Pål André Holme
Position: Professor II, MD, PhD
Phone: +47 23 07 36 11
Email:
 

Author network for Pål Andre Holme by COREMINE medical


Publications 2017

Berntorp E, Dargaud Y, Hart D, Lobet S, Mancuso ME, d'Oiron R, Perry D, Pollard D, van den Berg M, Blatný J, Chambost H, Doria AS, Holme PA, Kaczmarek R, Mantovani L, McLaughlin P, Nanayakkara L, Petrini P, Sannié T, Laane E, Maia R, Dettoraki A, Farrell A, Halimeh S, Raza S et al. (2017)
The second Team Haemophilia Education Meeting, 2016, Frankfurt, Germany
Eur J Haematol, 98 Suppl 85, 1-15
PubMed 28101938

Osooli M, Steen Carlsson K, Baghaei F, Holmström M, Rauchensteiner S, Holme PA, Hvitfeldt L, Astermark J, Berntorp E (2017)
The association between health utility and joint status among people with severe haemophilia A: findings from the KAPPA register
Haemophilia, 23 (3), e180-e187
PubMed 28393468

Schultz NH, Tran HTT, Bjørnsen S, Henriksson CE, Sandset PM, Holme PA (2017)
The reversal effect of prothrombin complex concentrate (PCC), activated PCC and recombinant activated factor VII against anticoagulation of Xa inhibitor
Thromb J, 15, 6
PubMed 28239301

Publications 2016

Barratt-Due A, Floisand Y, Orrem HL, Kvam AK, Holme PA, Bergseth G, Tjonnfjore GE, Mollnes TE (2016)
Complement activation is a crucial pathogenic factor in catastrophic antiphospholipid syndrome
RHEUMATOLOGY, 55 (7), 1337-1340

Barratt-Due A, Fløisand Y, Orrem HL, Kvam AK, Holme PA, Bergseth G, Tjønnfjord GE, Mollnes TE (2016)
Complement activation is a crucial pathogenic factor in catastrophic antiphospholipid syndrome
Rheumatology (Oxford), 55 (7), 1337-9
PubMed 27105662

Berger K, Schopohl D, Lowe G, Holme PA, Tait RC, Combescure C, Rauchensteiner S, Klamroth R (2016)
How to compare cardiovascular disease and risk factors in elderly patients with haemophilia with the general population
Haemophilia, 22 (5), e406-16
PubMed 27650262

Haig Y, Enden T, Grøtta O, Kløw NE, Slagsvold CE, Ghanima W, Sandvik L, Hafsahl G, Holme PA, Holmen LO, Njaaastad AM, Sandbæk G, Sandset PM, CaVenT Study Group (2016)
Post-thrombotic syndrome after catheter-directed thrombolysis for deep vein thrombosis (CaVenT): 5-year follow-up results of an open-label, randomised controlled trial
Lancet Haematol, 3 (2), e64-71
PubMed 26853645

James PD, Mahlangu J, Bidlingmaier C, Mingot-Castellano ME, Chitlur M, Fogarty PF, Cuker A, Mancuso ME, Holme PA, Grabell J, Satkunam N, Hopman WM, Mathew P, Global Emerging HEmostasis Experts Panel (GEHEP) (2016)
Evaluation of the utility of the ISTH-BAT in haemophilia carriers: a multinational study
Haemophilia, 22 (6), 912-918
PubMed 27868369

Publications 2015

De Moerloose P, Holme PA, Combescure C, Tait R, Rauchensteiner S, Berntorp E, Adv Working Grp (2015)
Prophylaxis for Older People with Haemophilia in Europe - The H3 Study
Haemophilia, 21 2, 20

