Induction of coronary risk factors, including endothelial dysfunction and inflammation in patients treated for cancer and in healthy subjects. Significance for morbidity and mortality.
Supervisor: John Kjekshus
Collaborators: Pål Aukrust, Sophie Fosså, Rune Andersen
To study the development of coronary risk factors and cardiovascular morbidity and mortality in long-term survivors of testicular cancer treated with chemotherapy and/or radiotherapy
To study the long-term consequences of treatment for patients who have had Hodgkin’s disease with respect to the development of cardiovascular disease (and with emphasis on cardiac valve regurgitations)
To study the induction of lipid streaks in connection with induced inflammation after vaccination for typhoid fever in young healthy individuals.
To measure endothelial function in young healthy males with different methods before and after work load and correlate these results with indices of inflammation and endothelial dysfunction measured in blood samples.
Endogenous and exogenous causes for endothelial dysfunction
Supervisors: John Kjekshus, Sopie D. Fosså
Collaborators: Department of Clinical Cancer Research, Research Institute for Internal Medicine, Department of Radiology, Department of Respiratory Medicine
To analyze the long-term consequences of modern cancer therapy on cardiovascular morbidity, mortality and endothelial function. To investigate the relation between different methods measuring endothelial dysfunction in healthy individuals and measure if the endothelial function is altered by vaccination against typhoid fever.
Valvular Dysfunction in Lymphoma Survivors Treated With Autologous Stem Cell Transplantation: A National Cross-Sectional Study
JACC Cardiovasc Imaging, 9 (3), 230-9
Heart Failure and Asymptomatic Left Ventricular Systolic Dysfunction in Lymphoma Survivors Treated With Autologous Stem-Cell Transplantation: A National Cross-Sectional Study
J Clin Oncol, 33 (24), 2683-91
Comparison of the validity of stroke diagnoses in a medical quality register and an administrative health register
Scand J Public Health, 44 (2), 143-9
Exercise-induced vasodilation in healthy males: A marker of reduced endothelial function
Scand Cardiovasc J, 49 (3), 123-9
Atherosclerotic lesions in lymphoma survivors treated with radiotherapy
Radiother Oncol, 110 (3), 448-54
Left ventricular function assessed by two-dimensional speckle tracking echocardiography in long-term survivors of Hodgkin's lymphoma treated by mediastinal radiotherapy with or without anthracycline therapy
Am J Cardiol, 107 (3), 472-7
Cardiovascular risk factors and morbidity in long-term survivors of testicular cancer: a 20-year follow-up study
J Clin Oncol, 28 (30), 4649-57
C-reactive protein; a potential marker of second cancer and cardiovascular disease in testicular cancer survivors?
Eur J Cancer, 46 (18), 3425-33
Valvular dysfunction and left ventricular changes in Hodgkin's lymphoma survivors. A longitudinal study
Br J Cancer, 101 (4), 575-81
Treatment-related differences in cardiovascular risk factors in long-term survivors of testicular cancer
J Cancer Surviv, 1 (1), 8-16