Based on research by Sigurd Bøe in the group, two patents have been filed. These describe the combination of photochemical internalization (PCI) treatment and PNA molecules and siRNA molecules, respectively. Two articles in the journal Oligonucleotides describe apsects of the content.
Cell where the nucleus is shown with green fluorescence, the nucleus is stained blue, the lysosomes are stained red. As can be seen, the green is diffused across the nucleus and also lysosomes, thereby producing the compound color.
Cell where the nucleus is shown with green fluorescence, the nucleus is stained blue, the lysosomes are stained red. As can be seen, the green is diffused across the nucleus and also lysosomes, thereby producing the compound color.
As scientists working with PCI at the Radium Hospital are bound by overriding contracts, PCI opted for inclusion of the commercial potential in this research. The work clearly shows the potential for the combination of PCI and siRNA/PNA for targeted treatment of cancer by modifying the expression of selected target genes. The company issued a stock exchange note related to the agreemnt. The PNA article is available from the publisher, or on request, while the siRNA article has been accepted for publication. This research is mostly part of the doctoral work of Sigurd Bøe. Some information on his research may be inspected on Sigurds page. And some illustrations of the mechanisms may also be found.
 
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