Fogarty PF, Mancuso ME, Kasthuri R, Bidlingmaier C, Chitlur M, Gomez K, Holme PA, James P, Kruse-Jarres R, Mahlangu J, Mingot-Castellano ME, Soni A, Global Emerging Hemophilia Panel (GEHEP) (2015)
Presentation and management of acute coronary syndromes among adult persons with haemophilia: results of an international, retrospective, 10-year survey
Haemophilia, 21 (5), 589-97
PubMed 25689278

Ghanima W, Khelif A, Waage A, Michel M, Tjønnfjord GE, Romdhan NB, Kahrs J, Darne B, Holme PA, RITP study group (2015)
Rituximab as second-line treatment for adult immune thrombocytopenia (the RITP trial): a multicentre, randomised, double-blind, placebo-controlled trial
Lancet, 385 (9978), 1653-61
PubMed 25662413

Hermans C, Negrier C, Holme PA (2015)
Is Thromboprophylaxis Required Among Patients With Haemophilia Undergoing Major Orthopedic Surgery: Combining Epidemiological studies and survey results within the advance working group
Haemophilia, 21 2, 80

Holme PA (2015)
Do global assays have a role in clinical practice?
Haemophilia, 21 2, 10

Holme PA, Combescure C, Tait RC, Berntorp E, Rauchensteiner S, de Moerloose P, ADVANCE Working Group (2015)
Hypertension, haematuria and renal functioning in haemophilia - a cross-sectional study in Europe
Haemophilia, 22 (2), 248-255
PubMed 27880029

Valentino LA, Holme PA (2015)
Should anti-inhibitor coagulant complex and tranexamic acid be used concomitantly?
Haemophilia, 21 (6), 709-14
PubMed 26036756

Publications 2014

Husøy MA, Brinch L, Tjønnfjord GE, Gedde-Dahl T, Heldal D, Holme PA, Dybedal I, Kolstad A, Akkök ÇA, Rollag H, Gaustad P, Bergan S, Egeland T, Josefsen D, Kvalheim G, Fløisand Y (2014)
[Allogeneic stem-cell transplantation in adults 1985-2012: results and development]
Tidsskr Nor Laegeforen, 134 (16), 1569-75
PubMed 25178233

Kristiansen A, Brandt L, Agoritsas T, Akl EA, Berge E, Bondi J, Dahm AE, Granan LP, Halvorsen S, Holme PA, Flem Jacobsen A, Jacobsen EM, Neumann I, Sandset PM, Sætre T, Tveit A, Vartdal T, Guyatt G, Vandvik PO (2014)
Adaptation of trustworthy guidelines developed using the GRADE methodology: a novel five-step process
Chest, 146 (3), 727-34
PubMed 25180723

Misceo D, Holmgren A, Louch WE, Holme PA, Mizobuchi M, Morales RJ, De Paula AM, Stray-Pedersen A, Lyle R, Dalhus B, Christensen G, Stormorken H, Tjønnfjord GE, Frengen E (2014)
A dominant STIM1 mutation causes Stormorken syndrome
Hum Mutat, 35 (5), 556-64
PubMed 24619930

Tran HT, Sørensen B, Bjørnsen S, Pripp AH, Tjønnfjord GE, Andre Holme P (2014)
Monitoring bypassing agent therapy - a prospective crossover study comparing thromboelastometry and thrombin generation assay
Haemophilia, 21 (2), 275-83
PubMed 25521720

Tvedt TH, Holme PA, Bruserud Ø (2014)
[A man in his 80s with muscle stiffness and skin bleeding]
Tidsskr Nor Laegeforen, 134 (10), 1058-61
PubMed 24865732

Vandvik PO, Granan LP, Holme PA, Bondi J (2014)
[Antithrombotic therapy in surgery]
Tidsskr Nor Laegeforen, 134 (9), 925
PubMed 24828716

Publications 2013

Mathijssen NC, Masereeuw R, Holme PA, van Kraaij MG, Laros-van Gorkom BA, Peyvandi F, van Heerde WL (2013)
Increased volume of distribution for recombinant activated factor VII and longer plasma-derived factor VII half-life may explain their long lasting prophylactic effect
Thromb Res, 132 (2), 256-62
PubMed 23834817

