enhanced magnetic resonance imaging
Magn Reson Med, 40 (1), 89-98
PubMed 9660558

Lyng H, Sundfor K, Rofstad EK (1998)
Oxygen tension and not vascular density or apoptosis predicts for metastasis in human cervix carcinoma
20TH EUROPEAN CONFERENCE ON MICROCIRCULATION, 13-17

Lyng H, Sundfør K, Rofstad EK (1998)
Oxygen tension in human squamous cell carcinoma and adenocarcinoma of the uterine cervix
Adv Exp Med Biol, 454, 635-41
PubMed 9889944

Sundfør K, Lyng H, Rofstad EK (1998)
Tumour hypoxia and vascular density as predictors of metastasis in squamous cell carcinoma of the uterine cervix
Br J Cancer, 78 (6), 822-7
PubMed 9743308

Sundfør K, Lyng H, Rofstad EK (1998)
Oxygen tension and vascular density in adenocarcinoma and squamous cell carcinoma of the uterine cervix
Acta Oncol, 37 (7-8), 665-70
PubMed 10050984

Tufto I, Lyng H, Rofstad EK (1998)
Vascular density in human melanoma xenografts: relationship to angiogenesis, perfusion and necrosis
Cancer Lett, 123 (2), 159-65
PubMed 9489483

Publications 1997

Lyng H, Sundfør K, Rofstad EK (1997)
Oxygen tension in human tumours measured with polarographic needle electrodes and its relationship to vascular density, necrosis and hypoxia
Radiother Oncol, 44 (2), 163-9
PubMed 9288845

Lyng H, Sundfør K, Tanum G, Rofstad EK (1997)
Oxygen tension in primary tumours of the uterine cervix and lymph node metastases of the head and neck
Adv Exp Med Biol, 428, 55-60
PubMed 9500029

Lyng H, Tufto I, Skretting A, Rofstad EK (1997)
Proton relaxation times and interstitial fluid pressure in human melanoma xenografts
Br J Cancer, 75 (2), 180-3
PubMed 9010023

Sundfør K, Lyng H, Kongsgård UL, Tropé C, Rofstad EK (1997)
Polarographic measurement of pO2 in cervix carcinoma
Gynecol Oncol, 64 (2), 230-6
PubMed 9038268

Walenta S, Salameh A, Lyng H, Evensen JF, Mitze M, Rofstad EK, Mueller-Klieser W (1997)
Correlation of high lactate levels in head and neck tumors with incidence of metastasis
Am J Pathol, 150 (2), 409-15
PubMed 9033256

Publications 1996

Lyng H, Sundfør K, Tropé C, Rofstad EK (1996)
Oxygen tension and vascular density in human cervix carcinoma
Br J Cancer, 74 (10), 1559-63
PubMed 8932335

Rofstad EK, Eide K, Skøyum R, Hystad ME, Lyng H (1996)
Apoptosis, energy metabolism, and fraction of radiobiologically hypoxic cells: a study of human melanoma multicellular spheroids
Int J Radiat Biol, 70 (3), 241-9
PubMed 8800195

Rofstad EK, Johnsen NM, Lyng H (1996)
Hypoxia-induced tetraploidisation of a diploid human melanoma cell line in vitro
Br J Cancer Suppl, 27, S136-9
PubMed 8763866

Rofstad EK, Lyng H (1996)
Xenograft model systems for human melanoma
Mol Med Today, 2 (9), 394-403
PubMed 8885259

Tufto I, Lyng H, Rofstad EK (1996)
Interstitial fluid pressure, perfusion rate and oxygen tension in human melanoma xenografts
Br J Cancer Suppl, 27, S252-5
PubMed 8763891

Publications 1995

Jakobsen I, Kaalhus O, Lyng H, Rofstad EK (1995)
Detection of necrosis in human tumour xenografts by proton magnetic resonance imaging
Br J Cancer, 71 (3), 456-61
PubMed 7880724

Jakobsen I, Lyng H, Kaalhus O, Rofstad EK (1995)
MRI of human tumor xenografts in vivo: proton relaxation times and extracellular tumor volume
Magn Reson Imaging, 13 (5), 693-700
PubMed 8569443

