Article on classification of GISTs by array CGH published in "Cancer Research"
Histologically related connective tissue tumors, leiomyosarcomas (LMSs) and gastrointestinal stromal tumors (GISTs), were until recently diagnosed as one tumor type. Leonardo Meza-Zepeda et al has shown that that the patterns of genome copy-number aberrations reflect the underlying biology of the tumors. These important findings were recently published in the well reputed journal "Cancer Research" (impact factor 7,6). Meza-Zepeda is working as a post doc in Ola Myklebost's group at the Department of Tumor Biology.
By global array CGH analysis they could, without supervision, separate completely the two tumor types. Because GISTs are sensitive to specific tyrosinase inhibitors, this may indicate clinical utility for array CGH to assist in this clinically important distinction.
From major journals, first or last author from the Institute for Cancer Research
Brativnyk A, Ankill J, Helland Å, Fleischer T(2024) Multi-omics analysis reveals epigenetically regulated processes and patient classification in lung adenocarcinoma Int J Cancer(in press) DOI 10.1002/ijc.34915, PubMed 38489486
Haakensen VD, Öjlert ÅK, Thunold S, Farooqi S, Nowak AK, Chin WL, Grundberg O, Szejniuk WM, Cedres S, Sørensen JB, Dalen TS, Lund-Iversen M, Bjaanæs M, Helland Å(2024) UV1 telomerase vaccine with ipilimumab and nivolumab as second line treatment for pleural mesothelioma - A phase II randomised trial Eur J Cancer, 202, 113973(in press) DOI 10.1016/j.ejca.2024.113973, PubMed 38447379
Zhao Z, Zobolas J, Zucknick M, Aittokallio T(2024) Tutorial on survival modeling with applications to omics data Bioinformatics(in press) DOI 10.1093/bioinformatics/btae132, PubMed 38445722
Wang HL, Siow R, Schmauck-Medina T, Zhang J, Sandset PM, Filshie C, Lund Ø, Partridge L, Bergersen LH, Juel Rasmussen L, Palikaras K, Sotiropoulos I, Storm-Mathisen J, Rubinsztein DC, Spillantini MG, De Zeeuw CI, Watne LO, Vyhnalek M, Veverova K, Liang KX, Tavernarakis N, Bohr VA, Yokote K, Saarela J, Nilsen Het al.(2024) Meeting Summary of The NYO3 5th NO-Age/AD Meeting and the 1st Norway-UK Joint Meeting on Aging and Dementia: Recent Progress on the Mechanisms and Interventional Strategies J Gerontol A Biol Sci Med Sci, 79(4) DOI 10.1093/gerona/glae029, PubMed 38289789
Huynh TM, Falk RS, Hellebust TP, Dale E, Astrup GL, Hjermstad MJ, Malinen E, Bjordal K, Kiserud CE, Herlofson BB, Nome R, Amdal CD(2024) Chronic fatigue in long-term survivors of head and neck cancer treated with radiotherapy Radiother Oncol, 195, 110231(in press) DOI 10.1016/j.radonc.2024.110231, PubMed 38518958
Lukovic J, Pintilie M, Han K, Fyles AW, Bruce JP, Quevedo R, Pugh TJ, Fjeldbo CS, Lyng H, Milosevic MF(2024) An Immune Gene Expression Risk Score for Distant Metastases after Radiotherapy for Cervical Cancer Clin Cancer Res, 30(6), 1200-1207 DOI 10.1158/1078-0432.CCR-23-2085, PubMed 38180733