Tran HT, Sørensen B, Rea CJ, Bjørnsen S, Ueland T, Pripp AH, Tjønnfjord GE, Holme PA (2013)
Tranexamic acid as adjunct therapy to bypassing agents in haemophilia A patients with inhibitors
Haemophilia, 20 (3), 369-75
PubMed 24251535

Tran HT, Tjønnfjord GE, Holme PA (2013)
Use of thromboelastography and thrombin generation assay to predict clinical phenotype in patients with severe FVII deficiency
Haemophilia, 20 (1), 141-6
PubMed 23992369

van Geffen M, Mathijssen NC, Holme PA, Laros-van Gorkom BA, van Kraaij MG, Masereeuw R, Peyvandi F, van Heerde WL (2013)
Pharmacodynamics of recombinant activated factor VII and plasma-derived factor VII in a cohort of severe FVII deficient patients
Thromb Res, 132 (1), 116-22
PubMed 23731565

Westberg M, Paus AC, Holme PA, Tjønnfjord GE (2013)
Haemophilic arthropathy: long-term outcomes in 107 primary total knee arthroplasties
Knee, 21 (1), 147-50
PubMed 24156923

Publications 2012

Batorova A, Holme P, Gringeri A, Richards M, Hermans C, Altisent C, Lopez-Fernández M, Fijnvandraat K, European Haemophilia Treatment Standardisation Board (2012)
Continuous infusion in haemophilia: current practice in Europe
Haemophilia, 18 (5), 753-9
PubMed 22530687

Holmström M, Tran HT, Holme PA (2012)
Combined treatment with APCC (FEIBA®) and tranexamic acid in patients with haemophilia A with inhibitors and in patients with acquired haemophilia A--a two-centre experience
Haemophilia, 18 (4), 544-9
PubMed 22348384

Publications 2011

Enden T, Haig Y, Kløw NE, Slagsvold CE, Sandvik L, Ghanima W, Hafsahl G, Holme PA, Holmen LO, Njaastad AM, Sandbæk G, Sandset PM, CaVenT Study Group (2011)
Long-term outcome after additional catheter-directed thrombolysis versus standard treatment for acute iliofemoral deep vein thrombosis (the CaVenT study): a randomised controlled trial
Lancet, 379 (9810), 31-8
PubMed 22172244

Ghanima W, Kleven IW, Enden T, Rosales A, Wik HS, Pederstad L, Holme PA, Sandset PM (2011)
Recurrent venous thrombosis, post-thrombotic syndrome and quality of life after catheter-directed thrombolysis in severe proximal deep vein thrombosis
J Thromb Haemost, 9 (6), 1261-3
PubMed 21489133

Lassila R, Holme PA, Landorph A, Petrini P, Onundarson PT, Hillarp A (2011)
Nordic Haemophilia Council's practical guidelines on diagnosis and management of von Willebrand disease
Semin Thromb Hemost, 37 (5), 495-502
PubMed 22102192

Tran HT, Tjønnfjord GE, Paus A, Holme PA (2011)
rFVIIa administered by continuous infusion during surgery in patients with severe congenital FVII deficiency
Haemophilia, 17 (5), 764-70
PubMed 21707871

Vetlesen A, Holme PA, Lyberg T, Kjeldsen-Kragh J (2011)
Recovery, survival, and function of transfused platelets and detection of platelet engraftment after allogeneic stem cell transplantation
Transfusion, 52 (6), 1321-32
PubMed 22084943

Publications 2010

Astermark J, Altisent C, Batorova A, Diniz MJ, Gringeri A, Holme PA, Karafoulidou A, Lopez-Fernández MF, Reipert BM, Rocino A, Schiavoni M, von Depka M, Windyga J, Fijnvandraat K, European Haemophilia Therapy Standardisation Board (2010)
Non-genetic risk factors and the development of inhibitors in haemophilia: a comprehensive review and consensus report
Haemophilia, 16 (5), 747-66
PubMed 20398077

