Haemostasis and Bleeding Disorders
Pål André Holme
Our scientific interests are focused on clinical and basic aspects of normal and disturbed haemostasis.
The clinical part is concerned with diagnosis and treatment of disturbances of the thrombohaemorrhagic balance as seen in:
- Glanzmann’s thrombasthenia and in the Bernard-Soulier Syndrome
- Storage Pool Disease
- Sticky Platelet Syndrome
- Drug-dependent platelet hyper/hypo-aggregability
- Hereditary and acquired coagulation factor deficiencies with special emphasis on development of inhibitors and management
The basic part of our research concerns platelet metabolic and morphologic changes caused by activation by physiological agonist; i.e. microparticle formation, secretion of chemokines/interleukins, interaction with endothelium and monocytes, initiation and support of coagulation factor activation, intraplatelet protein synthesis.
Tools and methods used in the above mentioned research are those common to all advanced cell biology, enzymology and protein chemistry.
From left: Stine Bjørnsen, Pål Andre Holme, Adelheid Holm, Ragnhild J Måseide and Nina Haagenrud Schultz
Growth coordination during development
Mar 27, 2017
Jørgen Wesche appointed group leader for the Mesenchymal Cancer Biology Group at the Department of Tumor Biology
Mar 15, 2017
Prestigious research prize from the Norwegian Cancer Society to pioneer in autophagy research
Mar 7, 2017
Pål André Holme
The second Team Haemophilia Education Meeting, 2016, Frankfurt, Germany
Eur J Haematol, 98 Suppl 85, 1-15
Hypertension, haematuria and renal functioning in haemophilia - a cross-sectional study in Europe
Haemophilia, 22 (2), 248-255