|Stine Aske Danielsen|
|Phone:||+47 2278 1732|
I work as a Post.doc in the Molecular Genetics group led by Prof. Ragnhild A. Lothe. Both my MSc and PhD in cancer genetics were obtained in Lothe’s laboratory through the University of Oslo.
My main focus is alterations in cancer critical genes and their respective signaling pathways in colorectal cancer. Additionally, the more rare malignant peripheral nerve sheath tumors are also occupying some of my time. For the most part I use traditional genetic techniques such as PCR, Sanger sequencing, and fragment analysis for detection of DNA mutations and alterations.
More specifically, I am currently involved in two projects with international collaboration partners in which both are focusing on genes that if altered may predispose to colorectal cancer. Of internal projects, one is dealing with a potential prognostic marker for colorectal cancer, whereas another study is focusing on the exome of colorectal tumors with a microsatellite instable phenotype.
Portrait of the PI3K/AKT pathway in colorectal cancer
Biochim Biophys Acta, 1855 (1), 104-21
Epigenetic and genetic features of 24 colon cancer cell lines
Oncogenesis, 2, e71
A tissue-based comparative effectiveness analysis of biomarkers for early detection of colorectal tumors
Clin Transl Gastroenterol, 3, e27
MiR-9, -31, and -182 deregulation promote proliferation and tumor cell survival in colon cancer
Neoplasia, 14 (9), 868-79
Three epigenetic biomarkers, GDF15, TMEFF2, and VIM, accurately predict bladder cancer from DNA-based analyses of urine samples
Clin Cancer Res, 16 (23), 5842-51
Germline and somatic NF1 mutations in sporadic and NF1-associated malignant peripheral nerve sheath tumours
J Pathol, 217 (5), 693-701
RAS signaling in colorectal carcinomas through alteration of RAS, RAF, NF1, and/or RASSF1A
Neoplasia, 10 (7), 680-6, 2 p following 686