Ghanima W, Holme PA, Tjønnfjord GE (2010)
[Immune thrombocytopenia--pathophysiology and treatment]
Tidsskr Nor Laegeforen, 130 (21), 2120-3
PubMed 21052113

Publications 2009

Astermark J, Negrier C, Hermans C, Holme PA, Klamroth R, Kotsi P, de Moerloose P, Pasi J, Rocino A, von Depka M, Windyga J, Ludlam CA, Interdisciplinary Working Group IDWG (2009)
European curriculum for thrombosis and haemostasis
Haemophilia, 15 (1), 337-44
PubMed 19149857

Enden T, Kløw NE, Sandvik L, Slagsvold CE, Ghanima W, Hafsahl G, Holme PA, Holmen LO, Njaastad AM, Sandbaek G, Sandset PM, CaVenT study group (2009)
Catheter-directed thrombolysis vs. anticoagulant therapy alone in deep vein thrombosis: results of an open randomized, controlled trial reporting on short-term patency
J Thromb Haemost, 7 (8), 1268-75
PubMed 19422443

Holme PA, Glomstein A, Grønhaug S, Tjønnfjord GE (2009)
Home treatment with bypassing products in inhibitor patients: a 7.5-year experience
Haemophilia, 15 (3), 727-32
PubMed 19320748

Perry D, Berntorp E, Tait C, Dolan G, Holme PA, Laffan M, Lassila R, Mumford A, Pasi J, Wilde J, Will A, Yee TT (2009)
FEIBA prophylaxis in haemophilia patients: a clinical update and treatment recommendations
Haemophilia, 16 (1), 80-9
PubMed 19780845

Vik A, Holme PA, Singh K, Dorenberg E, Nordhus KC, Kumar S, Hansen JB (2009)
Catheter-directed thrombolysis for treatment of deep venous thrombosis in the upper extremities
Cardiovasc Intervent Radiol, 32 (5), 980-7
PubMed 19641959

Publications 2008

Brinch L, Tjønnfjord G, Gedde-Dahl T, Heldal D, Holme PA, Dybedal I (2008)
[Allogeneic stem cell transplantation in acute myelogenous leukemia]
Tidsskr Nor Laegeforen, 128 (15), 1681-2; author reply 1682
PubMed 18704137

Fløisand Y, Brinch L, Dybedal I, Gedde-Dahl T, Heldal D, Holme PA, Egeland T, Tjønnfjord GE (2008)
[Allogeneic stem cell transplantation in adults with acute lymphoblastic leukaemia]
Tidsskr Nor Laegeforen, 128 (22), 2563-6
PubMed 19023351

Holme PA, Michelsen AE (2008)
[A 40-year old woman with dizziness and vomiting]
Tidsskr Nor Laegeforen, 128 (12), 1413-5
PubMed 18584769

Negaard HF, Iversen PO, Østenstad B, Iversen N, Holme PA, Sandset PM (2008)
Hypercoagulability in patients with haematological neoplasia: no apparent initiation by tissue factor
Thromb Haemost, 99 (6), 1040-8
PubMed 18521506

Publications 2007

Enden T, Sandvik L, Kløw NE, Hafsahl G, Holme PA, Holmen LO, Ghanima W, Njaastad AM, Sandbaek G, Slagsvold CE, Sandset PM (2007)
Catheter-directed Venous Thrombolysis in acute iliofemoral vein thrombosis--the CaVenT study: rationale and design of a multicenter, randomized, controlled, clinical trial (NCT00251771)
Am Heart J, 154 (5), 808-14
PubMed 17967583

Holme PA (2007)
[Deficient thrombosis prophylaxis]
Tidsskr Nor Laegeforen, 127 (9), 1176
PubMed 17479132

