Ovarian cancer

This project is supported by Mr. John Fredriksen and Ms. Inger Fredriksen Foundation

Team members: Tropé, Rokkones, Kærn, Davidson, Nesland, Giercksky, Gaudernack, Ekstrøm, Lothe, Dørum, Wang , Silins, Abeler, Elstrand, Paulsson, Flørenes, Yuan, Suo, Skei-Jensen, Holm, Hetland, Oksefjell, Risberg, Sandstad, Mikkelsen, Liavåg, Dahl, Huitfeldt

• Quality of life

• Translational research
  We collaborate with several research groups (in molecular genetics, pathology and tumor biology) at the Norwegian Radium Hospital, together with research groups at universities abroad, around the investigation of biological conditions around ovarian cancer.

• Diagnostic procedures for an ovarian cancer laboratory
  • Background
  • Part I: Survival and drug resistance mechanisms of OC cells in effusions (PI: Ben
    Davidson, MD PhD)
  • Part II: Markers of cell cycle and apoptosis in OC (PI: Ruth Holm, PhD)
  • Part III: In vitro chemo-response testing of ovarian carcinomas (PI: Vivi Ann Flørenes,
    PhD)
  • Part IV: Tumor-targeted treatment of ovarian cancer (PI: Henrik Huitfeldt, MD PhD)
  • Part V: Detection of disseminated tumor cells in the bone marrow and blood of patients with epithelial ovarian cancer - micrometastasis project (PI: Janne Kærn MD PhD)
  • Part VI: Isolation and characterization of ovarian cancer stem cells for ovarian targeted cancer immuno-gene therapy (PI: Zhenhe Suo, MD PhD)

• Molecular mechanisms in development and progression of ovarian cancers

• Fertility saving surgery
• Hereditary cancer
  
• Completed studies with ongoing follow-up of patients
• Ongoing clinical studies
  
• Clinical studies planned to start in 2005