Clinical immunology and infectious diseases
The research group focus on immunopathogenesis in primary and secondary immunodeficiency (such as CVID and HIV) and selected infectious diseases, in particular the study of chronic inflammation characterising these disorders. The aim is to improve the understanding of disease mechanisms and to discover new targets for therapeutic intervention. The group works in a translational setting combining close contact to the clinic, in particular Section of Clinical Immunology and Infectious Diseases at OUS, with access to a wide range of immunological methods through extensive collaboration with other groups.
Chronic inflammation is a common feature of both immunodeficiencies and many infectious disorders. While inflammation is vital to the clearance of both invading microbes and potentially malignant cells a continued or exaggerated response will further compromise the patients health. Identifying the factors leading to such an exaggerated response will potentially enable clinicians to modify the inflammatory response of the individual patient with agents targeting anything from intracellular signalling pathways to intercellular cytokine networks and microbiota.
From left: Kari Otterdal, Jan-Cato Holter, Břrre Fevang, Elisabeth Astrup, William Siljan, Magnhild Eide Macpherson, Liv Hesstvedt, Silje Jřrgensen, Ingvild Nordřy
Growth coordination during development
Mar 27, 2017
Jřrgen Wesche appointed group leader for the Mesenchymal Cancer Biology Group at the Department of Tumor Biology
Mar 15, 2017
Prestigious research prize from the Norwegian Cancer Society to pioneer in autophagy research
Mar 7, 2017
CVID and Celiac Disease
Am J Gastroenterol, 112 (2), 393