Tjønnfjord GE, Holme PA (2007)
Factor eight inhibitor bypass activity (FEIBA) in the management of bleeds in hemophilia patients with high-titer inhibitors
Vasc Health Risk Manag, 3 (4), 527-31
PubMed 17969383

Publications 2005

Holme PA, Brosstad F, Tjønnfjord GE (2005)
Acquired haemophilia: management of bleeds and immune therapy to eradicate autoantibodies
Haemophilia, 11 (5), 510-5
PubMed 16128896

Publications 1998

Holme PA, Müller F, Solum NO, Brosstad F, Frøland SS, Aukrust P (1998)
Enhanced activation of platelets with abnormal release of RANTES in human immunodeficiency virus type 1 infection
FASEB J, 12 (1), 79-89
PubMed 9438413

Holme PA, Solum NO, Brosstad F, Pedersen T, Kveine M (1998)
Microvesicles bind soluble fibrinogen, adhere to immobilized fibrinogen and coaggregate with platelets
Thromb Haemost, 79 (2), 389-94
PubMed 9493596

Sakariassen KS, Holme PA, Orvim U, Barstad RM, Solum NO, Brosstad FR (1998)
Shear-induced platelet activation and platelet microparticle formation in native human blood
Thromb Res, 92 (6 Suppl 2), S33-41
PubMed 9886908

Publications 1997

Holme PA, Orvim U, Hamers MJ, Solum NO, Brosstad FR, Barstad RM, Sakariassen KS (1997)
Shear-induced platelet activation and platelet microparticle formation at blood flow conditions as in arteries with a severe stenosis
Arterioscler Thromb Vasc Biol, 17 (4), 646-53
PubMed 9108776

Publications 1996

Holme PA, Røsger M, Solum NO, Brosstad F, Larsen AM, Hovig T (1996)
Glycoprotein IIb-IIIa on platelet-derived microparticles, and microparticle structures studied by electron microscopy, confocal laser microscopy and crossed radio-immunoelectrophoresis
Platelets, 7 (4), 207-14
PubMed 21043689

Publications 1995

Holme PA, Brosstad F, Solum NO (1995)
Platelet-derived microvesicles and activated platelets express factor Xa activity
Blood Coagul Fibrinolysis, 6 (4), 302-10
PubMed 7548677

Holme PA, Solum NO, Brosstad F, Egberg N, Lindahl TL (1995)
Stimulated Glanzmann's thrombasthenia platelets produced microvesicles. Microvesiculation correlates better to exposure of procoagulant surface than to activation of GPIIb-IIIa
Thromb Haemost, 74 (6), 1533-40
PubMed 8772233

Røger M, Høgåsen K, Holme PA, Halstensen TS, Mollnes TE, Hovig T (1995)
The Fluid-phase SC5b-9 Terminal Complement Complex Binds to the GPIIb/IIIa Complex of Thrombin-stimulated Human Blood Platelets Inhibiting Platelet Aggregation
Platelets, 6 (3), 160-8
PubMed 21043620

Solum NO, Holme PA, Pedersen TM (1995)
Detection of biotinylated proteins in crossed immunoelectrophoresis gels: studies on platelet membrane receptors and microparticles
Electrophoresis, 16 (8), 1408-13
PubMed 8529606

Publications 1994

Holme PA, Solum NO, Brosstad F, Røger M, Abdelnoor M (1994)
Demonstration of platelet-derived microvesicles in blood from patients with activated coagulation and fibrinolysis using a filtration technique and western blotting
Thromb Haemost, 72 (5), 666-71
PubMed 7900071

Publications 1993

Holme PA, Brosstad F, Solum NO (1993)
The difference between platelet and plasma FXIII used to study the mechanism of platelet microvesicle formation
Thromb Haemost, 70 (4), 681-6
PubMed 8115996