Lyng H, Olsen DR, Petersen SB, Rofstad EK (1995)
31P NMR spectroscopy studies of phospholipid metabolism in human melanoma xenograft lines differing in rate of tumour cell proliferation
NMR Biomed, 8 (2), 65-71
PubMed 7547188

Lyng H, Rofstad EK (1995)
Treatment failure following sequential thermoradiotherapy of locally advanced breast carcinoma occurs primarily in poorly vascularized tumors
Oncology, 52 (6), 443-7
PubMed 7478428

Olsen DR, Lyng H, Petersen S, Rofstad EK (1995)
Spin-lattice relaxation time of inorganic phosphate in human tumor xenografts measured in vivo by 31P-magnetic resonance spectroscopy. Influence of oxygen tension
Acta Oncol, 34 (3), 339-43
PubMed 7779420

Olsen DR, Lyng H, Petersen SB, Rofstad EK (1995)
Effect of melanin on phosphorus T1S in human melanoma xenografts studied by 31P MRS
Magn Reson Imaging, 13 (6), 847-52
PubMed 8544656

Publications 1994

Olsen DR, Lyng H, Southon TE, Rofstad EK (1994)
31P-nuclear magnetic resonance spectroscopy in vivo of four human melanoma xenograft lines: spin-lattice relaxation times
Radiother Oncol, 32 (1), 54-62
PubMed 7938679

Rofstad EK, Lyng H, Olsen DR, Steinsland E (1994)
Non-invasive assessment of tumor oxygenation status by integrated 31P NMR spectroscopy and 1H NMR imaging
Adv Exp Med Biol, 345, 531-8
PubMed 8079755

Rofstad EK, Steinsland E, Kaalhus O, Chang YB, Høvik B, Lyng H (1994)
Magnetic resonance imaging of human melanoma xenografts in vivo: proton spin-lattice and spin-spin relaxation times versus fractional tumour water content and fraction of necrotic tumour tissue
Int J Radiat Biol, 65 (3), 387-401
PubMed 7908318

Publications 1993

Lyng H, Monge OR, Sager EM, Rofstad EK (1993)
Prediction of treatment temperatures in clinical hyperthermia of locally advanced breast carcinoma: the use of contrast enhanced computed tomography
Int J Radiat Oncol Biol Phys, 26 (3), 451-7
PubMed 8390419

Lyng H, Olsen DR, Southon TE, Rofstad EK (1993)
31P-nuclear magnetic resonance spectroscopy in vivo of six human melanoma xenograft lines: tumour bioenergetic status and blood supply
Br J Cancer, 68 (6), 1061-70
PubMed 8260356

Lyng H, Rofstad EK (1993)
Thermal dose and secondary tumour cell death
Int J Hyperthermia, 9 (5), 755-61
PubMed 8245585

Publications 1992

Lyng H, Skretting A, Rofstad EK (1992)
Blood flow in six human melanoma xenograft lines with different growth characteristics
Cancer Res, 52 (3), 584-92
PubMed 1732046

Publications 1991

Lyng H, Monge OR, Bøhler PJ, Rofstad EK (1991)
The relevance of tumour and surrounding normal tissue vascular density in clinical hyperthermia of locally advanced breast carcinoma
Int J Radiat Biol, 60 (1-2), 189-93
PubMed 1677970

Lyng H, Monge OR, Bøhler PJ, Rofstad EK (1991)
Temperature distribution in locally advanced breast carcinoma during hyperthermic treatment: relationship to perfusion, vascular density, and histology
Int J Radiat Oncol Biol Phys, 21 (2), 423-30
PubMed 1648045

Lyng H, Monge OR, Bøhler PJ, Rofstad EK (1991)
Relationships between thermal dose and heat-induced tissue and vascular damage after thermoradiotherapy of locally advanced breast carcinoma
Int J Hyperthermia, 7 (3), 403-15
PubMed 1919137

Lyng H, Monge OR, Bøhler PJ, Rofstad EK (1991)
Changes in temperatures and thermal doses with fraction number during hyperthermic treatment of locally advanced breast carcinoma
Int J Hyperthermia, 7 (6), 815-25
PubMed 1666900

Publications 1990

Monge OR, Lindsköld L, Lyng H, Sager EM (1990)
Positioning of temperature measurement points using multiplanar computed tomography
Int J Hyperthermia, 6 (5), 957-60
PubMed 2250121